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| Number | Title | Issue Date |
| 8143448 | Process for the preparation of (3S)-3-amino-N-cyclopropyl-2-hydroxyalkanamide derivatives The present invention relates to a process for the preparation of (2S,3S)-3-amino-N-cyclopropyl-2-hydroxyalkanamides as well as novel compounds prepared or used in the process. ... | 03/27/2012 |
| 7348327 | Compounds The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms. ... | 03/25/2008 |
| 7285600 | Reagents for heat activated polymer crosslinking The present invention is directed to nitrile-oxide precursor compounds, and their preparation and use as an irreversible cross-linking agent in polymers having appropriate functionality, i.e., alkenes, alkynes nitriles, and isocyanates. The present invention is also... | 10/23/2007 |
| 7256217 | Prodrugs of excitatory amino acids This invention relates to synthetic excitatory amino acid prodrugs according to formula (I) and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurolo... | 08/14/2007 |
| 7217845 | Bifunctional polyethylene glycol derivatives The present invention provides novel heterobifunctional and monobifunctional polyethylene glycol derivatives for the pegylation of therapeutically active proteins. The heterobifunctional PEGs which bear two different functional groups as well as the monobifunctional... | 05/15/2007 |
| 7208631 | 2-alkylcysteinamide or salt thereof, process for producing these, and use of these A process for producing a 2-alkylcysteinamide, which comprises hydrolysis of a 4-alkylthiazolidine-4-carboxamide represented by the general formula (2) or a salt thereof: wherein R represents a lower alkyl group ... | 04/24/2007 |
| 7161016 | Cannabimimetic lipid amides as useful medications Novel analogs of arachidonylethanolamide are presented which have higher affinities for the cannabinoid CB1 and/or CB2 receptor sites. Further, most of the analogs exhibit greater metabolic stability than arachidonylethanolamide. The improved receptor affinity and s... | 01/09/2007 |
| 7144897 | Hydroxy alkyl amines Disclosed are compounds of formula X, which are useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions comprising compounds of formula X and methods of preparing the compou... | 12/05/2006 |
| 7119229 | Alkaloid derivative and a pharmaceutical composition containing the same Colchicine derivatives represented by the formula (I) with a halogen or nitric ester group, or pharmaceutically acceptable salts thereof, are described. Pharmaceutical compositions containing the same as effectiv... | 10/10/2006 |
| 7067697 | Cationic liposomes for gene transfer The present invention relates to synthetic cationic lipids, liposome formulations and the use of such compounds to introduce functional bioactive agents into cultured cells. ... | 06/27/2006 |
| 7041855 | Monofunctional polyethylene glycol aldehydes The present invention provides novel monofunctional polyethylene glycol aldehydes for the pegylation of therapeutically active proteins. The pegylated protein conjugates that are produced, retain a substantial portion of their therapeutic activity and are less immun... | 05/09/2006 |
| 7015349 | Reduction of hair growth Compositions including a conjugate of α-difluoromethylornithine can be applied topically to reduce hair growth. ... | 03/21/2006 |
| 6949658 | Process for producing optically active α-amino acid and optically active α-amino acid amide The present invention provides a process for efficiently producing an optically active α-amino acid and an optically active α-amino acid amide. After contacting with cells or processed cells thereof having an ability to asymmetrically hydrolyse, a water solvent is... | 09/27/2005 |
| 6916767 | Antioxidant amines based on n-(4aniliophenyl) amides antioxidant amines based on n-(4-anilinophenyl) amides A composition of matter is disclosed wherein the composition comprises an N-aromatic substituted acid amide compound selected from the group consisting of compounds of formula (I) wherein A and B are independently selected alkylene groups; R1 is selected ... | 07/12/2005 |
| 6864386 | Fluorinated compounds Fluorinated compounds and emulsions including the compounds. The compositions are useful as oxygen carriers and surfactants. In one embodiment, the fluorinated compound is pH sensitive. In one embodiment, the fluorinated compound is a vitamin E derivative. In one em... | 03/08/2005 |
| 6835807 | Drug complex and drug delivery system A drug complex useful as a DDS compound, which is represented by the following formula: A-R—NH—Y—CH2—O—CO-Q, wherein A is a polymer as a drug carrier; R is a spacer, wherein the spacer is an amino acid or an oligopeptide comprising 2 to 8 amino ... | 12/28/2004 |
| 6784315 | Stilbene derivative crystal and method for producing the same A Type IV crystal of (Z)-N-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serinamide hydrochloride, which can be produced by crystallization using a solvent containing water at 2% by weight at the maximum and which has a X ray powder diffraction pattern con... | 08/31/2004 |
| 6770754 | Universal supports for oligonucleotide synthesis Universal supports for oligonucleotide synthesis include a support material represented by the following formula: In this formula, substituent A is selected from H, alkyl, aryl, or a polymeric or silica base material; su... | 08/03/2004 |
| 6759555 | Process for the preparation of combretastatins The present invention provides novel processes for the preparation of combretastatins or stilbene compounds of formulae (I) and (III) wherein A is NH2 or and PG is... | 07/06/2004 |
| 6740780 | Process for the preparation of 1,5-dideoxy-1,5-imino hexitols from oximes or imines A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as drugs. ... | 05/25/2004 |
