Quotables
"It is my heart-warmed and world-embracing Christmas hope and aspiration that all of us, the high, the low, the rich, the poor, the admired, the despised, the loved, the hated, the civilized, the savage (every man and brother of us all throughout the whole earth), may eventually be gathered together in a heaven of everlasting rest and peace and bliss, except the inventor of the telephone. "
Mark Twain ; Christmas greetings, 1890
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| Number | Title | Issue Date |
| 8138372 | Zwitterionic compounds and use thereof The present invention covers zwitterionic, non-surface-active compounds in the form of carboxymethylated, short-chain dialkylaminoalkylamides and use thereof as therapeutic agent. ... | 03/20/2012 |
| 7919653 | Method of inhibiting nonspecific interaction between molecules on solid phase support The present invention provides a method of suppressing the nonspecific interaction between molecules, characterized in that in a process to immobilize a molecule onto a solid phase carrier and analyze the specific interaction between the molecule and a molecule that... | 04/05/2011 |
| 7772428 | Creatine hydroxycitric acids salts and methods for their production and use in individuals Methods of production for Tricreatine Hydroxycitrate are disclosed. Tricreatine hydroxycitrate can be used as supplemental dietary ingredient for the purposes of reducing adiposity, suppression of appetite, improvement of muscle and exercise performance and recovery... | 08/10/2010 |
| 7511173 | Creatine salt with enhanced nutritional and therapeutic efficacy and compositions containing same The novel salt creatine glycinate and compositions (dietary supplements, energy drinks, and dietetic or pharmaceutical products containing the same are described. ... | 03/31/2009 |
| 7420002 | Amino acid conjugates providing for sustained systemic concentrations of GABA analogues Compounds that provide for sustained systemic concentrations of GABA analogs following oral administration to animals are disclosed. Pharmaceutical compositions including, and methods using, such compounds are also disclosed. ... | 09/02/2008 |
| 7351852 | T-butoxycarbonylaminoethylamine for the synthesis of PNA monomer units, amino acid derivatives, intermediates therof, and processes for productions of them A process for amino acid derivatives shown by the below general formula (I): (wherein R1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms.) having an object to provide... | 04/01/2008 |
| 7321045 | Vitronectin receptor antagonist pharmaceuticals The present invention describes novel compounds of the formula: (Q)d-Ln-Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. Th... | 01/22/2008 |
| 7319164 | 5-azido-laevulinic acid, method for the production thereof and its use The present invention relates to 5-azido levulinic acid, a process for its preparation, its use. Using 5-azido levulinic acid as starting material for the synthesis of 5-amino levulinic acid hydrochloride it is possible to obtain the latter in good yield an in pharm... | 01/15/2008 |
| 7163810 | Method for producing target substance In a method for producing a target substance by using a microorganism comprising culturing a microorganism having an ability to produce the target substance in a medium to produce and accumulate the target substance in the medium or cells of the microorganism and co... | 01/16/2007 |
| 7157092 | Acyl pseudodipeptides, preparation method and pharmaceutical compositions containing same Compounds of the formula wherein the substitutents are defined as in the specification useful for modulating immune responses in warm-blooded animals. ... | 01/02/2007 |
| 7135587 | Urea and urethane derivatives as integrin inhibitors Novel urea and urethane derivatives of general formula (I) in which R1, R2, R3, R5, R5′, X, Y, B, m, n and o are as defined in Patent Claim 1, and physiologically acceptable salts or solvates thereof are integrin inhibitors and can be employed for combating... | 11/14/2006 |
| 7125852 | Geranyl compounds This invention provides compounds having excellent antitumor activity, which are represented by the following formulae in which R1, R2, R3, m, n and R4 have the significa... | 10/24/2006 |
| 7015349 | Reduction of hair growth Compositions including a conjugate of α-difluoromethylornithine can be applied topically to reduce hair growth. ... | 03/21/2006 |
| 7012158 | Processes for the production of α-difluoromethyl ornithine (DFMO) Provided are processes and synthetic intermediates useful for the preparation of α-difluoromethylornithine (DFMO) having the formula ... | 03/14/2006 |
| 7012152 | Method for producing lysine derivative The present invention provides a method for industrially producing an optically active lysine derivative useful as a pharmaceutical intermediate. More particularly, the present invention provides a production method including protecting an amino group or an amino gr... | 03/14/2006 |
| 6992067 | Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.... | 01/31/2006 |
| 6969703 | Inhibitors of the ICE/ced-3 family of cysteine proteases This invention is directed to novel sulfonimide (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds having the following structure: wherein A, B, X, R, R1, R2, n, q, and r are as def... | 11/29/2005 |
| 6953865 | Process for the preparation of (r)- or (s)-aminocarnitine inner salt, the salts and derivatives thereof A process for the production of (R)- or (S)-aminocarnitine starting respectively from (R)- or (S)-nitryloxycarnitine, through the formation and hydrogenation of the azidocarnitine intermediate with the same absolute configuration is described. (R)-aminocarnitine inn... | 10/11/2005 |
| 6888022 | Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or i... | 05/03/2005 |
| 6861554 | Creatine salt having enhanced nutritional and therapeutic efficacy and compositions containing same A novel salt, creatine taurinate, and the compositions containing same (health foods, dietary supplements or drugs) are disclosed. ... | 03/01/2005 |
