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| Number | Title | Issue Date |
| 7662995 | 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases 1-Phenylalkanecarboxylic acid derivatives, the processes for the preparation thereof and the use thereof in the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease. ... | 02/16/2010 |
| 7432400 | Biphenylene compounds These are described biphenylene compounds of formula (I) wherein R1 is a C1-C18alkyl, C2-C18alkenyl, C6-C10aryl or C6-C10aryl or C6-C10heteroaryl... | 10/07/2008 |
| 7288671 | Interleukin-1 and tumor necrosis factor-α modulators, synthesis of said modulators and their enantiomers and methods of using said modulators Novel compounds are disclosed that have the following chemical structures, and prodrug esters and acid-addition salts thereof, that are useful as Interleukin-1 and Tumor Necrosis Factor-α modulators, and thus are useful in the treatment of various diseases. ... | 10/30/2007 |
| RE39744 | Adamantane derivatives and process for producing them In the presence of an imide compound (e.g., N-hydroxyphthalimide) shown by the formula (2): wherein R1 and R2 independently represents a hydrogen atom, a halogen atom, an alkyl group... | 07/24/2007 |
| 7232798 | Neuroprotection and neuroegenisis by administering cyclic prolyl glycine The invention relates to the use of cyclic Prolyl Glycine (“cyclic PG” or “cPG”) and analogs and mimetics thereof, as neuroprotective agents for the treatment and or prevention of neurological disorders including but not limited to cerebral ischemia or cereb... | 06/19/2007 |
| 7205432 | Process for the preparation of adamantane derivatives The invention relates to a process for the preparation of 3-hydroxyadamantaneglyoxylic acid of the general formula (1) or a derivative or salt thereof. In the process, an 1-acyl derivative of adamantane having th... | 04/17/2007 |
| 7119223 | Interleukin-1 and tumor necrosis factor-α modulators, synthesis of said modulators and their enantiomers and methods of using said modulators Novel compounds are disclosed that have the following chemical structures, and prodrug esters and acid-addition salts thereof, that are useful as Interleukin-1 and Tumor Necrosis Factor-α modulators, and thus are useful in the treatment of various diseases. ... | 10/10/2006 |
| 7102027 | Adamantanetricarboxylic acid derivatives An adamantanetricarboxylic acid derivative is represented by following Formula (1): wherein X is a hydrogen atom or a hydrocarbon group; and R1, R2 and R3 may be the same as or di... | 09/05/2006 |
| 6881857 | Tricyclic diterpene derivatives Disclosed herein are novel tricyclic diterpene compounds. These compounds, including their prodrug esters and acid-addition salts, are useful as Interleukin-1 and Tumor Necrosis Factor-α modulators, and thus are useful in the treatment of various diseases. A... | 04/19/2005 |
| 6875764 | Urea and thiourea compounds useful for treatment of coccidiosis The present invention relates to novel compounds, pharmaceutical compositions containing the same as well as a method for treatment of parasitic disorders, wherein said compounds are administered. The present compounds are especially well suited for treatment of coc... | 04/05/2005 |
| 6846941 | Process for separating unsaponifiable valuable products from raw materials Disclosed are processes for separating valuable products, including unsaponifiable materials, from any given matrix of raw materials that is mainly composed of saponifiable components and unsaponifiable components. Preferred methods include converting sodium or pota... | 01/25/2005 |
| 6750364 | Bridged tricyclic analogs of 2-(carboxycyclopropyl)glycine as inhibitors of glutamate transport This invention provides compounds of the formula: wherein X is (CH2)n, O, S, SO, SO2 or CR1R2; n is 1 or 2; R1 and R2 are H, halogen, hydroxy, ... | 06/15/2004 |
| 6689905 | Stereoisomers of 3-aminotricyclo[2.2.1.0(2.6)]heptane-1,3-dicarboxylic acid This invention provides a process for the preparation of all four stereoisomers of formula I or a pharmaceutically acceptable salt thereof ##STR1## which may be represented by the following structures: ##STR2##... | 02/10/2004 |
