Quotables
"Without question, the greatest invention in the history of mankind is beer. Oh, I grant you that the wheel was also a fine invention, but the wheel does not go nearly as well with pizza."
Dave Barry
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7851650 | Compounds for treating inflammation and pain The present invention is directed to a compound of 2-N halo-4-methylsulfonyl-butyric acid, such as 2-N chloro-4-methylsulfonyl-butyric acid, or a pharmaceutically acceptable salt or solvate thereof. The present invention is also directed to a pharmaceutical composit... | 12/14/2010 |
| 7316996 | Bisacyloxypropylcysteine conjugates and the use thereof The invention provides lipopeptide conjugates in which a cysteine that is double-substituted by a fatty acid is bonded by means of the carboxyl group to a highly soluble, physiologically compatible and non-immunogenic, polymeric conjugate group. The conjugates exhib... | 01/08/2008 |
| 7317070 | Process for the preparation of polyamino acids Among the various aspects of the present invention is an improved process for the preparation of polyamino acids generally, and more specifically, polyglutamic acid and polyaspartic acid. Another aspect is a process for the large scale (i.e. >1 kg) preparation of po... | 01/08/2008 |
| 7317040 | Nitric oxide synthase inhibitor phosphate salt A compound of formula (I): namely (2S)-2-amino-4-{[2-(ethanimidoylamino)ethyl]thio}butanoic acid, compound with phosphoric acid, or a solvate or physiologically functional derivative thereof, is useful as a relat... | 01/08/2008 |
| 7304181 | Methods for making intermediates and oxytocin analogues More efficient and/or economical methods for synthesizing heptapeptide alcohol analogs of oxytocin are provided along with novel intermediates which are useful in synthesizing such oxytocin analogs. Efficient and economical methods for synthesizing intermediates use... | 12/04/2007 |
| 7279301 | Methods of determining deficiencies in intracellular levels on cysteine and glutathione The present invention provides a method for determining an antioxidant deficiency in a lymphocyte by determining the level of intracellular cysteine in the lymphocyte by measuring lymphocyte growth in a serum-free cell culture medium comprising cumene hydroperoxide ... | 10/09/2007 |
| 7205385 | Polymerization method for the synthesis of polypeptide imaging agents A method for synthesizing extended poly(amino acids) conjugated to imaging agents, such as DTPA, is disclosed. The amino acid is initially conjugated to the imaging agent at the monomer stage, followed by formation of the corresponding N-carboxyanhydride. The method... | 04/17/2007 |
| RE39576 | Enzyme inhibitors A compound of formula (I) wherein R1 is a C1-6 straight or branched chain alkyl group, a C2-6alkenyl group, a C2-6 alkynyl group, a C3-6cyc... | 04/17/2007 |
| 7195772 | Amino-acid iodine complex An amino-acid iodine complex, viz. amino-acid amino-carboxyl iodine complex, was provided wherein its coordinate center is iodine molecule, complex reagent is amino-acid, sites of complexing reaction are amino and carboxyl groups of amino-acid. The complex can be us... | 03/27/2007 |
| 6987193 | Illudin analogs useful as antitumor agents The present invention provides illudin analogs of the general formula (I): where R1 is (CH2)n—X—Y or H; n is 0 to 4; X is O or S or N or absent; and Y is an... | 01/17/2006 |
| 6966944 | Anticurling agent, ink jet ink, method for ink jet recording and method for reducing curling The present invention provides an anti-curl agent containing an amide compound of specific structure and molecular weight, an ink jet ink containing the amide compound, a method for ink jet recording to form images by ejecting the ink, and a method for reducing curl... | 11/22/2005 |
| 6949382 | Cell culture media containing N-acetyl-L-cysteine and uses thereof The present invention provides cell culture media and methods useful for determining levels of intracellular function of glutathione or cysteine and for providing biochemical analysis of antioxidant function in human lymphocytes. ... | 09/27/2005 |
| 6916850 | Pyruvate derivatives Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, but are not limited to oximes... | 07/12/2005 |
| 6906171 | Process for the deprotection of protected thiols The synthesis of peptides comprising disulphide bridges is challenging since it is difficult to ensure that the correct cysteine residues combine to form the desired disulphide bridges. The present invention describes novel protection techniques useful in the prepar... | 06/14/2005 |
| 6846843 | β-thioamino acids Thio-alpha-amino acids of general formula (I), wherein R1, R2 and R3 have the meanings given in the description, methods for producing them, and medicaments containing these compounds. The invention also provides methods for treating... | 01/25/2005 |
| 6713511 | Fatty acid derivatives The invention relates to a novel acylate which is the reaction product of (a) a substance which is selected from the group consisting of naturally occuring alpha-aminocarboxylic acids, neurotransmitters other than such acids, and central or peripheral nervous system... | 03/30/2004 |
| 6706923 | Perfluoroalkyl-substituted amines, acids, amino acids and thioether acids Perfluoroalkyl-substituted amines, acids, amino acids and thioether acid compounds containing a perfluoroalkyl-iodoalkyl or perfluoroalkyl-alkene group as well as derivatives thereof, are described. They are useful as surfactants in a variety of applications where l... | 03/16/2004 |
| 6686494 | Synthesis of S-alkyl and S-aryl thiocarbamates, one-pot two-step general synthesis A method for preparing S-alkyl and S-aryl thiocarbamates comprising reacting a precursor thiol reagent with trichloroacetyl chloride to produce an S-alkyl and S-aryl trichloroacetyl thioester intermediate, which is reacted with an amine to yield the corre... | 02/03/2004 |
