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| Number | Title | Issue Date |
| 7205007 | Peri-operative and peri-procedure nutritional supplementation The invention provides a nutritional supplement system and program for patients undergoing or who have undergone a surgical or other invasive or stressful procedure, or who have suffered an injury. This nutritional supplement for the peri-operative period is designe... | 04/17/2007 |
| 7163810 | Method for producing target substance In a method for producing a target substance by using a microorganism comprising culturing a microorganism having an ability to produce the target substance in a medium to produce and accumulate the target substance in the medium or cells of the microorganism and co... | 01/16/2007 |
| 7161029 | DiL-lysine monosulfate trihydrate crystal and method of making A diL-lysine monosulfate trihydrate crystal which has a large tabular form and is more easily separable from the mother liquor. The crystal is obtained by a novel process of conducting crystallization at a lower temperature. ... | 01/09/2007 |
| 7125872 | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins There are disclosed β-sheet mimetics and methods relating to the same for imparting or stabilizing the β-sheet structure of a peptide, protein or molecule. In one aspect, β-sheet mimetics are disclosed having utility as protease inhibitors in general and, more sp... | 10/24/2006 |
| 7026297 | Neuroprotective agents Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN—, (where X and Y are hydrogen or various groups); Ra represents alkylene; Rb and Rc each represents alkylene, the total number... | 04/11/2006 |
| 6992067 | Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.... | 01/31/2006 |
| 6916947 | Method of producing amino carboxylic acids The present invention is directed to a method for producing amino acids by reacting halogenated carboxylic acid ester (haloacid esters) with a metal cyanate in the presence of an alcohol and by subsequent acidic saponification of the urethane carbonic acid formed. T... | 07/12/2005 |
| 6911470 | Polyoxometalate compounds as antiviral agents Polyoxometalate compounds which exhibit anti-retroviral activity are disclosed. Compounds with anti-retroviral activity include those having the following general molecular formulas: M7PW11O39 M8SiW | 06/28/2005 |
| 6893848 | Desensitized aspartokinase The present invention relates to a novel aspartokinase derived from a Coryneform bacterium; a DNA encoding the enzyme; a recombinant DNA containing the above DNA; a Coryneform bacterium having the above recombinant DNA or a Coryneform bacterium having the DNA on its... | 05/17/2005 |
| 6797699 | Neuroprotective agents Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN—, (where X and Y are hydrogen or various groups); Ra represents alkylene; Rb and Rc each represents alkylene, the total number... | 09/28/2004 |
| 6756510 | Making a variety of L-lysine feed supplements Liquid lysine can be made with almost any particular specification that may be reasonably expected. A multistep process for producing lysine includes at least: fermentation, ultrafiltration, evaporation, and mixing. Depending upon the particular specifications that ... | 06/29/2004 |
| 6703042 | Salts of L-carnitine and lower alkanoyl L-carnitine The present invention relates to stable, non-hygroscopic salts of L-carnitine and lower alkanoyl L-carnitine endowed with enhanced nutritional and /or therapeutical efficacy with respect to their inner salts congeners and tom solid compositions containing... | 03/09/2004 |
| 6699869 | ଲ-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins There are disclosed ଲ-sheet mimetics and methods relating to the same for imparting or stabilizing the ଲ-sheet structure of a peptide, protein or molecule. In one aspect, ଲ-sheet mimetics are disclosed having utility as protease inhibito... | 03/02/2004 |
| 6696611 | Chemical methods The present invention provides a method for enantioselectively reducing a prochiral carbon centered radical having one or more electron donator groups attached directly to the central prochiral carbon atom of the radical, and/or attached to a carbon atom ... | 02/24/2004 |
| 6632961 | Antiangiogenic drug to treat cancer, arthritis and retinopathy Compounds having Formula I ##STR1## or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions c... | 10/14/2003 |
| 6632921 | Seryl-lysyl-based peptide and peptidomimetic inhibitors of N-myristoyl transferase as anti-infective agents Seryl-lysyl-based peptide and peptidomimetic compounds are described as inhibitors of the enzyme N-myristoyl transferase to provide selective control of the fungal organism Candida albicans. Peptidomimetic compounds of particular interest are those of the... | 10/14/2003 |
| 6495716 | [S,S]-ethylenediamine-N,N'-disuccinic acid crystal with high bulk density and process for obtaining the same Crystals of [S,S]-ethylenediamine-N,N'-disuccinic acid which have a bulk density of 0.45 to 1.2 g/cm3, and a process for obtaining these crystals comprising the steps of adjusting an aqueous solution of an [S,S]-ethylenediamine-N,N'-disuccinic ... | 12/17/2002 |
| 6492542 | Method for producing carboxylic acid tertiary alkyl ester A carboxylic acid tertiary alkyl ester (Chemical formula 1) of high purity is obtained at a high yield ratio, by continually adding an esterification agent possessing a monovalent acid group, which agent is ester-interchangeable with a tertiary alcohol, t... | 12/10/2002 |
| 6492489 | Synthetic hypusine peptides The invention relates to novel peptides synthesized according a method utilizing the hypusine reagent: ##STR1## wherein: Q1 Q2 and Q3 may be the same or different and are amino protective groups, provided that Q3 | 12/10/2002 |
| 6414189 | Crystals of [S,S]-ethylenediamine-N,N'-disuccinic acid with high bulk density and method of obtaining the same Crystals of [S,S]-ethylenediamine-N,N'-disuccinic acid which have a bulk density of 0.45 to 1.2 g/cm3, and a process for obtaining these crystals comprising the steps of adjusting an aqueous solution of an [S,S]-ethylenediamine-N,N'-disuccinic ... | 07/02/2002 |
