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| Number | Title | Issue Date |
| 8071808 | Processes for preparing a substituted gamma-amino acid The present invention is related to processes suitable for industrial synthesis of pregabalin from (R)-(−)-3-(carbamoylmethyl)-5-methylhexanoic using sodium hypochlorite as described herein. In addition, the present invention is related to pregabalin which is subs... | 12/06/2011 |
| 8063244 | Process for the synthesis of pregabalin A process for the preparation of a compound of formula (I) is disclosed, which comprises: a) the reaction of a compound of formula (II) ... | 11/22/2011 |
| 8034974 | Beta-amino acids and methods intermediates for making same Disclosed are β-amino acids that are unsubstituted in the β position; that are substituted in the β position with an aryl group; that are substituted in the α position with an aryl group; that bear two substituents in the α position; and/or that are substituted... | 10/11/2011 |
| 7982066 | High protein supplement The present disclosure relates to high protein dietary supplements for treating various symptoms and diseases associated with protein deficiency including weight gain, obesity, catabolic diseases, fibromyalgia, anxiety reactions, posttraumatic stress and chronic fat... | 07/19/2011 |
| 7973196 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid The invention encompasses processes for the synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin, and intermediates of (S)-Pregabalin. ... | 07/05/2011 |
| 7960583 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid The invention encompasses processes for the synthesis of (S)-(+)-3-(aminomethyl) -5-methylhexanoic acid, (S)-Pregabalin, and intermediates of (S)-Pregabalin. ... | 06/14/2011 |
| 7923575 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid The invention encompasses processes for the synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin, and intermediates of (S)-Pregabalin. ... | 04/12/2011 |
| 7820857 | Method for treating pain in trigeminal neuralgia The present invention is directed to the use of a class of peptide compounds for treating pain in trigeminal neuralgia. ... | 10/26/2010 |
| 7820858 | Concise β-amino acid synthesis via organocatalytic aminomethylation The present invention provides a method for the synthesis of β2-amino acids. The method also provides methods yielding α-substituted β-amino aldehydes and β-substituted γ-amino alcohols. The present method according to this invention allows for incre... | 10/26/2010 |
| 7772427 | Uses for amino acid anticonvulsants The present invention relates to the use of compounds of the formula for treating obsessive compulsive neurosis. ... | 08/10/2010 |
| 7763749 | Method for the preparation of Pregabalin and salts thereof Processes for preparing and purifying Pregabalin and salts thereof are provided. ... | 07/27/2010 |
| 7470812 | Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the synthesis of (S)-Pregabalin The invention encompasses the synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin, via the intermediate, (3R)-5-methyl-3-(2-oxo-2{[(1R)-1-phenylethyl]amino}ethyl)hexanoic acid. ... | 12/30/2008 |
| 7465826 | Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the synthesis of (S)-pregabalin The invention encompasses the synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin, via the intermediate, (3R)-5-methyl-3-(2-oxo-2{[(1R)-1-phenylethyl]amino}ethyl)hexanoic acid. ... | 12/16/2008 |
| 7462737 | Pregabalin free of isobutylglutaric acid and a process for preparation thereof A Pregabalin having a low level of 3-isobutylglutaric acid is provided. ... | 12/09/2008 |
| 7462738 | Processes for the preparation of R-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof Provided are processes for the synthesis of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof, intermediates in the synthesis of S-pregabalin. ... | 12/09/2008 |
| 7439350 | Nucleotide analogs Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed i... | 10/21/2008 |
| 7435845 | Corrosion and gas hydrate inhibitors having improved water solubility and increased biodegradability Corrosion and gas hydrate inhibitors having improved water solubility and increased biodegradability The invention thus provides the use of compounds of the formula (1) where R... | 10/14/2008 |
| 7429674 | Process for preparing fluoroleucine alkyl esters This invention relates to a stereoselective preparation of fluoroleucine alkyl esters. ... | 09/30/2008 |
| 7417165 | Crystalline forms of pregabalin Crystalline form of Pregabalin characterized by X-ray powder diffraction peaks at about 5.8, 18.4, 19.2, 20.7, and 23.7° 2θ±0.2° 2θ, methods for its preparation, its pharmaceutical compositions thereof, and methods for the preparation of crystalline form of Pre... | 08/26/2008 |
| 7411062 | 7α-biscarbonyl-substituted steroid compounds The present invention involves intermediates, including a 7α-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent. ... | 08/12/2008 |
| 7378548 | Tertiary amine compounds having an ester structure and processes for preparing the same The present invention provides ester group-containing tertiary amine compounds of the formula (R1OCH2CH2)nN(CH2CH2CO2R2)3-n which, when used as additives in chemical a... | 05/27/2008 |
