Class 564/129 - Acid hydrolysis only of nitrile

Subclass of Class 564 - Organic compounds -- part of the class 532-570 series
Definition: Processes wherein the sole chemicl reaction for amide formation
No. of patents: 35
Last issue date: 06/05/2007

Number	Title	Issue Date
7227036	Production process of aminomethyl group-containing benzamide compound There is provided a process for producing an aminomethyl group-containing benzamide compound represented by the general formula (II): wherein —CONH2 and —X represent a substituent on the benzene ring and —CONH2 exists at the meta- or para-position of —CH2NH2...	06/05/2007
7067512	Substituted 1,4-benzodiazepines and uses thereof The present invention is directed to novel 1,4-benzodiazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: or a solvate, hydrate or ...	06/27/2006
6660880	Process for the preparation of hydroxy 4-methyl thiobutyric acid esters A process, for the preparation of an ester of 2-hydroxy-4-methylthiobutyric acid which is substantially in the monomeric form, which process, being capable of industrial application and which comprises reacting 2-hydroxy-4-methylthiobutyric acid with an a...	12/09/2003
6521794	Method for production of aromatic compounds For the production of an aromatic compound by hydrolyzing and decarboxylating a corresponding aromatic cyano compound in the presence of an acidic substance, this invention provides a method for the production of the aromaic compound, characterized by car...	02/18/2003
6492553	Methods for preparing N-[(aliphatic or aromatic)carbonyl)]-2-aminoaetamide compounds and for cyclizing such compounds A method for preparing a N-[(aliphatic or aromatic)carbonyl)]-2-aminoacetamide compound, and for preparing a cyclized compound therefrom, as well as novel resin bound intermediate compounds that are useful for preparing such compounds....	12/10/2002
6482983	Process for obtaining N-monosubstituted amides A process for obtaining an amide of the general formula R--(CO)--NH--CH2 --X involves contacting a nitrile of the general formula R--CN with: a) an acid; and c) an alkoxy-containing compound comprising at least one alkoxy functionality of the g...	11/19/2002
6479695	Process for the preparation of hydroxy methylthiobutyric acid esters A process for the preparation of 2-hydroxy-4-methylthiobutyric acid ester which comprises (a) a first step of reacting 2-hydroxy-4-methylthiobutyronitrile with sulphuric acid to produce 2-hydroxy-4-methylthiobutyramide, and (b) a second step of reacting t...	11/12/2002
6437183	Method for making amides The invention relates to the manufacture of amide compounds provided through the reaction of nitrile compounds and a sulfate compound to form the related amide compound. In a preferred embodiment a diol or a triol is employed as a solvent, thereby increas...	08/20/2002
6303817	Method for making amides The invention relates to the manufacture of amide compounds provided through the reaction of nitrile compounds and a sulfate compound to form the related amide compound. In a preferred embodiment a diol or a triol is employed as a solvent, thereby increas...	10/16/2001
6184414	Process for producing ammonium-2-hydroxy-4-(methylthio)-butyrate, mixtures containing the same in liquid form and their use Process for producing ammonium-2-hydroxy-4-(methylthio)-butyrate, mixtures containing the same in liquid form and their use. In order to produce ammonium-2-hydroxy-4-methylthio-n-butyrate and mixtures containing the same with a remarkable fluidity and a v...	02/06/2001
5811580	Process for the preparation of N-hydrocarbyl-substituted amides via the ritter reaction using solid clay catalysts Hydrocarbyl-substituted amides can be prepared in a catalyzed Ritter reaction by contacting a nitrile with a hydrocarbylating agent, in the presence of an acidified clay as the catalyst, under conditions conducive to the formation of the hydrocarbyl-subst...	09/22/1998
5763661	Preparation of acylated ଱-amino carboxylic acid amides A method of preparing acylated ଱-amino carboxylic acid amides directly from amino nitriles in high yield and purity. The method involves acylating the amino nitrile with an acyl halide under Schotten-Baumann conditions, and hydrolyzing the resulting...	06/09/1998
5633288	Tri (lower alkoxy) benzene derivatives This invention relates to a tri(lower alkoxy)benzene derivative of the general formula (I), or its salt, optical isomer or solvate, ##STR1## wherein: R1, R2 and R3 : same or different and each represents a lower alkyl...	05/27/1997
5436371	Process for preparing p-nitroaromatic amides and products thereof A process for preparing p-nitroaromatic amides is provided which comprises contacting a nitrile, nitrobenzene, a suitable base and water in the presence of a suitable solvent system to form a mixture, and reacting the mixture at a suitable temperature in ...	07/25/1995
5414122	Process for producing alpha-ketoamide derivative There is disclosed an efficient process for producing ଱-ketoacetamide of the formula: ##STR1## which is useful as an intermediate for the production of various alkoxyiminoacetamide compounds to be used for agricultural fungicides. In this ...	05/09/1995
5258551	Process for producing ଱-ketoamide derivative There is disclosed an efficient process for producing ଱-ketoacetamide of the formula: ##STR1## which is useful as an intermediate for the production of various alkoxyiminoacetamide compounds to be used for agricultural fungicides. In this ...	11/02/1993
5087751	Method of preparing optically active 3,4-dihydroxy butyric acid derivatives The present invention presents a method for preparation of S-3,4-dihydroxy butyronitrile expressed by the structural formula (II) ##STR1## characterized by causing R-3-chloro-1,2-propanediol expressed by the structural formula (I) ##STR2## ...	02/11/1992