| 6392094 | Method for recovering amino acids A method for recovering amino acids, which comprises supplying a mixed solution containing inorganic acid salts, amino acids and non-electrolytes such as saccharides to a first-step resin layer comprising an Na type or K type strongly acidic ion exchange ... | 05/21/2002 |
| 6376544 | Nutritional product for a person having renal failure L-arginine found essential to enhance the glomerular function of the kidneys is used $c; formulate a low viscosity, calorie-dense, nutritional product for a person having renal failure. In a product free of citric acid or citrates, for oral ingestion, ... | 04/23/2002 |
| 6364914 | Method of crystallization with the particle size distribution being controlled Herein is disclosed a method of crystallization with the particle size distribution being controlled, characterized in that while crystals are being precipitated by vacuum concentration crystallization, the temperature of the slurry is periodically varied... | 04/02/2002 |
| 6344483 | Halogenated amidino amino acid deviratives useful as nitric oxide synthase inhibitors The current invention discloses halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors, and pharmaceutically acceptable salts thereof.... | 02/05/2002 |
| 6329548 | Aqueous stable lysine solution Herein is disclosed an aqueous stable lysine solution containing an acid radical in such amount that the solubility of lysine therein has been increased than in the corresponding aqueous lysine base solution, whereby during storage of lysine in the form o... | 12/11/2001 |
| 6288116 | Method of administration of a nutritional product to a person having renal failure L-arginine found essential to enhance the glomerular function of the kidneys is used to formulate a low viscosity, calorie-dense, nutritional product for a person having renal failure. In a product free of citric acid or citrates, for oral ingestion, the ... | 09/11/2001 |
| 6255503 | Water-soluble salts of dodecandioic acid and pharmaceutical and nutritional compositions containing same Water-soluble dodecandioates wherein the cationic moiety is selected from the group comprising the cations of basic aminoacids (e.g. lysine) and choline and orally or parenterally administrable compositions containing same, are disclosed.... | 07/03/2001 |
| 6248866 | Hypusine reagent for peptide synthesis A derivative of hypusine useful as a reagent for synthesizing peptides containing hypusine, as well as an improved method for synthesizing the same, the derivative having the formula: ##STR1## wherein: Q1 and Q2 may be the same or di... | 06/19/2001 |
| 6069172 | (R)-2-(3-benzoylphenyl) propionic acid salts and pharmaceutical preparations containing them A new use of the enantiomer (R)-ketoprofen and of its salts with suitable organic and inorganic bases in the therapy of neutrophil-dependent diseases and phlogistic processes is described as well as pharmaceutical preparations containing such compounds an... | 05/30/2000 |
| 6060586 | Ureins derived from alpha, omega-diamono acids and process for their preparation Ureins are obtained by reaction, in basic medium, between an Nω -(aryloxycarbonyl)diamino acid and a compound containing a free amino group. The chirality of the compounds is outstandingly well preserved.... | 05/09/2000 |
| 6057297 | Inhibitor compounds of zinc-dependent metalloproteinases associated with pathological conditions, and therapeutic use thereof Peptidomimetic compounds capable of inhibiting zinc-dependent metalloproteinases to treat pathological conditions associated with activation of endogenous metalloproteinases in mammals.... | 05/02/2000 |
| 6020331 | ଲ-sheet mimetics and use thereof as protease inhibitors There are disclosed ଲ-sheet mimetics and methods relating to the same for imparting or stabilizing the ଲ-sheet structure of a peptide, protein or molecule. In one aspect, the ଲ-sheet mimetics are covalently attached at the end or within ... | 02/01/2000 |
| 6017555 | Process for making L-lysine feed supplement A process produces an L-Lysine feed supplement with a final L-Lysine purity in the range theoretically between about 35% and 80%, measured as a percent of free-base per kg, and more preferably between about 50% and 80% L-Lysine. The process comprises addi... | 01/25/2000 |
| 6015792 | Specific eatable taste modifiers Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.... | 01/18/2000 |
| 6008250 | Specific eatable taste modifiers Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.... | 12/28/1999 |
| 5998594 | Self-assembling, chromogenic receptors for the recognition of medically important substrates and their method of use A chromogenic receptor comprises a self-assembled chromogenic compound having at least one intrinsic binding site. The chromogenic compound is characterized by the property of producing a reversible color change responsive to binding a target substrate to... | 12/07/1999 |
| 5990350 | Process for making granular L-lysine Process for the efficient production of a substantially dust-free, free flowing granular L-Lysine in which the L-Lysine content is adjustable. Cells are removed from a fermentation broth containing L-Lysine to make a substantially cell free L-Lysine broth... | 11/23/1999 |
| 5981564 | Water-soluble derivatives of paclitaxel, method for producing same and uses thereof The invention relates to new paclitaxel derivatives showing an increased solubility in water. More particularly, the invention relates to glutarylpaclitaxel, glutarylpaclitaxel 6-aminohexanol glucuronide and to different amino acid derivatives of the glut... | 11/09/1999 |
| 5973113 | Hypusine reagent for peptide synthesis A derivative of hypusine useful as a reagent for synthesizing peptides containing hypusine, as well as a method for synthesizing the same, the derivative having the formula: ##STR1## wherein: Q1 and Q2 may be the same or differe... | 10/26/1999 |
| 5965770 | N-aryloxycarbonyl amino acids and peptides and their derivatives Compounds having the general formula: ##STR1## in which R3 represents an aryl group which is unsubstituted or substituted by one or more alkyl groups containing 1 to 4 carbon atoms; R4 represents a hydrogen atom, a group for protecting the amino func... | 10/12/1999 |
