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| Number | Title | Issue Date |
| 7329780 | Method of preparing optically pure phenethylamine derivatives Provided is a method of preparing an optically pure compound having formula 1 or its salts. The method includes: reacting (R)-2-(4-methoxy-3-aminosulfonyl-phenyl)-1 -methylethylamine or its salts with a compound selected from the group consisting of chloroacetic aci... | 02/12/2008 |
| 7154007 | Luminous compounds and labeling reagents using the same This invention provides: a compound represented by formula (I): R—Y—(—X-Phe-COCH2COCnF2n+1)m (I) wherein R denotes hydrogen, alkyl, phenyl, or a group capable of binding to a protein, peptid... | 12/26/2006 |
| 7053245 | N-acylamino benzyl ether derivatives This invention relates to N-acylamino aryl derivatives of the formula where R1, R21, R22, R23, R24, R3, R4, R5, R | 05/30/2006 |
| 6673967 | Method of processing of hydrogen for reductive acylation of nitro, azido and cyano arenes A method for processing of hydrogen for the reductive acylation of nitro, azido and cyano arenes is disclosed. More particularly, improved process for the preparation of amides and anilides using C3 -C7 carboxylic acids as proton sou... | 01/06/2004 |
| 6630602 | Propylisopropyl acetic acid and propylisopropyl acetamide stereoisomers, a method for their synthesis and pharmaceutical compositions containing them The present invention relates to racemic propylisopropyl acetic acid and propylisopropyl acetamide and their isomers in their racemic and stereospecific forms, for use in treatment of neurological and psychotic disorders, and affective disorders and to tr... | 10/07/2003 |
| 6562963 | Process for the preparation of macrocyclic metalloprotease inhibitors The present invention is directed to a process for the preparation of a compound of formula (X-a) ##STR1## or a pharmaceutically acceptable salt form thereof, wherein: R1 is selected from the group consisting of: C1-5 alkyl substituted wi... | 05/13/2003 |
| 6552226 | Tandem acyl-Claisen rearrangement in the preparation of chiral products A novel tandem acyl-Claisen rearrangement reaction is provided. An allylic reactant such as an allylic amine or an allylic thioether, having at least two functional groups that enable the reactant to undergo at least two successive Claisen rearrangement r... | 04/22/2003 |
| 6509500 | Continuous preparation of incorporated photographic amides This invention relates to a method of making an incorporated photographic amide comprising a) continuously combining an amine capable of forming an incorporated photographic amide, an acid chloride, one or more acid-absorbing reagents, and one or more wat... | 01/21/2003 |
| 6420604 | Process for the acylation of amino alcohols The present invention discloses an improved process for the N-acylation of amino alcohols employing an organic acid in the form of an acid halogenide, wherein the acylation occurs in an organic solvent in the additional presence of water.... | 07/16/2002 |
| 6417399 | Amelioration of neurological disorders by the administration of (2R),(3S), and/or (2S),3(S) stereoisomers of valnoctamide The present invention generally relates to the individual stereoisomers of the drug valnoctamide (a mixture of four stereoisomer kinds, VCD-valmethamide or 2-ethyl-3-methyl pentanamide) useful in treatment of neurological and psychotic disorders such as d... | 07/09/2002 |
| 6384279 | Synthesis of a tetraamido macrocycle ligand from a novel diamidodiol A new composition of matter for a diamidodiol and a method for preparing the diamidodiol. The exemplary diamidodiol has the formula C15 H30 N2 O4 and is prepared by reacting a first quantity of 2-amino-2-methyl-... | 05/07/2002 |
| 6369249 | Process for the preparation of N-substituted acrylamides The present invention relates to a process for the preparation of N-substituted acrylamides of the general formula CH2.dbd.CH--CONHR, wherein, R is alkyl group having carbon 1 to 22 or acyl group having carbon 1 to 18. The process for the prepa... | 04/09/2002 |
| 6323365 | Active derivative of valproic acid for the treatment of neurological and psychotic disorders and a method for their preparation The invention relates to pharmaceutical compositions and methods of preparation thereof suitable for the treatment of neurological, affective and psychotic disorders and for the treatment of pain and migraine comprising as an active ingredient an effectiv... | 11/27/2001 |