| 6689904 | Bridged tricyclic analogs of 2-(carboxycyclopropyl)glycine This invention provides processes for preparing a group of novel bridged tricyclic compounds having the formula: ##STR1## wherein X is (CH2)n, O, S, SO, SO2 or CR1 R2 ; n is 1 or 2; and R1 ... | 02/10/2004 |
| 6603041 | Bicyclic enamide derivatives Enamide derivatives of formula (1) are described: ##STR1## wherein R1 is a group Ar1 L2 Ar2 Alk- in which Ar1 is an optionally substituted aromatic or heteroaromatic group, L2 is a covalent... | 08/05/2003 |
| 6593363 | Diterpene derivatives and anti-inflammatory analgesic agents comprising the same The present invention relates to diterpene derivatives prepared from the components which are extracted from Acanthopanax Koreanum and represented by Chemical Formula (1).... | 07/15/2003 |
| 6562782 | Oligocycloalkanoid compounds and methods of use The present invention related to an oligocycloalkanoid compound comprising formula (I) ##STR1## wherein m, n, and o are independently an integer from 0 to 2; A1 through A10 are independently a direct link, alkylene, alkylene-O--, ... | 05/13/2003 |
| 6492422 | Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases Tricyclic sulfonamide compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and strome... | 12/10/2002 |
| 6476258 | Process for producing aryloxyacetic acids An industrially advantageous process for producing an aryloxyacetic acid represented by the formula (2): ##STR1## wherein m represents an integer of 1 or 2, n represents an integer from 0 to 4, Ar represents a aromatic hydrocarbon ring, each Rs independen... | 11/05/2002 |
| 6448413 | Process for the synthesis of a-nor-seco compounds with sterane skeleton The invention relates to a new process for the synthesis of 17ଲ-hydroxy-17-methyl-1,3-seco-2-nor-5-androstane-3-aci d derivatives of formula (I) ##STR1## wherein the meaning of Z is carboxyl or formyl group and to the new secoindoxylide... | 09/10/2002 |
| 6392104 | Adamantane derivatives and process for producing them In the presence of an imide compound (e.g., N-hydroxyphthalimide) shown by the formula (2): ##STR1## wherein R1 and R2 independently represents a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cycloalkyl group; or ... | 05/21/2002 |
| 6365768 | Interleukin-1 and tumor necrosis factors- modulators, syntheses of said modulators and methods of using modulators Novel compounds are disclosed that have the chemical structure of Formula (IIB), and its prodrug esters and acid-addition salts, and that are useful as Interleukin-1 and Tumor Necrosis Factor- modulators, and thus are useful in the treatment of var... | 04/02/2002 |
| 6020370 | Bridged cyclic amino acids as pharmaceutical agents Bridged cyclic amino acids of formula ##STR1## are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain and neuropathological... | 02/01/2000 |
| 5998471 | Acetylenes disubstituted with a 5 alkyl, aryl or heteroaryl substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity Compounds of the formula ##STR1## the symbols have the meaning described in the specification.... | 12/07/1999 |
| 5770763 | Difunctional bitricyclodecatriene monomers Novel difunctionalized cyclobutabenzene monomers of the general formula: ##STR1## wherein Z can be hydrogens or a cyclobutane ring; and X and Y are carboxyl, amino, alcohol, isocyanate, acid halide, or bis-acyl halide groups. Exemplary difunctional b... | 06/23/1998 |
| 5730903 | Compound and thin film composed of the discotic compound A thin film comprising a discotic compound having diacetylene groups at the side chain moiety thereof, and a compound represented by formula (1): ##STR1## wherein R2 represents an alkyl group or an aryl group.... | 03/24/1998 |
| 5723494 | Derivatives of glutamic and aspartic acids, a method of preparing them, and their use as drugs for enhancing memory and learning Compounds represented by general formula (I) and (II), in which r is 1 or 2, R2 and R3 are selected independently from H, CH3, C2 H5 and CHO, provided that R2 and R3 are not simu... | 03/03/1998 |
