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| Number | Title | Issue Date |
| 7205273 | Fusogenic liposomes The present invention relates to liposomes and virosomes and, more particularly, to liposomal and virosomal delivery systems for transporting materials such as drugs, nucleic acids and proteins. ... | 04/17/2007 |
| 7157449 | Medicament for the treatment of diseases caused by parasitic protozoa The present invention relates to the use of an inhibitor of CTP synthetase, such as a glutamine analogue, and a substance capable of suppressing toxic effects thereof in vivo, in the manufacture of a medicament for the treatment of a disease caused by a parasitic pr... | 01/02/2007 |
| 7129375 | Metal complexes of α amino dicarboxylic acids Neutral alpha amino diacid complexes of trace minerals and their use for animal nutrition. ... | 10/31/2006 |
| 7101855 | Pyroglutamic acid derivatives and related compounds which inhibit leukocyte adhesion mediated by VLA-4 Disclosed are pyroglutamic acid derivatives and related compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseas... | 09/05/2006 |
| 6992067 | Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.... | 01/31/2006 |
| 6977311 | Process for synthesizing L-γ-methylene glutamic acid and analogs A process for synthesizing substantially enantiomerically pure L-amino acids, particularly L-γ-methylene glutamic acid, and esters and salts thereof. The process includes the derivatization of (2S)-pyroglutamic acid, and the decyclization of the resulting derivativ... | 12/20/2005 |
| 6942803 | Process for purifying an organic acid A process is disclosed for purifying an aqueous feed stream comprising a product organic acid, such as lactic acid, and a strong contaminant, such as pyruvic acid or oxalic acid. The molar concentration of the product organic acid in the feed stream typically is at ... | 09/13/2005 |
| 6911431 | Pharmaceutical angiostatic dipeptide compositions and methods of use thereof Disclosed are methods of inhibiting neovascularization in a subject by administering to the subject a pharmaceutical preparation of R′-Glu-Trp-R″. ... | 06/28/2005 |
| 6881861 | Method of purifying glutamic acid by transition recrystallization Disclosed herein is a method of purifying L-glutamic acid by transformation recrystallization which method comprises maintaining crude crystals of L-glutamic acid containing α crystals of L-glutamic acid in an aqueous solvent at a temperature of from 50° C. to the... | 04/19/2005 |
| 6777396 | Feed for livestock A composition for livestock feed, comprising a feed for livestock and at least two additives selected from the group consisting of nucleic acid, glutamine and glutamic acid; and a method for increasing body weight gain efficiency and feed efficiency in livestock, co... | 08/17/2004 |
| 6696611 | Chemical methods The present invention provides a method for enantioselectively reducing a prochiral carbon centered radical having one or more electron donator groups attached directly to the central prochiral carbon atom of the radical, and/or attached to a carbon atom ... | 02/24/2004 |
| 6673942 | Resolution of DL-racemic mixtures The present invention relates to a process for the resolution of DL-racemic mixtures of compounds which crystalize in the form of a conglumerate. Both, the D and L-enantiomers are obtained according to the invention in a industrially feasable process by a... | 01/06/2004 |
| 6627732 | Glutathione derivatives and their dosage forms The present invention provides a glutathione derivative having a dramatically enhanced hematopoiesis promoting effect in the living body represented by the formula (I): ##STR1## where A represents H or a C1-C20 acyl group; R1 represents a C... | 09/30/2003 |
| 6600069 | Benzene tricarboxylic acid derivatives as insulin receptor activators Compounds of Formula I, and pharmaceutical compositions containing these compounds, activate the insulin receptor kinase, which leads to an increased sensitivity to insulin and an increase in glucose uptake, and are therefore useful for the treatment of a... | 07/29/2003 |
| 6599940 | Synthesis of 2-hydroxymethylglutamic acid and congeners thereof One aspect of the present invention relates to 2-hydroxymethylglutamic acid and congeners thereof. A second aspect of the invention relates to a method of synthesizing 2-hydroxymethylglutamic acid and congeners thereof.... | 07/29/2003 |
| 6414029 | Vanadium complexes of monohydroxamates and pharmaceutical compositions comprising them Monohydroxamate vanadium complexes of the formula (1): R--CO--NHOH.X, wherein R is a residue selected from: (i) H2 N--CH(COY)--(CH2)n --, wherein n is 1, 2 or 3, and Y is OH or NH2 ; (ii) H2 N--CH | 07/02/2002 |
| 6392094 | Method for recovering amino acids A method for recovering amino acids, which comprises supplying a mixed solution containing inorganic acid salts, amino acids and non-electrolytes such as saccharides to a first-step resin layer comprising an Na type or K type strongly acidic ion exchange ... | 05/21/2002 |
| 6306840 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 10/23/2001 |
| 6201132 | Inhibitors of DP-mediated processes, compositions, and therapeutic methods thereof Compounds selected from those of general formula ##STR1## and A is selected from specified aminoacyl compounds are inhibitors of DP-IV mediated processes.... | 03/13/2001 |
| 6147259 | Process for producing glutamic acid An indirect acidulation process for producing glutamic acid from an aqueous feed containing a glutamate resulting from fermentation includes: a) contacting an aqueous feed stream at an elevated temperature with a weak acid cation exchanger (WACE) which is... | 11/14/2000 |
| 6051734 | Process for the optical resolution of 3-(p-chlorophenyl)-glutaramide A process for the optical resolution of racemic 3-(p-chlorophenyl)glutaramide (GAM) into its R isomer R--COOH and its S isomer S--COOH, which process includes the steps of either: (1) reacting racemic 3-(p-chlorophenyl)-glutaramide dissolved in a suitable ... | 04/18/2000 |
