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| Number | Title | Issue Date |
| 8143443 | Process for preparing gabapentin A process for preparing gabapentin of formula 1, which comprises Formula (I) converting 1-allyl-cyclohexanecarboxaldehyde into 1-allyl-cyclohexanecarbonitrile; ozonizing 1-allyl-cyclohexanecarbonitrile to obtain 1-cyano-cyclohexaneacetaldehyde; acetalizing 1-cyano-c... | 03/27/2012 |
| 7989658 | Process for the purification of gabapentin The present invention relates to a process for the purification of gabapentin. The process relates to the addition of hydrochloric acid to an aqueous solution or suspension of gabapentin, before, during or after the concentration step of that solution, and the subse... | 08/02/2011 |
| 7803967 | 4-alkoxy-cyclohexane-1-amino-carboxylic esters and processes for their preparation The invention relates to novel 4-alkoxy-cyclohexane-1-amino-carboxylic esters of the formula (IV) in which R1 and R2 are as defined in the description, to intermediates and processes for thei... | 09/28/2010 |
| 7759517 | Process for the preparation of gabapentin The present invention relates to a process for the preparation of gabapentin and, more in particular, to a method of synthesis of 1,1-cyclohexane acetic acid monoamide, an intermediate used in the preparation of gabapentin, comprising the basic hydrolysis reaction o... | 07/20/2010 |
| 7550628 | Process for preparing phenolic acid salts of gabapentin The present invention provides a novel process for preparation of the tannate salt of gabapentin for human and veterinary pharmaceutical use. Tannate salts of active pharmaceutical ingredients are used in sustained release applications and to improve certain organol... | 06/23/2009 |
| 7534915 | Non-symmetrical gelling agent The present invention relates to a novel trisubstituted cyclic thickener or gelator. The present invention further relates to a method for thickening or gelating a solution comprising the use of such a gelator or thickener. A gelator or thickener according to the in... | 05/19/2009 |
| 7514580 | Process for the preparation of 4,5-diamino shikimic acid derivatives The present invention relates to a process for the preparation of a 4,5-diamino shikimic acid derivative of formula and pharmaceutically acceptable addition salts thereof wherein R1, R... | 04/07/2009 |
| 7456312 | Phenolic acid salts of gabapentin in solid dosage forms and methods of use The present invention relates to pharmaceutical compositions of gabapentin tannate in solid dosage form, processes for production of those compositions and methods of use of those compositions. Tannate salts of active pharmaceutical ingredients are used in sustained... | 11/25/2008 |
| 7442834 | Process suitable for industrial scale production of gabapentin This invention relates to an improved process for the preparation of substantially pure, stable anhydrous gabapentin. Thus, cyclohexane 1,1-diacetic acid monoamide is first treated with NaOH/NaClO to form 3,3-pentamethylenebutyrolactam, which is treated with aqueous... | 10/28/2008 |
| 7439387 | Process for the preparation of Gabapentin form-II The present invention relates to a new industrial feasible process for the preparation of Gabapentin Form-II via a novel intermediate Gabapentin hemisulphate hemihydrate with out forming Gabapentin Form-III by neutralizing the Gabapentin hemisulphate hemihydrate sol... | 10/21/2008 |
| 7419981 | Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor The instant invention relates to a combination of an alpha-2-delta ligand and a PDEV inhibitor for use in therapy, particularly in the treatment of pain, particularly neuropathic pain. Particularly preferred alpha-2-delta ligands are gabapentin and pregabalin. A par... | 09/02/2008 |
| 7417166 | Process for the preparation of gabapentin The present invention relates to a process for the preparation of gabapentin and, more particularly, it relates to a precipitation process of gabapentin by acidification of an aqueous solution deriving from the Hofmann rearrangement of 1,1-cyclohexanediacetic acid m... | 08/26/2008 |
| 7393975 | Process for the purification of gabapentin A process for the preparation of gabapentin which comprises the passage of a gabapentin inorganic salt through a strong cationic ionic exchange resin, the elution of gabapentin fixed on the column, the concentration of the resultant solution and the cristallization ... | 07/01/2008 |
| 7393974 | Process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid A conversion process of gabapentin hydrochloride into gabapentin comprising: a) dissolution of gabapentin hydrochloride in a solvent in which the gabapentin hydrochloride and the gabapentin are completely soluble; and b) subsequent addition of an amine that allows t... | 07/01/2008 |
| 7390922 | Phenolic acid salts of gabapentin in liquid and/or semi-solid dosage forms and methods of use The present invention relates to pharmaceutical compositions of gabapentin tannate, processes for production of those compositions and methods of use of those compositions. The present invention provides a novel process for preparation of the tannate salt of gabapen... | 06/24/2008 |
| 7381823 | Process for preparing cyclohexanediacetic acid monoamide A new process is described for synthesising cyclohexanediacetic acid monoamide, a key compound in the synthesis of grabapentin precursors. The process of the invention is characterised by reacting cyclohexanone with cynoacetamide and immediately after, with a suitab... | 06/03/2008 |
| 7365226 | Process for the purification of gabapentin A process for the preparation of gabapentin comprising the passage of a salt of the same through a ionic exchange resin of strong cationic type, the elution of the gabapentin which has fixed onto the column and the crystallization from organic solvent, characterized... | 04/29/2008 |
| 7365227 | Process for the preparation of gabapentin A process for the purification of gabapentin by treatment of a crude aqueous gabapentin hydrochloride solution with a strong cationic ion exchange resin. ... | 04/29/2008 |
