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| Number | Title | Issue Date |
| 8110705 | Processes for making hydrazides A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continu... | 02/07/2012 |
| 7985879 | Process for making galantamine A novel process for the preparation of N-methyl-N-(2-[4-hydroxyphenyl]ethyl)-5-hydroxy-4-methoxy benzene carboxamide, which is useful as an intermediate in the synthesis of (−)-galantamine, comprises the reaction of a 5-hydroxy-4-methoxy benzoic acid derivative wi... | 07/26/2011 |
| 7531691 | Method for producing naphthalene carboxylic acid amide compound The present invention provides a method for producing a naphthalenecarboxylic acid amide compound represented by formula [1] comprising, reacting a naphthalenecarboxylic acid halide compound represented by formula [2] with ammonium acetate in a solvent having an eth... | 05/12/2009 |
| 7390923 | Propionamide derivatives useful as androgen receptor modulators Compounds of formula (I) wherein R1 to R4, X and A are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective andro... | 06/24/2008 |
| 7288619 | Fluorinated polyether polyamine and method of making the same A composition comprises a condensation product of an amine-reactive fluorinated polyether and a polyamine. The compositions may be in dispersed in water. ... | 10/30/2007 |
| 7205436 | Process for manufacture of quaternary ammonium tosylate salts of cinnamidoalkylamines and / or benzamidoalkylamines An efficient, simple, high yielding, eco-friendly process for the manufacture of tosylates quaternary ammonium salts of cinnamidoalkylamines and/or benzamidoalkylamines (Formula I) has been described. These compounds are substantive UV-absorbers. They are useful in ... | 04/17/2007 |
| 7188055 | Method, system, and computer program for displaying chemical data A system, method, and computer program product for visualizing and interactively analyzing data relating to chemical compounds. A user selects a plurality of compounds to map, and also selects a method for evaluating similarity/dissimilarity between the selected com... | 03/06/2007 |
| 7169813 | 4-oxo-fenretinide, administered alone and in combination with fenretinide, as preventive and therapeutic agent for cancer A drug based on a metabolite of fenretinide, or N-(4hydroxyphenyl) retinamide (4-HPR), specifically 4-oxo-N-(4-hydroxyphenyl) retinamide (4-oxo-4-HPR), is used in the treatment of different kinds of tumors, in particular in the treatment of ovarian carcinoma, breast... | 01/30/2007 |
| 7039621 | System, method, and computer program product for representing object relationships in a multidimensional space A method and computer product is presented for mapping n-dimensional input patterns into an m-dimensional space so as to preserve relationships that may exist in the n-dimensional space. A subset of the input patterns is chosen and mapped into the m-dimensional spac... | 05/02/2006 |
| 6995284 | Synthesis of selective androgen receptor modulators The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. The agents define a new subc... | 02/07/2006 |
| 6965048 | Hydroxyalkylamide derivatives The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, X, W, m and n are as defined hereinabove. The compounds are useful for the treatment and/or ... | 11/15/2005 |
| 6696606 | Solid phase synthesis of arylretinamides A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent; reactin... | 02/24/2004 |
| 6667341 | Delta dicarbonyl compounds and methods for using the same Amidomethyl esters, carbonylmercaptomethyl esters, keto-containing esters, amidomethyl thioesters, amidomethyl amides, and methylene dithioesters are disclosed. The novel compounds have two carbonyl groups connected by a linking moiety having an oxygen, s... | 12/23/2003 |
| 6570037 | Nitro-benzamides useful as anti-arrhythmic agents A compound of formula (I): or a salt thereof, or a solvate thereof, wherein Ar represents substituted or unsubstituted aryl, wherein the optional substituents are selected from alkyl, hydroxy or alkoxy or, if attached to adjacent carbon atoms any two subs... | 05/27/2003 |
