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| Number | Title | Issue Date |
| 7732638 | Method of amidocarbonylation reaction A novel method of an amidocarbonylation reaction among an aldehyde compound, an amide compound, and carbon monoxide, which comprises using a palladium-supporting crosslinked-polymer composition containing palladium clusters having a major-axis length of 20 nm or sho... | 06/08/2010 |
| 7399860 | Manufacture of polyglutamate-therapeutic agent conjugates The invention provides new processes for preparing polyglutamic acid-therapeutic agent conjugates for clinical development and pharmaceutical use, and polyglutamic acid-therapeutic agent conjugates prepared by these processes. ... | 07/15/2008 |
| 7329778 | Process and catalyst for dehydrogenating primary alcohols to make carboxylic acid salts This invention is directed to a process for making a salt of a carboxylic acid. The process comprises contacting a catalyst with an alkaline mixture comprising a primary alcohol. In one embodiment, for example, the catalyst comprises a metal support (preferab... | 02/12/2008 |
| 7256047 | Measurement of gluconeogenesis and intermediary metabolism using stable isotopes The present invention provides a combination of carbon-13 and deuterium metabolic tracers and methods that when used in conjunction with nuclear magnetic resonance spectroscopy, provide a measurement of metabolic fluxes in the target organisms. The tracers of the pr... | 08/14/2007 |
| 7235357 | Method of reducing background in fluoresence detection The present invention provides a method for detecting fluorescence by using a solid support to which a probe molecule to be detected is fixed, wherein background is reduced by using a quenching agent. By using present invention, detection sensitivity of a DNA chip c... | 06/26/2007 |
| 7186859 | Uses for amino acid anticonvulsants The present invention is directed to the use of compounds of the formula: for treating pain, in particular neuropathic pain, bipolar disease and migraine headaches. ... | 03/06/2007 |
| 7148378 | Uses for amino acid anticonvulsants The present invention is directed to the use of compounds of the formula: for treating pain, in particular neuropathic pain, bipolar disease and migraine headaches. ... | 12/12/2006 |
| 7132295 | Isotopically coded affinity markers 3 This application relates to isotopically labeled affinity markers of the formula (II) for mass spectrometric analysis of proteins. In formula (II), the groups A, PRG, S, Z, L', Z', R, R',... | 11/07/2006 |
| 7122642 | Method for producing crystal polymorphs and crystal polymorphs produced thereby A method to prepare new or unexpected polymorphs of materials which have not been observed, or to obtain a known polymorph under different conditions than those in which it is usually made, by using a laser to cause nucleation and crystal growth to occur in a supers... | 10/17/2006 |
| 7074165 | Exercise device An exercise device for exercising the abdominal muscles, the back muscles, and the arm muscles of a user. The exercise device comprises a rectangular tubular frame having a seat pad. The frame has a right-angled pull bar assembly pivotally affixed thereunto. The pul... | 07/11/2006 |
| 7056450 | Highly concentrated aqueous solutions of N,N-dialkyl-glycines and process for preparation thereof An aqueous high-concentration solution of N,N-dialkylglycine, economical, easy to handle, and useful for subsequent organic chemical reactions, is provided. Also is provided a process for production thereof. The aqueous high-concentration solution of N,N-dialkylglyc... | 06/06/2006 |
| 7005543 | Method of producing Betaine compound A process for preparing Anhydrous Betaine and Betaine Hydrochloride comprises treating a chloroacetic acid with sodium carbonate, and then dropping liquid trimethylamine to obtain Betaine products, wherein ion exchange resin and decompression process are utilized to... | 02/28/2006 |
| 6992067 | Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.... | 01/31/2006 |
| 6975896 | Fiducial markers for MRI Fiducials (50) are disposed in an imaging region (14) along with a subject. The fiducials are mounted either to the subject itself, a surgical tool (52), an imaging probe or receive coil (80), or the like. The fiducials are filled with a ... | 12/13/2005 |
| 6939855 | Anti-inflammatory compositions and method The disclosed invention includes pharmaceutical compositions and methods for treating inflammatory conditions, particularly those that are characterized by increased binding of alpha-9 integrin to one or more of its ligands. Also disclosed are methods for selecting ... | 09/06/2005 |
| 6897337 | Site-specific isotopically-labeled proteins, amino acids, and biochemical precursors therefor Site-specific isotopically-labeled valine, leucine, and isoleucine and biosynthetic precursors for these amino acids are provided. The amino acids are labeled with 13C or 14C at the methyl group carbon atom(s) most remote from the carboxyl grou... | 05/24/2005 |
| 6884910 | Uses for amino acid anticonvulsants The present invention is directed to the use of compounds of the formula: for treating pain, in particular neuropathic pain, bipolar disease and migraine headaches. ... | 04/26/2005 |
| 6875890 | Method of producing N, N-dimethyl glycine hydrochloride A process for preparing N,N-Dimethyl Glycine Hydrochloride, comprises treating a chloroacetic acid with aqueous dimethylamine, and then dropping by hydrochloric acid to obtain N,N-dimethyl glycine as well as its hydrochloride salt, wherein decompression process is u... | 04/05/2005 |
| 6822116 | Method for producing D-allo -isoleucine A method for producing D-allo-isoleucine is provided. The method comprises converting L-isoleucine to the corresponding hydantoin. A mixture containing the hydantoin is contacted with a D-hydantoinase to stereoselectively hydrolyze any D-allo-isoleucine hydantoin in... | 11/23/2004 |
| 6759521 | Polarization switching to control crystal form A method to select and prepare polymorphs of materials by switching the polarization state of light employing non-photochemical laser-induced nucleation. ... | 07/06/2004 |
