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| Number | Title | Issue Date |
| 8183410 | Preparation of free flowing granules of methylglycine diacetic acid The present invention concerns a process for the preparation of free flowing granules of low hygroscopicity of one or more methylglycine diacetic acid (MGDA) salts, of the formula wherein R═CH3 and M is hydrogen, alkali metal, alkaline earth metal, ammonium or sub... | 05/22/2012 |
| 7671234 | Method for producing methylglycine-N,N-diethanoic acid-trialkali metal salts with a low by-product content The invention relates to a process for preparing low-by-product, light-color methylglycine-N,N-diacetic acid tri(alkali metal) salt by alkaline hydrolysis of methylglycinediacetonitrile (MGDN), comprising the steps in the sequence (a) to (f): ... | 03/02/2010 |
| 7319165 | Aminopolycarboxylic acid aqueous solution composition and stabilization method of aminopolycarboxlic acid The present invention is to provide a stabilized aqueous aminopolycarboxylate solution composition and a method of stabilizing the aminopolycarboxylate through preventing the same from caking. An aqueous aminopolycarboxylate solution composition containing an... | 01/15/2008 |
| 7288624 | Inhibitors of interleukin-1β converting enzyme The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmace... | 10/30/2007 |
| 7183429 | Preparation and use of iminodisuccinic acid ammonium metal salts The invention relates to a process for the preparation of iminodisuccinic acid ammonium metal salts, characterized in that, in a first stage, maleic anhydride (MA), alkali metal hydroxide and water are mixed in the molar ratio of 2:0–3:5–30 and then ammonia is m... | 02/27/2007 |
| 7129375 | Metal complexes of α amino dicarboxylic acids Neutral alpha amino diacid complexes of trace minerals and their use for animal nutrition. ... | 10/31/2006 |
| 7084298 | Method for producing n-phosphonomethyl iminodiacetic acid The present invention relates to a process for the preparation of N-phosphonomethyliminodiacetic acid by reacting an alkali metal salt of iminodiacetic acid with phosphorus trichloride in aqueous solution with formation of the hydrochloride of iminodiacetic acid, ph... | 08/01/2006 |
| 7064235 | Process for making iminodiacetic acid compounds from monoethanolamine substrates This invention is directed to a process for making an iminodiacetic acid compound from a monoethanolamine substrate having the formula: wherein R1 is hydrogen, hydrocarbyl, or substituted hydrocarbyl. ... | 06/20/2006 |
| 7033520 | Metal chelating compositions for protein purification, detection or binding A metal chelating composition having the formula: wherein Q is a carrier; S1 is a spacer; L is -A-T-CH(X)— or —C(═O)—; ... | 04/25/2006 |
| 6992067 | Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.... | 01/31/2006 |
| 6977311 | Process for synthesizing L-γ-methylene glutamic acid and analogs A process for synthesizing substantially enantiomerically pure L-amino acids, particularly L-γ-methylene glutamic acid, and esters and salts thereof. The process includes the derivatization of (2S)-pyroglutamic acid, and the decyclization of the resulting derivativ... | 12/20/2005 |
| 6924309 | Anti-inflammatory nitro and thia-fatty acids The present invention relates to compounds of the general formula: NO2-A-B wherein A is a saturated or unsaturated hydrocarbon chain of 14-26 carbon atoms and B is (CH2)n(COOH)m in which n is an integer from 0 to 2 and m i... | 08/02/2005 |
| 6821760 | Methods for producing L-aspartic acid This invention relates to a method for producing L-aspartic acid comprising treating an ammonium fumarate solution with aspartase to generate an ammonium L-aspartate solution; adding fumaric acid to the solution; and then crystallizing L-aspartic acid from the solut... | 11/23/2004 |
| 6797700 | Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides The present invention relates to peptides and pseudopeptides which inhibit platelet aggregation and thrombus formation thereby being useful in the prevention and treatment of thrombosis associated with disease states such as myocardial infarction, stroke, peripheral... | 09/28/2004 |
