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| Number | Title | Issue Date |
| 8049037 | Sphingosine-1-phosphate (S1P) receptor antagonists and methods for use thereof This invention provides compounds as shown below, in which either all of Z1-6 are carbon or one of Z1-6 is nitrogen and the rest are carbon, and in which other substituents are defined herein, which are sphingosine-1-phosphate antagonists. ... | 11/01/2011 |
| 7932421 | N-cyclohexyl benzamides and benzeneacetamides as inhibitors of 11-beta-hydroxysteroid dehydrogenases The present invention provides N-cyclohexyl benzamide and benzeneacetamide compounds according to formula (I): where R1, R2, R3, R4, R5, R6, R7, R... | 04/26/2011 |
| 7763750 | Process for producing 2-halogenobenzamide compound A novel process for producing a 2-halogenobenzamide compound useful as a raw material or active ingredient for medicines and agricultural chemicals. The process, which is for producing a 2-halogenobenzamide compound represented by the general formula (I): | 07/27/2010 |
| 7371887 | Oligo(p-phenylene vinylene) amphiphiles and methods for self-assembly Amphiphilic oligo(p-phenylene vinylene) compounds and methods of use en route to self-assembled composites and device fabrication. ... | 05/13/2008 |
| 7297818 | Adamantane derivatives The invention provides adamantane derivatives of formula (I), a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy. In formula (I) D represents CH2 ... | 11/20/2007 |
| 7235692 | Adamantane derivatives The invention provides adamantane derivatives of formula (I), a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy. In formula (I) D represents CH2 ... | 06/26/2007 |
| 7230018 | Substituted propane-1,3-diamine derivatives and the pharmaceutical use thereof Substituted propane-1,3-diamine derivatives, methods for producing such derivatives, and medicaments and pharmaceutical compositions containing such derivatives useful for the treatment or prophylaxis of pain, urinary incontinence, itching, tinitus aurium, or diarrh... | 06/12/2007 |
| 7041702 | Pharmaceutically active compounds and methods of use The present invention relates to pharmaceutically acceptable compounds, including acylguanidine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly usefu... | 05/09/2006 |
| 7012160 | Fluorine-containing acetophenone derivative, surface layer material containing the same as photo initiator, article with composite hard coat layer, and method for forming composite hard coat layer The present invention provides a new fluorine-containing acetophenone derivative useful as a photo initiator, and a surface layer material containing the fluorine-containing acetophenone derivative. The present invention provides inexpensively an article with a hard... | 03/14/2006 |
| 6936736 | Amide derivative A compound of the formula: wherein Ar is optionally substituted phenyl, etc.; n is 0, 1 or 2; R1 is hydogen atom, optionally substituted alkyl, etc.; R2 and R | 08/30/2005 |
| 6881754 | Adamantane derivatives The invention provides adamantane derivatives of formula (I), a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy. In formula (I) D represents CH2 ... | 04/19/2005 |
| 6790965 | Combinatorial dihydrobenzopyran library Combinatorial libraries are disclosed which are represented by Formula I: (T′—L)q—Ŝ—C(O)—L′—II′ I wherein: Ŝ is a solid support; T′—L— is an identifier residue; and —L′—II′ is a l... | 09/14/2004 |
| 6596902 | Process for the preparation of 2-aryl-5- (perfluoro-alkyl)pyrrole compounds from N-[1-chloro-1-(perfluoroalkyl)methyl] arylimidoyl chloride compounds There is provided a process for the preparation of 2-aryl-5-(perfluoroalkyl)pyrrole compounds from N-[1-chloro-1-(perfluoroalkyl)methyl]arylimidoyl chloride compounds. The 2-aryl-5-(perfluoroalkyl)pyrrole compounds are useful for the control of insec... | 07/22/2003 |
| 6566403 | N-acetonylbenzamide fungicides This invention relates to new compositions comprising predominantly one enantiomer of an N-acetonylbenzamide fungicide, methods of preparing N-acetonylbenzamides, and their use as fungicides.... | 05/20/2003 |