| RE38506 | Potent inducers of terminal differentiation and methods of use thereof The present invention provides the compound having the structure: wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each i... | 04/20/2004 |
| 6696605 | Process for preparing -hydroxyamides and -ketoamides on a solid phase support The present invention relates to a process for preparing a -hydroxyamide or -ketoamide, said process comprising the steps of: a) reacting a resin which comprises a polymer-supported isocyanide with an aldehyde in the presence of a cataly... | 02/24/2004 |
| 6686503 | Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries The invention relates to methods of synthesizing libraries of diverse and complex highly substituted 2,4-dioxopiperidine compounds of the general formula: ##STR1## wherein R1, R2 and R3 are as herein described, novel ... | 02/03/2004 |
| 6653436 | Water dispersible epoxy resins A amidoamine composition containing oligomeric amidoamine compounds having the structure: ##STR1## the average of x based on the amidoamine composition is at least 0.2, and Z is the residue of a polyoxyalkylene polyether polycarboxylic acid compound,... | 11/25/2003 |
| 6518458 | (Aminoiminomethyl) amino) alkane-carboxamides and their applications in therapy The invention to a pharmaceutical composition comprising as active principle a compound of general formula (I), in which R1, R2, R3, and A are as defined in claim 1. These compositions can be used in the treatment of patho... | 02/11/2003 |
| 6506910 | Process for preparing discodermolide and analogues thereof A more practical synthesis for preparing discodermolide and structurally related analogues, novel compounds useful in the process and novel compounds prepared by the process.... | 01/14/2003 |
| 6498150 | Low molecular weight cell, bone marrow and immune stimulants The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccinatio... | 12/24/2002 |
| 6465686 | Halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors The present invention discloses halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.... | 10/15/2002 |
| 6455502 | Compounds and compositions as protease inhibitors The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.... | 09/24/2002 |
| 6410594 | Substituted cyclopentane compounds useful as neuraminidase inhibitors Compounds represented by formula (I), and pharmaceutically acceptacle salts thereof; and their method of preparation are provided. Compounds of the above formula are influenza virus neuraminidase inhibitors and can be used in treating patients infected wi... | 06/25/2002 |
| 6365590 | Compounds, compositions and methods for treating erectile dysfunction Vasoactive compounds are described for the treatment of erectile dysfunction and impotence. The compounds are reaction products of an anionic or negatively charged vasoactive or erection-inducing component (such as alprostadil) and a cationic or positivel... | 04/02/2002 |
| 6355838 | Reagents for heat activated polymer crosslinking The present invention is directed to nitrile-oxide precursor compounds, and their preparation and use as an irreversible cross-linking agent in polymers having appropriate functionality, i.e., alkenes, alkynes nitrites, and isocyanates. The present invent... | 03/12/2002 |
| 6313346 | Catalyst compositions for the production of polyurethanes A composition having the formula: ##STR1## wherein R is a linear alkyl, branched alkyl, cycloalkyl, polycyclic alkyl, alkylaminoalkyl, or alkyloxyalkyl group having 1 to 20 carbon atoms and at least one primary, secondary, or tertiary amino functional gro... | 11/06/2001 |
| 6281371 | Lipopolyamines, and the preparation and use thereof The present invention relates to new lipopolyamines (including salts thereof) characterised by a symmetrical, highly flexible lipophilic moiety having buffering capacity at physiological pH, and to the use thereof for the in vivo or in vitro introduction ... | 08/28/2001 |
| 6255120 | Combinatorial library of substituted statine esters and amides via a novel acid-catalyzed rearrangement A combinatorial chemical library comprising a plurality of members of the Formula [S]--C(O)--L'-Z containing hydroxyamides is disclosed, in which [S] represents a solid support and L'-Z is a linker/compound residue. In this library, Z is ##STR1## and... | 07/03/2001 |
| 6194612 | Template for solution phase synthesis of combination libraries This invention features a template for synthesizing combinatorial libraries, methods of synthesizing combiatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this inven... | 02/27/2001 |
| 6190673 | Gel compositions containing gellants in the form of alkyl amides of tri-carboxylic acids The present invention relates to gel compositions comprising alkyl amides of tri-basic carboxylic acids and methods of making gel compositions.... | 02/20/2001 |
| 6147258 | Preparation of substituted guanidine derivatives Substituted guanidine derivatives of the formula I ##STR1## are prepared by reacting calcium cyanamide with a primary or secondary amino carboxylic acid or a primary or secondary amino sulfonic acid or their derivatives of the formula II ##STR2#... | 11/14/2000 |
| 6130315 | Peptidase inhibitors This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide... | 10/10/2000 |
| 6114391 | -amino acid amides, preparation thereof and the therapeutical use thereof The present invention relates to serinamide, glycinamide, alaninamide and phenylalaninamide derivatives of formula (I) wherein R, R', R1 and R2 are as defined in the disclosure. The compounds (I) are useful for the treatment of neuro... | 09/05/2000 |