| 6552217 | Process for the preparation of alkyl 1-methylcyclopropanecarboxylate Disclosed is a 4-step process for the preparation of alkyl esters of 1-methylcyclopropanecarboxylic acid which comprises the steps of (1) converting γ-butyrolactone to -methyl-γ-butyrolactone; (2) converting the -methyl-γ-butyrolactone fr... | 04/22/2003 |
| 6552226 | Tandem acyl-Claisen rearrangement in the preparation of chiral products A novel tandem acyl-Claisen rearrangement reaction is provided. An allylic reactant such as an allylic amine or an allylic thioether, having at least two functional groups that enable the reactant to undergo at least two successive Claisen rearrangement r... | 04/22/2003 |
| 6548702 | Method for the preparation of 2-methoxy-4-(N-t-butylamino-carbonyl)-benzenesulfonyl chloride The invention relates to a process for the preparation of 2-methoxy-4-(N-t-butylaminocarbonyl)benzenesulfonyl chloride by sulfonating m-hydroxybenzoic acid, methylating the hydroxy group of the resulting sulfonic acid or its salt, transforming the carboxy... | 04/15/2003 |
| 6515175 | Mono-and polyamides of perfluoroalkyl-substituted unsaturated acids Novel perfluoroalkyl-substituted mono-, di- and poly-amide compounds which are reaction products of a mono-, di- or polyamine of 60 to 2000 molecular weight with a perfluoroalkyl substituted unsaturated acid or its corresponding lower alkyl ester and opti... | 02/04/2003 |
| 6509500 | Continuous preparation of incorporated photographic amides This invention relates to a method of making an incorporated photographic amide comprising a) continuously combining an amine capable of forming an incorporated photographic amide, an acid chloride, one or more acid-absorbing reagents, and one or more wat... | 01/21/2003 |
| 6504057 | Fluorophenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them This invention relates to fluorophenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them. An embodiment of the invention embraces compounds of the formula ... | 01/07/2003 |
| 6426435 | Substantive water-soluble bis-quaternary salts of cinnamidoalkylamines Substantive UV-absorbing water-soluble quaternary salts of cinnamidoalkylamine of formula I. Hair, skin and fabric care compositions containing the compounds of formula I; ##STR1## wherein R1 represents up to four substituents, same or differen... | 07/30/2002 |
| 6420604 | Process for the acylation of amino alcohols The present invention discloses an improved process for the N-acylation of amino alcohols employing an organic acid in the form of an acid halogenide, wherein the acylation occurs in an organic solvent in the additional presence of water.... | 07/16/2002 |
| 6417399 | Amelioration of neurological disorders by the administration of (2R),(3S), and/or (2S),3(S) stereoisomers of valnoctamide The present invention generally relates to the individual stereoisomers of the drug valnoctamide (a mixture of four stereoisomer kinds, VCD-valmethamide or 2-ethyl-3-methyl pentanamide) useful in treatment of neurological and psychotic disorders such as d... | 07/09/2002 |
| 6417396 | Quenching reagents for solution phase synthesis A method for enhancing the purity of a desired compound comprising: Step (a) treating a crude reaction product which contains at least one desired compound, unreacted starting materials and/or byproducts with at least one bifunctional quenching agent that is c... | 07/09/2002 |
| 6384279 | Synthesis of a tetraamido macrocycle ligand from a novel diamidodiol A new composition of matter for a diamidodiol and a method for preparing the diamidodiol. The exemplary diamidodiol has the formula C15 H30 N2 O4 and is prepared by reacting a first quantity of 2-amino-2-methyl-... | 05/07/2002 |
| 6384278 | Boron-mediated amidation of carboxylic acids The present invention provides an inexpensive one-step method for preparing an aromatic carboxamide, such as a phenyl substituted carboxamide) by reacting an aromatic amine (e.g. a phenylamine) and a carboxylic acid (e.g. an alkanoic acid or ester thereof... | 05/07/2002 |
| 6359174 | Lewis acid-catalyzed claisen rearrangement in the preparation of chiral products A novel Claisen rearrangement reaction is provided. An allylic reactant such as an allylic amine, an allylic ether or an allylic thioether is reacted with an acid chloride in the presence of a Lewis acid catalyst composition composed of a Lewis acid and a... | 03/19/2002 |