| 7371897 | Preparation method for (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid Provided is a novel preparation method of (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid represented by the following formula (1), a key intermediate of cilastatin used as a supplement to imipenem. The novel preparation method of the inventi... | 05/13/2008 |
| 7371867 | Non-racemic trifluoroleucine, and methods of making and using One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the invention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides compri... | 05/13/2008 |
| 7348451 | Additives for inhibiting gas hydrate formation The invention provides the use of compounds of the formula (1) where R1, R2 are each independently C1- to C22-alkyl, C2- to C22-alkenyl, C6... | 03/25/2008 |
| 7329778 | Process and catalyst for dehydrogenating primary alcohols to make carboxylic acid salts This invention is directed to a process for making a salt of a carboxylic acid. The process comprises contacting a catalyst with an alkaline mixture comprising a primary alcohol. In one embodiment, for example, the catalyst comprises a metal support (preferab... | 02/12/2008 |
| 7319165 | Aminopolycarboxylic acid aqueous solution composition and stabilization method of aminopolycarboxlic acid The present invention is to provide a stabilized aqueous aminopolycarboxylate solution composition and a method of stabilizing the aminopolycarboxylate through preventing the same from caking. An aqueous aminopolycarboxylate solution composition containing an... | 01/15/2008 |
| 7282605 | Optically active 2-allylcarboxylic acid derivative and process for producing the same The present invention provides a process for producing an optically active 2-allylcarboxylic acid derivative, which is useful as a pharmaceutical intermediate, from readily available and inexpensive starting materials by the process which can be practiced on a comme... | 10/16/2007 |
| 7279550 | Irreversible cysteine protease inhibitors of legumain Presented are compounds represented by the following general formulas (I) and (II), for inhibiting cysteine protease legumain for modulating associated disease states in subjects ... | 10/09/2007 |
| 7276484 | Dipeptide inhibitors of β-secretase Dipeptide derived inhibitors of the β-secretase enzyme are provided which are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of Aβ peptide in a mammal. The compounds of the invention provide useful methods of treatmen... | 10/02/2007 |
| 7268252 | Binaphthol derivatives and their use in optical resolution or optical transformation Disclosed herein are novel binaphthol derivatives and methods for the optical resolution of amino acids or amino alcohols and for the optical transformation of D, L-forms of amino acids using the same. ... | 09/11/2007 |
| 7247741 | Acetylamino benzoic acid compounds and their use for nonsense suppression and the treatment of disease Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature transla... | 07/24/2007 |
| 7238503 | Process for making fluoroleucine ethyl esters The instant invention describes a novel reaction that includes spontaneous racemization of an azalactone via enol tautomerization. This racemization results in improved yield and ee over other reactions previously described. ... | 07/03/2007 |
| 7229970 | Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4 Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, su... | 06/12/2007 |
| 7223879 | Ligands for metals and improved metal-catalyzed processes based thereon One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. ... | 05/29/2007 |
| 7223797 | Meldonium salts, method of their preparation and pharmaceutical composition on their basis New salts of Meldonium, the method of their preparation, and pharmaceutical formulation on their basis have been described. The general formula of these salts is X−(CH3)3N+NHCH2CH2COOH where X− is an acid anion selected from the group of ph... | 05/29/2007 |
| 7214814 | Additives for inhibiting gas hydrate formation The invention provides the use of compounds of the formula (1) where R1, R2 are each independently C1- to C22-alkyl, C2- to C22-alken... | 05/08/2007 |
| 7205433 | Crystal of amino acid ester salt and process for producing the same The present invention provides a novel crystal of alanine alkyl ester sulfonate having low hygroscopicity and low corrosiveness, which can be produced industrially economically. The present invention provides crystals of alanine alkyl ester sulfonates represented by... | 04/17/2007 |
| 7186859 | Uses for amino acid anticonvulsants The present invention is directed to the use of compounds of the formula: for treating pain, in particular neuropathic pain, bipolar disease and migraine headaches. ... | 03/06/2007 |
| 7166580 | Compounds which inhibit leukocyte adhesion mediated by VLA-4 Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, su... | 01/23/2007 |
| 7164034 | Alpha2delta ligands for fibromyalgia and other disorders This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs syndrome, premenstrual dysphoric disorder, hot flashes, and fibromyalgia by a... | 01/16/2007 |