| 6774259 | Method for synthesis of n-[(s)]-1-carboxybutyl-(s)-alanine esters and use in synthesis of perindopril A stereoselective process for the industrial synthesis of compounds of formula (I): wherein R represents linear or branched (C1-C6)alkyl, and application in the synthesis of perindopril and p... | 08/10/2004 |
| 6703518 | Fluoride-releasing compositions Chelating monomers and fluoride-releasing compositions are disclosed that may be incorporated into dental composite restorative materials or other dental materials, to produce materials with high fluoride release rates, and high fluoride recharge capabili... | 03/09/2004 |
| 6627771 | Gamma amino butyric and acid analogs The instant invention is improved gamma amino butyric acid analogs, processes for their preparation, and methods of using them as agents for treating epilepsy and other neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disor... | 09/30/2003 |
| 6624147 | Inhibitors of prenylated pyrophosphate consuming enzymes Novel peptide-like FPP-analogues suitable for inhibiting protein:prenyl transferases, such as protein:geranylgeranyl transferase-1, and other prenyl pyrophosphate-consuming enzymes such as squalene synthase and geranylgeranyl pyrophosphate synthase are di... | 09/23/2003 |
| 6623655 | Metal chelating compositions A metal chelating composition having the formula: ##STR1## wherein Q is a carrier; S1 is a spacer; L is --A--T--CH(X)-- or --C(.dbd.O)--; A is an ether, thioether, selenoether, or amide linkage; T is a bond or substituted or unsubstit... | 09/23/2003 |
| 6599940 | Synthesis of 2-hydroxymethylglutamic acid and congeners thereof One aspect of the present invention relates to 2-hydroxymethylglutamic acid and congeners thereof. A second aspect of the invention relates to a method of synthesizing 2-hydroxymethylglutamic acid and congeners thereof.... | 07/29/2003 |
| 6576614 | Peptide analogs as irreversible interleukin-1ଲ protease inhibitors Disclosed are compounds, compositions, and methods for inhibiting interleukin-1ଲ protease activity, wherein the compounds are -substituted methyl ketones having formula (I) as set forth herein. These compounds are inhibitors of IL-1ଲ co... | 06/10/2003 |
| 6569829 | Process for producing long chain N-acyl acidic amino acid A process for producing a long chain N-acyl acidic amino acid removes impurities by separating a mixture composed of a long chain N-acyl acidic amino acid containing an inorganic salt and a medium containing water and tertiary butanol into an aqueous laye... | 05/27/2003 |
| 6555120 | ISOLATION, STRUCTURAL DETERMINATION, SYNTHESIS, BIOLOGICAL ACTIVITY AND APPLICATION AS CONTROL AGENT OF THE HOST MARKING PHEROMONE (AND DERIVATIVES THEREOF) OF THE FRUIT FLIES OF THE TYPE ANASTREPHA (DIPTERA: TEPHRITIDAE) The 2-(2,14-Dimethyl-pentadecanoylamin)-pentanedioic acid (I) and compounds of the formula (II), ##STR1## wherein the substituents have the meaning disclosed in the specification, are used as oviposition deterring pheromones against the following fruit ... | 04/29/2003 |
| 6534545 | Unsaturated derivatives at the 4-position of 6-tert-butyl-1,1-dimethylindane and their use in human and veterinary medicine and cosmetics 6-tert-Butyl-1,1-dimethylindane derivatives which are unsaturated in the 4-position of formula: ##STR1## X represents: (i) either a radical of formula: (a) ##STR2## and Y represents a radical of formula: (b) ##STR3## (ii) or a radical of formula: (c... | 03/18/2003 |
| 6504054 | Amino acid derivative and producing method thereof An amino acid derivative composition which comprises two or more kinds of amino acid derivatives represented by the general formula (1): ##STR1## wherein R's are the same or different and each represents a hydrogen atom or an alkyl group containing 1 to 1... | 01/07/2003 |
| 6420593 | Method for producing long-chain glycine-N,N-diacetic acid derivatives A process for preparing compounds of the formula IIb ##STR1## where R is C6 -C30 -alkyl or C6 -C30 -alkenyl, which may additionally have upto 5 hydroxyl groups, formyl groups, C1 -C4 -alko... | 07/16/2002 |
| 6420522 | Inhibitors of interleukin-1ଲ converting enzyme The present invention relates to novel classes of compounds which are inhibitors of interleukin-1ଲ converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also rel... | 07/16/2002 |