| 6291712 | Process for producing saturated aliphatic carboxylic acid amide A process for producing a saturated aliphatic carboxylic acid amide, comprising reacting a saturated aliphatic carboxylic acid with ammonia to thereby obtain a saturated aliphatic ammonium carboxylate and subjecting the saturated aliphatic ammonium carbox... | 09/18/2001 |
| 6262295 | Process for the preparation of a racemic or optically active 4-(hydroxymethyl)-2-cyclopentene derivative A process for the preparation of a racemic or optically active compound of the formula ##STR1## where the group R1 is an unsubstituted or a halogen substituted C1-4 -alkyl, a C1-4 -alkoxy, an aryl, an arylalkyl, an aryloxy... | 07/17/2001 |
| 6166243 | Process for the preparation of insecticidal phenylhydrazine derivatives Disclosed herein is a method for making compounds having the structural formulae (I) or (II): ##STR1## wherein: X is a) phenyl; lower phenylalkoxy; phenoxy; or benzyl; or b) one substituent from group a) and one or more substituents selected from ... | 12/26/2000 |
| 6156893 | Process for the preparation of (1S,4R)- or (1R,4S)- 4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol A novel process for the preparation of (1S,4R)- or (1R,4S)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclo-pentene-1-methanol of the formulae ##STR1## is described. This entails in the first stage (&#b1;)-2-aza-bicyclo[2.2.1]hept-5-en-3-one of the fo... | 12/05/2000 |
| 6107498 | Process for making carboxylic amides Methods for producing carboxylic amides involves combining near-stoichiometric amounts of carboxylic acid and amine in a reaction vessel and reacting under pressures greater than atmospheric pressure. Alternatively, an excess of amine is reacted with carb... | 08/22/2000 |
| 6008390 | Process for producing N-long-chain acyl acidic amino acids or salts thereof N-long-chain acyl acidic amino acids or salts thereof are prepared by condensing an acidic amino acid or a salt thereof and a C8 -C22 long-chain fatty acid chloride in an aqueous solvent with stirring at a stirring power of not less ... | 12/28/1999 |
| 5859300 | Process for the hydrogenation of imines A process for the hydrogenation of imines with hydrogen under elevated pressure in the presence of iridium catalysts containing diphosphine ligands, with or without an inert solvent, the reaction mixture containing a soluble ammonium chloride, bromide or ... | 01/12/1999 |
| 5859299 | Process for making nitro and amino substituted benzamides A process is provided for the production of nitrobenzamides or aminobenzamides having the formula: ##STR1## in which n is 1 or 2, preferably 1, X is an amino or nitro group and R is hydrogen, unsubstituted alkyl or alkyl substituted by halogen, C | 01/12/1999 |
| 5831126 | Herbicidal compositions based on N-(4-fluoro-phenyl)-N-isopropyl-chloroacetamide, and process for the preparation of this compound The invention relates to the use of the compound N-(4-fluoro-phenyl)-N-isopropyl-chloroacetamide of the formula (I) ##STR1## which is known, as active compound in selective herbicidal compositions, for example for combating weeds in maize cultures, a... | 11/03/1998 |
| 5763661 | Preparation of acylated -amino carboxylic acid amides A method of preparing acylated -amino carboxylic acid amides directly from amino nitriles in high yield and purity. The method involves acylating the amino nitrile with an acyl halide under Schotten-Baumann conditions, and hydrolyzing the resulting... | 06/09/1998 |
| 5723665 | Ethenyl amide compound production process A process for producing an ethenyl amide compound, which comprises reacting a Schiff base compound having a carbon atom adjacent to a carbon atom constituting an imino group and at least one hydrogen atom on the carbon atom with an acylhalide at a reduced... | 03/03/1998 |
| 5650540 | Method of producing amide compound Provided is a method of producing a highly pure amide compound in a high yield, wherein a silazane compound and/or a silane compound having at least one silicone-nitrogen bond are added to a reaction mixture obtained by reacting an acylfluoride group-cont... | 07/22/1997 |
| 5587513 | Polyether-substituted imide compounds and their use The present invention relates to novel polyether-substituted compounds of imides and their use as surface-active agents.... | 12/24/1996 |