| 6551761 | Photoactivatable nitrogen-containing bases based on -ammonium ketones, iminium ketones or amidinium ketones and aryl borates This invention relates to -ammonium ketones, iminium ketones or amidinium ketones in the form of their tetraaryl- or triarylalkylborate salts which can be photochemically converted into amines, imines or amidines as well as to a process for their p... | 04/22/2003 |
| 6506733 | Compounds and compositions as protease inhibitors Compounds of the formula: ##STR1## are provided, and are useful as cysteine protease inhibitors, particularly in the treatment of diseases such as osteoporosis or autoimmune disorders in which cathepsins K or S contribute to the pathology or symptomatolgy... | 01/14/2003 |
| 6486349 | Amide therapeutics and methods for treating inflammatory bowel disease Disclosed are methods for treating or preventing inflammatory bowel disease (IBD) using amide and related compounds. Pharmaceutical compositions containing amide compounds which are useful for the treatment or prophylaxis of IBD are also disclosed.... | 11/26/2002 |
| 6441233 | Process for the preparation of aromatic carboxylic acid amides A process for the preparation of primary aromatic carboxamides by the carbonylation of an aromatic compound, which contains at least one leaving group, with carbon monoxide, in the presence of a homogeneous or heterogeneous Pd catalyst and at least stoich... | 08/27/2002 |
| 6436925 | Substituted benzamides, their production and their use as cysteine protease inhibitors Benzamides of the formula I ##STR1## and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings: R1 --C1 -... | 08/20/2002 |
| 6423870 | Tricyclic compounds, preparation method and pharmaceutical compositions containing same The invention concerns compounds of formula (I) in which: A forms a tricyclic system of formula A1, A2, A3 or A4 ; R1 represents a hydrogen atom, an alkyl, hydroxy, alkoxy or oxo group; (R2... | 07/23/2002 |
| 6420605 | Benzamidoxim derivatives, intermediate products and methods for preparing and using them as fungicides The invention relates to benzamidoxim derivatives of formula (I) wherein the substituents have the following meanings: R1 represents difluoromethyl or trifluoromethyl, R2 represents hydrogen or fluorine, R3 represents C | 07/16/2002 |
| 6391175 | Carbonate ionophore with improved selectivity The invention pertains to a novel ionophore having the general structure: ##STR1## wherein R1, R2, R3 and R4 are independently straight or branched chain alkyl having 4 to 12 carbon atoms or the alkyl groups may ... | 05/21/2002 |
| 6339157 | Synthesis of carboxamides from the catalyzed reaction of aldehydes and amines Aldehydes are catalytically combined with amines to form carboxamides in one step using an oxidant and a metal-ligand complex or metal/ligand composition.... | 01/15/2002 |
| 6326517 | Method of producing benzamides A method of producing benzamides represented by the following general formula (1): ##STR1## where R is trifluoromethyl group, trifluoromethyloxy group, halogen (fluorine, chlorine, bromine or iodine), nitro group, acetyl group, cyano group, alkyl gro... | 12/04/2001 |
| 6323315 | Dolastatin peptides The present invention provides compounds of the formula ##STR1## where R1 -R5 are each, independently, a hydrogen atom or a normal or branched C1 -C6 -alkyl group; A is a methionyl, phenylalanyl or phenylglycyl ... | 11/27/2001 |
| 6313302 | Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists A compound of the following formula: ##STR1## and the salts thereof, wherein A is hydrogen, halo, or hydroxy; the broken line represents an optional double bond with proviso that if the broken line is a double bond, then A is absent; Ar1 is opt... | 11/06/2001 |
| 6235789 | Benzocycloalkene compounds, their production and use A compound of the formula ##STR1## wherein R1 and R2 are H, a hydrocarbon group or a heterocyclic group, or R1 and R2 are combinedly a spiro ring; R3 is a hydrocarbon group, a substituted amino group,... | 05/22/2001 |
