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| Number | Title | Issue Date |
| 8173840 | Compounds with high therapeutic index The present invention is directed to novel therapeutic compounds comprised of an amino acid bonded to a medicament or drug having a hydroxy, amino, carboxy or acylating derivative thereon. These high therapeutic index derivatives have the same utility as the drug fr... | 05/08/2012 |
| 8173839 | 5-aminolevulinic acid salt, process for producing the same and use thereof A 5-aminolevulinic acid salt which is useful in fields of microorganisms, fermentation, animals, medicaments, plants and the like; a process for producing the same; a medical composition comprising the same; and a plant activator composition comprising the same.... | 05/08/2012 |
| 8168823 | Process for the preparation of betaines Betaines of formula R3N+-Q-COO− (I), wherein R is C1-4 alkyl and Q is C1-4 alkanediyl, optionally substituted with hydroxy, are prepared in one step by adding an ω-halocarboxylate of formula X-Q-COOR′ (II),... | 05/01/2012 |
| 8158821 | Crystal of 5-aminolevulinic acid phosphate and process for producing the same To provide a novel crystal of 5-aminolevulinic acid phosphate having a high thermal stability, a high melting point, and an excellent moisture absorption resistance as well as a process for producing the same. A crystal of 5-aminolevulinic acid phosphate, which show... | 04/17/2012 |
| 7851651 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (S)-Pregabalin, which has the chemical name (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, is useful in anticonvulsant therapy, primarily due a mechanism that serves to promote the production of gamma-amino butyric acid, an inhibitory neurotransmitter. The invention... | 12/14/2010 |
| 7851652 | Biological buffers with wide buffering ranges Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa'... | 12/14/2010 |
| 7772429 | Diphenylazetidinone with improved physiological properties, process for its preparation, medicaments comprising this compound, and its use The invention relates to the compound of the formula 1 and to its physiologically acceptable salts. The compound is suitable, for example, as a hypolipidemic. ... | 08/10/2010 |
| 7732637 | Acylamide compounds having secretagogue or inducer activity of adiponectin The present invention provides an acylamide compound of the following formula (1), prodrugs thereof, or pharmaceutically acceptable salts thereof; and an adiponectin inducer or secretagogue, therapeutic agent of metabolic syndromes, therapeutic agent of hypoadiponec... | 06/08/2010 |
| 7420087 | Method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof The invention concerns a method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof of general formula (I), characterized in that it consists in reducing an isoxazole derivative of formula (II) in conditions directly resulting ... | 09/02/2008 |
| 7371897 | Preparation method for (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid Provided is a novel preparation method of (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid represented by the following formula (1), a key intermediate of cilastatin used as a supplement to imipenem. The novel preparation method of the inventi... | 05/13/2008 |
| 7348361 | Solution for diagnosing or treating tissue pathologies The invention concerns a 5-aminolevulinic acid ester (E-ALA) solution for producing a pharmaceutical preparation useful for diagnosing and/or treating tissue and/or cell pathologies by local radiation exposure using radiation emitted by a light source energy followe... | 03/25/2008 |
| 7339073 | Method for obtaining 5-halogenolaevulinic acid alkyl esters A method for obtaining a 5-bromolevulinic acid methyl ester or a 5-chlorolevulinic acid methyl ester from either a bromination mixture or a chlorination mixture, containing either a 5-bromo-levulinic acid methyl ester or a 5-chlorolevulinic acid methyl ester, respec... | 03/04/2008 |
| 7319164 | 5-azido-laevulinic acid, method for the production thereof and its use The present invention relates to 5-azido levulinic acid, a process for its preparation, its use. Using 5-azido levulinic acid as starting material for the synthesis of 5-amino levulinic acid hydrochloride it is possible to obtain the latter in good yield an in pharm... | 01/15/2008 |
| 7317123 | Process for preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra′ and Rc | 01/08/2008 |
| 7294742 | Ring-opened azlactone initiators for atom transfer radical polymerization Initiators for atom transfer radical polymerizations are described. The initiators have an azlactone or ring-opened azlactone moiety to provide telechelic (co)polymers. ... | 11/13/2007 |
| 7268253 | Process for preparing α, α-dialkyl-α-hydroxymethyl-carboxylic acid derivatives The invention relates to a novel process for hydroxymethylating noncyclic α,α-dialkylcarboxylic acid derivatives with formaldehyde using amide bases at temperatures of from −40° C. up to the boiling point of the solvent or solvent mixture used. ... | 09/11/2007 |
| 7259273 | Compositions containing lysophosphotidic acids which inhabit apoptosis and uses thereof The invention provides anti-apoptotic compositions containing lysophosphatidic acids and methods for making and using the compositions. Such compositions may also contain LPA potentiating agents, including proteins, lipid membrane structures and polymers such as pol... | 08/21/2007 |
| 7253169 | Aza compounds, pharmaceutical compositions and methods of use The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities. ... | 08/07/2007 |
| 7205290 | Diphenylazetidinone with improved physiological properties, process for its preparation, medicaments comprising this compound, and its use The invention relates to the compound of the formula 1 and to its physiologically acceptable salts. The compound is suitable, for example, as a hypolipidemic. ... | 04/17/2007 |
| 7186859 | Uses for amino acid anticonvulsants The present invention is directed to the use of compounds of the formula: for treating pain, in particular neuropathic pain, bipolar disease and migraine headaches. ... | 03/06/2007 |
