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| Number | Title | Issue Date |
| 7323592 | Methods for crystallization of hydroxycarboxylic acids The invention aims at producing high-purity crystals of a hydroxycarboxylic acid represented by the following formula (1): in high yield. Provided are a method for crystallization of a compound (1) which ... | 01/29/2008 |
| RE39744 | Adamantane derivatives and process for producing them In the presence of an imide compound (e.g., N-hydroxyphthalimide) shown by the formula (2): wherein R1 and R2 independently represents a hydrogen atom, a halogen atom, an alkyl group... | 07/24/2007 |
| 7163696 | Pharmaceutical formulations The invention provides a controlled-release pharmaceutical formulation for oral administration comprising 4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline, or a pharmaceutically acceptable salt thereof; and a p... | 01/16/2007 |
| 7157594 | 6-Fluorobicyclo[3.1.0]hexane derivatives An antidepressant comprising, as an active ingredient, a compound having an antagonistic effect on group II metabotropic glutamate receptors, as well as a 2-amino-3-alkoxy-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative of Formula [I]: | 01/02/2007 |
| 7038077 | Prodrugs of excitatory amino acids This invention relates to synthetic excitatory amino acid prodrugs and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorders and psych... | 05/02/2006 |
| 7034180 | Method for crystallization of hydroxycarboxylic acids The invention aims at producing high-purity crystals of a hydroxycarboxylic acid represented by the following formula (1): in high yield. Provided are a method for crystallization of a compound (1) which compris... | 04/25/2006 |
| 7018818 | Intermediates in the preparation of therapeutic fused bicyclic amino acids The invention presents compounds of formula (I), where R represents H or a suitable carboxylic acid protecting group, which are intermediates in the preparation of therapeutic fused bicyclic amino acids. ... | 03/28/2006 |
| 7019152 | Process for the optical resolution of a precursor of sclareolide The present invention relates to the field of organic synthesis and more particularly to a new process for the optical resolution of a precursor of sclareolide. This process includes the reaction of [(1RS,2RS,4aSR,8aSR)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphtha... | 03/28/2006 |
| 6987193 | Illudin analogs useful as antitumor agents The present invention provides illudin analogs of the general formula (I): where R1 is (CH2)n—X—Y or H; n is 0 to 4; X is O or S or N or absent; and Y is an... | 01/17/2006 |
| 6911555 | Cyclic nitromethyl acetic acid derivatives The invention provides salts of formula (I) wherein X is a basic counterion selected from a group I or group II metal and a primary, secondary or tertiary amine; n is 0, 1 or 2; and R1 | 06/28/2005 |
| 6770676 | Dicarboxylic acid derivatives The present invention relates to 2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives represented by the formula: the pharmaceutically acceptable salts thereof, or the hydrates thereof. The compounds of... | 08/03/2004 |
| 6596900 | Fused bicyclic or tricyclic amino acids The compounds of the instant invention are bicyclic or tricyclic amino acids useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, arthritis, neuropathologica... | 07/22/2003 |
| 6576786 | Process for preparing substituted cyclopentane derivatives and novel crystalline structures thereof The invention relates to a process for preparing substituted cyclopentane derivatives represented by the formula (I) ##STR1## wherein R1, R2, R3, R4, X and Y are as described in the specification, and pharmaceut... | 06/10/2003 |
| 6541515 | HIV integrase inhibitors Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination w... | 04/01/2003 |
| 6506929 | Process to manufacture simvastatin and intermediates A process is disclosed for the preparation of simvastatin which enables highly regio selective C-methylation of the 2'-position group of lovastatin without requiring protection/deprotection of 13-OH of lovastatin and lactone ring opening/closure.... | 01/14/2003 |
| 6392104 | Adamantane derivatives and process for producing them In the presence of an imide compound (e.g., N-hydroxyphthalimide) shown by the formula (2): ##STR1## wherein R1 and R2 independently represents a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cycloalkyl group; or ... | 05/21/2002 |
| 6392086 | Intermediates and process for producing fluorine-containing amino acid compound by using the same The present inventions relate to a (1S,5R,6S)- or (1SR, 5RS, 6SR)-3-fluoro-2-oxobicyclo[3.1.0]hex-3-ene-6-carboxylic acid derivative represented by Formula (1): ##STR1## [in the formula, R represents OR1 or NR1 R2, wherein... | 05/21/2002 |
| 6326369 | Bicyclic quinone compounds, their production and use A compound of the formula: ##STR1## wherein R1 and R2 each represents a lower alkyl, or R1 and R2 may be bonded together to form a ring; X represents a spacer of which the number of atoms constituting the princi... | 12/04/2001 |
| 6316498 | Fluorine-containing amino acid derivatives Fluorine-containing amino acid derivatives represented general formula (I), pharmaceutically acceptable salts thereof or hydrates of the same, wherein X1 represents hydrogen or fluorine; and R1 and R2 are the same or diffe... | 11/13/2001 |
| 6204292 | Bicyclic metabotropic glutamate receptor ligands The present invention provides bicyclic metabotropic glutamate receptor ligands, as well as compositions comprising such ligands, and and methods for their use.... | 03/20/2001 |
