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| Number | Title | Issue Date |
| RE43327 | Hydrophobic polyamine analogs and methods for their use The disclosed invention provides new polyamine analogs and derivatives containing a hydrophobic region and a polyamine region as well as methods and compositions for their use. ... | 04/24/2012 |
| 8158827 | Transfection reagents Disclosed are cationic lipid compounds and compositions of lipid aggregates for delivery of macromolecules and other compounds into cells. The compounds can be used alone or in combination with other compounds to prepare liposomes and other lipid aggregates suitable... | 04/17/2012 |
| 7943799 | Method for producing optically active cycloalkylidenebisoxazoline compound and intermediate thereof It is provided to an optically active cycloalkylidenebisamidoalcohol compound represented by the formula (3): wherein R1 represents a C1-6 alkyl group, an optionally substituted phenyl gr... | 05/17/2011 |
| 7842839 | Method for producing optically active cycloalkylidenebisoxazoline compound and intermediate thereof It is provided to an optically active cycloalkylidenebisamidoalcohol compound represented by the formula (3): wherein R1 represents a C1-6 alkyl group, an optionally substituted phenyl gr... | 11/30/2010 |
| 7662999 | Recognition of oligosaccharide molecular targets by polycationic small molecule inhibitors and treatment of immunological disorders and infectious diseases Small molecule polycationic agents are used to modulate or interrupt biological processes by binding to oligosaccharide-based biomolecules. Compounds that inhibit nitric oxide, TNFα or other immunomodulators are provided and are useful for treating immunological di... | 02/16/2010 |
| 7488848 | Alpha ketoamide compounds as cysteine protease inhibitors The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compo... | 02/10/2009 |
| 7442558 | Phthalamide-lanthanide complexes for use as luminescent markers The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention ... | 10/28/2008 |
| 7439394 | Cyclohexyl-1,4-diamine compounds Novel cyclohexyl-1,4-diamine compounds corresponding to formula I, processes for the production thereof, pharmaceutical compositions containing these compounds, methods of producing pharmaceutical compositions including the... | 10/21/2008 |
| 7435845 | Corrosion and gas hydrate inhibitors having improved water solubility and increased biodegradability Corrosion and gas hydrate inhibitors having improved water solubility and increased biodegradability The invention thus provides the use of compounds of the formula (1) where R... | 10/14/2008 |
| 7425527 | Organic activator The present invention relates to organic activators having the following general formula: Wherein R1 is a substituted or unsubstituted alkyl or aryl moiety comprising at least five carbons, R2 is a sub... | 09/16/2008 |
| 7411100 | Process for the preparation of ring compounds In a process for the preparation of ring compounds via a combinatorial synthesis, the reaction procedure is based on a Suzuki coupling, subsequent halo-demetallation and finally a further Suzuki coupling. The Suzuki couplings are each carried out with a boronic acid... | 08/12/2008 |
| 7404912 | Salicylamide-lanthanide complexes for use as luminescent markers The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the inventio... | 07/29/2008 |
| 7399879 | Process for preparing alkylidene-substituted-1,4-dions derivatives A process for the preparation of a monoalkylidene substituted 1,4-dions derivatives of formula (Ia) or (Ib) or a mixture of (Ia) and (Ib): wherein: R1, R2 and R3, equal to or different from each other, are hydrogen atoms or C1 | 07/15/2008 |
| 7378409 | Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis. | 05/27/2008 |
| 7358394 | Process for preparing N,N′-dialkoxy-N, N′-dialkyl oxamide The present invention provides a process for preparing an N,N′-dialkoxy-N,N′-dialkyl oxamide represented by the formula (3): wherein R2 and R3 may be the same or different ... | 04/15/2008 |
| 7358264 | Statine derivatives for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment ... | 04/15/2008 |
| 7354943 | Statine derivatives for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment ... | 04/08/2008 |
| 7351862 | Alpha, omega-difunctional aldaramides Alpha, omega-difunctional aldaramides, in particular diaminoaldaramides, dihydroxyaldaramides, bis(alkoxycarbonylalkyl)aldaramides, and bis(carboxyalkyl)aldaramides, and processes for preparing the aldaramides are provided. ... | 04/01/2008 |
| 7351861 | Method and probe for identifying bacterial virulence modifying agents, agents thus identified, and their use A method for identifying antibacterial agents comprises depleting bacteria of a strain comprising a luxAB construct of Ca2+, incubating the Ca2+ depleted bacteria with an agent the antibacterial effect of which shall be determined, recording th... | 04/01/2008 |
| 7348451 | Additives for inhibiting gas hydrate formation The invention provides the use of compounds of the formula (1) where R1, R2 are each independently C1- to C22-alkyl, C2- to C22-alkenyl, C6... | 03/25/2008 |
| 7338978 | Insecticidal anthranilamides This invention provides compounds of Formula 1, their N-oxides and agriculturally suitable salts wherein A, B, J, R1, R2, R3 and R4 and n are as... | 03/04/2008 |
