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| Number | Title | Issue Date |
| 8067635 | Method for producing tertiary amides of alkylphenyl carboxylic acids The invention relates to a method for producing tertiary amides of alkylphenyl carboxylic acids by reacting at least one secondary amine with at least one alkylphenyl carboxylic acid to form an ammonium salt, said ammonium salt being subsequently converted into the ... | 11/29/2011 |
| 7612236 | Method for producing optically active bisamidoalcohol compound It is provided that a method for producing an optically active bisamidoalcohol compound represented by the formula (3): wherein R1 represents a C1-6 alkyl group, an optionally substituted phenyl group, an optiona... | 11/03/2009 |
| 7462740 | Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[[1(r)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I ... | 12/09/2008 |
| 7329780 | Method of preparing optically pure phenethylamine derivatives Provided is a method of preparing an optically pure compound having formula 1 or its salts. The method includes: reacting (R)-2-(4-methoxy-3-aminosulfonyl-phenyl)-1 -methylethylamine or its salts with a compound selected from the group consisting of chloroacetic aci... | 02/12/2008 |
| 7291621 | Substituted biaryl amides C5a receptor modulators Substituted biaryl amides of Formula I are provided. Such compounds are ligands that may be used to modulate C5a receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological C5... | 11/06/2007 |
| 7291615 | Cyclic derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis and ... | 11/06/2007 |
| 7189873 | Propargylether derivatives, a process for their preparation and their use for controlling phytopathogenic microorganisms The invention relates to 4-propargyloxy-benzyl dervatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl or optionally ... | 03/13/2007 |
| 7148225 | Substituted biaryl amides as C5A receptor modulators Substituted biaryl amides of Formula I are provided. Such compounds are ligands that may be used to modulate C5a receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological C5a receptor activation in... | 12/12/2006 |
| 7109371 | Prostaglandin synthesis A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C1–C6 alkyl groups; C7–C16 aralk... | 09/19/2006 |
| 7045139 | Process for manufacture of quaternary ammonium tosylate salts of cinnamidoalkylamines and/or benzamidoalkylamines An efficient, simple, high yielding, eco-friendly process for the manufacture of tosylates quaternary ammonium salts of cinnamidoalkylamines and/or benzamidoalkylamines (Formula I) has been described. These compounds are substantive UV-absorbers. They are useful in ... | 05/16/2006 |
| 7045521 | Cyclic derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis and ... | 05/16/2006 |
| 6921839 | Synthesis of N,N-dimethyl-3-(4-methyl) benzoyl propionamide a key intermediate of zolpidem The present invention relates to an improved and industrially advantageous process for the preparation of N,N-dimethyl-3-(4-methyl)benzoyl propionamide of Formula I, which is a key intermediate in the synthesis of zolp... | 07/26/2005 |
| 6908934 | Therapeutic compounds for treating dyslipidemic conditions Compounds of Formula I and the pharmaceutically acceptable salts and esters thereof, wherein Z is selected from the group consisting of: (a) Formula Ia | 06/21/2005 |
| 6891049 | Method for producing N-alkoxy-N-alkylamides The method for producing N-alkoxy-N-alkylamides of general formula (I): wherein R1 represents C1-10-alkyl, cyclo-C5-7-alkyl, cyclo-C5-7-alkenyl, C2-10-alkenyl, ary... | 05/10/2005 |
| 6878750 | Benzocycloheptenes, process for their production, pharmaceutical preparations that contain the latter as well as their use for the production of pharmaceutical agents This invention describes the new benzocycloheptenes of general formula I in which R1, R2 and SK have the meanings that are indicated in the description. The new ... | 04/12/2005 |
| 6821965 | Amidobenzamide derivatives which are useful as cytokine inhibitors The invention concerns amide derivatives of the Formula (I) wherein R3 is (1-6C)alkyl or halogeno; Q is aryl or heteroaryl which optionally bears 1, 2, 3 or 4 substituents such as hydroxy, halogeno, trifluor... | 11/23/2004 |
| 6706712 | Cyclic derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma. | 03/16/2004 |
| 6683211 | Phenyl-propargylether derivatives The invention relates to phenyl-propargylether derivatives of the general formula I ##STR1## including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R... | 01/27/2004 |
| 6613340 | Substantive hydrophobic cationic UV-absorbing compounds Substantive UV absorbing organic-soluble quaternary salts of cinnamidoalkylamine are described. Hair, skin and fabric care compositions containing the compounds of formula I. ##STR1## wherein R1 is a substituent, selected from H, halo, --OH... | 09/02/2003 |
| 6603043 | Process for the preparation of (schiff bases of) -alkyl--amino acid amides Process for the preparation of a Schiff base of an -alkyl--amino acid amide and an aldehyde, wherein the corresponding -aminonitrile is contacted with a base and the aldehyde and wherein it is ensured that the reagents are in good con... | 08/05/2003 |
| 6562963 | Process for the preparation of macrocyclic metalloprotease inhibitors The present invention is directed to a process for the preparation of a compound of formula (X-a) ##STR1## or a pharmaceutically acceptable salt form thereof, wherein: R1 is selected from the group consisting of: C1-5 alkyl substituted wi... | 05/13/2003 |
| 6555709 | Aromatic amides, their preparation process and their use as pesticides Aromatic amides, their preparation process and their use as pesticides. ##STR1##... | 04/29/2003 |
