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| Number | Title | Issue Date |
| 8044241 | Ligands for estrogen related receptors and methods for synthesis of said ligands Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described. ... | 10/25/2011 |
| 7709683 | Synthesis of bis(thio-hydrazide amide) salts A method of preparing a bis(thio-hydrazide amide) disalt includes the steps of combining a neutral bis(thio-hydrazide amide), an organic solvent and a base to form a bis(thio-hydrazide amide) solution; and combining the solution and methyl tert-butyl ether, thereby ... | 05/04/2010 |
| 7619115 | Ortho-substituted N'-benzylidene-(3-hydroxyphenyl)acethydrazides Novel ortho-substituted N′-benzylidene-(3-hydroxyphenyl)acetohydrazides of the formula (I), in which R1-R9 have the meanings indicated in claim 1, are SGK inhibitors and can be used for the treatment of SGK-induced diseases and conditi... | 11/17/2009 |
| 7544838 | Ligands for estrogen related receptors and methods for synthesis of said ligands Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described. ... | 06/09/2009 |
| 7456315 | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding dom... | 11/25/2008 |
| 7405239 | Acylhydrazone derivatives and the use thereof in the inhibition, regulation and/or modulation of kinase signal transduction The invention relates to acylhydrazone derivatives of formula (I), which are SGK inhibitors and can be used for the treatment of diseases and afflictions associated with SGK, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systematic and pulmonary hyp... | 07/29/2008 |
| 7368473 | Paclitaxel enhancer compounds One embodiment of the present invention is a compound represented by the Structural Formula (I): Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with b... | 05/06/2008 |
| 7317125 | Diacylglycerol acyltransferase inhibitors Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutica... | 01/08/2008 |
| 7173063 | Topoisomerase poisons for the treatment of proliferative disorders Methods for the treatment of a proliferative disorder are provided in which a subject in need of such treatment is administered an effective amount of a compound selected from: compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein X1 | 02/06/2007 |
| 7153815 | Insecticide containing hydrazone derivative as the active ingredient and novel hydrazone derivative A insecticide characterized by containing as active ingredient a hydrazone derivative of formula (I) wherein A and Q are an aryl or a heterocyclic group, W is oxygen atom, an aminylene, an alkylene group, an oxya... | 12/26/2006 |
| 7074959 | Methods and systems for remediating hydrazine-contaminated equipment and/or surfaces Methods of and systems for remediating hydrazine spills, solutions and hydrazine-contaminated objects including areas thereof. Initially, an aqueous solution comprising a dicarbonyl-compound can be prepared. The aqueous solution can then be provided for application ... | 07/11/2006 |
| 7049343 | Substituted hydrazine derivatives A method for the inhibition of high affinity glycine transporters, compounds that inhibit these transporters; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevent... | 05/23/2006 |
| 7038074 | Arginine mimetics as factor Xinhibitors The invention relates generally to a novel type of arginine mimetics which are inhibitors of factor Xa; to pharmaceutical compositions which comprise these mimetics; and to the use of these arginine mimetics for producing compositions for antithrombotic t... | 05/02/2006 |
| 6924312 | Taxol enhancer compounds Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, ... | 08/02/2005 |
| 6825235 | Synthesis of taxol enhancers Disclosed is a method of preparing a thiohydrazide product compound from a hydrazide starting compound. The hydrazide starting compound is represented by Structural Formula (I): The thiohydrazide product compound is re... | 11/30/2004 |
| 6800660 | Taxol enhancer compounds Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C... | 10/05/2004 |
| 6762204 | Taxol enhancer compounds One embodiment of the present invention is a compound represented by the Structural Formula (I): Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together w... | 07/13/2004 |
| 6706765 | Aminoguanidines and alkoxyguanidines as protease inhibitors Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: wherein X is O or NR9 and R1-R4, R6-R9, R11, R12, Ra | 03/16/2004 |
| 6596863 | Medical composition containing nitroetheneamine Derivative or salt there of as active constituent Process for producing a nitroetheneamine derivative ##STR1## or its stereoisomer, its tautomer or a salt thereof comprising reacting a compound of the formula ##STR2## with a compound of the formula R6 --CH2 NO2 to obtain ... | 07/22/2003 |
| 6528685 | Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives Novel derivatives of 1-aminoindan and their salts are described. Optically active 1-aminoindan derivatives are prepared by reacting a N-benzyl analog of the desired compound with an enantiomer of mandelic acid. Parkinson's disease, dementia, epilepsy, con... | 03/04/2003 |
| 6518310 | Aminoguanidines and alkoxyguanidines as protease inhibitors Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: ##STR1## wherein X is O or NR9 and R1 -R4, R6 -R9, R11, R12, Ra, Rb, R | 02/11/2003 |
| 6455515 | Salicylohydrazide derivatives, processes and intermediates for their preparation, compositions comprising them, and their use Salicylohydrazide derivatives of the formula I ##STR1## in which the index and the substituents have the following meanings: X is halogen, NO2, cyano, alkyl or alkoxy; m is 0, 1, 2 or 3, it being possible for the substituents X to differ from each o... | 09/24/2002 |