| 6828456 | 2-amino-2-alkyl-3 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors The present invention relates to 2-amino-2-alkyl-3 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors. ... | 12/07/2004 |
| 6822115 | Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives are prepared using starting from aspartic acid with the same configuration as the desired compounds. Th... | 11/23/2004 |
| 6803456 | Process for the production of arginine-silicate complex A method of making an arginine silicate-containing complex and its use in the prevention and treatment of atherosclerosis and as a dietary supplement are claimed. The arginine silicate complex is synthesized by combining arginine, potassium silicate and inositol. | 10/12/2004 |
| 6756406 | 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors. ... | 06/29/2004 |
| 6750253 | Aminobenzophenones as inhibitors of il-1β and tnf-α The present invention relates to compounds of the formula wherein R1 independently represents one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifl... | 06/15/2004 |
| 6733985 | Preparation of stable liquid and dried synthetic prothrombin time reagents A reagent for determining prothrombin time (PT) including a recombinant protein tissue factor, a mixture of synthetic phospholipids, and a beta, gamma, or delta amino acid stabilizing compound is described for monitoring extrinsic blood coagulation activities. The s... | 05/11/2004 |
| 6730809 | Processes for the production of α-difluoromethyl ornithine (DFMO) Provided are processes and synthetic intermediates useful for the preparation of α-difluoromethylornithine (DFMO) having the formula ... | 05/04/2004 |
| 6703042 | Salts of L-carnitine and lower alkanoyl L-carnitine The present invention relates to stable, non-hygroscopic salts of L-carnitine and lower alkanoyl L-carnitine endowed with enhanced nutritional and /or therapeutical efficacy with respect to their inner salts congeners and tom solid compositions containing... | 03/09/2004 |
| 6693187 | Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge Phosphinoamidite carboxylates and analogs are provided that have the structure of formula (I) ##STR1## wherein R1, R2, R3, R4, X, Y, Z and n are as defined herein. The compounds are useful as phosphitylating age... | 02/17/2004 |
| 6673942 | Resolution of DL-racemic mixtures The present invention relates to a process for the resolution of DL-racemic mixtures of compounds which crystalize in the form of a conglumerate. Both, the D and L-enantiomers are obtained according to the invention in a industrially feasable process by a... | 01/06/2004 |
| 6664412 | Method for producing lysine derivative The present invention provides a method for industrially producing an optically active lysine derivative useful as a pharmaceutical intermediate. More particularly, the present invention provides a production method including protecting an amino group or ... | 12/16/2003 |
| 6652834 | Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents Substituted polycarboxylic ligand molecules and corresponding metal complexes of said ligands, preferably paramagnetic metals complexes for generating responses in the field of magnetic resonance imaging (MRI) The paramagnetic complexes of the polycarboxy... | 11/25/2003 |
| 6653504 | Non-hygroscopic salts of active ingredients having therapeutical and/or nutritional activities and orally administrable compositions containing same Derivatives of active ingredients with creatine and ornithine are disclosed having enhanced nutritional and/or therapeutic effects which favorably lend themselves to the preparation of orally administrable solid compositions.... | 11/25/2003 |
| 6649613 | Diacylhydrazine derivatives Diacylhydrazine derivatives of general formula (I) ##STR1## wherein X, Y, Z, R1, 2 and R3 are as defined herein, and their physiologically acceptable salts or solvates thereof, are integrin inhibitors and can be used to co... | 11/18/2003 |
| 6586403 | Treating allergic reactions and inflammatory responses with tri-and dipeptides This invention relates to methods and compositions of tripeptides and dipeptides having anti-inflammatory activities that can be used for the treatment of allergic and inflammatory reactions. A peptide of the formula: X-R.sub. 1 -R2 -R3 | 07/01/2003 |
| 6569411 | Serine carbonates Serine carbonates of formula I are precursors for organoleptic compounds, masking agents and antimicrobial agents. Further they are alternative substrates for malodor producing enzymes. The symbols in formula I are defined in claim 1.... | 05/27/2003 |
| 6528684 | Synthesis of (R) and (S) -aminocarnitine and their derivatives starting from D- and L-aspartic acid R or S aminocarnitine and their derivatives with formula (I) ##STR1## where Y is as described in the description, starting with aspartic acid with the same configuration as the aminocarnitine desired. This process has advantage in the type of reactants us... | 03/04/2003 |
| 6525024 | Inhibitors of the ICE/ced-3 family of cysteine proteases This invention is directed to novel sulfonimide (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds having the following structure: ##STR1## wherein A, B, X, R, R1, R2, n, q, and r are as defined herein. The invent... | 02/25/2003 |
| 6504047 | 2,6-diamino-6-methyl-heptanoic acid and derivatives, process for the preparation thereof and use thereof The present invention is directed towards compounds of the general formula (I) ##STR1## (I) are important intermediates for the preparation of pharmaceuticals. Further intermediates, process for the preparation of (I) and use thereof.... | 01/07/2003 |
| 6495522 | Substituted alpha-hydroxy acid caspase inhibitors and the use thereof The present invention is directed to novel substituted -hydroxy acid thereof, represented by the general Formula I: ##STR1## where R1 -R5, X and Z are defined herein. The present invention also relates to the discovery that co... | 12/17/2002 |
