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| Number | Title | Issue Date |
| 8053599 | Drug containing (2R)-2-propyloctanoic acid as the active ingredient The present invention relates to a medicament which is useful for neurodegenerative diseases, which comprises about 1 to about 5 equivalents of a basic metal ion based on 1 equivalent of (2R)-2-propyloctanoic acid or a salt thereof, which is supplied from a metal sa... | 11/08/2011 |
| 8049036 | Multi-staged catalyst systems and process for converting alkanes to alkenes and to their corresponding oxygenated products Alkenes, unsaturated saturated carboxylic acids, saturated carboxylic acids and their higher analogues are prepared cumulatively from corresponding alkanes utilizing using a multi-staged catalyst system and a multi-stage process which comprises steam cracking of alk... | 11/01/2011 |
| 7884235 | Method for gas-phase catalytic oxidation using a fixed bed reactor The invention provides a method of gas-phase catalytic oxidation, in particular, a production method of (meth)acrylic acid, which enables stable continuous operation of gas-phase catalytic oxidation over a long term, maintaining high yield and suppressing increase i... | 02/08/2011 |
| 7812191 | Removing hydrocarbon impurities from acetic acid by ionic liquid extraction A method for removing hydrocarbon impurities from acetic acid is disclosed. The method comprises extracting acetic acid with a hydrophilic imidazolium salt. The imidazolium salt preferably has the general structure of where... | 10/12/2010 |
| 7777074 | Amino acid compounds An Amino Acid Compound is described. The Amino Acid Compound may comprise an Amino Acid and one of a Nitrate and a Nitrite. The Amino Acid may be one of Agmatine, Arginine, Beta Alanine, Citrulline, Creatine, Glutamine, L-Histidine, Isoleucine, Leucine, Norvaline, O... | 08/17/2010 |
| 7667071 | Process for the preparation of gabapentin hydrochloride A process for preparation of gabapentin hydrochloride by converting 1,5-dicyano-2,4-dioxo-3-azaspiro[5,5]-undecane into 1,5-diaminoformyl-2,4-dioxo-3-azaspiro[5,5]-undecane at a temperature of 65° C. to 85° C. in the presence of a strong acid, and then carrying ou... | 02/23/2010 |
| 7572936 | Optimized liquid-phase oxidation Disclosed is an optimized process and apparatus for more efficiently and economically carrying out the liquid-phase oxidation of an oxidizable compound. Such liquid-phase oxidation is carried out in a bubble column reactor that provides for a highly efficient reacti... | 08/11/2009 |
| 7498462 | Process for producing α,β-unsaturated carboxylic acid The object of the present invention is to provide a method for producing an α,β-unsaturated carboxylic acid in higher selectivity. The present invention resides in a method for producing an α,β-unsaturated carboxylic acid from an olefin or an α,β-unsaturated a... | 03/03/2009 |
| 7456313 | Liquid-phase (AMM)oxidation process A process for oxidizing a hydrocarbon, which comprises subjecting the hydrocarbon to a liquid phase catalytic oxidation reaction in the presence of at least one oxidation catalyst to form an oxidized product. ... | 11/25/2008 |
| 7419981 | Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor The instant invention relates to a combination of an alpha-2-delta ligand and a PDEV inhibitor for use in therapy, particularly in the treatment of pain, particularly neuropathic pain. Particularly preferred alpha-2-delta ligands are gabapentin and pregabalin. A par... | 09/02/2008 |
| 7381823 | Process for preparing cyclohexanediacetic acid monoamide A new process is described for synthesising cyclohexanediacetic acid monoamide, a key compound in the synthesis of grabapentin precursors. The process of the invention is characterised by reacting cyclohexanone with cynoacetamide and immediately after, with a suitab... | 06/03/2008 |
| 7345196 | Convenient process of manufacture for difluoromethylornithine and related compounds A process for the manufacture of α-Difluoromethylornithine, analogs and derivatives is described from ornithine hydrochloride or from Nδ-phthaloyl ornithine hydrochloride, conversion to an alkyl ester, conversion to solid derivatives through the formati... | 03/18/2008 |
| 7335799 | Hydroxyl compounds and compositions for cholesterol management and related uses The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular ... | 02/26/2008 |
