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| Number | Title | Issue Date |
| 8129566 | Polycationic compounds and uses thereof Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use a... | 03/06/2012 |
| 8124806 | Contrast agents The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic centr... | 02/28/2012 |
| 8071811 | Contrast agents The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic centr... | 12/06/2011 |
| 8067637 | Contrast agents The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing a hydrophilic alip... | 11/29/2011 |
| 7999135 | Crystallization of iodixanol using ultrasound This invention relates to the manufacture of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis (2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the purification of iodixanol by crystallization by using ultrasound. ... | 08/16/2011 |
| 7999134 | Crystallization of iodixanol using milling This invention relates to the manufacture of iodixanol(1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the purification of iodixanol by crystallization by using wet milling. ... | 08/16/2011 |
| 7968745 | Purification process of iodixanol A process for the manufacture of iodixanol by performing a purification process of the crude product in a solvent comprising n-propanol. The crude product may be obtained in aqueous solution from dimerization of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-trii... | 06/28/2011 |
| 7875747 | Branched succinimide dispersant compounds and methods of making the compounds In accordance with the disclosure, one aspect of the present application is directed to a dispersant compound comprising the reaction product of (i) a hydrocarbyl carbonyl compound, (ii) a polycarbonyl compound having at least three carbonyl acylating functions, and... | 01/25/2011 |
| 7863484 | Method for reducing aminoisophthalic acid bisamide related impurities in preparation of non-ionic X-ray contrast agents This invention relates generally to the preparation of non-ionic X-ray contrast agents, iohexyl, ioversol, and iodixanol. It further relates to a method for improving the purity of 5-amino-N,N′-bis(2,3-dihydroxypropyl)-isophthalamide (or ABA), an intermediate in t... | 01/04/2011 |
| 7772431 | Performance of energy storage devices: potential areas for dendritic chemistry involvement A compound consists of a fractal-like, plain or organometallic array useful for energy storage devices. A dendrimer useful in the synthesis of the fractal-like compound includes a single ligating moiety bound to a surface of each quadrant of the dendrimer. A method ... | 08/10/2010 |
| 7759519 | Amide and peptide derivatives of dialkylenetriamines and their use as transfection agents This invention relates to newly identified spermidine based surfactant compounds, to the use of such compounds and to their production. The invention also relates to the use of the spermidine based compounds to facilitate the transfer of polynucleotides into cells. | 07/20/2010 |
| 7754918 | Crystallization of iodixanol in isopropanol and methanol A process for the manufacture of iodixanol by performing a crystallization process of the crude product in a solvent mixture comprising water, methanol and isopropanol. The crude product may be obtained in aqueous solution from dimerisation of 5-acetamido-N,N′-bis... | 07/13/2010 |
| 7745662 | Polycationic compounds and uses thereof Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use a... | 06/29/2010 |
| 7723544 | Process for recovery of iopromide, suitable for pharmaceutical purposes, from mother liquors This invention describes a process for recovery of iopromide, suitable for pharmaceutical purposes, by heat treatment of the mother liquors or the secondary crystallizate in a reactor and subsequent crystallization. ... | 05/25/2010 |
| 7696380 | Amide-based compound, polyolefin resin composition and molded product Disclosed are a mixture of at least two amide-based compounds represented by General Formula (1): wherein a represents an integer of 2 to 6, R1 represents a C2-30 saturated or unsaturated aliphatic pol... | 04/13/2010 |
| 7696381 | Alternative dimerisation reagents for synthesis of iodixanol This invention relates generally to non-ionic X-ray contrast agents. It further relates to the synthesis of iodixanol. In particular, it relates to alternative dimerisation reagents in the conversion of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisopht... | 04/13/2010 |
| 7541494 | Process for the manufacture of iohexol A process for the production of iohexol comprises alkylating 5-Acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide using 2(2-methoxy-ethoxy)-ethanol as solvent in the presence of a base, and optionally isolating crude iohexol from the reaction mixt... | 06/02/2009 |
| 7485753 | Contrast agents The present invention relates to iodine containing compounds containing a central cyclopropane scaffolding moiety allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic composition... | 02/03/2009 |
| 7390875 | Method for binding, in solution, a peptide and a lipophilic vector and uses thereof The invention concerns a method for binding, in solution, at least a peptide composition and at least a lipophilic vector bearing an aldehyde function, the coupling comprising a step which consists in producing a hydrazone bond between the peptide compound and the l... | 06/24/2008 |