| 5670696 | Alicyclic bifunctional compounds and processes for their preparation The invention provides an alicyclic bifunctional compound represented by the formula ##STR1## wherein R is a carboxyl group, a lower alkoxycarbonyl group or a hydroxymethyl group and n is 0 or 1.... | 09/23/1997 |
| 5595996 | 7-substituted 4-aza cholanic acid derivatives and their use Compounds of the Formula I ##STR1## wherein: the dotted line indicates that a double bond may be present or absent; R1 is H, methyl or ethyl; R2 is - or ଲ-C1-10 straight or branched alkyl; R3 i... | 01/21/1997 |
| 5578726 | Process for producing 7 ଲ-substituted-4-aza-5 -androstan-3-ones Described is a new process for producing 7ଲ-substituted-4-aza-5-androstan-3-ones and related compounds which are 5-reductase inhibitors, consisting of reducing the corresponding androsteneone with lithium and liquid ammonia, contacting... | 11/26/1996 |
| 5576355 | Diamondoid derivatives for pharmaceutical use A method of inhibiting viruses in which a virus is contacted with diamondoid alcohol, ketone, ketone derivative, adamantyl amino acid, quaternary salt or combinations thereof which have antiviral properties. These diamondoid derivatives are shown to have ... | 11/19/1996 |
| 5545654 | Pleuromutilin derivatives A compound of formula (I), in which each of R1 and R2 is independently hydrogen, alkyi or, together with the carbon atom to which it is bonded, a cycloalkyl; and each of R3 and R4 is independently hydrogen, alky... | 08/13/1996 |
| 5434274 | Benz(epsilon)indene compounds Neuroactive benz[e]indene compounds ##STR1## are prepared by a total synthesis from the following three starting materials ##STR2##... | 07/18/1995 |
| 5405870 | Carbacyclin compounds; pharmaceutical compositions and method of use Compounds of formula (Ic): ##STR1## having valuable platelet-aggregation inhibitory activities useful for the prophylaxis and treatment of such diseases as thrombosis and pharmaceutical compositions containing said compounds.... | 04/11/1995 |
| 5405978 | Oxidative preparation of 3,5-secoandrost-5-one-3,17 ଲ-dioic acid The present invention is an oxidative process for the conversion of 21-unsaturated progesterones (I) ##STR1## to the corresponding 3,5-secoandrost-5-one-3,17ଲ-dioic acids (II) ##STR2## by use of either ozone or an oxidizing agent, which ar... | 04/11/1995 |
| 5292906 | Tricyclic steroid analogs Novel tricyclic steroid analogs are disclosed which are 1H-benz[e]indene dodecahydro compounds that are useful for enhancing GABA-induced chloride currents at the GABA receptor/chloride ionophore complex and can be represented by the following structural ... | 03/08/1994 |
| 5228898 | Substituted bicycloheptandione derivatives This invention relates to substituted bicycloheptadione derivatives with high herbicidal activity which are represented by general formula (I) ##STR1## (where R1 is a lower alkyl group, a phenyl group which may be substituted, an aralkyl g... | 07/20/1993 |
| 5206415 | Tricyclic steroid analogs Novel tricyclic steriod analogs are disclosed which are 1H-benz[e]indene dodecahydro compounds that are useful for enhancing GABA-induced chloride currents at the GABA receptor/chloride ionophore complex and can be represented by the following structural ... | 04/27/1993 |
| 5191115 | Method for obtaining carboxylic acids by reaction of alkanes and formiates To produce a carboxylic acid R1 --COOH, in which R1 is a tertiary branched alkyl residue or a cycloalkyl residue with one or more rings, which may be attached, and possibly substituted by at least one alkyl residue, the alpha carbon ... | 03/02/1993 |
| 4976893 | Process for preparing carboxylic acids The invention relates to a process for preparing carboxylic acids by platinum-catalyzed oxidation of primary alcohols of limited water solubility with oxygen in a mixture of water and a solubilizer. The solubilizer used is an ether of the general formula ... | 12/11/1990 |
