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| Number | Title | Issue Date |
| 7763748 | Process for preparation of highly pure isotretinoin The present invention relates to a process for preparation of isotretinoin and more specifically, to a purification process for obtaining highly pure isotretinoin that is useful as a keratolytic agent, particularly useful for the treatment of acne. The process invol... | 07/27/2010 |
| 7371889 | Chemical entities with multiple modes of anti-inflammatory action The invention relates to new chemical compounds that inhibit the various enzymes in the arachidonic acid pathway implicated in inflammatory disease conditions. ... | 05/13/2008 |
| 7241435 | System and process for producing halogen oxides A system and process for oxidizing inorganic or organic species is disclosed. The system and process includes mixing a dilute aqueous alkali metal halite solution with a mixture of protic acids to produce an effluent containing a halous acid; and contacting the effl... | 07/10/2007 |
| 7173149 | Process for preparing alkynecarboxylic acids by oxidation of alkyne alcohols A process for preparing alkynecarboxylic acids includes the oxidation of an alkyne alcohol with a hypohalite in the presence of a nitroxyl compound at a pH of greater than 7 with continual addition of the alkyne alcohol and of the hypohalite to the reaction mixture.... | 02/06/2007 |
| 7173151 | Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals The invention relates to arylcycloalkyl-substituted derivatives and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the formula I, i... | 02/06/2007 |
| 7109383 | Fluorine-containing allyl ether compounds, their copolymers, and resist compositions and anti-reflection film materials using such copolymers The invention relates to a fluorine-containing allyl ether compound represented by the formula 1, wherein R represents an organic group containing at least one fluorine atom and an alicyclic structure. The invent... | 09/19/2006 |
| 7015353 | Process for the production of 9-(Z)-retinoic acid A process for the production of 9-(Z)-retinoic acid is described which comprises reacting an alkali metal salt of 3-methyl-4-oxocrotonic acid with a C15-triphenyl-phosphonium salt. 9-(Z)-retinoic acid is used in the treatment of dermatological diseases. | 03/21/2006 |
| 6943272 | Norbornane and norbornene derivatives, use thereof and perfumed products containing same The invention concerns a novel compounds of formula (I), wherein the dotted line bond is present or not, and wherein R1 represents: when the dotted line bond is present —CHCH3OH or —CHCH3OCOR or —CHCH3XCH2... | 09/13/2005 |
| 6909003 | Process for the manufacture of organic compounds The invention relates to a process for the manufacture of a compound of formula or a salt, especially a pharmaceutically acceptable salt with a base, thereof or a lactone thereof wherein the element represents —CH | 06/21/2005 |
| 6855832 | O- or S-substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity. ... | 02/15/2005 |
| 6806281 | Analogs of cocaine The invention provides a compound of formula (I): wherein R1, R2, R3, and Y have any of the meanings defined in the specification; as well a pharmaceutical composition comprising a comp... | 10/19/2004 |
| 6794164 | Process for the isolation of polyhydroxy cyclic carboxylic acids This invention is directed to the use of crystallization acids, such as acetic, lactic and propionic acids, to obtain high purity polyhydroxyl cyclic carboxylic acids (PCCA) from low purity aqueous solutions. The preferred PCCA is shikimic acid and the preferred cry... | 09/21/2004 |
| 6777574 | 2-alkyl-5-halogen-pent-4-ene carboxylic acids and their production Compounds of formula I in the form of their racemates or enantiomers, preferably compounds of formula Ia wherein R4 is C1-C6alkyl, Z i... | 08/17/2004 |
| 6573337 | Oligosaccharide synthesis The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-g... | 06/03/2003 |