| 7378551 | Amide compound A gelling agent having a high ability of gelling an oily base which is capable of giving a gel composition having a strong gel strength and a good transparency, a gel composition having a strong gel strength and a good transparency, an external composition having a ... | 05/27/2008 |
| 7368101 | Process for the preparation of iopamidol and the new intermediates therein A process for the preparation of (S)-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxo-propyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamide (iopamidol) starting from 5-amino-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-2,4,6-triiodo-1,3-benzenedicarbox... | 05/06/2008 |
| 7368479 | Alpha-sulfonylamino-acetonitriles The invention relates to α-sulfonylamino-acetonitrile derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein Ar1, and Ar2 independently of each other stand for an optionally substitut... | 05/06/2008 |
| 7358264 | Statine derivatives for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment ... | 04/15/2008 |
| 7354943 | Statine derivatives for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment ... | 04/08/2008 |
| 7355074 | Compounds having aromatic rings and side-chain amide-functionality and a method for transporting monovalent anions across biological membranes using the same A compound containing at least two aromatic rings covalently bonded together, with each aromatic ring containing at least one oxyacetamide-based side chain, the compound being capable of forming a chloride ion channel across a lipid bilayer, and transporting chlorid... | 04/08/2008 |
| 7314956 | Multifunctional carrier for the delivery of a pharmacological agent or genetic material into a cell The present invention provides a drug delivery vehicle that can improve the pharmacokinetics of pharmacological agents. The invention relates to a multifunctional carrier capable of delivering a carried material such as a pharmacological agent or genetic material to... | 01/01/2008 |
| 7309792 | Dimeric small molecule potentiators of apoptosis Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an ef... | 12/18/2007 |
| 7291620 | N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and which are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also direct... | 11/06/2007 |
| 7282607 | Process for the preparation of iopamidol The present invention discloses a process for the preparation of pure non-ionic contrast agents. The invention also includes a method for purifying the non-ionic contrast agents. ... | 10/16/2007 |
| 7271284 | Process for making curable amide gellant compounds Disclosed is a process for preparing a compound of the formula wherein R1 is an alkyl group having at least one ethylenic unsaturation, an arylalkyl group having at least one ethylenic unsaturation, or... | 09/18/2007 |
| 7271288 | Aromatic compounds Disclosed is an aromatic compound expressed by the general formula (I), wherein A represents of a fused aromatic hydrocarbon moiety such as triphenylene, X represents a hydrogen-bonding site such as an atomic group containing an amide linkage, Y represents a chain f... | 09/18/2007 |
| 7265220 | Amino acid derivatives, method for production thereof and pharmaceutical compositions comprising said derivative Compound of formula (I): wherein: R1 represents aryl, heteroaryl or alkyl which is optionally substituted, or a group of formula —(CO)—CR6R7NR8R9 ... | 09/04/2007 |
| 7262223 | Amidine derivatives for treating amyloidosis The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a t... | 08/28/2007 |
| 7259275 | Method for preparing curable amide gellant compounds Disclosed is a process for preparing a compound of the formula wherein R1 is an alkyl group having at least one ethylenic unsaturation, an arylalkyl group having at least one ethylenic unsaturation, or... | 08/21/2007 |
| 7253210 | Methylene-bridged selective androgen receptor modulators and methods of use thereof This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and a... | 08/07/2007 |
| 7250153 | Contrast media formulations having improved biological tolerance This invention comprises new formulations of radiographic contrast media including dimeric non-ionic media, with an organic amine and a carboxylic acid. Formulations of this invention increase the biological tolerance of such media, thereby increasing their safety. | 07/31/2007 |
| 7247604 | Oil-based drilling fluid comprising a temperature-stable and non-polluting emulsifying system A temperature-stable, non eco-toxic oil-base well fluid that is particularly suitable for high pressure/high temperature drilling comprises an emulsification system comprising at least one superamide that may or may not be polyalkoxylated, optionally associated with... | 07/24/2007 |
| 7244864 | Process for the preparation of N,N-substituted 5-amino-1,3-benzenedicarboxamides The invention relates to a process for the preparation of a compound of formula (I), wherein R represents a 2,3-dihydroxy-1-propyl or a 1,3-dihydroxy-2-propyl radical, via direct amidation of a dialkyl ester of 5-amino-1,3-benzenedicarboxylic acid of formula (V), wh... | 07/17/2007 |
| 7235191 | Polypropylene resin compositions A polypropylene composition containing the components: a) a crystallizable polypropylene homopolymer, random copolymer, alternating or segmented copolymer, block copolymer or a blend of polypropylene with another synthetic polymer, and b) 0.001 to 5% relative to the... | 06/26/2007 |
| 7235695 | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearin... | 06/26/2007 |
