Class 562/621 - Hydroxamic acids, chalcogen analogs or salts thereof (i.e., compounds having the -C(=X)-N(R)-XH group or the -C(XH)=NXR group, wherein R may be hydrogen or substitution for hydrogen, the X's in each group may be the same or diverse chalcogens, and H of -XH in each group may be replaced by a group IA or IIA light metal, or by substituted or unsubstituted ammonium)

Subclass of Class 562 - Organic compounds -- part of the class 532-570 series
Definition: Compounds under Class 532, ... which contain either of
No. of patents: 195
Last issue date: 04/10/2012

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Number	Title	Issue Date
8153843	Antibacterial agents Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacteria...	04/10/2012
8022249	Compounds for the treatment of metabolic disorders Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. wherein n is 1 or 2; m is 0, 1, 2, 3, 4 or 5...	09/20/2011
7994362	Histone deacetylases, and uses related thereto The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available composi...	08/09/2011
7951972	Human adam-10 inhibitors The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions ...	05/31/2011
7534918	Histone deacetylase inhibitors This invention relates to hydroxamic acid derivatives having a sulfonamide linkage, that are inhibitors of histone deacetylase (HDAC), and are useful in the prevention and/or treatment of cellular proliferative diseases, for example cancer, autoimmune, allergic and ...	05/19/2009
7507858	Histone deacetylase inhibitors This invention relates to iminodiacetic acid and diamine hydroxamic acid derivatives, that are inhibitors of histone deacetylase (HDAC), and are useful in the prevention and/or treatment of cellular proliferative diseases, for example cancer, autoimmune, allergic an...	03/24/2009
7504537	Hydroxamic acid derivative and MMP inhibitor containing the same as active ingredient A hydroxamic acid derivative represented by the following general formula (1) having selective MMP inhibitory activity, wherein R1 and R2 each represents hydrogen atom, lower alkyl group, lower haloalk...	03/17/2009
7485750	Hydroxamic acid derivatives and the preparation method thereof The present invention provides hydroxamic acid derivatives represented by the formula, having antioxidation, collagen biosynthesis promotion and skin pore contraction effects, and a method for preparation thereof. Further, the present invention provides skin-care ex...	02/03/2009
7323448	Antibacterial agents Compounds of formula (I) or a pharmaceutically or veterinarily acceptable salts thereof wherein R1 represents hydrogen, C1-C6 alkyl or C1-C6 alkyl substitute...	01/29/2008
7319163	Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac arrhythmias, thyrotoxicosis and subclinical hyperthyrodism. ...	01/15/2008
7319096	Thyroid hormone receptor antagonists for cardiac and metabolic disorders II This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac and metabolic disorders, such as cardiac arrhythmias, thyrotoxicosis, subclinical hyperthyrodism...	01/15/2008
7282522	Hydroxamic acid derivatives and the method for preparing thereof The present invention provides hydroxamic acid derivatives which have anti-aging efficacy and a method for preparation thereof. It is further provided skin-care external compositions for preventing skin aging, containing the hydroxamic acid derivatives represented b...	10/16/2007
7247745	Process for preparing 1,5-diaryl-3-substituted pyrazoles A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III	07/24/2007
7241921	Bacterial enzyme inhibitors Compounds of formula (I) are antibacterial agents: wherein: Z is —N(OH)CH(═O) or —C(═O)NH(OH); R1 represents hydrogen, methyl or trifluoromethyl or, except when Z is a radical of formula —N(OH)CH(═O), a hydroxy, halo or amino group; R2	07/10/2007
7235689	Hydroxamic acid derivatives having anti-inflammatory action Compounds of formula (I), inhibit TNFα production and may therefore be useful in the treatment of inflammation, of auto-immune diseases, and of pathological conditions which involve excessive production of that cytokine. The compounds of formula (I) are also inhibi...	06/26/2007
7183319	Phenylethylamine derivatives and their use in the treatment of melanoma Novel mono- and dihydroxy phenylethylamine derivatives useful in treating melanoma are provided having the formulae (Ia, Ib or Ic). In the above formulae, Ra is hydrogen or —COORb, Rb is hydrogen or C1-6 alkyl; Re	02/27/2007
7169808	Compounds useful for the preparation of medicaments with phosphodiesterase IV inhibitory activity Formula (I) compounds are described, where the groups are defined in the description, as well as processes for their preparation and their use as medicaments, particularly as selective phosphodiesterase IV inhibitors. ...	01/30/2007
7148198	Antibacterial agents A compound of formula (I) or a pharmaceutically or veterinarily acceptable salt thereof for the inhibition of activity of bacterial PDF enzyme: wherein A represents a group of formula (IA) or (IB)	12/12/2006