| 6509480 | Glucose and lipid lowering compounds Provided are, among other things, lipid-lowering or glucose-lowering methods and compounds, particularly lipid-lowering or glucose-lowering compounds, with an A-B ring structure as follows: ##STR1## wherein the dotted line between carbons 5 and 6, the dot... | 01/21/2003 |
| 6495711 | Process for preparing (-)-(1S, 4R) N-protected 4-amino-2-cyclopentene-1-carboxylate esters The invention relates to a process for preparing (-)-(1S,4R) N protected 4-amino-2-cylcopentene-1-carboxylate esters represented by the formula (I) ##STR1## wherein R1 and R2 are as described within the specification.... | 12/17/2002 |
| 6441226 | Process for the preparation of isotretinoin The present invention relates to a process for the preparation of 13-cis isomer of Vitamin A acid, commonly known as isotretinoin, in a single step.... | 08/27/2002 |
| 6437160 | 3-heteroatom substituted and two carbon homologs of 15-HETE and methods of use 3-heteroatom substituted and two carbon homologs of 15-HETE, and their derivatives, compositions and methods of their use for treating dry eye are disclosed.... | 08/20/2002 |
| 6420612 | Bicycloheptene derivatives and processes for the preparation of the same Bicycloheptene compounds represented by general formula (1) and being useful as intermediates for the production of agricultural chemicals or drugs (wherein X is hydroxycarbonyl, hydroxymethyl, halogenomethyl, nitromethyl, or methylthiomethyl); and a proc... | 07/16/2002 |
| 6392086 | Intermediates and process for producing fluorine-containing amino acid compound by using the same The present inventions relate to a (1S,5R,6S)- or (1SR, 5RS, 6SR)-3-fluoro-2-oxobicyclo[3.1.0]hex-3-ene-6-carboxylic acid derivative represented by Formula (1): ##STR1## [in the formula, R represents OR1 or NR1 R2, wherein... | 05/21/2002 |
| 6384242 | Geranic acid derivatives 4-Methyl-4-(4-mlthylpent-3-en-1-yl)-2-oxetanone of formula (1): ##STR1## or its oligomer is an intermediate product for the preparation of a series of geranic acid derivatives, which are important synthetic building blocks in the preparation of perfumes a... | 05/07/2002 |
| 6331644 | 3-heteroatom substituted and two carbon homologs of 15-HETE and methods of use 3-heteroatom substituted and two carbon homologs of 15-HETE, and their derivatives, compositions and methods of their use for treating dry eye are disclosed.... | 12/18/2001 |
| 6319948 | Retinoid antagonists and uses thereof Retinoid antagonist compounds have been found to be useful in the prevention and/or minimization of surgical adhesion formation. Also provided by the invention are certain novel substituted (5,6)-dihydronaphthalenyl compounds which are retinoid antagonists and... | 11/20/2001 |
| 6215023 | Process for the preparation of cyclopropane carboxylic acids Preparation of cyclopropane carboxylic acids usable as intermediates and of formula (II), wherein R1 represents halogen, preferably Cl or Br, or haloalkyl, preferably CF3, and X2 represents halogen, preferably Cl or Br, wh... | 04/10/2001 |
| 6211197 | Prostaglandin receptor ligands Compounds and methods for treating prostaglandin mediated diseases, and certain pharmaceutical compositions thereof are disclosed. The compounds are represented by formula II: Ar1 --W--Ar2 --X--Q II The compounds of the invention are str... | 04/03/2001 |
| 6207859 | Stabilization and transport of , ଲ-unsaturated carboxylic acid and removal of stabilizer A process for inhibiting free-radical polymerization of an alpha,beta-unsaturated (,ଲ-unsaturated) carboxylic acid, and for providing desired grade ,ଲ-unsaturated carboxylic acid for use following storage and transport is describ... | 03/27/2001 |
| 6172112 | Retinoids and use thereof The present invention provides new retinoid compounds and uses of the compounds in humans and animals for chemoprevention of skin and/or breast cancer and for therapy of leukemia.... | 01/09/2001 |