| 6451792 | Medical composition containing nitroetheneamine derivative or salt thereof as active constituent A medical composition containing, as an active constituent, a nitroetheneamine derivative represented by the formula (I): ##STR1## wherein the substituents are as defined in the disclosure, its stereoisomers, its tautomers or a salt thereof.... | 09/17/2002 |
| 6444848 | Process for the preparation of symmetrical diacylhydrazines Process for the preparation of symmetrical diacylhydrazines having general formula (I): R1 --CO--NH--NH--CO--R1 wherein R1 represents a linear or branched C1 -C18 alkyl group; a linear or branched C | 09/03/2002 |
| 6365745 | Method for producing hydrazine derivative The present invention provides a method for producing a hydrazine derivative of the formula [2]: ##STR1## wherein R1 is alkyl group having 1-12 carbon atoms and the like, R2 is alkyl group having 1-12 carbon atoms and the like, and A... | 04/02/2002 |
| 6319894 | Complexes and combinations of fetuin with therapeutic agents There is disclosed a complex and a combination of the glycosylated polypeptide fetuin and a therapeutically active small molecule compound having a net positive charge at physiological pH. The presence of fetuin as a drug complex or in combination with th... | 11/20/2001 |
| 6271263 | Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives Novel derivatives of 1-aminoindan and their salts are described. Optically active 1-aminoindan derivatives are prepared by reacting a N-benzyl analog of the desired compound with an enantiomer of mandelic acid. Parkinson's disease, dementia, epilepsy, con... | 08/07/2001 |
| 6235787 | Hydrazine derivatives Hydrazine derivatives of the formula ##STR1## wherein Y is CO or SO2 ; R1 is lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl; R2 is lower alkyl, halo-lower alkyl, aryl-l... | 05/22/2001 |
| 6177594 | 4-(4-oxocyclohexyl) benzamides as intermediate products for medicaments Benzamides of the formula I: ##STR1## wherein R1 and R2 independently of one another are each alkyl having 1-6 C atoms, or R1 and R2 together are alkylene, and their salts, are suitable as intermediates in the synthe... | 01/23/2001 |
| 6172108 | Hydrazide compounds Compounds of formula (I): R--NH--A--CO--NH--NH--(W)n --Z (I) wherein: n is 0 or 1, W represents --CO-- or S(O)r wherein r is 0, 1 or 2, Z represents a group selected from aryl, arylalkyl, heteroaryl and heteroarylalkyl, each optionally substi... | 01/09/2001 |
| 6096890 | Process for substituted hydrazides using carboxylic acids This invention provides a convenient process for the preparation of monoacylhydrazines from carboxylic acids or their salts and hydrazine or substituted hydrazine in the presence of a 1,3,5-triazine substituted with at least one chloro or fluoro. The resu... | 08/01/2000 |
| 6063819 | Neuroprotective poly-guanidino compounds which block presynaptic N and P/Q calcium channels Neuroprotective drugs are disclosed with at least 3 branches extending outwardly from a center atom or group, each branch having a guanidino group at its terminus. All branches preferably should be identical, and distributed around the center atom or grou... | 05/16/2000 |
| 6015904 | Stable reagents for the preparation of radio pharmaceuticals This invention provides novel reagents for the preparation of radiopharmaceuticals useful as imaging agents for the diagnosis of cardiovascular disorders, infection, inflammation and cancer, diagnostic kits comprising said reagents and intermediate compou... | 01/18/2000 |
| 5989774 | Photographic material containing a new hydrazide type A silver halide photographic material is disclosed containing a new type of hydrazide compound represented by following general formula I, the different symbols of which are defined in the description. ##STR1## In a preferred embodiment Q is pyridini... | 11/23/1999 |
| 5981138 | Hydrazine compound and silver halide photographic light-sensitive material using the same A hydrazine compound represented by the following formula (I): Ar1 --NH--NH--G1 --R1 (I) wherein Ar1 represents an aromatic group; G1 represents a carbonyl group, a sulfonyl group, a sulfo... | 11/09/1999 |
| 5962722 | -hydrazino acid derivatives and method for making same An -hydrazino acid derivative of general formula (I) is described, wherein R1, R2, R3 are hydrogen or a carbon radical, such that when R2 and R3 are different, C* is an asymmetric carbon of L, ... | 10/05/1999 |
| 5942644 | Precursors for the production of chiral vicinal aminoalcohols The disclosure describes new compositions of matter useful for the preparation of optically-active vicinal aminoalcohols. The compositions are chiral ଲ-hydroxycarboxamides, ଲ-hydroxyhydraxides, and ଲ-hydroxyhydroxamic acids.... | 08/24/1999 |
| 5929281 | Process for producing heterocyclic aromatic amine or arylamine A heterocyclic aromatic halide or an aryl halide is reacted with an amine compound in the presence of a base to give a heterocyclic aromatic amine or an arylamine, respectively. In this reaction, a catalyst comprising a palladium compound and a tertiary p... | 07/27/1999 |
| 5912352 | Intermediates for the preparation of peptide analogues The invention relates to a novel process for the preparation of compounds of formula I ##STR1## wherein R1 is hydrogen or a suitable amino-protecting group, R2 is unsubstituted or substituted alkyl, R3 is hydrogen, aryl, h... | 06/15/1999 |
| 5811456 | Monoamine oxidase B inhibitors, processes for their preparation and use thereof Novel monoamine oxidase B inhibitors of formula (I), wherein R1 .dbd.H, an optionally substituted benzyloxy or phenylethoxy group; p=0-3; R3 .dbd.H, a CN, OH, CCH group, a C1 -C3 alkoxy-carbonyl group, or a C | 09/22/1998 |