7148257	Methods of treating mesothelioma with suberoylanilide hydroxamic acid Methods for treating mesothelioma comprising administering the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) are disclosed. ...	12/12/2006
7091378	Preparation of hydroxamic acids from esters in solution and on the solid phase The present invention provides a novel method for the formation of hydroxamic acids comprising reacting under suitable conditions an ester with hydroxylamine in the presence of cyanide anion. ...	08/15/2006
7067551	Deacetylase inhibitors The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties. ...	06/27/2006
7019003	Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ...	03/28/2006
7007805	Hydroxamate composition and method for froth flotation The invention relates to a hydroxamate composition for collection of minerals by froth flotation, the composition including an aqueous mixture of hydroxamate wherein the pH of the composition is at least 11 and a method of collecting mineral values from an aqueous o...	03/07/2006
6967220	Peptide deformylase inhibitors PDF inhibitors and novel methods for their use are provided. ...	11/22/2005
6960685	Carbamic acid compounds comprising an ether linkage as HDAC inhibitors This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: wherein: A is an aryl group; Q1 is a covalent bond or an aryl leader group;...	11/01/2005
6924308	Therapeutic process for inhibiting NF-κB A therapeutic process is provided for the inhibition of NF-κB in mammals in whose cells NF-κB has been activated by an agency external to said cell. ...	08/02/2005
6908911	Antibacterial agents Selected compounds of formula (I) are antibacterial agents: formula (I) wherein R2 represents a substituted or unsubstituted C1-C6 alkyl, cycloalkyl (C1-C6 alkyl)- or aryl (C1-C6 alkyl)-gro...	06/21/2005
6888027	Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: (I) A is an aryl group; Q1 is a covalent bond or an aryl leader group; J is a sulfonamide linkage selected from: —S(═O)...	05/03/2005
6852882	Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ...	02/08/2005
6787522	Antibacterial agents Compounds of formula (I) are antibacterials: wherein: R1 represents hydrogen, or C1-C6 alkyl or C1-C6 alkyl substituted by one or more halogen atoms; R2 ...	09/07/2004
6770644	Hydroxamic acid derivatives, process for the production thereof and drug containing the same as the active ingredient Hydroxamic acid derivatives of the formula (I) (wherein all the symbols have the same meaning as defined in the specification.), non-toxic salt thereof or prodrugs thereof. The compounds of the formula (I) ...	08/03/2004
6739454	Mineral collector compositions and processes for making and using same Collector compositions of a mixture of a C6 to C22 fatty hydroxamic acid and an oil for use in a method the removal of impurities from mineral ores by the froth flotation method. The collectors are prepared by reacting an ester of a C6	05/25/2004
6716844	Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds An aromatic sulfonyl aipha-hydroxy hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed, as is a treatment process that comprises administering a contemplated aromatic sulfonyl alpha-hydroxy hydroxamic acid compound in an MM...	04/06/2004
6716878	Antimicrobial agents Compounds of formula (I) are antibacterial agents: wherein Z represents a radical of formula —N(OH)CH(═O) or of formula —C(═O)NH(OH), and R1-R4 are as defined in the specification. A method ...	04/06/2004
6710208	Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and α,β-unsaturated carboxylic acid and aldehyde compounds This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and α,β-unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor. ...	03/23/2004
6683200	N-substituted-N'-substituted urea derivatives and pharmaceutical compositions containing the derivatives N-Substituted-N'-substituted urea derivatives represented by the following formula, analogs thereof or pharmaceutically acceptable salts thereof are herein provided. These compounds show a TNF-଱ production inhibitory activity. ##STR1##...	01/27/2004
6673965	Hydroxamic acid derivative as inhibitor of the formation of soluble human CD23 A compound of formula (I) ##STR1## wherein: R isopropyl; n is 0; R1 is naphthylmethyl; R2 is t-butyl; and R3 is methyl; is useful in the treatment of disorders mediated by s-CD23....	01/06/2004
6610710	Phenylalanine derivatives Phenylalanine derivatives of the following formula and analogues thereof have an antagonistic activity to 댔댧 integrin and a selectivity toward 댔댡 integrin. They are used as therapeutic agents for various diseases to which ...	08/26/2003
6605742	Cyclo azaphospha hydrocarbons Novel cyclo azaphospha hydrocarbons according to formula I ##STR1## are provided. The compounds are useful as metalloprotease inhibitors....	08/12/2003
6566384	Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity....	05/20/2003

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