| 7304093 | Ketone compounds and compositions for cholesterol management and related uses The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a com... | 12/04/2007 |
| 7179941 | Carbonylamino-substituted acyl phenyl urea derivatives, process for their preparation and their use The invention relates to compounds of the formula I in which the radicals are defined as specified, and also to their physiologically tolerated salts. The compounds are suitable, for example, as medicaments for p... | 02/20/2007 |
| 7164034 | Alpha2delta ligands for fibromyalgia and other disorders This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs syndrome, premenstrual dysphoric disorder, hot flashes, and fibromyalgia by a... | 01/16/2007 |
| 7138542 | Method of treating tinnitus The invention relates to a method of treating tinnitus by administering an alpha2delta ligand such as, for example, a compound of Formula and pharmaceutically acceptable salts thereof, wherein R1 is hy... | 11/21/2006 |
| 7109362 | Process for the preparation of lipoic acid and dihydrolipoic acid The present invention relates to a process for the preparation of R- and S-lipoic acid and R- and S-dihydrolipoic acid comprising (a) reaction of where MS is SO | 09/19/2006 |
| 7067696 | Process for producing (meth)acrolein or (meth)acrylic acid In the process for producing (meth)acrolein or (meth)acrylic acid, which comprises feeding a raw material of the (meth)acrolein or (meth)acrylic acid, and a molecular oxygen-containing gas mixed with a diluting gas and compressed by a compressor, to an oxidation rea... | 06/27/2006 |
| 7041619 | Phosphonium salts and processes for production of and uses for the same, and phosphines deriving the same and processes for production of the phosphines Phosphonium salts represented by the general formula (I) wherein R1 and R2 each represents a phenyl group which may be substituted by a lower alkyl group, R3 represents a phenylen... | 05/09/2006 |
| 7041199 | Process and device for hydrolytically obtaining a carboxylic acid alcohol from the corresponding carboxylate A process and a device for the catalytic hydrolysis of a carboxylate, e.g., methyl acetate, ethyl acetate, i- or n-propyl acetate, i- or n-butyl acetate, allyl acetate and methyl formate, into the corresponding carboxylic acid and alcohol, by a combination of a pre-... | 05/09/2006 |
| 7038078 | Methods of synthesizing and using derivatives of [2-(2-aminoethoxy)ethoxy] acetic acid A synthetic reaction to produce [2-(2-aminoethoxy)ethoxy] acetic acid (AEEA) derivatives. This synthetic reaction does not require isolation and purification of intermediates. The AEEA derivatives can be used to synthesize high load polystyrene-polyethylene glycol-l... | 05/02/2006 |
| 7033520 | Metal chelating compositions for protein purification, detection or binding A metal chelating composition having the formula: wherein Q is a carrier; S1 is a spacer; L is -A-T-CH(X)— or —C(═O)—; ... | 04/25/2006 |
| 7026505 | Method of treating tinnitus The invention relates to a method of treating tinnitus by administering an alpha2delta ligand such as, for example, a compound of Formula and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen ... | 04/11/2006 |
| 7008636 | 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia. ... | 03/07/2006 |
| 6878683 | Polymers used as controllable dispersing agents Polymers of a poly(meth)acrylic acid main chain in which, based on the main chain, 0 to 30% by weight of the (meth)acrylic acid basic building blocks may be replaced by maleic acid (anhydride) basic building blocks, fumaric acid basic building blocks or mixtures the... | 04/12/2005 |
| 6875874 | Processes for the preparation of oxo-oxazoline or alloamino acid derivatives A method for producing a compound represented by the general formula (I-A) or the general formula (I-B), comprising the following step: wherein R1 is an optionally substituted lower alkyl, and the like; R | 04/05/2005 |
| 6875890 | Method of producing N, N-dimethyl glycine hydrochloride A process for preparing N,N-Dimethyl Glycine Hydrochloride, comprises treating a chloroacetic acid with aqueous dimethylamine, and then dropping by hydrochloric acid to obtain N,N-dimethyl glycine as well as its hydrochloride salt, wherein decompression process is u... | 04/05/2005 |
