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...Daniel Webster invented a "bull plow" to pull out tree stumps. It didn't catch on because it was huge and required four oxen to pull it!
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| Number | Title | Issue Date |
| 8168827 | Amide derivative Amide derivatives represented by the formula (I): wherein: A is a cycloalkyl group, an aryl group or a heteroaryl group; X is a nitrogen atom or CR17; Y is —NRa-, —(CRbRb′)m-, and th... | 05/01/2012 |
| 8101800 | 5,6-dihydro-1-pyridin-2-one compounds The invention is directed to a 5,6-dihydro-1H-pyridin-2-one compound selected from: ... | 01/24/2012 |
| 7893299 | Interleukin-1 and tumor necrosis factor-αmodulators; syntheses of such modulators and methods of using such modulators Described herein are chemical compounds and pharmaceutical compositions, including novel chemical compounds and pharmaceutical compositions thereof, useful in the treatment of various diseases and disease states. Also described are methods of synthesizing natural pr... | 02/22/2011 |
| 7649113 | Mono, di and tri cyclic compounds useful for lowering IgE concentrations The present invention is directed to novel compounds which are derivatives of minocycline or doxycycline, pharmaceutical compositions containing same and use thereof in lowering excess IgE levels in a mammal suffering from a disease where IgE is pathogenic. ... | 01/19/2010 |
| 7381827 | Processes and intermediates The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof. ... | 06/03/2008 |
| 7365196 | Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ... | 04/29/2008 |
| 7202404 | Fungicidal amides Compounds of Formula I are disclosed which are useful as fungicides wherein R1 is hydrogen; halogen; C1–C2 alkoxy; C1–C2 | 04/10/2007 |
| 7179943 | Bicyclic derivatives that modulate voltage-gated potassium channels and methods of use thereof Bicyclic amide derivatives of formula (I) or tautomers or pharmaceutically acceptable salts thereof or both are provided: Also provided are processes for preparing the bicyclic amide derivatives as well as pharma... | 02/20/2007 |
| 7132457 | Adamantane derivatives The invention provides adamantane derivatives of formula (I), a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy. In formula (I) D represents CH2 ... | 11/07/2006 |
| 6995285 | ABCA-1 elevating compounds The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery dis... | 02/07/2006 |
| 6963010 | Hydrophobic polyamine analogs and methods for their use The disclosed invention provides new polyamine analogs and derivatives containing a hydrophobic region and a polyamine region as well as methods and compositions for their use. ... | 11/08/2005 |
| 6756504 | Sphingolipids The invention relates to compounds of the general formula (I), as defined, and to pharmaceutical compositions containing them. The compounds of formula (I) are inhibitors of various lipid-related enzymes. They can be used in reducing accumulation of sphingoli... | 06/29/2004 |
| RE38506 | Potent inducers of terminal differentiation and methods of use thereof The present invention provides the compound having the structure: wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each i... | 04/20/2004 |
| 6713650 | ABCA-1 elevating compounds The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery dis... | 03/30/2004 |
| 6670400 | Phenoxyethylamine derivatives having high affinity for the 5-HT1A receptor, preparation thereof, use thereof as drugs, and pharmaceutical compositions containing said derivatives Phenoxyethylamine derivatives of general formula (I) having high affinity for the 5-HT1A receptor, methods for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as gastric acid secretion inhib... | 12/30/2003 |
| 6593312 | Cyclic -amino-γ-hydroxyamide compounds A compound of formula (I): ##STR1## wherein: ##STR2## represents an optionally substituted saturated carbon ring having from 4 to 8 ring members, R1 and R4, which may be identical or different, each represents hydrogen or acyl, ... | 07/15/2003 |
| 6562782 | Oligocycloalkanoid compounds and methods of use The present invention related to an oligocycloalkanoid compound comprising formula (I) ##STR1## wherein m, n, and o are independently an integer from 0 to 2; A1 through A10 are independently a direct link, alkylene, alkylene-O--, ... | 05/13/2003 |
| 6468487 | Nitration or carboxylation catalysts In the presence of an imide compound (e.g., N-hydroxyphthalimide) shown by the following formula (1): ##STR1## wherein R1 and R2 represent a hydrogen atom, a halogen atom, an alkyl group, an aryl group and a cycloalkyl group, and R | 10/22/2002 |
| 6444702 | Aminoadamantane derivatives as therapeutic agents The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases using the derivatives ... | 09/03/2002 |
| 6441232 | Selective nitrogen functionalization of organic compounds There is provided a method of selectively replacing a carbon-hydrogen bond at an unactivated saturated sp3 hybridised carbon atom in an organic compound by a carbon-nitrogen bond, the method comprising reacting the compound with a fluorinating agent in a ... | 08/27/2002 |
| 6426365 | CETP activity inhibitors The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I): ##STR1## wherein R represents a straight chain or branched alkyl group; a straight chain or branched alkenyl group; a lo... | 07/30/2002 |