| 6201024 | Adamantane derivatives The invention provides adamantane derivatives, a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy.... | 03/13/2001 |
| 6177463 | Oxime derivatives and their use as pesticides The invention relates to new oxime derivatives, to a plurality of processes for their preparation, and to their use as pesticides.... | 01/23/2001 |
| 6166273 | Processes for fluorinating aromatic ring compounds A process is provided for increasing the fluorine content of benzene or pyridine rings which are optionally substituted with from 1 to 3 inert substituents. The process involves (a) contacting the ring with a metal fluoride composition comprising cupric f... | 12/26/2000 |
| 6083987 | Phenylenediamine derivative, radical scavenger, brain-infarction depressant, and brain-edema depressant A phenylenediamine derivative or a salt thereof in accordance with the present invention is expressed by the following formula 1: ##STR1## wherein A represents a group expressed by --CO--, --CH2 CO--, --CS--, or --SO2 --; Y repr... | 07/04/2000 |
| 6066766 | Process for the preparation of 4-chlorobiphenyls 4-Chlorobiphenyls are prepared by reacting a haloaromatic with an aryl Grignard compound, where halogen is chlorine, bromine or iodine, in the presence of a palladium catalyst of the formula (IV) ##STR1##... | 05/23/2000 |
| 6054457 | Benzamide derivatives and their use as vasopressin antagonists This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc, and represented by general formula (I): ##STR1## wherein R1 is aryl optionally substituted with lower alkoxy, etc., R2 is lower... | 04/25/2000 |
| 6001880 | Alkylenediamine derivative, anti-ulcer drug, and antibacterial drug An alkylenediamine derivative or a salt thereof expressed by the following formula 1: ##STR1## wherein each of R1 and R2 represents a lower alkyl group, and W represents a group expressed by any of the following formulas 2 and 3... | 12/14/1999 |
| 5994507 | Method for binding albumin and means to be used in the method A method for binding albumin by contacting an aqueous liquid containing an albumin with an albumin-binding compound is selected from albumin-binding compounds containing the scaffold --CO--NH--C(.dbd.C--)--CO--, and conjugates that are capable of binding ... | 11/30/1999 |
| 5965744 | Ortho-substituted benzoylguanidines, including composition and methods of using them The present invention relates to ortho-substituted benzoylguanidines of the formula I, defined in the specification. The invention also embraces processes for making these compounds, as well as compositions and methods of using them. The compounds of the ... | 10/12/1999 |
| 5925763 | Process to chloroketones using oxazolines This invention relates to a process for the preparation of an -chloroketone compound comprising the steps of (i) cyclizing an alkynyl amide to form a 5-methyleneoxazoline ##STR1## (ii) chlorinating the 5-methyleneoxazoline using trichloroisocyanuri... | 07/20/1999 |
| 5869531 | Fluoroalkyl substituted benzoylguanidines Disclosed are 4-(2'-trifluoromethylethyl)benzoylguanidine and 3-methylsulfonyl-4-(2'-trifluoromethylethyl)benzoylguanidine. Also disclosed are pharmaceutical compositions and the use of the compounds in the treatment of disorders induced by ischemia.... | 02/09/1999 |
| 5856574 | Ortho-subsituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament containing them Ortho-substituted benzoylguanidines of the formula I ##STR1## in which R(2) and R(3) have the meanings given in the... | 01/05/1999 |
| 5824821 | Process for the preparation of iodinated contrast agents and intermediates therefor The invention provides a process for the production of a 2,3-dihydroxypropylamino compound, said process comprising the reaction steps of: (i) obtaining an allylamino compound; (ii) epoxidizing said allylamino compound to yield an epoxypropylamino compoun... | 10/20/1998 |