| 6528230 | Dye precursor, image forming material, and image forming method The present invention provides a dye precursor for forming color through contact with a base and which is represented by either of the following formulas (1) and (2): ##STR1## wherein Ar represents an aromatic ring or a heterocyclic ring, each of whi... | 03/04/2003 |
| 6495607 | Benzocycloheptenes, process for their production, pharmaceutical preparations that contain the latter as well as their use for the production of pharmaceutical agents Benzocycloheptenes of general formula I ##STR1## in which R1, R2 and Y have the meanings indicated herein, have antiestrogenic activity on and are suitable for the production of pharmaceutical agents, especially for prophylaxis and t... | 12/17/2002 |
| 6486347 | Preparation of phosphine ligands A process for the preparation of a compound having the formula R3 R4 P--Ar--CO--X wherein Ar is an aryl group bearing the PR3 R4 and COX groups in a 1,2-relationship, and optionally bearing also one or more non-inter... | 11/26/2002 |
| 6472435 | Anti-tumor agents The invention concerns anti-tumor agents of formula (I), wherein each of R1, R2 and R3 has the meanings defined in the specification including hydrogen, (1-4C)alkyl, (3-4C)alkynyl and (1-4C)alkoxyl; each of R4 a... | 10/29/2002 |
| 6458948 | Process for producing carboxylic acid derivative and condensing agent comprising quaternary ammonium salt A method of preparing carboxylic acid derivatives comprising mixing a quaternary ammonium salt having a particular triazine ring in the molecules thereof, a carboxylic acid compound and a compound having a nucleophilic functional group, to condense the ca... | 10/01/2002 |
| 6441235 | Preparation of 5-amino-isophthalamides A process for preparing 5-amino-N,N'-bis(R)isophthalamides, where A is 2,3-dihydroxypropyl or 1,3-dihydroxyisopropyl, useful as intermediates in preparing iodinated diagnostic agents, which comprises reacting a di-lower-alkyl 5-nitroisophthalate with a co... | 08/27/2002 |
| 6384278 | Boron-mediated amidation of carboxylic acids The present invention provides an inexpensive one-step method for preparing an aromatic carboxamide, such as a phenyl substituted carboxamide) by reacting an aromatic amine (e.g. a phenylamine) and a carboxylic acid (e.g. an alkanoic acid or ester thereof... | 05/07/2002 |
| 6319925 | O-benzyl oxime ether derivatives and their use in crop protection compositions ##STR1## Oxime ethers of formula (I) in which a) X is an N atom and Y is an oxygen atom or NH, or b) X is CH and Y is an oxygen atom, in which furthermore R1 is C1 -C4 alkyl; R2 is hydrogen, C1 -C4 | 11/20/2001 |
| 6265611 | Hydroxymandelic acid amides of phenolic amines The present invention relates to hydroxymandelic acid amides of phenolic amines which can be used as antioxidants or as free-radical scavengers, particularly in the cosmetic or dermatological field, in foods and in cosmetic and dermatological compositions... | 07/24/2001 |
| 6207861 | Method for producing and screening mass coded combinatorial libraries for drug discovery and target validation The present invention provides a method for producing a mass-coded combinatorial library comprising a set of compounds having the general formula X(Y)n, where X is a scaffold, each Y is, independently, a peripheral moiety, and n is an integer g... | 03/27/2001 |
| 6130315 | Peptidase inhibitors This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide... | 10/10/2000 |
| 6130312 | Production of aromatic polyamide A process for producing an aromatic polyamide which comprises: (a) a dicarboxylic acid component which consists of 30-100 mol % of terephthalic acid and optionally 0-70 mol % of at least one dicarboxylic acid other than terephthalic acid, and (b) a diamine com... | 10/10/2000 |
| 6124502 | Mercaptoketones and mercaptoalcohols and a process for their preparation This invention relates to matrix metalloproteinase (MMP) inhibiting compounds of the formula: ##STR1## where R1 is C1 -C12 alkyl, straight or branched and optionally substituted by halogen, hydroxy, C1 -C | 09/26/2000 |
| 6121326 | Substituted alkyltetraamine derivatives Compounds which are useful as a tachykinin antagonist are substituted alkyltetraamine derivatives which are represented by the following formula (I) or a pharmaceutically acceptable salt, a complex compound or a solvate thereof. ##STR1## wherein... | 09/19/2000 |
| 6117365 | Phenolic acid amides of hydroxy-substituted benzylamines The invention relates to specific phenolic acid amides of hydroxy-substituted benzylamines of the formula I ##STR1## to a process for their preparation and to their use as antioxidants or as free-radical scavengers, in particular in the cosmetic or d... | 09/12/2000 |
| 6107498 | Process for making carboxylic amides Methods for producing carboxylic amides involves combining near-stoichiometric amounts of carboxylic acid and amine in a reaction vessel and reacting under pressures greater than atmospheric pressure. Alternatively, an excess of amine is reacted with carb... | 08/22/2000 |
| 6057322 | Basically-substituted benzoylguanidines, a process for preparing them, their use as a medicament or diagnostic agent, and a medicament containing them Compounds of the formula I ##STR1## and the pharmaceutically tolerated salts thereof, are described. A process for their preparation and their use as medicaments in cardiovascular diseases are also described.... | 05/02/2000 |
| 6043282 | Azinooximethers, processes and intermediate products for manufacturing same, and the uses thereof in combating harmful fungi and pests Azinooxime ethers of the formula I ##STR1## (X=NOCH3, CHOCH3, CHCH3 ; Y=O, NZ, where Z=H, alkyl; R1 =H, alkyl; R2 =cyano, nitro, trifluoromethyl, halogen, alkyl, alkoxy; m=0, 1, 2, it being possi... | 03/28/2000 |