| 6084120 | ଲ-Alkoxyacrylates against malaria The present invention relates to compounds having the formulae ##STR1## wherein R, R1, R6, R7, Rn8, X, and Z are defined herein, which are useful in the treatment or prophylaxis of malaria. The compounds of... | 07/04/2000 |
| 5986131 | RXR selective ligands Novel nonatetraenoic acid derivatives which selectively bind to retinoic acid X-receptors (RXR) and which have anti-acne acitvity and which potentiate the activity of retinoids having RAR activity are disclosed.... | 11/16/1999 |
| 5916919 | Retrovirus protease inhibitors A compound composition and method of treating a retrovirus infection are disclosed. In particular, isolated triterpenes have been shown to have significant inhibitory activity against HIV-1.... | 06/29/1999 |
| 5908957 | Isomerization process A process is disclosed for the catalyzed isomerization of a Z-isomer of a vitamin A compound or of a mixture of several of such isomers into a mixture of the corresponding all-E- and 13-Z-isomers of this vitamin A compound. The process utilizes nitrogen m... | 06/01/1999 |
| 5905127 | Polymerizable mesophases based on substituted unsaturated carboxylic acids Mesogens are provided based on substituted unsaturated carboxylic acids such as acrylic and methacrylic acid. Substitution of a variety of hydrophobic tails onto the carboxylic acid or acid derivative via the vinyl carbon proximal to the carbonyl of the c... | 05/18/1999 |
| 5892104 | Cycloheptenols and their derivatives, methods of making thereof, and utilization thereof as fragrances This invention relates to a compound having the formula I: ##STR1## wherein n is an integer of from 0 to 1; when n is 1, one of dashed lines a and b is a single bond and the other of dashed lines a and b is a double bond, dashed line c is not present... | 04/06/1999 |
| 5808148 | Preparation of ,ଲ-unsaturated carboxylic acids and esters Disclosed is a process for the preparation of ,ଲ-unsaturated carboxylic acids and esters thereof which comprises contacting formaldehyde or a source of formaldehyde with a carboxylic acid, ester or anhydride in the presence of a catalyst comp... | 09/15/1998 |
| 5763651 | Process for manufacturing polyene esters and acids A process for the manufacture of polyene esters or polyene acids comprises reacting a polyene O,O-dialkylacetal of di(O,O-dialkylacetal) with a vinylketene acetal or analogue thereof in the presence of a Lewis acid, hydrolyzing the reaction mixture depend... | 06/09/1998 |
| 5639902 | (Cyclohexyl)alkene compounds The invention relates to a compound selected from these of formula (I): ##STR1## in which R1, R2, R3, R4, R5 and B are as defined in the description, their enantiomers and diastereoisomers, their Z an... | 06/17/1997 |
| 5545665 | Cyclopentane(ene) heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents The invention relates to 7-[5-hydroxy-2-(hydroxyhydrocarbyl or heteroatom-substituted hydroxy hydrocarbyl)-3-hydroxycyclopentyl(enyl)] heptanoic or heptenoic acids and derivatives of said acids, wherein one or more of said hydroxy groups are replaced by a... | 08/13/1996 |
| 5514825 | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity Compounds of the formula ##STR1## wherein R1 is hydrogen or alkyl of 1 to 10 carbons; R2 and R3 are hydrogen, or alkyl of 1 to 6 carbons and the substituted ethynyl group occupies either the 2 or the 3 position of the... | 05/07/1996 |
| 5492896 | Pseudopeptides having an antiviral action The invention relates to new pseudopeptides having an antiviral action, oft he general formula (I) ##STR1## with the meanings given in the description for the substituents, to a process for their preparation and to their use as antiviral agents, in ... | 02/20/1996 |
| 5473103 | Biopolymers derived from hydrolyzable diacid fats A monomeric diacid derivative includes at least two fatty acids coupled by a hydrolytically or enzymatically degradable bond. In a biological environment, the bond degrades forming naturally occurring fatty acid products thereby allowing elimination.... | 12/05/1995 |
