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Class 562/503 - Cyclopentyl (e.g., prostoglandins, etc.)


Subclass of Class 562 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the acid contains a cyclopentyl nucleus,
No. of patents: 850
Last issue date: 04/26/2011


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NumberTitleIssue Date
7932420Sulfonamides
The present invention provides wherein R1 is selected from the group consisting of C1-C10 alkoxy, OH and NR4R5; R2 is selected from the group...
04/26/2011
7683211Jasmonate derivative compounds pharmaceutical compounds and methods of use thereof
The present invention provides novel jasmonate derivative compounds, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for treatment of ca...
03/23/2010
7491844Therapeutic cyclopentane derivatives
Described herein are compounds having a formula and therapeutic methods, compositions, and medicaments, related thereto. ...
02/17/2009
7459583Method for providing a cathartic effect
The present invention relates to a novel method for providing a cathartic effort to a patient in need of cathartic induction, which comprises administering to the patient a cathartic-inducing effective amount of halogenated bioactive lipid comprising the following p...
12/02/2008
7425651Jasmonate derivative compounds, pharmaceuticals compounds and methods of use thereof
The present invention provides novel jasmonate derivative compounds, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for treatment of ca...
09/16/2008
7396946Compound for treatment of external secretion disorders
Disclosed is a method for treatment of external secretion disorders, which comprises administering a fatty 5 acid derivative to a subject in need of said treatment. The method of the present invention is useful for treatment of at least one condition selected from h...
07/08/2008
7321057Method for manufacturing prostaglandin analogue
The present invention provides a new method for manufacturing a prostaglandin analogue having one or more keto groups on the 5-membered ring and/or omega chain, which comprises the step of treating a corresponding hydroxyl group containing compound with a co-oxidize...
01/22/2008
7314890Sulfonamides
The present invention provides wherein R1 is selected from the group consisting of C1-C10 alkoxy, OH and NR4R5; R2
01/01/2008
7179937Cyclopentenone derivatives for cancer therapy
The invention relates to the use of derivatives of cyclopentenone for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing such compounds. The invention relates more specifically to the use of deriv...
02/20/2007
7173151Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals
The invention relates to arylcycloalkyl-substituted derivatives and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the formula I, i...
02/06/2007
7141606Gabapentin analogues for sleep disorders
The invention provides a new use of compounds for formula 1 or 1A or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment of insomnia and related disorders. ...
11/28/2006
709123112-Aryl prostaglandin analogs
Compounds comprising are disclosed, wherein Y, A, X, R, D, and n are as described. A compound comprising a prostaglandin EP2 selective agonist wherein the ω-chain comprises a substituted pheny...
08/15/2006
7071355Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
The present invention relates to compounds of the general formula (I) and salt and physiologically functional derivatives thereof, wherein A is a non-aromatic ring system...
07/04/2006
6956056Method for providing a cathartic effect
The present invention relates to a novel method for providing a cathartic effect to a patient in need of cathartic induction, which comprises administering to the patient a cathartic-inducing effective amount of halogenated bioactive lipid comprising the following p...
10/18/2005
6909014Intermediates for the synthesis of ether compounds
The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a compo...
06/21/2005
6878723LTA4 hydrolase inhibitors
The invention concerns compounds inhibiting LTA4 hydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications. ...
04/12/2005
6864390Method for the stereoselective synthesis of cyclic amino acids
The instant invention is a route to stereospecific 3-substituted 5-membered ring isomers of Formula (A). The final products are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression,...
03/08/2005
6740772Prostaglandin derivatives
A prostaglandin derivative represented by the formula: wherein X is a halogen atom in the α- or β-position, Y is an ethylene group, a vinylene group or an ethynylene group, A is a group represented by the formul...
05/25/2004
6689906Bicyclic amino acids as pharmaceutical agents
The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritabl...
02/10/2004
668033915-fluoro prostaglandins as ocular hypotensives
15-fluoro substituted analogs of PGF2଱ and methods of their use in treating glaucoma and ocular hypertension are disclosed....
01/20/2004
6667284Lubricant for magnetic recording medium and use thereof
A magnetic recording medium and method for forming the magnetic recording medium are described. The magnetic recording medium includes a magnetic layer formed on a non-magnetic support, and a lubricant layer over the magnetic layer. The lubricant layer in...
12/23/2003
664965315-fluoro prostaglandins as ocular hypotensives
15-Fluoro substituted analogs of PGF2଱ and methods of their use in treating glaucoma and ocular hypertension are disclosed....
