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| Number | Title | Issue Date |
| 8106238 | Method for producing glycolic acid Provided is a production method of glycolic acid having a first step of preparing glycolonitrile from formaldehyde and hydrocyanic acid and a second step of hydrolyzing the glycolonitrile into glycolic acid directly or via a glycolate salt, which method can produce ... | 01/31/2012 |
| 7339073 | Method for obtaining 5-halogenolaevulinic acid alkyl esters A method for obtaining a 5-bromolevulinic acid methyl ester or a 5-chlorolevulinic acid methyl ester from either a bromination mixture or a chlorination mixture, containing either a 5-bromo-levulinic acid methyl ester or a 5-chlorolevulinic acid methyl ester, respec... | 03/04/2008 |
| 7262219 | Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gamma-hydroxybutyrate that are also resistant to the conversion into GBL. Disclosed are methods to treat sleep disorde... | 08/28/2007 |
| 7230144 | Methods of making intermediates from polyhydroxyalkanoates Methods of forming intermediates from PHAs are disclosed. ... | 06/12/2007 |
| 7220870 | Hydrolytic kinetic resolution of cyclic substrates The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisome... | 05/22/2007 |
| 7211687 | Process for making carboxyalkylates of branched alcohols Process for carboxy-alkylation, particularly carboxymethylation, of branched alcohols includes the reaction of isoalcohols with potassium-t-butoxide or sodium-t-butoxide and with salt of halogenated alkanoic acid in the presence of the isoalcohol (starting alcohol) ... | 05/01/2007 |
| 7179941 | Carbonylamino-substituted acyl phenyl urea derivatives, process for their preparation and their use The invention relates to compounds of the formula I in which the radicals are defined as specified, and also to their physiologically tolerated salts. The compounds are suitable, for example, as medicaments for p... | 02/20/2007 |
| 7173141 | Chiral lactones Lactones represented by the formula 2a or 2b: are provided, where each Ph is, independently, an unsubstituted or substituted phenyl group. These lactones are suitable for the synthesis of various α... | 02/06/2007 |
| 7169774 | Cephalotaxane derivatives and their processes of preparation and purification The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constit... | 01/30/2007 |
| 7166743 | Methods of making intermediates from polyhydroxyalkanoates Methods of forming acrylic acid by heating a PHA are disclosed. The PHA can be derived from a biomass of a non-fossil source. The PHA can be, for example, poly 3-hydroxypropionate or a 3-hydroxypropionate containing polymer. The methods can include, for example, hea... | 01/23/2007 |
| 7094840 | Compositions comprising low molecular weight polyhydroxyalkanoates and methods employing same Polyhydroxyalkanoate compositions including hot melt adhesive compositions, biodegradable wax compositions, and protective coating compositions are provided and include a low molecular weight polyhydroxyalkanoate, a terminally-modified polyhydroxyalkanoate, or both.... | 08/22/2006 |
| 7056935 | Rotamase enzyme activity inhibitors This invention relates to methods of using neurotrophic compounds having an affinity for FKBP-type immunophilins to stimulate or promote neuronal growth or regeneration and to prevent neuronal degeneration. ... | 06/06/2006 |
| 7057038 | Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or diastereomer... | 06/06/2006 |
| 7053230 | Aspirin-triggered lipid mediators Aspirin triggered lipid mediators (ATLMs) are disclosed which are useful for the treatment of prevention of inflammation associated with various diseases, including ischemia. ... | 05/30/2006 |
| 7026507 | Method for the production of solid formulations of sodium 3-hydroxy-3-methylbutyrate A process for preparing solid formulations of sodium 3-hydroxy-3-methylbutyrate of the formula in which, in a first process step, 4,4-dimethyloxetan-2-one is reacted with aqueous sodium hydroxide to form a solution of s... | 04/11/2006 |
| 6933404 | Methods of making intermediates from polyhydroxyalkanoates In some embodiments, this invention relates to a method that includes contacting a PHA with an aprotic catalyst to form an ester. The ester has only one monomer unit from the PHA. In certain embodiments, this invention relates to a method that includes treating a PH... | 08/23/2005 |
| 6891048 | Glycolide production process, and glycolic acid composition The invention provides a process for producing glycolide by depolymerization by heating of a glycolic acid oligomer in the presence or absence of a solvent, which process ensures stable depolymerization. The depolymerization reaction is carried out while the content... | 05/10/2005 |
| 6864389 | Method for producing α-hydroxycarboxylic acid The present invention relates to: a method for producing α-hydroxycarboxylic acid, which comprises hydrolyzing cyanohydrin in the presence of a hydrocarbon solvent; a method for producing optically active α-hydroxycarboxylic acid, which c... | 03/08/2005 |
| 6818423 | Process for the preparation of chiral α-hydroxycarboxylic acids A process for the preparation of chiral α-hydroxycarboxylic acids: in which R1 is optionally halogen substituted C1-C2-alkyl and R2 is optionally halogen substituted C2-C3-a... | 11/16/2004 |
| 6815559 | Process for producing 3,3,3-trifluoro-2-hydroxypropionic acid or its derivative The invention relates to a process for producing 3,3,3-trifluoro-2-hydroxypropionic acid. This process includes the step of (a) bringing a 1,1-dihalogeno-3,3,3-trifluoroacetone into contact with a basic aqueous solution. The obtained 3,3,3-trifluoro-2-hydroxypropion... | 11/09/2004 |
