Did You Know...
...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.
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| Number | Title | Issue Date |
| 8148571 | Compound, composition comprising the same, and process for production of polymerizable amide A novel compound (I) represented by the following formula (1) is provided which is suitable for a dental composition and has a polymerizable group, a carboxyl group and a phosphoric acid group. A method for producing a polymerizable amide is provided, which method c... | 04/03/2012 |
| 8097752 | Antiprotozoal ring-substituted phospholipids Disclosed are novel ring containing phospholipids represented by the structural formula A-X—PO3—W and physiologically acceptable salts thereof and a process for the preparation of these compounds. The compounds can be used for the treatment of protozo... | 01/17/2012 |
| 7888527 | Aryl amide sphingosine 1-phosphate analogs The present invention provides compounds that have antagonist activity at the S1P1 and/or S1P3 receptors. These compounds have enhanced selectivity and potency at the S1P1 and/or S1P3 receptors. ... | 02/15/2011 |
| 7635785 | Process for preparation of dialkylphosphinic salts The invention relates to a process for preparation of salts of dialkylphosphinic acids, which comprises a) reacting hypophosphorous acid and/or its salts with olefins in the presence of a free-radical initiator to give dialkylphosphinic acids and/or the... | 12/22/2009 |
| 7541488 | Process for the preparation of mono- and bis(fluoroalkyl)phosphoranes and the corresponding acids and phosphates The invention relates to a method for producing mono(fluoroalkyl)phosphoric acids or bis(fluoroalkyl)phosphoric acids, mono(fluoroalkyl)phosphates or bis(fluoroalkyl)phosphates, and the corresponding phosphoranes thereof. The inventive method comprises at least the ... | 06/02/2009 |
| 7442831 | Methods of synthesizing phosphonic compounds and compounds thereof Described herein are methods for producing phosphonic compounds and compounds thereof. ... | 10/28/2008 |
| 7438833 | Organic species that facilitate charge transfer to or from nanostructures The present invention provides compositions (small molecules, oligomers and polymers) that can be used to modify charge transport across a nanocrystal surface or within a nanocrystal-containing matrix, as well as methods for making and using the novel compositions. | 10/21/2008 |
| 7420081 | Methods for synthesizing phosphonic compounds and compounds thereof Described herein are methods for producing phosphonic compounds and compounds thereof. ... | 09/02/2008 |
| 7405317 | Phosphate-bearing prodrugs of sulfonyl hydrazines as hypoxia-selective antineoplastic agents Novel phosphate-bearing prodrugs of sulfonyl hydrazines have the formula presented below. Pharmaceutical compositions and uses thereof in the treatment of cancer are claimed. The aforementioned prodrugs include enantiomers, stereoisomers and tautomers thereof, as we... | 07/29/2008 |
| 7319163 | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac arrhythmias, thyrotoxicosis and subclinical hyperthyrodism. ... | 01/15/2008 |
| 7294733 | Method for preparing formylphosphonic acid An improved process for the manufacture of formylphosphonic acid derivatives is reported. An aminomethylphosphonic acid substrate is contacted with a reagent selected from the group consisting of water, an alcohol, a phenol compound, and mixtures thereof and an oxid... | 11/13/2007 |
| 7211231 | Ion exchange materials for use in a Bi generator A bismuth-213 generator comprising an insoluble composition having the general formula Zr(Phosponate)x(HPO4)2−x.nH2O, wherein x is between 0 and 2; and n is the number of waters of hydration; and wherein cations of radio... | 05/01/2007 |
| 7208554 | Polyoxyalkylene phosphonates and improved process for their synthesis A process for preparing polyoxyalkylene phosphonates in high yield and purity without extensive isolation procedures. The process also enables hydroxy terminated polyoxyalkylene phosphonates to be produced with their attendant high aqueous solubility and the availab... | 04/24/2007 |