11/18/2003
6642274Methods and compositions for preventing and treating prostate disorders
The present invention relates to methods, compositions, devices and kits for the prevention and treatment of prostate disorders in mammals, including, but not limited to, benign prostatic hypertrophy, carcinoma of the prostate, prostadynia, prostatitis, a...
11/04/2003
65766636-Keto prostaglandin F1଱ and analogs for treating dry eye
Compositions and methods for the treatment of dry eye and related diseases utilizing 6-keto-PGF1଱ and its analogs are disclosed....
06/10/2003
6576786Process for preparing substituted cyclopentane derivatives and novel crystalline structures thereof
The invention relates to a process for preparing substituted cyclopentane derivatives represented by the formula (I) ##STR1## wherein R1, R2, R3, R4, X and Y are as described in the specification, and pharmaceut...
06/10/2003
6562861Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors
##STR1## Compounds I-III wherein U is CH, O, or S; Z is mono- or di-substituted carbon; R is (CH2)nCO2H, (CH2)nSO3H, (CH2)nPO3H2, (CH2)nNO2, CH(SCH3)3, esters; R1 is H, hydroxyalkyl, aminoalkyl, alkoxyalkyl; RR1 is O; n is 0-4; R2, R3 is H, hydroxyalkyl, ...
05/13/2003
6531485Prostaglandin agonists
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for t...
03/11/2003
6528688Prostacyclin derivatives
An improved method is described for making 9-deoxy-PGF1 -type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds....
03/04/2003
6512139Oxidation inhibitors in prostane derivatives
The invention relates to the use of an oxidation inhibitor, i.e. active carbon, for ambient air in industrial manufacturing, especially in the processing of prostane derivatives, whereby the oxidation inhibitor removes ozone from the process air before co...
01/28/2003
6495725Process for the preparation of optically active enones and intermediates thereof
The present invention provides a simplified and convenient process for the preparation of an optically active enone such as 7,7-dimethyl-6,8-dioxabicyclo-[3,3,0]oct-3-en-2-one. The invention further provides novel optically active intermediate compounds. ...
12/17/2002
6455584Prostaglandin E1 derivatives
To provide a prostaglandin derivative represented by the formula: ##STR1## wherein A is an ethylene group, a vinylene group, an ethynylene group, O(CH2)q or S(O)r (CH2)q, R1 is a C3-10
09/24/2002
6444840C11 oxymyl and hydroxylamino prostaglandins useful as FP agonists
The invention provides novel prostaglandin analogs. In particular, the present invention relates to compounds having a structure according to formula (I) wherein R1, R2, R3, R4, R5, R6, W, ...
09/03/2002
6441245Process for stereoselective synthesis of prostacyclin derivatives
An improved method is described for making 9-deoxy-PGF1 -type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds....
08/27/2002
6433014Compounds consisting in particular of effectors of the central nervous system receptors sensitive excitatory amino acids, preparation and biological applications
The invention concerns compounds of formula (I): ##STR1## in which: R1 to R4, identical or different, represent hydrogen, alkyl or aryl, themselves substituted if required, R1 and R2 together further capable of ...
08/13/2002
6423727Certain thiol inhibitors of endothelin-converting enzyme
Disclosed as endothelin converting enzyme inhibitors are the compounds of the formula ##STR1## wherein the variables have the meanings as defined hereinbefore....
07/23/2002
6410780C11 oxymyl and hydroxylamino prostaglandins useful as medicaments
The invention provides novel prostaglandin analogs. In particular, the present invention relates to compounds having a structure according to formula (I) wherein R1, R2, R3, R4, R5, R6, W, ...
06/25/2002
64105913,7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure
The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma a therapeutically effective amount of a 3, 7 or 3 and 7 thia or oxa prostanoic acid deriv...
06/25/2002
6388128Stannane synthesis of prostanoids
The present invention is directed to novel methods of prostanoid synthesis. Specifically, the invention is directed to the addition of alpha chains to prostanoids using cis-alkenylstannane intermediates....
05/14/2002
63802625-membered ring compounds
##STR1## 5-Membered ring compounds represented by general formula (I), optically active isomers thereof or salts of the same. These compounds have physiological activities including a carcinostatic effect. In said formula the bond shown by the dotted line...
04/30/2002
635300011-halo prostaglandins for the treatment of glaucoma or ocular hypertension
A method of treating glaucoma or ocular hypertension in a patient, which comprises administering to the patient a pharmaceutically effective amount of a compound of formula I: ##STR1##...
03/05/2002
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