5051525	N-acyl-2-amino acid amides containing phosphinic esters, process for their preparation, and N-acyl-2-amino acids nitriles as precursors N-acyl-2-amino acid amides containing phosphinic esters, process for their preparation, and N-acyl-2-amino acid nitriles as precursors Phosphorus-containing N-acyl-2-amino acid amides of the general formula (I) ##STR1## where R1 is alkyl, optio...	09/24/1991
4950788	Process for producing unsaturated carboxylic acids Acrylic acid or other unsaturated carboxylic acid is made by hydrolysing the corresponding nitrile in the presence of excess sulphuric acid to form amide sulphate, adding amide in an amount such that the total amount of amide and nitrile fed to the proces...	08/21/1990
4851576	Process for catalytic hydrolysis of an ଱-amino- nitrile in heterogeneous phase, and polymeric resins having catalytic activity for affecting the process This invention relates to a process for the catalytic hydrolysis of an ଱-aminonitrile in the heterogeneous phase, and to polymeric resins having a catalytic activity for carrying out the present process. The process according to this invention is charact...	07/25/1989
4731447	Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof A process for the preparation of piperidylidene-dihydro-dibenzo[a,d]cycloheptene or aza-derivatives thereof and intermediates in such process are disclosed....	03/15/1988
4719303	Preparation of substituted and unsubstituted 2-[(1-carbamoyl-1,2-dimethylpropyl)-carbamoyl]-3-quinolinecarboxylic, nicotinic and benzoic acids A method for the preparation of substituted and unsubstituted 2-[(1-carbamoyl-1,2-dimethyl-propyl) carbamoyl]-3-quinolinecarboxylic, nicotinic and benzoic acids....	01/12/1988
4611067	Process for the preparation of HMG-CoA reductase inhibitors and intermediate compounds employed therein This invention relates to a novel process for the preparation of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase inhibitors which contain a 4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one moiety, such as compactin and mevinolin, by utilizing an alkyl...	09/09/1986
4596885	Process for the preparation of phenylglyoxylic acid esters A process for the preparation of a phenylglyocylic acid ester of the formula ##STR1## wherein R1 represents alkyl, X represents halogen, alkyl, halogenoalkyl, alkoxy or nitro, and n represents 0, 1, 2, or 3 by contacting a benzoyl cyanide of th...	06/24/1986
4552982	Synthesis of 9-carbamoyl-9-(3-aminopropyl)fluorenes 9-Carbamoyl-9-(2-cyanoethyl)fluorenes are converted to 9-carbamoyl-9-(3-aminopropyl)fluorenes by catalytic hydrogenation in the presence of a strong acid....	11/12/1985
4524077	Liquid 2-hydroxy-4-methylthiobutyric acid and process for the preparation thereof A process for the preparation of 2-hydroxy-4-methylthiobutyric acid having improved color, odor and lower viscosity. 2-hydroxy-4-methylthiobutyric acid which is also known as 2-hydroxy-4-(methylthio) butanoic acid, is hydrolyzed with sulfuric acid having ...	06/18/1985
4250111	Mixed catalyst for the hydrolysis of nitriles to amides An improved process for catalytically hydrolyzing a nitrile to a corresponding amide which employs a reduced copper and another reduced metal catalyst. This catalyst is prepared by precipitating from an aqueous solution comprised of a mixture of a copper ...	02/10/1981
4217306	଱-Aryl-଱,଱-bis[ω-(disubstituted amino)alkyl]-acetamides Novel ଱-aryl-଱,଱-bis[ω-(disubstituted amino)alkyl]acetamides are described herein. The compounds are useful as anti-arrhythmic agents. The compounds are prepared by reacting an appropriate disubstituted acetonitrile with an appropriate ...	08/12/1980
4161491	Process for the production of alpha-ketocarboxylic acid amides and cycloaliphatic products There are prepared ଱-ketocarboxylic acid amides of the formula ##STR1## where R is hydrogen, R1 and R2 are the same or different, R1 is alkyl of 1 to 18 carbon atoms or haloalkyl, preferably chloroalkyl, of 1 to...	07/17/1979
4127604	Process for the preparation of acetic acid derivatives Process for the preparation of di-n-propyl acetic acid of formula: ##STR1## and its non-toxic alkali and alkaline earth metal salts whereby in a single stage, sodium n-propylate in n-propanol medium is added to a reaction medium formed of a cyanaceti...	11/28/1978
4127607	Process for the preparation of an acetamide derivative Process for preparing di-n-propyl acetamide of the formula: ##STR1## whereby di-n-propyl acetonitrile is hydrolyzed by means of 80% sulphuric acid aqueous solution in the proportion of 2 to 2.5 g of dilute acid/g of nitrile, at a temperature between ...	11/28/1978
4117009	Method of making N-[4-chlorophenyl)amino]carbonyl)-2,6-difluorobenzamide In accordance with the sought-after features of an improved process for the preparation of Dimilin, there is provided herein a process which comprises first extracting 2,6-difluorobenzamide from an aqueous acid solution with a selective solvent which is a...	09/26/1978
4022830	Process for preparing polychlorobenzamide derivatives A novel process for preparing polychlorobenzamide derivatives, useful as biocidal agents, flame retardants in plastic resins, and the like, from corresponding polychlorobenzonitrile compound in near quantitative yields is disclosed. A polychlorobenzonitri...	05/10/1977
4017510	Imidazoisoindolediones and the use thereof as herbicidal agents The invention relates to novel imidazoisoindoledione compounds including the optical isomers thereof. This invention also relates to a method for the control of undesirable plant species with the imidazoisoindolediones and their optical isomers, and furth...	04/12/1977
3937732	Oxamide by hydrolysis of cyanogen A method for collecting a solid product from a liquid phase or liquid phase-gaseous phase feed stock. A solid forming zone is provided for accommodating the liquid phase or liquid phase-gaseous phase feed stock having a density greater than that of a liqu...	02/10/1976

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Class 564/129 - Acid hydrolysis only of nitrile