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| Number | Title | Issue Date |
| 8178724 | Compounds for inhibition of 5-hydroxytryptamine and norepinephrine reuptake or for treatment of depression disorders, their preparation processes and uses thereof The present invention discloses compounds of formula (I), their optical isomers or pharmaceutically acceptable salts thereof, their preparation and uses thereof, wherein the definitions of R1, R2, R3 and R4 are shown in the description. These compounds are optical i... | 05/15/2012 |
| 8148576 | Solid state forms of aliskiren compounds The invention relates to solid states of pharmaceutically acceptable compounds of aliskiren, and processes for preparation thereof. The invention further provides pharmaceutical formulations comprising the amorphous or crystalline forms of pharmaceutically acceptabl... | 04/03/2012 |
| 7872153 | Salt of aliskiren with sulfuric acid The invention relates to a new salt of aliskiren, the respective production and usage, and pharmaceutical preparations containing such a salt. ... | 01/18/2011 |
| 7390925 | Oxime-containing acyl guanidines as beta-secretase inhibitors There is provided a series of substituted oxime-containing acyl guanidines of Formula (I) or a stereoisomer; or a nontoxic pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R | 06/24/2008 |
| 7312360 | Substituted hydroxyethylamines Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein the variables G, L, A, W, E, R2, R3, R4, R5, RN, and Rc are defined herein. These compounds i... | 12/25/2007 |
| 7291647 | Guanylhydrazone compounds, compositions, methods of making and using The present invention relates to compounds having the formula: salts thereof; compositions comprising one or more of the compounds and/or salts thereof; methods of using; and methods of m... | 11/06/2007 |
| 7250415 | 1,1-Disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives thereof as factor Xa inhibitors The present application describes 1,1-disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives thereof of Formula I: P-M-M1I or a stereo... | 07/31/2007 |
| 7244765 | Guanylhydrazone salts, compositions, processes of making and methods of using The invention relates to pharmaceutically acceptable salts of guanylhydrazone-containing compounds, for example, Semapimod. The invention also relates to pharmaceutically acceptable compositions comprising the salts and methods for their use. ... | 07/17/2007 |
| 7238834 | Piperidine derivatives and process for their production The present invention relates to substantially pure piperidine derivative compounds of the formulae: wherein R1 is hydrogen or hydroxy; R2 | 07/03/2007 |
| 7220781 | Meta-benzamidine derivatives as serine protease inhibitors Compounds of formula I in which R1, R2, R3, each X, L, Y, Cy, Lp, D and n have the meanings as set out in the specification, and corresponding compounds in which the unsubstituted... | 05/22/2007 |
| 7205436 | Process for manufacture of quaternary ammonium tosylate salts of cinnamidoalkylamines and / or benzamidoalkylamines An efficient, simple, high yielding, eco-friendly process for the manufacture of tosylates quaternary ammonium salts of cinnamidoalkylamines and/or benzamidoalkylamines (Formula I) has been described. These compounds are substantive UV-absorbers. They are useful in ... | 04/17/2007 |
| 7183431 | Dihydroxy aromatic compounds and methods for preparation A dihydroxy aromatic compound having a Formula (I), wherein R1 is a C6–C60 aromatic divalent functionality, R2 at each occurrence, can be the same or different and is... | 02/27/2007 |
| 7153869 | Substituted amino acids as erythropoietin mimetics This invention relates to a series of substitituted amino acids of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are small molec... | 12/26/2006 |
| 7135586 | Biphenylcarboxamides useful as lipid lowering agents Biphenylcarboxamide compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyp... | 11/14/2006 |
| 7084196 | Flame retardant compositions Polymeric substrates, for example polyolefins such as polypropylene, can be made flame retardant by the incorporation therein of a synergistic mixture of (i.) at least one compound selected from the group consisting of nitroxyl stabilizers, hydroxylamine stabilizers... | 08/01/2006 |
| 7053245 | N-acylamino benzyl ether derivatives This invention relates to N-acylamino aryl derivatives of the formula where R1, R21, R22, R23, R24, R3, R4, R5, R | 05/30/2006 |
| 7034015 | Aminobenzoephenones The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compounds, and to the use of said ... | 04/25/2006 |
| 7026500 | Halogenated selective androgen receptor modulators and methods of use thereof This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and a... | 04/11/2006 |
| 7022390 | Polyester and polyamide compositions of low residual aldehyde content A mixture of a polyester, such as poly(ethylene terephthalate) PET, or a polyamide, and a suitable stabilizer selected from the group consisting of hydroxylamine stabilizers, substituted hydroxylamine stabilizers, nitrone stabilizers and amine oxide stabilizers, whe... | 04/04/2006 |