| 7333907 | System and methods for characterization of chemical arrays for quality control Systems, methods and computer readable media for characterizing a chemical array. At least one metric indicative of accuracy of location of features on the chemical array by a feature extraction process used to extract signals from features of the chemical array may... | 02/19/2008 |
| 7294278 | Method for oxygenating wastewater A method and apparatus creates gas-enriched fluid that is used to treat wastewater. In one embodiment, the wastewater is withdrawn from a supply of wastewater to be treated, and the wastewater is delivered in an atomized manner to a vessel pressurized with gas to fo... | 11/13/2007 |
| 7285600 | Reagents for heat activated polymer crosslinking The present invention is directed to nitrile-oxide precursor compounds, and their preparation and use as an irreversible cross-linking agent in polymers having appropriate functionality, i.e., alkenes, alkynes nitriles, and isocyanates. The present invention is also... | 10/23/2007 |
| 7285680 | β-alanine derivatives and the use thereof A compound of the general formula (I) (wherein the symbols are as defined in the description), or a prodrug or a salt thereof. This compound engages in LPA receptor bonding and antagonism and hence is use... | 10/23/2007 |
| 7262223 | Amidine derivatives for treating amyloidosis The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a t... | 08/28/2007 |
| 7262208 | Hydroxypropyl amides for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the... | 08/28/2007 |
| 7244765 | Guanylhydrazone salts, compositions, processes of making and methods of using The invention relates to pharmaceutically acceptable salts of guanylhydrazone-containing compounds, for example, Semapimod. The invention also relates to pharmaceutically acceptable compositions comprising the salts and methods for their use. ... | 07/17/2007 |
| 7232923 | Method of hydroaminating N-alkenoylcarbamates with primary aromatic amines The invention provides methods for hydroaminating N-alkenoyl carbamates with aromatic amines. ... | 06/19/2007 |
| 7220814 | Hydrophilicized blocked polyisocyanates The present invention relates to new hydrophilicized blocked polyisocyanates, a process for preparing them and their use. ... | 05/22/2007 |
| 7214814 | Additives for inhibiting gas hydrate formation The invention provides the use of compounds of the formula (1) where R1, R2 are each independently C1- to C22-alkyl, C2- to C22-alken... | 05/08/2007 |
| 7201876 | Ion-detecting sensors comprising plasticizer-free copolymers Ion-detecting sensors for detecting a target ion in a sample are provided. The sensor comprises a plasticizer-free copolymer comprised of polymerized units of methacrylate monomers having pendent alkyl groups of different length and a functionalized ionophore of sai... | 04/10/2007 |
| 7199267 | Recognition of oligiosaccaride molecular targets by polycationic small molecule inhibitors and treatment of immunological disorders and infectious diseases Small molecule polycationic agents are used to modulate or interrupt biological processes by binding to oligosaccharide-based biomolecules. Compounds that inhibit nitric oxide, TNFα or other immunomodulators are provided and are useful for treating immunological di... | 04/03/2007 |
| 7183279 | Histogranin-like peptides and non-peptides, processes for their preparation and uses thereof The invention relates to new basic amino acid derivatives of general formulae I, II and III, and the preparation and use thereof in treatment of pain. The compounds have histogranin-like antinociceptive, morphine potentiating and COX-2 induction modulating activitie... | 02/27/2007 |
| 7169760 | Peptides as NS3-serine protease inhibitors of hepatitis C virus The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as metho... | 01/30/2007 |
| 7105539 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula: useful as inhibitors of PHEX. These derivatives are useful for promoting gene... | 09/12/2006 |
| 7102027 | Adamantanetricarboxylic acid derivatives An adamantanetricarboxylic acid derivative is represented by following Formula (1): wherein X is a hydrogen atom or a hydrocarbon group; and R1, R2 and R3 may be the same as or di... | 09/05/2006 |
| 7087646 | Composition for external application The present invention relates to a composition for external application, a humectant and a skin barrier function reinforcing agent, each containing a diamide derivative represented by the following formula (1): (... | 08/08/2006 |
| 7074786 | Histogranin-like peptides, processes for their preparation and uses thereof The invention relates to new basic amino acid derivatives of general formulae I, II and III, and the preparation and use thereof in treatment of pain. The compounds have histogranin-like antinociceptive, morphine potentiating and COX-2 induction modulating activitie... | 07/11/2006 |
| 7067697 | Cationic liposomes for gene transfer The present invention relates to synthetic cationic lipids, liposome formulations and the use of such compounds to introduce functional bioactive agents into cultured cells. ... | 06/27/2006 |