| 7202379 | Process for the preparation of bis(perfluoroalkyl)phosphinic acids and salts thereof The present invention relates to a process for the preparation of bis(perfluoroalkyl)phosphinic acids comprising at least the reaction of at least one difluorotris(perfluoroalkyl)phosphorane or at least one trifluorobis(perfluoroalkyl)phosphorane with hydrogen fluor... | 04/10/2007 |
| 7179403 | Anti-corrosion solutions for air dehumidification systems Anti-corrosion solutions useful for air dehumidification processes are disclosed. Phosphonate corrosion inhibiting agents or mixtures thereof can be added to halide solutions of alkali metals, alkaline earth metals, or mixtures thereof, to minimize corrosion of the ... | 02/20/2007 |
| 7169838 | Halogen-free flameproof polyester The invention relates to thermoplastic moulding materials containing A) between 20 and 97 wt. % of a thermoplastic polyester; B) between 1 and 40 wt. % of a phosphinic acid salt and/or a diphosphinic acid salt and/or the polymers thereof, constituent B) having an av... | 01/30/2007 |
| 7163977 | Method to reduce the aldehyde content of polymers Methods to decrease aldehyde content of a polymer are provided. An effective amount of an additive that contains a P—H functionality is incorporated into the polymer in the presence of an acidic of basic catalyst compositions are also provided. ... | 01/16/2007 |
| 7163932 | Aryldifluoromethylphosphonic acids for treatment of diabetes The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions which include the compo... | 01/16/2007 |
| 7147712 | Method of semiconductor nanoparticle synthesis A method is described for the manufacture of semiconductor nanoparticles. Improved yields are obtained by use of a reducing agent or oxygen reaction promoter. ... | 12/12/2006 |
| 7145034 | Method for producing N-phosphonomethylglycine The invention relates to a process for preparing N-phosphono-methylglycine by reacting a hexahydrotriazine compound with a triacyl phosphite in an organic solvent, hydrolyzing the resulting phosphono compound after prior extraction into an aqueous phase and separati... | 12/05/2006 |
| 7091376 | Method for preparing formylphosphonic acid An improved process for the manufacture of formylphosphonic acid derivatives is reported. An aminomethylphosphonic acid substrate is contacted with a reagent selected from the group consisting of water, an alcohol, a phenol compound, and mixtures thereof and an oxid... | 08/15/2006 |
| 7057065 | Process for production of vinylphosphonic acids and silyl esters thereof A process for preparing vinylphosphonic acid compounds and silyl esters thereof in which a bis(haloalkyl)vinylphosphonate is reacted with an organosilyl halide to produce a silyl ester which can then be converted to the acid by reaction with a proton donor. ... | 06/06/2006 |
| 7049463 | Process for the preparation of highly purified, dialkyl phosphinic acids In a process for the production of dialkylphosphinic acids, especially branched, dialkylphosphinic acids in high purity via the reaction of an alpha olefin with a hypophosphorous acid or a salt thereof, the improvement comprising conducting the reaction in the prese... | 05/23/2006 |
| 7034054 | Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols The present invention provides method for the treatment of a symptom of neuronal damage associated with cerebral ischemia comprising administering gamma-, beta-, or delta-tocopherol enriched tocopherol compositions. ... | 04/25/2006 |
| 7018987 | Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof The present invention relates to novel water-soluble, stable derivatives of combretastatin A-4, and novel synthesis methods therefore. The combretastatin A-4 prodrugs described herein appear to be useful in the treatment of neoplastic disease. ... | 03/28/2006 |
| 7009071 | Process for the preparation of 4-amino-1-hydroxybutylidene-1, 1-biphosphonic acid This invention is related with the preparation of 4-amino-1-hydroxybutylidene-1,1-biphosphonic acid or salts thereof. The reaction of 4-aminobutyric acid with phosphorous acid and phosphorus trichloride in the presence of aralkyl or alkyl ethoxylates or triglyceride... | 03/07/2006 |
| 6984752 | Process for preparing vinyl phosphonic acid Vinyl phosphonic acid is produced by the hydrolysis of a vinyl phosphonic acid ester (e.g. “Bis Beta”) in the presence of a carbonyl compound (e.g. a monofunctional or difunctional aldehyde or a ketone). ... | 01/10/2006 |