| 6350909 | Methoxymino-phenylacetamide derivatives and their utilization as pesticides The invention relates to new imides, to a plurality of processes for their preparation and to their use as fungicides.... | 02/26/2002 |
| 6350908 | Process for the preparation of S-N,N'-bis [2-hydroxy-1-(hydroxymethyl) ethyl]-5- [(2-hydroxy-1-oxopropyl) amino]-2,4,6-triiodo-1,3-benzenedicarboxamide A process for the preparation of S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)ami no]-2,4,6-triiodo-1,3-benzenedicarboxamide, comprising the reaction of S-(-)-5-[[2-(acetyloxy)-1-oxopropyl]amino]-2,4,6-triiodo-1,3-benzenedicarb ... | 02/26/2002 |
| 6319925 | O-benzyl oxime ether derivatives and their use in crop protection compositions ##STR1## Oxime ethers of formula (I) in which a) X is an N atom and Y is an oxygen atom or NH, or b) X is CH and Y is an oxygen atom, in which furthermore R1 is C1 -C4 alkyl; R2 is hydrogen, C1 -C4 | 11/20/2001 |
| 6265611 | Hydroxymandelic acid amides of phenolic amines The present invention relates to hydroxymandelic acid amides of phenolic amines which can be used as antioxidants or as free-radical scavengers, particularly in the cosmetic or dermatological field, in foods and in cosmetic and dermatological compositions... | 07/24/2001 |
| 6262295 | Process for the preparation of a racemic or optically active 4-(hydroxymethyl)-2-cyclopentene derivative A process for the preparation of a racemic or optically active compound of the formula ##STR1## where the group R1 is an unsubstituted or a halogen substituted C1-4 -alkyl, a C1-4 -alkoxy, an aryl, an arylalkyl, an aryloxy... | 07/17/2001 |
| 6262303 | Process for the preparation of S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)-am ino]-2,4,6-triiodo-1,3-benzenedicarboxamide A process for the preparation of S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)ami no]-2,4,6-triiodo-1,3-benzenedicarboxamide, comprising the formation of S-N,N'-bis[2-hydro-xy-1-(hydroxymethyl)ethyl]-5-[(2-(acetyloxy)-1-oxopro-p ... | 07/17/2001 |
| 6211384 | Methods for the acylation of amine compounds Method for the acylation of amines are disclosed in which includes reacting a first reactant containing an amine group with a second reactant containing an acyl halide group, wherein the reaction takes place in the presence of secondary carboxylic acid sa... | 04/03/2001 |
| 6156893 | Process for the preparation of (1S,4R)- or (1R,4S)- 4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol A novel process for the preparation of (1S,4R)- or (1R,4S)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclo-pentene-1-methanol of the formulae ##STR1## is described. This entails in the first stage (&#b1;)-2-aza-bicyclo[2.2.1]hept-5-en-3-one of the fo... | 12/05/2000 |
| 6153651 | Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them. Ortho-substituted benzoylguanidines of the formula I ##STR1## in which R(1) to R(4) have the meanings given in the... | 11/28/2000 |
| 6121488 | Quenching reagents for solution phase synthesis A method for enhancing the purity of a desired compound comprising: Step (a) treating a crude reaction product which contains at least one desired compound, unreacted starting materials and/or byproducts with at least one bifunctional quenching agent that is c... | 09/19/2000 |
| 6121326 | Substituted alkyltetraamine derivatives Compounds which are useful as a tachykinin antagonist are substituted alkyltetraamine derivatives which are represented by the following formula (I) or a pharmaceutically acceptable salt, a complex compound or a solvate thereof. ##STR1## wherein... | 09/19/2000 |
| 6114391 | -amino acid amides, preparation thereof and the therapeutical use thereof The present invention relates to serinamide, glycinamide, alaninamide and phenylalaninamide derivatives of formula (I) wherein R, R', R1 and R2 are as defined in the disclosure. The compounds (I) are useful for the treatment of neuro... | 09/05/2000 |
| 6110976 | Perfluoro (alkoxycycloalkane) carbonyl fluoride compositions and their use This invention provides perfluoro(alkoxycycloalkane) carbonyl fluoride compounds wherein, pendant from the fluorinated ring, are from 2 to 5 perfluoroalkoxy groups having from 1 to 4, preferably 1 to 2, carbon atoms with the proviso that when one or more ... | 08/29/2000 |