| 6639105 | Illudin analogs useful as antitumor agents The present invention provides illudin analogs of the general formula (I): ##STR1## where R1 is (CH2)n --X--Y or H; n is 0 to 4; X is O or S or N or absent; and Y is an optionally substituted (C1 -C8)alkyl... | 10/28/2003 |
| 6630512 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 10/07/2003 |
| 6620848 | Nitric oxide synthase inhibitors The present invention relates to novel amidino compound of formula (I): ##STR1## to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use as selective inhibitors of inducible ... | 09/16/2003 |
| 6605590 | Oligomers and oligomeric segments of alpha-hydroxy carboxylic acids and alpha-amino acids An enzymatic synthesis and composition of -hydroxy carboxylic acid and -amino acid or peptide co-oligomers is disclosed wherein a residue of the -hydroxy carboxylic acid is linked to a residue of the -amino acid or peptide by a... | 08/12/2003 |
| 6570024 | Process and intermediates Processes for preparing N-methyl-L-alanine derivatives and novel intermediates of the process. The derivatives and intermediates are useful for preparing cell-binding agent/maytansinoid complexes.... | 05/27/2003 |
| 6552222 | Hydrolysis of acylamino acids A process for the preparation of racemic amino acids, characterized in that an acylamino acid of the formula R1 --CH(NH--CO--R2)COOH wherein R1 is hydrogen, a linear, branched or cyclic alkyl that has from 1 to 7 carbon atoms a... | 04/22/2003 |
| 6548700 | Process for the precipitation of cystine A process for precipitating cystine from a solution in sulfuric acid, includes forming a mixture of a solution of cystine in aqueous sulfuric acid and of an aqueous solution of a base by simultaneous metering the cystine solution and the aqueous base solu... | 04/15/2003 |
| 6528684 | Synthesis of (R) and (S) -aminocarnitine and their derivatives starting from D- and L-aspartic acid R or S aminocarnitine and their derivatives with formula (I) ##STR1## where Y is as described in the description, starting with aspartic acid with the same configuration as the aminocarnitine desired. This process has advantage in the type of reactants us... | 03/04/2003 |
| 6506934 | Water soluble halogen-containing compounds This invention relates to a compound that is represented by the following Structure I: R1 --SO2 --C(R2)R3 --(CO)m --(L)n --SG I wherein R1 is an aliphatic or cyclic group, R2 a... | 01/14/2003 |
| 6458844 | Diphenyl carbocyclic thioamide derivatives It has been discovered that compounds of the formula: ##STR1## and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated wit... | 10/01/2002 |
| 6441040 | Oral preparations comprising S-(3-hydroxypropyl)-L-cysteine A preparation for oral administration which comprises S-(3-hydroxypropyl)-L-cysteine and one or more excipients, where the excipients do not cause discoloration of S-(3-hydroxypropyl)-L-cysteine is disclosled. According to an embodiment of the invention, ... | 08/27/2002 |
| 6420429 | Brain targeted low molecular weight hydrophobic antioxidant compounds Novel brain targeted low molecular weight, hydrophobic antioxidants and use of antioxidants in treatment of central nervous system neurodegenerative disorders such as Parkinson's, Alzheimer's and Creutzfeldt-Jakob's diseases and in treatment of conditions... | 07/16/2002 |
| 6395930 | Quenching reagents for solution phase synthesis A method for enhancing the purity of a desired compound comprising: Step (a) treating a crude reaction product which contains at least one desired compound, unreacted starting materials and/or byproducts with at least one bifunctional quenching agent that is c... | 05/28/2002 |
| 6380403 | Illudin analogs useful as antitumor agents The present invention provides illudin analogs of the general formula (I): ##STR1## where R1 is (CH2)n --X--Y or H; n is 0 to 4; X is O or S or N or absent; and Y is an optionally substituted (C1 -C8)alkyl... | 04/30/2002 |
| 6369272 | Nitric oxide synthase inhibitors The present invention relates to novel amidino compound of formula (I). ##STR1## to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use as selective inhibitors of inducible ... | 04/09/2002 |
| 6344483 | Halogenated amidino amino acid deviratives useful as nitric oxide synthase inhibitors The current invention discloses halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors, and pharmaceutically acceptable salts thereof.... | 02/05/2002 |
| 6306840 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 10/23/2001 |
| 6277876 | Matrix metalloproteinase inhibitors Compounds of the formula (I) ##STR1## where X is a --CO2 H or --CONHOH group; Y and Z are independently sulphur or oxygen, at least one being sulphur; R1 is hydrogen, hydroxy, (C1 -C6)alkyl, (C2 -C | 08/21/2001 |
| 6255277 | Localized use of nitric oxide-adducts to prevent internal tissue damage A method for preventing adverse effects associated with the use of a medical device in a patient by introducing into the patient a device of which at least a portion includes a prophylactic or therapeutic amount of a nitric oxide adduct. The nitric oxide ... | 07/03/2001 |
| 6254850 | Metal complexes, suitable for use in diagnosis and therapy The invention relates to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and an... | 07/03/2001 |
| 6239111 | In vivo method of improving survival rate of brain neurons The present invention discloses the use, in the manufacture of a preventive and therapeutic drug of a brain disease, of a compound represented by formula (1): [wherein R represents a hydrogen atom, an alkyl group, an alkenyl group, a substituted alkyl gro... | 05/29/2001 |
| 6201122 | Fluoroaliphatic radical-containing anionic sulfonamido compounds Novel fluoroaliphatic radical-containing anionic sulfonamido compounds, methods of preparation and methods of use, including use as surfactants, are disclosed. Said compounds are conveniently prepared by the Michael addition of a fluoroaliphatic radical-c... | 03/13/2001 |