| 6998500 | Selective androgen receptor modulators and methods of use thereof This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and a... | 02/14/2006 |
| 6992207 | Melphalan derivatives and their use as cancer chemotherapeutic drugs The invention refers to new alkylating di- and tripeptides based on a melphalan unit, and one or two additional amino acids or amino acid derivatives, which can be used in the treatment of carcinogenic diseases. Further, the invention refers to a pharmaceutical comp... | 01/31/2006 |
| 6969757 | Differential labeling for quantitative analysis of complex protein mixtures The present invention relates to a method of simultaneously identifying and determining the levels of expression of cysteine-containing proteins in normal and perturbed cells, a method for proteomic analysis, a process for preparing fusion proteins, and compounds of... | 11/29/2005 |
| 6916957 | Serine protease inhibitors Compounds of formula (I) where R5, R6a, each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents. ... | 07/12/2005 |
| 6908650 | Polyester and polyamide compositions of low residual aldehyde content A mixture of a polyester, such as poly(ethylene terephthalate) PET, or a polyamide, and a suitable stabilizer selected from the group consisting of hydroxylamine stabilizers, substituted hydroxylamine stabilizers, nitrone stabilizers and amine oxide stabilizers, whe... | 06/21/2005 |
| 6855826 | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states This invention provides a class of therapeutic compounds and methods for the treatment of mammals with physiological disorders, such as for example a frequently occurring type of essential hypertension, which are critically associated with the decreased binding of m... | 02/15/2005 |
| 6852761 | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade The invention relates to polycyclic aryl and heteroaryl substituted benzene compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety ... | 02/08/2005 |
| 6846925 | Colchinol derivatives as angiogenesis inhibitors The invention related to colchinol derivatives of the formula (I): Wherein: R1; R2 and R3 are each independently hydroxy, phosphoryloxy (—OP3H2), C1-4alkoxy or an in vivo hydrolysable ester of hydro... | 01/25/2005 |
| 6844367 | Benzamides and related inhibitors of factor Xa Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders. ... | 01/18/2005 |
| 6841702 | Highly selective inhibitors of the urokinase plasminogen activator The invention relates to novel selective inhibitors of the urokinase plasminogen activator (uPA, EC 3.4.21.31), of the arylguanidine type. ... | 01/11/2005 |
| 6841701 | Inhibitors for the blood-clotting factor Xa The invention relates to derivatives of amidino-benzylamine, especially derivatives of 4-amidino-benzylamine, with two bonded amino acids. These derivatives represent a novel group of highly active and very selective F Xa-inhibitors for treating cardiovascular disea... | 01/11/2005 |
| 6838580 | Opioid derivative 1. A peptide derivative represented by the following formula (1) or a salt thereof; wherein R1 is hydrogen atom or methyl group, R2 is hydrogen atom or hydroxy group and n is an integer of 1-8, pr... | 01/04/2005 |
| 6831196 | Urokinase inhibitors The invention relates to a highly active, highly specific urokinase inhibitor which is suitable for therapeutic applications and can be synthesized in an extremely simple manner. Surprisingly, it was found that amidino benzylamine derivatives, especially 4-amidino-b... | 12/14/2004 |
| 6770778 | N-(4-substituted phenyl)-anthranilic acid hydroxamate esters The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions, and methods of use thereof. ... | 08/03/2004 |
| 6762320 | N-acylamino benzyl ether derivatives This invention relates to N-acylamino aryl derivatives of the formula where R1, R21, R22, R23, R24, R3, R4, R5 R6,... | 07/13/2004 |
| 6753327 | Substituted amides, their preparation and use An amide of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings: ... | 06/22/2004 |
| 6740682 | Meta-benzamidine derivatives as serine protease inhibitors The novel compound 3-amidinobenzoyl-D-phenylglycine-3-phenylanilide is useful as a serine protease inhibitor. ... | 05/25/2004 |
| 6720452 | Adamantane derivatives The invention provides adamantane derivatives of formula (I), a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therap... | 04/13/2004 |
| 6720323 | Colchinol derivatives as angiogenesis inhibitors The invention related to colchinol derivatives of the formula (I): Wherein: R1, R2 and R3 are each independently hydroxy, phosphoryloxy (—OPO3H2), C1-4alkoxy or an in vivo hydrolysable ester of hydr... | 04/13/2004 |
| 6703379 | Benzene derivatives and pharmaceutical use thereof The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammat... | 03/09/2004 |
| 6696424 | Cytofectin dimers and methods of use thereof A composition is provided comprising a novel cationic lipid compound having hydrophobic tails and two quaternary ammonium headgroups bridged by a linker. The composition is useful as a cytofectin for facilitating delivery and transfection of biologically ... | 02/24/2004 |