| 6177586 | Vitamin D3 derivative and production process thereof The starting materials for a production process of a vitamin D3 derivative are disclosed, e.g., a cyclopentene derivative represented by the formula (1-2): ##STR1## wherein R11 is a hydrogen atom, tri(C1 to C | 01/23/2001 |
| 6160009 | Excitatory amino acid receptor modulators Compounds of the formula ##STR1## in which R1 and R2 are as defined in the specification, and non-toxic metabolically labile ester and amides thereof are useful as modulators of metabotropic glutamate receptor function.... | 12/12/2000 |
| 6143783 | Excitatory amino acid receptor modulators The present invention relates to compounds of the formula ##STR1## in which R1 is defined in the specification, and non-toxic metabolically labile esters and amides thereof are useful as modulators of metabotropic glutamate receptor functi... | 11/07/2000 |
| 6107342 | 2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives and a process for the preparation thereof The present invention relates to the compound of formulae ##STR1## and to a process for the manufacture of compounds of the general formula ##STR2## which are ligands for the metabotropic glutamate receptors of group II, wherein T is tritium; R | 08/22/2000 |
| 5958960 | Excitatory amino acid receptor modulators Compounds of the formula ##STR1## in which R1 and R2 are as defined in the specification, and non-toxic metabolically labile ester and amides thereof are useful as modulators of metabotropic glutamate receptor function.... | 09/28/1999 |
| 5925782 | Synthetic excitatory amino acids The present invention provides novel compounds that affect certain excitatory amino acid receptors, and are useful in the treatment of neurological disorders and psychiatric disorders.... | 07/20/1999 |
| 5916920 | 3-substituted Bicyclo3.1.0!hexane-6-carboxylic acids Compounds of the formula ##STR1## in which X represents a bond, S, O or NRa ; and R is as defined in the specification are useful as modulators of metabotropic glutamate receptor function.... | 06/29/1999 |
| 5780676 | Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to members of the subclass... | 07/14/1998 |
| 5750566 | Synthetic excitatory amino acids The present invention provides novel compounds that affect certain excitatory amino acid receptors, and are useful in the treatment of neurological disorders and psychiatric disorders.... | 05/12/1998 |
| 5739160 | Cyclopentane- and -pentene-ଲ-amino acids New Cyclopentane- or cyclopentene-beta-aminoacid derivatives and their isomers, acid additional salts and metal salt complexes have strong antimicrobial and broad-spectrum antimycotic acitivity. As antimycotics they are especially active against dermatoph... | 04/14/1998 |
| 5726320 | Preparation of bicyclohexane derivative A process for the preparation of (+)-2-amino-bicyclo3.1.0!-hexane-2-6-dicarboxylic acid, or a pharmaceutically acceptable salt thereof, which comprises hydrolysing (-)-2-spiro-5'-hydantoinbicyclo3.1.0!hexane-6-carboxylic acid or a salt thereof, a... | 03/10/1998 |
| 5723494 | Derivatives of glutamic and aspartic acids, a method of preparing them, and their use as drugs for enhancing memory and learning Compounds represented by general formula (I) and (II), in which r is 1 or 2, R2 and R3 are selected independently from H, CH3, C2 H5 and CHO, provided that R2 and R3 are not simu... | 03/03/1998 |
| 5700833 | Isocarbacyclin derivatives The present invention provides novel isocarbacyclin derivatives useful for search and study of prostacyclin receptor and as a therapeutic drug for central nervous system diseases, which derivatives are expressed by the following formula I!: ##STR1#... | 12/23/1997 |
| 5532408 | -chain-modified isocarbacyclins and process for the production thereof Provided are -chain-modified isocarbacyclins of which the -chain is modified with a phenylene group, a cycloalkylene group or a thiophendiyl group, and these -chain-modified isocarbacyclins show the activity for inhibiting the DNA syn... | 07/02/1996 |
| 5489613 | Carbacyclin derivatives, process for their preparation and compositions containing them Compounds of formula (I): ##STR1## have valuable platelet-aggregation inhibitory activities and may be used for the prophylaxis and treatment of such diseases as thrombosis.... | 02/06/1996 |
| 5449684 | Cytotoxic compounds Compounds isolated from a marine sponge, and derivatives thereof, have the formulae: ##STR1## in which R1 is H or lower alkyl; R2 is OH or CH3 ; R3 is OH or CH3, and R4 H or MPTA. The ... | 09/12/1995 |
| 5405870 | Carbacyclin compounds; pharmaceutical compositions and method of use Compounds of formula (Ic): ##STR1## having valuable platelet-aggregation inhibitory activities useful for the prophylaxis and treatment of such diseases as thrombosis and pharmaceutical compositions containing said compounds.... | 04/11/1995 |
| 5374654 | 9-substituted carbacyclin derivatives, processes for their preparation, and their use as medicinal agents The invention relates to carbacyclin derivatives of Formula I ##STR1## wherein the various substituents are defined herein, including, inter alia, if R2 is a hydrogen atom, their salts with physiologically compatible bases, their cyclodext... | 12/20/1994 |
| 5347048 | Process for producing (&#b1;)-2,5,5,8a-tetramethyl-1-(carboxymethyl)-2-hydroxydecalin A process for producing (&#b1;)-2,2,2,5a-tetramethyl-1-(carboxymethyl)-2-hydroxydecalin, comprising the steps of allowing a carbonate of dihydro-ଲ-vinyl-ionol to react with carbon monoxide in the presence of a palladium catalyst to form ଲ... | 09/13/1994 |
| 5294616 | Fibrinogen receptor antagonists A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.... | 03/15/1994 |