| 5523485 | Preparation of high-purity isobutyramide A process for preparing high-purity isobutyramide which comprises reacting isobutyryl chloride in toluene or xylene at -15° to 30° C. with ammonia is described.... | 06/04/1996 |
| 5312985 | Method of synthesizing the precursor pyruvamide A method for administering pyruvate is disclosed which comprises administering a therapeutically effective amount of a pyruvate precursor to a mammal in the form of pyruvamide or a pyruvyl-amino acid. The pyruvyl-amino acid is preferably selected from the... | 05/17/1994 |
| 5183938 | N,N'-bis(4,4,4-trinitrobutyryl)hydrazine N,N'-Bis(4,4,4-trinitrobutyryl)hydrazine which is prepared by reacting 4,-trinitrobutyryl chloride with hydrazine in methanol at low temperature. This compound is sensitive enough to be used as an initiating explosive and thermally stable enough to be us... | 02/02/1993 |
| 5105009 | Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoropropane derivatives Intermediates of Formula ##STR1## where R is a methylthio, methylsulfoxy, methylsulfonyl or a nitro group; and X1 is hydrogen, 1-6 C alkyl, 1-6 C haloalkyl, 3-6 C cycloalkyl, phenyl or phenylalkyl(1-6C), where the phenyl ring may be substituted by on... | 04/14/1992 |
| 4990671 | Method for making aminophenols and their amide derivatives N-acylated dialkylaminophenols are produced at greater yields under mild reaction conditions by a novel in situ process which begins with catalytic hydrogenation of dialkylnitrosophenols in an aprotic organic reaction medium.... | 02/05/1991 |
| 4973750 | Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols A novel sequence of highly selective chemical reactions for conversion of 3-Aryl-2-propyn-1-ols into cis-1-Aryl-3-fluoro-1-propene and into D,L-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanols is disclosed. Preparation of D-(threo)-1-Aryl-2-acylamido-3-flu... | 11/27/1990 |
| 4946983 | Process for the acylation of N,N-diallylaniline or a mixture of N,N-diallylaniline and N-allylaniline A process for the preparation of N-acyl-N-allylaniline. A solution of diallylaniline or a mixture of monoallyl and diallylaniline is placed in contact with a carboxylic acid halide.... | 08/07/1990 |
| 4871872 | 2-[(2-aminoacetyl)amino]acetamide derivatives Compounds are provided of the following general structure: ##STR1## wherein R1, R2, R3 and R4 are hydrogen or methyl and where R5 and R6 are independently selected from hydrogen or flu... | 10/03/1989 |
| 4731480 | Process for preparing 2-acyl-3,4-dialkoxyanilines A process for preparing 2-acyl-3,4-dialkoxyanilines is described. The 2-acyl-3,4-dialkoxyanilines are useful intermediates in the preparation of 5,6-dialkoxy-4-alkyl-2(1H)-quinazolinones. The substituted quinazolinones are active as cardiotonic agents.... | 03/15/1988 |
| 4721797 | Process for the preparation of N-acyl-N-alkyl-2,6-dialkyl-3-chloroanilines N-acyl-N-alkyl-2,6-dialkyl-3-chloroanilines of the formula ##STR1## wherein R1 is methyl or ethyl, R2 is alkoxymethyl, chloromethyl or 2-tetrahydrofuryl, R3 is alkoxymethyl, carboxy or alkoxycarbonyl and R4... | 01/26/1988 |
| 4655972 | Catalytic preparation of carbonamides Carbonamides are prepared from carboxylic acids and ammonia in the presence of a catalytic amount of a hydrated oxide. Preferably a hydrated titanium-, zirconium- or tin oxide in an amount between 0.05 to 10% by weight is used. The hydrated oxide contains at ... | 04/07/1987 |
| 4568765 | Isoprenylamine derivatives This invention relates to new isoprenylamine derivatives and acid addition salts thereof, which are useful as medicines for controlling virus infection of vertebrate animals, or the intermediates therefor.... | 02/04/1986 |
| 4562201 | Aminomethyl benzanilides The present invention relates to new compounds of the formula ##STR1## where X is ##STR2## alkylene, or --S-- where R1 is hydrogen, alkyl, or aryl; W is hydrogen, hydroxy, amino, alkyloxy, aryloxy, O-alkyl, or O-aralkyl; (Y)... | 12/31/1985 |
| 4511736 | Process for the preparation of substituted chloroacetanilides The invention relates to a novel process for preparing chloroacetanilides of the formula ##STR1## wherein: R1 and R2 represent independently from each other a hydrogen atom or a C1-8 alkyl or C1-8 alkoxy gr... | 04/16/1985 |