| 7309719 | Stabilized pharmaceutical preparation of gamma-aminobutyric acid derivatives and process for preparing the same The present invention provides a stabilized pharmaceutical preparation of a 4-amino-3-substituted-butanoic acid derivative which can be obtained by incorporating an amino acid as a stabilizer. ... | 12/18/2007 |
| 7199266 | Process for the preparation of gabapentin A process for the purification of gabapentin by treatment of a crude aqueous gabapentin hydrochloride solution with a strong cationic ion exchange resin. ... | 04/03/2007 |
| 7196216 | Process for preparation of Gabapentin A process for producing gabapentin, (1-(aminomethyl)-1-cyclohexaneacetic acid) from gabapentin hydrochloride salt. In the disclosed process, the gabapentin hydrochloride is converted to gabapentin using an inorganic base, such as barium hydroxide. Gabapentin hydroch... | 03/27/2007 |
| 7173151 | Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals The invention relates to arylcycloalkyl-substituted derivatives and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the formula I, i... | 02/06/2007 |
| 7169812 | Process for producing injectable gabapentin compositions Injectable compositions containing gabapentin and processes for preparing sterile injectable compositions containing gabapentin are discussed. The process includes subjecting the compositions to heat. Heating results in increased production of gabapentin lactam, whi... | 01/30/2007 |
| 7151193 | Process for the preparation of pure gabapentin “Form II” Pure gabapentin form II can be directly obtained adding the solution of the corresponding hydrochloride in dry ethanol (from which the inorganic salts have been filtered off) with a tertiary amine and a small amount of water. ... | 12/19/2006 |
| 7148377 | 4-Alkoxy cyclohexane-1-amino-carboxylic acid esters and method for the production thereof The invention relates to novel 4-alkoxy-cyclohexane-1-amino-carboxylic esters of the formula (IV) in which R1 represents OR3, R2 represents alkyl, and R3 represents alk... | 12/12/2006 |
| 7141695 | Methods for producing substituted acrylic acid esters and use of the latter for producing substituted γ-amino acids The invention relates to methods for producing substituted acrylic acid esters and to the use of the latter for producing substituted γ-amino acids, such as gabapentin and pregabalin. The substituted acrylic acid esters are produced by Wadsworth-Emmons olefination ... | 11/28/2006 |
| 7138542 | Method of treating tinnitus The invention relates to a method of treating tinnitus by administering an alpha2delta ligand such as, for example, a compound of Formula and pharmaceutically acceptable salts thereof, wherein R1 is hy... | 11/21/2006 |
| 7122678 | Cyclic amino acids and derivatives thereof useful as pharmaceutical agents The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syn... | 10/17/2006 |
| 7109383 | Fluorine-containing allyl ether compounds, their copolymers, and resist compositions and anti-reflection film materials using such copolymers The invention relates to a fluorine-containing allyl ether compound represented by the formula 1, wherein R represents an organic group containing at least one fluorine atom and an alicyclic structure. The invent... | 09/19/2006 |
| 7098361 | Rigid ring amino acids and polyamides there from This invention is a family of α,ω amino acids based on 1,4 substituted rigid ring structures and the useful polyamides made from them. ... | 08/29/2006 |
| 7098362 | Processes for the preparation of gabapentin The present invention relates to new processes for the preparation of gabapentin by the desilylation of a silylated gabapentin or by the silylation-desilylation of an acid addition salt of gabapentin with a silylating agent. ... | 08/29/2006 |
| 7071356 | Process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid A method of producing gabapentin (1-amino-methyl)-1-cyclohexaneacetic acid) from its hydrochloric salt in an anhydrous medium, the method consisting of: dissolving gabapentin hydrochloride in a non-aqueous organic solvent in which ... | 07/04/2006 |
| 7045655 | Preparation and purification of hydroxylamine stabilizers The invention relates to the preparation of ultra-high purity 1,2-diaminocyclohexane-tetraacetic acid being essentially free of unwanted metal and metal ion contaminants and its use as a stabilizer for ultra-high purity hydroxylamine compounds used extensively in th... | 05/16/2006 |
| 7030154 | Stability of lipoic acid A method of stabilizing R-α-lipoic acid includes combining R-α-lipoic acid with nicotinamide in a weight ratio between about 10:4 to about 10:8. A composition for treating oxidative stress includes R-α-lipoic acid and nicotinamide in a weight ratio of between abo... | 04/18/2006 |
| 7026505 | Method of treating tinnitus The invention relates to a method of treating tinnitus by administering an alpha2delta ligand such as, for example, a compound of Formula and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen ... | 04/11/2006 |
| 7022737 | Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses Mammals are treated for infections or for conditions associated with pathologically proliferating mammalian cell growth by administration of a manipulator of nitrosative stress to selectively kill or reduce the growth of the microbes or helminths causing the infecti... | 04/04/2006 |
| 7022678 | Pregabalin lactose conjugates In accordance with the present invention, there is provided pregabalin lactose conjugate compounds. Also provided as part of the present invention is a novel method of central nervous system disorders or diseases including seizure disorders, pain, depression,... | 04/04/2006 |
| 6984496 | Vitro assay for testing gabapentinoid activity An assay and method for selecting analogs and derivatives of gabapentin based on the compounds inhibitory activity toward MAP kinase and MAP kinase mediated reporter gene expression. The method includes the steps of activating the MAP kinase signaling pathway, detec... | 01/10/2006 |
| 6921835 | Cyclic amino acids and derivatives thereof useful as pharmaceutical agents The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syn... | 07/26/2005 |
| 6909014 | Intermediates for the synthesis of ether compounds The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a compo... | 06/21/2005 |