| 6963008 | Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof New hydrate forms of alendronate sodium, having water content of between about one and about twelve percent, and processes for their manufacture, are disclosed. New crystalline forms of alendronate sodium B, D, E, F, G and H, and processes for manufacturing them, ar... | 11/08/2005 |
| 6949206 | Organic species that facilitate charge transfer to or from nanostructures The present invention provides compositions (small molecules, oligomers and polymers) that can be used to modify charge transport across a nanocrystal surface or within a nanocrystal-containing matrix, as well as methods for making and using the novel compositions. | 09/27/2005 |
| 6936733 | Method for preparing disodium 2,2'-dithiobis(ethanesulphonate) The invention concerns a novel method for industrial preparation of disodium 2,2′-dithiobis(alkylsulphonates), and in particular disodium 2,2′-dithiobis(ethanesulphate) (dimesna). Said novel method is summarized by the reaction diagram (A). In diagram (A), Hal r... | 08/30/2005 |
| 6924389 | Method for producing diphosphines and the use thereof Diphosphine of formula I R1R2P—H2C—Ar—CH2PR1R2 (I) are prepared by a process that comprises a) reacting a dimethyl compound of formula II H3C—Ar... | 08/02/2005 |
| 6919322 | Phenyl Phosphonate Fructose-1,6-Bisphosphatase Inhibitors Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose. ... | 07/19/2005 |
| 6841698 | Aminopropylphosphinic acids Novel compounds of formula I, with the exception of i) the racemate of (3-amino-2-hydroxypropyl)phosphinic acid; and ii) (2R/S,3R)-(3-amino-2-hydroxybutyl)phosphinic acid, having affinity to one or more G... | 01/11/2005 |
| 6824882 | Fluorinated phosphonic acids Fluorinated phosphonic acid compounds, useful as treatments for substrate surfaces, have the formula: wherein: R1 is a straight chain alkylene group having from about 3 to ... | 11/30/2004 |
| 6815558 | Process for preparing (metal) alkylphosphonites II The invention relates to a process for the preparation of (metal) salts of alkylphosphonous acids, which comprises reacting elemental yellow phosphorus with alkyl halides in the presence of carbonates, bicarbonates, amides, alkoxides, amine bases and/or solid hydrox... | 11/09/2004 |
| 6806383 | Process for preparing (metal) alkylphosphonites I The invention relates to a process for the preparation of (metal) salts of alkylphosphonous acids, which comprises reacting elemental yellow phosphorus with halogen-free alkylating agents in the presence of at least one base. The invention also relates to the... | 10/19/2004 |
| 6781011 | Bis-H-phosphinic acid derivatives as precursors to therapeutic bisphosphonates and uses thereof A novel class of compounds, i.e., 1,1-bis-H-phosphinates (or 1,1-bis-H-phosphinic acid derivatives) are provided. Also provided are novel methods for producing 1,1-bis-H-phosphinates and 1,1-bis-H-phosphinate conjugates. These compounds and conjugates are used are p... | 08/24/2004 |
| 6770780 | Vinylphenylpropionic acid derivatives, production process therefor, polymer thereof and radiation sensitive resin composition Vinylphenylpropionic acid derivatives; processes for producing the derivatives; polymers of the same; and radiosensitive resin compositions containing the polymers. The above polymers exhibit low radiation absorption and are useful as the resin component of radiosen... | 08/03/2004 |
| 6770779 | Process for preparing alkylphosphonite esters The present invention relates to a process for the preparation of alkylphosphonous acid esters which comprises a) reacting elemental yellow phosphorus with alkylating agents in the presence of a base to give a mixture which comprises, as principal constituent... | 08/03/2004 |
| 6727378 | Process for the production of a phosphorus-containing organic compound A process for the production of an organic phosphorus-containing product, which comprises reacting a phosphorus-containing oxide with an unsaturated hydrocarbon in the presence of a boron-containing compound at a temperature of less than or equal to 50° C. ... | 04/27/2004 |