| 6858753 | Process for the preparation of carboxylic acids from aliphatic alcohols The present invention provides an improved process for the production of carboxylic acids by the carbonylation of alcohol. The process involves contacting an alcohol with carbon monoxide in the presence of a nickel compound, a heterocyclic organic compound and an io... | 02/22/2005 |
| 6818790 | Process for producing mixed gas of lower olefin and lower aliphatic carboxylic acid, and process for producing lower aliphatic ester using the mixed gas A process for producing a lower aliphatic ester by catalytically reacting a lower olefin and a lower aliphatic carboxylic acid in a gas phase, where the lower aliphatic carboxylic acid is gasified at a relatively low temperature and thereby a mixed gas of the lower ... | 11/16/2004 |
| 6815559 | Process for producing 3,3,3-trifluoro-2-hydroxypropionic acid or its derivative The invention relates to a process for producing 3,3,3-trifluoro-2-hydroxypropionic acid. This process includes the step of (a) bringing a 1,1-dihalogeno-3,3,3-trifluoroacetone into contact with a basic aqueous solution. The obtained 3,3,3-trifluoro-2-hydroxypropion... | 11/09/2004 |
| 6809210 | Method of solvating a metal in an aromatic organic liquid A method of solvating metal ions in an aromatic organic liquid. The method includes adding an ammonium salt having an organic acid reagent to the aromatic organic liquid. The organic acid reagent comprises a carboxylate having eight (8) or less carbon atoms. Thereaf... | 10/26/2004 |
| 6790987 | Process for the catalytic cleavage of lactones The present invention relates to a process of cleaving lactones optionally having functional groups to give carboxylic acids, where the corresponding lactone is reacted with hydrogen with catalysis by a compound of a metal of group VIII of the Periodic Table of the ... | 09/14/2004 |
| 6756471 | Process for the preparation of water-soluble polymers containing polyalkylene glycol ether side chains The invention relates to a process for the preparation of water-soluble polymers containing polyalkylene glycol ether side chains and having molecular weights of from 15,000 to 65,000 by solution polymerization of esters of ethylenically unsaturated carboxylic acids... | 06/29/2004 |
| 6747157 | Processes for the preparation of oxo-oxazoline or alloamino acid derivatives A method for producing a compound represented by the general formula (I-A) or the general formula (I-B), comprising the following step: wherein R1 is an optionally substituted lower alkyl, and the like; R... | 06/08/2004 |
| 6743946 | Method for separating hydroxymethylthiobutyric acid The invention concerns an improved method for separating hydroxymethylthiobutyric acid by neutralising hydroxymethylthiobutyronitrile sulphuric hydrolysate, decanting and treating each phase with an organic solvent. ... | 06/01/2004 |
| 6689907 | Process for the manufacture of mercaptocarboxylic acids from unsaturated carboxylic acids A mercaptocarboxylic acid of formula (I) is prepared by reacting an unsaturated carboxylic acid of formula (II) with a hydrosulphide of formula ASH, A being an alkali metal cation or a cation NR3 R4 R5 R6+, R | 02/10/2004 |
| 6686501 | Processes for preparing 3.3-dimethylbutyric acid A process for preparing 3,3-dimethylbutyric acid includes the steps of reacting trimethylpyruvic acid with a first portion of hydrazine to obtain a ketazine, and treating the ketazine with base and a second portion of hydrazine.... | 02/03/2004 |
| 6683208 | Optically active diphosphines, preparation thereof according to a process for the resolution of the racemic mixture and use thereof New optically active bis[1-phospha-2,3-diphenyl-4,5-dimethylnorbornadiene] diphosphines and new optically active transition metal complexes with said phosphines are described. The complexes are useful as catalysts to promote hydrogenation of substrates.... | 01/27/2004 |
| 6673951 | Process for catalytically hydrogenating phytosterols The present invention provides a process for catalytically hydrogenating unsaturated phytosterol compounds. The catalyst used for such hydrogenation is an alumina-supported transition metal selected from the group consisting of nickel, palladium, platinum... | 01/06/2004 |