| 7148378 | Uses for amino acid anticonvulsants The present invention is directed to the use of compounds of the formula: for treating pain, in particular neuropathic pain, bipolar disease and migraine headaches. ... | 12/12/2006 |
| 7141537 | Mixture of fluorinated polyethers and use thereof as surfactant The present invention provides the use of a fluorinated polyether composition as a surfactant, said fluorinated polyether composition comprising a mixture of fluorinated polyethers of the formula: (Rf)n—Xw—Z (I) | 11/28/2006 |
| 7110808 | Method of optimizing radiosurgery and radiotherapy with metalloporphyrins An apparatus and method for subsequent optimization of radiosurgery and radiotherapy is provided. The invention includes administering a metalloporphyrin to the patient, and then creating a 3-dimensional mapping of tissue through use of PET or SPECT. Malignant and p... | 09/19/2006 |
| 7081535 | Hydroxy-amino acids Hydroxy-amino acids are provided and are prepared by contacting a substituted β-ketodiester having a ketone group and two ester functional groups with a ketoreductase under conditions permitting the reduction of the keytone group to an alcohol. Only one of the este... | 07/25/2006 |
| 7067276 | Method of using metaloporphyrins for treatment of arteriosclerotic lesions A method for treating arteriosclerotic lesions is provided wherein the method is characterized by administering a chemical compound to the patient, the compound being a porphyrin complexed with a radioactive metal. Cells which exhibit an affinity for the porphyrin e... | 06/27/2006 |
| 7057066 | Process for producing 3-amino-2-hydroxypropionic acid derivatives The present invention provides a process for preparing 3-amino-2-hydroxypropionic acid derivatives (1) which does not use dangerous reagents, is economically advantageous, and is suitable for an industrial production, which process comprises: ... | 06/06/2006 |
| 7002010 | Process for the preparation of morpholinones as light stabilizers The instant invention discloses a process for the preparation of compounds of the formula I: wherein the general symbols are as defined in claim 1, which process comprises reacting a compound of formula II: | 02/21/2006 |
| 6992067 | Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.... | 01/31/2006 |
| 6992217 | Ring-opened azlactone initiators for atom transfer radical polymerization Initiators for atom transfer radical polymerizations are described. The initiators have an azlactone or ring-opened azlactone moiety to provide telechelic (co)polymers. ... | 01/31/2006 |
| 6949528 | Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof The invention provides anti-apoptotic compositions lysophosphatidic acids and methods for making and using the compositions. Such compositions can also contain LPA potentiating agents, including proteins, lipid membrane structures and polymers such as polyethylene g... | 09/27/2005 |
| 6884910 | Uses for amino acid anticonvulsants The present invention is directed to the use of compounds of the formula: for treating pain, in particular neuropathic pain, bipolar disease and migraine headaches. ... | 04/26/2005 |
| 6849756 | Process for making optically active α-amino ketones and selected novel optically active α-amino ketones The invention includes selected novel optically active α-amino ketones which either are themselves useful or are intermediates for the preparation of known ketomethylene pseudopeptides useful as antibiotics, antibiotic enhancers, or enzyme inhibitors. Further, the ... | 02/01/2005 |
| 6833471 | Methods for producing hydroxy amino acids and derivatives thereof A methods for producing a hydroxy-amino acid or derivative thereof, such as statine, phenylstatine or isostatine, is provided. A substituted β-ketodiester having a ketone group and two ester functional groups is contacted with a ketoreductase under conditions permi... | 12/21/2004 |
| 6822115 | Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives are prepared using starting from aspartic acid with the same configuration as the desired compounds. Th... | 11/23/2004 |
| 6706923 | Perfluoroalkyl-substituted amines, acids, amino acids and thioether acids Perfluoroalkyl-substituted amines, acids, amino acids and thioether acid compounds containing a perfluoroalkyl-iodoalkyl or perfluoroalkyl-alkene group as well as derivatives thereof, are described. They are useful as surfactants in a variety of applications where l... | 03/16/2004 |
| 6677476 | Process for preparing R-(-) -carnitine from S-(-)-chlorosuccinic acid or from a derivative thereof An inner salt of L-carnitine is prepared by reduction, with a suitable reducing agent, of a compound of formula (I): ##STR1## where X1 and X2, which may be the same or different, are hydroxy, C1 -C4 alkoxy, phen... | 01/13/2004 |
| 6632921 | Seryl-lysyl-based peptide and peptidomimetic inhibitors of N-myristoyl transferase as anti-infective agents Seryl-lysyl-based peptide and peptidomimetic compounds are described as inhibitors of the enzyme N-myristoyl transferase to provide selective control of the fungal organism Candida albicans. Peptidomimetic compounds of particular interest are those of the... | 10/14/2003 |
| 6627771 | Gamma amino butyric and acid analogs The instant invention is improved gamma amino butyric acid analogs, processes for their preparation, and methods of using them as agents for treating epilepsy and other neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disor... | 09/30/2003 |
| 6585987 | Complexes of hyaluronic acid/carnitines and pharmaceutical and cosmetic compositions Complexes of hyaluronic acid and carnitine of its derivatives and the simple combinations of them are useful in therapeutics and cosmetics. They have pharmacological activity, that is protective activity on tissues and cell plasma membrane, anti-inflammat... | 07/01/2003 |
| 6583317 | Synthesis of acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters A process of preparing an acid addition salt of delta-aminolevulinc acid comprising: a) dissolving a lower alkyl 5-bromolevulinate and hexamethylenetetramine in a solvent selected from the group consisting of water, ethyl acetate, chloroform, acetone, eth... | 06/24/2003 |