| 6423748 | Amido polybiguanides and the use thereof as antimicrobial agents Amido polybiguanides and their use as antimicrobial agents in pharmaceutical compositions are disclosed. A method of synthesis of amido polybiguanides is also disclosed. The amido polybiguanides are useful in the preservation of pharmaceutical composition... | 07/23/2002 |
| 6362183 | Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds An aromatic sulfonyl alpha-hydroxy hydroxamic acid compound that, inter alia, inhibits matrix metalloprotease activity is disclosed, as is a treatment process that comprises administering a contemplated aromatic sulfonyl alpha-hydroxy hydroxamic acid comp... | 03/26/2002 |
| 6348625 | Method for preparing some 1-adamantancecarboxamides This invention relates to a method for the novel preparation of 1-adamantanecarboxamides and 1-adamantaneacetamides. Adamantanecarboxamides and adamantaneacetamides are prepared in high yields (80-100%) by treating adamantanecarboxylic acid and adama... | 02/19/2002 |
| 6313346 | Catalyst compositions for the production of polyurethanes A composition having the formula: ##STR1## wherein R is a linear alkyl, branched alkyl, cycloalkyl, polycyclic alkyl, alkylaminoalkyl, or alkyloxyalkyl group having 1 to 20 carbon atoms and at least one primary, secondary, or tertiary amino functional gro... | 11/06/2001 |
| 6235851 | Polymerizable adamantane derivatives and process for producing the same A compound shown by the following formula: ##STR1## wherein each of R1a, R2a, R3a and R4a represents a substituent selected from a non-reactive atom, a non-reactive group, a hydroxyl group and an amino group, an... | 05/22/2001 |
| 6136225 | Polymerizable liquid-crystalline compounds Polymerizable liquid-crystalline compounds of the formula I Z1 --Y1 --A1 --Y3 --M--Y4 --A2 --Y2 --Z2 I where Z1 and Z | 10/24/2000 |
| 6110969 | Cycloalkyl-prostaglandin E2 derivatives A ω-cycloalkyl-prostaglandin E2 derivatives of the formula (I) ##STR1## wherein R is carboxy or hydroxymethyl; R1 is oxo, methylene or halogen atom; R2 is H, OH or C1-4 alkoxy; R3 is H, C1-8 alkyl, C2-8 al... | 08/29/2000 |
| 6090853 | Fungicidally active carboxylic acid amides Carboxamides of the formula I ##STR1## where the substituents have the following meanings: R1 is unsubstituted or substituted bicycloalkyl, tricycloalkyl or bicycloalkenyl; R2,R3 and R4 are each, independen... | 07/18/2000 |
| 6057460 | Polymerizable hybrid monomers Polymerizable hybrid monomers with norbornenyl or norbornadienyl groups are described which can be radically cured at room temperature and are suitable in particular for use in the dental field.... | 05/02/2000 |
| 5990278 | Protective or anchor groups and their use The invention relates to a carbamide of the general formula R1 --CO--NH--C(R2)(R3)--X--Y which is protected by a temporary protective group and wherein R1 --CO means a carbonyl residue which can be provided as a unit for ... | 11/23/1999 |
| 5948933 | Tropane analogs and methods for inhibition of monoamine transport New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8carbo and 8-oxo tropanes having 6- or 7-substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers. Certain pr... | 09/07/1999 |
| 5922771 | Benzocycloalkene compounds, their production and use A compound of the formula ##STR1## wherein R1 and R2 independently represent H or an optionally substituted hydrocarbon group; R3 represents an optionally substituted hydrocarbon group; R4 represents H or a... | 07/13/1999 |
| 5852007 | Cysteine and serine protease inhibitors containing D-amino acid at the P2 position, methods of making same, and methods of using same The present invention is directed to (D)-amino acid containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.... | 12/22/1998 |
| 5780512 | Alkylated (hetero) cyclic compounds The invention relates to a compounds selected from these of formula (I): ##STR1## in which: R1, R2, R3 and A are as defined in the description, and a medicinal product containing the same useful for treating a melaton... | 07/14/1998 |
| 5770736 | Reagents for cleavage or crosslinking of biomolecules using nondiffusible reactive intermediates Reagents for cleaving or crosslinking of biomolecules using nondiffusible reactive intermediates and a method of using the reagents. In one embodiment, the DNA binding element includes a phenyl group on each end, and each terminal phenyl group contains at... | 06/23/1998 |
| 5756733 | Vitamin D amide derivatives The invention relates to novel 1-hydroxy vitamin D derivatives and their 20-epi analogues, comprising compounds of general formula (I) ##STR1## where R1 and R2, which may be the same or different, each represents a hydrog... | 05/26/1998 |
| 5746998 | Targeted co-polymers for radiographic imaging A radiographic imaging agent including a plurality of block copolymers forming a micelle, the block copolymers including a hydrophilic polymer linked to a hydrophobic polymer, and the hydrophobic polymer including a backbone incorporating radiopaque molec... | 05/05/1998 |
| 5703129 | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of ଲ-amyloid protein production A series of 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives of Formula I have been synthesized. ##STR1## As inhibitors of the production of ଲ-amyloid protein from ଲ-amyloid precursor protein, these compounds are expected to be ... | 12/30/1997 |
| 5693630 | Phenylethyl and phenylpropylamines Compounds of the general formula ##STR1## or pharmaceutically acceptable salts thereof, wherein Z is a saturated or unsaturated 3 to 6 carbon chain, m is 2 or 3, R1 is a hydrogen atom, or a straight or branched C1-4 alkyl group,... | 12/02/1997 |