| 6346648 | Amphoteric surfactants based upon epoxy succinic acid The present invention deals with novel compounds their applications and a process their preparation. The compounds are novel amphoteric surfactants that contain a hydroxyl group and two carboxylic groups per hydroxyl group. The compounds have a unique str... | 02/12/2002 |
| 6344348 | Process for the production of aspartic acid condensate The invention provides a process for the production of aspartic acid poly-condensate from a carbohydrate comprising the steps of: fermenting a carbohydrate-containing medium by means of a fumaric acid-producing microorganism, whereby a fumarate-containing... | 02/05/2002 |
| 6306840 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 10/23/2001 |
| 6239312 | Method for the preparation of salts of carboxylic acids using copper catalyzed dehydrogenation A method for the production of a salt of carboxylic acid by catalytic dehydrogenation effected by reacting the corresponding primary alcohol in aqueous solution with an alkaline hydroxide in the present of a copper catalyst, in which, before the catalytic... | 05/29/2001 |
| 6190451 | Admixture of cement composition An additive for an admixture of a cement composition, especially, a retarder of a cement composition, capable of exhibiting excellent retardation effect with a smaller addition amount and easily controlling the retardation time by adjusting the addition a... | 02/20/2001 |
| 6180826 | Oil and alcohol repellent fluorinated surfactants and intermediates, derivatives and uses thereof New water-soluble polyperfluoroalkyl surfactants derived from functional polycarboxylic polymers, characterized by the fact they have alco-oleophobic properties, to be used in the make-up of protein or synthetic foam for extinguishing fires caused not onl... | 01/30/2001 |
| 6153775 | Polydentate imines and their metal complexes Tripodal chelating agents incorporating imine C.dbd.N bonds are disclosed for the formation of lanthanide and other metal complexes which are relatively stable in the presence of water at neutral pH.... | 11/28/2000 |
| 6124360 | Solid compositions suitable for oral administration comprising non hygroscopic salts of L-carnitine and alkanoyl-L-carnitine with 2-aminoethanesulfonic acid Stable and non hygroscopic salts of L-carnitine or lower alkanoyl-L-carnitine with 2-aminoethanesulfonic acid are disclosed suitable for preparing solid compositions useful as dietary/nutritional supplements for human use and as fodder supplement for vete... | 09/26/2000 |
| 6121470 | Glycine derivatives, intermediates therefor and cleanser compositions comprising them Glycine derivatives represented by the following formula (1) and cleanser compositions containing the same: ##STR1## wherein R is a linear or branched alkyl group having 11 to 13 carbon atoms, a linear or branched alkenyl group having 11 to 13 carbon... | 09/19/2000 |
| 6117840 | CS-1 peptidomimetics, compositions and methods of using the same The present invention contemplates a peptide that inhibits the binding between the VLA-4 receptor expressed on inflammatory leukocytes and the fibronectin CS-1 peptide expressed on endothelial cells that are involved in immunoinflammatory disease states. ... | 09/12/2000 |
| 6107518 | Preparation and use of iminodisuccinic acid salts A process for the preparation of iminodisuccinic acid alkali metal salts by reaction of maleic acid and ammonia in an aqueous medium in the presence of alkali metal hydroxides and working up thereof.... | 08/22/2000 |
| 6077962 | N-3, 3-dimethylbutyl-L-aspartic acid and esters thereof, the process of preparing the same, and the process for preparing N-(N-(3,3-dimethylbutyl) - L-aspartyl)-L- phenylalanine 1-methyl ester therefrom This invention relates to the chemical synthesis of N-[N-(3,3-dimethylbutyl)-L--aspartyl]-L-phenylalanine 1-methyl ester using peptide coupling methods. The coupling reaction is conducted by condensation of an activated derivative of novel N-neohex... | 06/20/2000 |
| 6071728 | Process for the production of crystalline aspartic acid The invention provides a process for the preparation of aspartic acid via a fermentation process for the preparation of ammonia fumarate, wherein the pH of the fermentation broth is controlled by the addition of a calcium base to produce a calcium fumarat... | 06/06/2000 |