| 5998594 | Self-assembling, chromogenic receptors for the recognition of medically important substrates and their method of use A chromogenic receptor comprises a self-assembled chromogenic compound having at least one intrinsic binding site. The chromogenic compound is characterized by the property of producing a reversible color change responsive to binding a target substrate to... | 12/07/1999 |
| 5994560 | Resolution of racemic mixtures using polymers containing chiral units Described herein is a novel process to resolve a racemic compound into its optically active isomers without need for chemical transformation such as salt formation. The process advantageously utilizes polymers containing chiral moieties in their repeat un... | 11/30/1999 |
| 5990165 | Pharmaceutical compounds A pharmaceutical compound of the formula: ##STR1## in which n is 1 or 2, R1 is --CO2 H, R2 is hydrogen or C1-4 alkyl and R3 is hydrogen, C1-10 alkyl, C2-10 alkenyl, optionally ... | 11/23/1999 |
| 5981564 | Water-soluble derivatives of paclitaxel, method for producing same and uses thereof The invention relates to new paclitaxel derivatives showing an increased solubility in water. More particularly, the invention relates to glutarylpaclitaxel, glutarylpaclitaxel 6-aminohexanol glucuronide and to different amino acid derivatives of the glut... | 11/09/1999 |
| 5907059 | Process for the preparation of monosodium glutamate The invention provides a process for the preparation of monosodium glutamate from a fermentatively prepared solution containing monoammonium glutamate, the process comprising: a) contacting the solution containing monoammonium glutamate salt with a basic ... | 05/25/1999 |
| 5837872 | Process for preparation of N-acyl-aminodiacids This invention relates to an improved process for preparing selected N-acyl-aminodiacids such as lauroyl glutamic acid.... | 11/17/1998 |
| 5770625 | Butyryl-tyrosinyl spermine, analogs thereof and methods of preparing and using same The present invention provides a compound having the structure: ##STR1## wherein R1 is hydrogen or a branched or unbranched, substituted or unsubstituted aminoalkyl having from two to twenty atoms in the chain, R2 is hydrogen, m... | 06/23/1998 |
| 5559092 | Cosmetic composition A composition suitable for topical application to mammalian skin and hair for inducing, maintaining or increasing hair growth comprises a hair growth promoter chosen from glutamine derivatives and salts thereof. The composition preferably also comprises a... | 09/24/1996 |
| 5536815 | Cyclopropyl based O- and N- and S-protecting groups The present invention is directed to the use of a cyclopropylmethyl derivative as a protecting group for compounds containing an amino group, carboxy group, amido group, mercapto group or hydroxy group and to the compounds formed having the cyclopropylmet... | 07/16/1996 |
| 5492895 | Inhibitors of thrombosis This invention relates to peptide aldehyde analogs that inhibit the thrombin or Factor Xa. The compounds are thought useful for preventing or treating conditions in mammal characterized by abnormal thrombosis.... | 02/20/1996 |
| 5428063 | Use of betaine as a hepatic generator of S-adenosylmethionine and as a protective agent against hepatotoxicity This invention encompasses pharmaceutical compositions in the dietary supplement for treating or preventing fatty infiltration, the first stage of cirrhosis of the liver comprising and administering of not less than 1500 mg of betaine per kg of body weigh... | 06/27/1995 |
| 5279744 | Method for purification of an amino acid using ion exchange resin A method for purification of an amino acid which comprises contacting an amino acid solution containing impurities with an ion exchange resin to selectively adsorb the amino acid onto the resin, eluting and recovering the adsorbed amino acid whereby the r... | 01/18/1994 |
| 5187270 | Racemization free attachment of amino acids to a solid phase This invention pertains to amino acids attached to a solid support in a racemization free manner and to a method of covalently linking amino acids to solid supports for use in solid phase peptide syntheses.... | 02/16/1993 |
| 5091559 | Process for the preparation of alkyl 4-oxobutyrate and its acetals A process is disclosed for forming alkyl 4-oxobutyrates and its acetals which comprises reacting under anhydrous conditions acrolein or its acetals with carbon monoxide and an alcohol of the formula R OH wherein R is lower alkyl in the presence of a catal... | 02/25/1992 |
| 5066828 | Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases This invention relates to certain conjugates of folates and antifolates with difluoroglutamic acid which are useful in the treatment of patients suffering from certain neoplastic diseases including leukemia, melanomas, carcinomas, sarcomas and mixed neopl... | 11/19/1991 |
| 4942248 | Tertiary-alkyl esters of 1H-benzotriazole-1-carboxylic acids Tertiary-butyl and tertiary-amyl esters of 1H-benzotriazole-1-carboxylic acids are useful blocking agents for blocking the amino or imino groups of amino acids. The six-membered ring of the blocking agent may be unsubstituted or substituted with one or mo... | 07/17/1990 |
| 4929755 | Process for making an optically active mixture of an N-acyl-amino acid or ester containing at least two chiral centers In the process of hydrocarboxylating an -enamide with CO and H2 O or an organic hydroxyl compound to produce an N-acyl--amino acid or ester, respectively, the improvement comprising using as the -enamide reactant, an ³... | 05/29/1990 |
| 4912228 | Process of extraction of amino acids from aqueous solutions thereof An improvement in the process of extraction of amino acids from aqueous solutions in which the amino acids are extracted with quaternary ammonium extractants. A pretreatment of the amino acid containing aqueous solution with a tertiary amine prior to extr... | 03/27/1990 |
| 4721803 | Method of making a diastereomeric mixture containing two diastereomeric N-acyl-amino acid esters In the process of hydrocarboxylating an -enamide with CO and an organic hydroxyl compound to produce a N-acyl--amino acid ester, the improvement comprising using as the organic hydroxyl compound reactant, an organic hydroxyl compound which h... | 01/26/1988 |