| 6703518 | Fluoride-releasing compositions Chelating monomers and fluoride-releasing compositions are disclosed that may be incorporated into dental composite restorative materials or other dental materials, to produce materials with high fluoride release rates, and high fluoride recharge capabili... | 03/09/2004 |
| 6696611 | Chemical methods The present invention provides a method for enantioselectively reducing a prochiral carbon centered radical having one or more electron donator groups attached directly to the central prochiral carbon atom of the radical, and/or attached to a carbon atom ... | 02/24/2004 |
| 6624327 | Process for preparing betaines The invention relates to a process for preparing betaines of formula (I) wherein R1 represents a C1 -C24 hydrocarbon group, and R2 and R3 independently represent a C1 -C3 hydrocarbon ... | 09/23/2003 |
| 6573387 | Synthesis of ,ଲ-substituted amino amides, esters, and acids ,ଲ-Unsaturated amides and esters are converted to ,ଲ-substituted amino amides, esters, and acids. An ,ଲunsaturated amide or ester is first converted to an ,ଲ-hydroxysulfonamide or hydroxycarbamate amide ... | 06/03/2003 |
| 6570024 | Process and intermediates Processes for preparing N-methyl-L-alanine derivatives and novel intermediates of the process. The derivatives and intermediates are useful for preparing cell-binding agent/maytansinoid complexes.... | 05/27/2003 |
| 6562815 | Morpholinones as light stabilizers The invention relates to new compounds containing 1-8 active groups of the type 3,3,6,6-polysubstituted 2-morpholinone and having the formula F (A'--Z)m --X (F), wherein m is a number from 1 to 8; X is an organic anchor group of valency m and in case th... | 05/13/2003 |
| 6555708 | N-&3xb5;-long chain acyllsine crystals, process for producing the same and cosmetics containing the same There are provided cosmetics which have not only a reduced effect on the "gleam" caused by irregular light reflection but also a reduced effect on "stickiness" based on an oil raw material, giving a good feeling during use such as spreadability, etc., and... | 04/29/2003 |
| 6551999 | Angiogenesis inhibitor An angiogenesis inhibitor comprising a cysteine protease inhibitory compound. As the preferable cysteine protease inhibitory compound, epoxysuccinic acid compounds, peptide halohydrazide compounds, calpain inhibitory compounds, compounds of the formula (I... | 04/22/2003 |
| 6548480 | Phosphonic acid derivatives with metallopeptidase inhibitory activity Compounds of formula (I) wherein R is an alkyl, aryl or arylalkyl group wherein the aryl is phenyl naphthyl or heterocycle; R1 and R2, the same or different, are hydrogen atoms or alkyl groups; R3 is an aryl or arylalkyl g... | 04/15/2003 |
| 6534545 | Unsaturated derivatives at the 4-position of 6-tert-butyl-1,1-dimethylindane and their use in human and veterinary medicine and cosmetics 6-tert-Butyl-1,1-dimethylindane derivatives which are unsaturated in the 4-position of formula: ##STR1## X represents: (i) either a radical of formula: (a) ##STR2## and Y represents a radical of formula: (b) ##STR3## (ii) or a radical of formula: (c... | 03/18/2003 |
| 6531499 | Matrix metalloproteinase inhibitors and method of using same Peptoid compounds of Formula I and Formula II are disclosed ##STR1## The compounds are useful in the treatment of matrix metalloproteinase-mediated disorders.... | 03/11/2003 |
| 6509350 | Stabilized pharmaceutical compositions comprising acid donors The invention relates to the use of certain acid donors as stabilizers in pharmaceutical compositions, and to the stabilized pharmaceutical compositions resulting therefrom.... | 01/21/2003 |
| 6448228 | Dipeptide compounds having a high fungicidal activity and their agronomic use The invention relates to dipeptide compounds having formula (I): ##STR1## The compounds having formula (I) have a high antifungal activity and are used for the control of phytopathogens in the agronomic field.... | 09/10/2002 |
| 6426406 | Method for using laser light to control crystal form A method to prepare new or unexpected polymorphs of materials which have not been observed, or to obtain a known polymorph under different conditions than those in which it is usually made, by using a laser to cause nucleation and crystal growth to occur ... | 07/30/2002 |
| 6420600 | Phenylalaninol derivatives It has been discovered that compounds of the formula: ##STR1## and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, are more readily absorbed and more bioavailable than the corresponding carboxylic acids from ... | 07/16/2002 |
| 6417395 | Process for preparing methionine The invention concerns a method for preparing methionine aminoamide. The invention also concerns the preparation of methionine without co-production of salts, from an aqueous solution containing essentially methionine aminonitrile by producing during a fi... | 07/09/2002 |
| 6407065 | VLA-4 antagonists Compounds of the formula I ##STR1## as defined, and their pharmaceutically acceptable salts are VLA-4 antagonists which are useful in inhibiting cell adhesion and in the therapeutic or prophylactic treatment of inflammatory and autoimmune diseases, p... | 06/18/2002 |
| 6403561 | Tripeptidylpeptidase inhibitors A compound of formula ##STR1## wherein the substituents are defined as in the specification and salts or hydrates thereof is disclosed as well as a method of treating disorders associated with the inactivation or excessive degradation of cholecystoki... | 06/11/2002 |
| 6384266 | Method of synthesis of betaine esters The present invention relates to an environmentally acceptable method of producing glycine betaine esters that produces no toxic by-products during the synthesis. The method produces only product, recyclable material for reuse in the process, and recovere... | 05/07/2002 |
| 6380254 | Method and composition for treating and preventing pathogenic effects caused by intracellular calcium overload The present invention provides a method and composition for treating or preventing pathogenic effects in a mammal caused by intracellular calcium overload, comprising administering to a mammal a mixture of sodium co-transport dependent amino carboxylic ac... | 04/30/2002 |