| 6743914 | Kinetic resolutions of chiral 2-and 3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or diastereomer... | 06/01/2004 |
| 6670396 | Aspirin-triggered lipid mediators Aspirin triggered lipid mediators (ATLMs) are disclosed which are useful for the treatment of prevention of inflammation associated with various diseases, including ischemia.... | 12/30/2003 |
| 6652820 | Methods of making cesium salts and other alkali metal salts A method of making a cesium salt is described and involves reacting a cesium sulfate containing solution with lime to form 1) a solution containing at least cesium hydroxide and 2) a residue comprising calcium sulfate. The method further involves removing... | 11/25/2003 |
| 6582943 | Method for producing 2-hydroxyisobutyric acid and methacrylic acid from acetone cyanohydrin The present invention relates to a method for producing 2-hydroxyisobutyric acid where acetone cyanohydrin is converted to 2-hydroxyisobutyric acid using an enzyme catalyst having nitrilase activity, or having a combination of nitrile hydratase and amidas... | 06/24/2003 |
| 6583312 | Process for preparing optically active trimethyllactic acid and its esters The invention relates to a novel process for preparing optically active trimethyllactic acid and/or its esters by catalytic hydrogenation of trimethylpyruvic acid and/or its esters in the presence of noble metal complex catalysts containing phosphorus lig... | 06/24/2003 |
| 6562966 | Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or d... | 05/13/2003 |
| 6562967 | Kinetic resolutions of chiral 2-and-3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or d... | 05/13/2003 |
| 6521780 | Cycloalkyl derivatives and the solid-phase synthesis of such derivatives The invention relates to cycloalkyl derivatives, a process for their preparation and their use.... | 02/18/2003 |
| 6506778 | Acylphenylurea derivatives, a process for their preparation and their use as pharmaceuticals The invention is directed to acylphenylurea derivatives and their physiologically tolerated salts and physiologically functional derivatives. Compounds of the formula I ##STR1## in which the radicals have the stated meanings, and their physiologically ... | 01/14/2003 |
| 6486331 | Substituted alkylketo compounds and process Substituted alkylketo compounds of the formula ##STR1## can be converted to the corresponding amino acid by a stereoselective enzymatic process. The resulting amino acid compounds can be employed as starting materials for pharmaceutically active compounds... | 11/26/2002 |
| 6465680 | Process for preparing malonate derivatives or ଲ-keto esters from epoxide derivatives A process for preparing a malonic acid monoester or ଲ-ketoester from an epoxide includes the steps of reacting an epoxide with carbon monoxide and an alcohol in the presence of a catalytic amount of a cobalt compound and at least one promoter to pro... | 10/15/2002 |
| 6448412 | Methods for the preparation and characterization of multi-substituted fullerenes The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of fo... | 09/10/2002 |
| 6436994 | Heteroatom-interrupted analogs of 15-hydroxyeicosatetraenoic acid and methods of use Heteroatom-interrupted HETE derivatives and methods of their use for treating dry eye are disclosed.... | 08/20/2002 |
| 6403832 | Process for producing optically active 3,3,3-Trifluoro-2-Hydroxy-2-Methylpropionic acid, and salt thereof There are disclosed are a diastereomer salt of formula (1): ##STR1## a process for producing the same, a process for producing optically active 3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid of formula (2'): ##STR2## a novel optically active amine compo... | 06/11/2002 |
| 6353012 | 15-Hydroxyeicosatetraenoic acid-related compounds and methods of use HETE derivatives and methods of their use for treating dry eye are disclosed.... | 03/05/2002 |
| 6288244 | Process for the preparation of 3, 4-dihydroxybutanoic acid and derivatives thereof from substituted pentose sugars A process for the preparation of 3,4-dihydroxybutanoic acid (I) and 3-hydroxy-γ-butyrolactone (V) thereof from a 3-leaving group substituted pentose source is described. In particular, the process relates to the synthesis of (R)-3,4-dihydroxybutanoic aci... | 09/11/2001 |
| 6235930 | Process for the preparation of 3,4-dihydroxybutanoic acid and derivatives thereof from substituted pentose sugars A process for the preparation of 3,4-dihydroxybutanoic acid (I) and 3-hydroxy-γ-butyrolactone (V) thereof from a 3-leaving group substituted pentose source is described. In particular, the process relates to the synthesis of (R)-3,4-dihydroxybutanoic aci... | 05/22/2001 |
| 6177591 | Optically active phosphine oxide carboxylic acid and method of producing the same An optically active 1-phenylethylamine is reacted to a phosphine oxide carboxylic acid of a racemic modification shown by the following general formula (2): ##STR1## and a produced diastereomeric salt is separated using the difference in solubility a... | 01/23/2001 |
| 6175024 | Synthesis of functionalized esters A method of preparing an ester of a carboxylic acid functionalized with a moiety selected from the group consisting of halides, sulfonates, ethers, hydroxyl, amines, and aldehydes, said method comprising: (a) providing either a carboxylic acid having a vi... | 01/16/2001 |
| 6066763 | Process for preparing free -hydroxy acids from ammonium salts thereof A process for preparing -hydroxy acids by heating ammonium salts of -hydroxy acids of general formula (I), removing the formed ammonia and water, adding water to the residue, and heating the obtained mixture, wherein R is hydrogen, C1 | 05/23/2000 |
