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| Number | Title | Issue Date |
| 8134025 | Method of fabricating mesocrystals of organic and organo-metallic compounds The present invention fabricates mesocrystals of organic and organo-metallic compounds. Supersaturated solutions are made with different sums of an organic or organo-metallic compound and the organic or organo-metallic compound is added with an excipient. Through a ... | 03/13/2012 |
| 7875745 | Compounds having lysophosphatidic acid receptor antagonism and uses thereof The present invention relates to a compound represented by formula (I): (wherein the symbols in formula were described in the description), a salt thereof, a solvate thereof or a prodrug thereof. Since the compound of the p... | 01/25/2011 |
| 7425649 | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia. ... | 09/16/2008 |
| 7408079 | Imaging agents and methods of imaging NAALADase or PSMA The present invention relates to compounds particularly asymmetric urea compounds which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express NAALADase and/or PSMA. In anoth... | 08/05/2008 |
| 7388098 | Dynamic resolution of isomers and resolved isomers Provided is a dynamic resolution method of enriching a desired isomer of an alpha-substituted carboxylic acid relative to an undesired isomer, the method comprising: (a) in a solvent, contacting the alpha-substituted carboxylic acid, wherein the alpha substitution i... | 06/17/2008 |
| 7381832 | Polyhalogen-substituted cinnamic acids and cinnamic acid derivatives and a process for the preparation of polyhalogen-substituted cinnamic acids and cinnamic acid derivatives Polyhalogenated cinnamic acids and cinnamic acid derivatives are prepared by reacting diazonium salts accessible from polyhalogenated anilines with acrylic acid or acrylic acid derivatives in the presence of a homogeneous, palladium-containing catalyst at about −5... | 06/03/2008 |
| 7368566 | Process and intermediates for preparing benzazepines Disclosed is a new process and intermediates for preparing benzazepines of Formula (I): wherein R1 and R2 are as defined herein. ... | 05/06/2008 |
| 7365225 | Aryl dicarboxamides The present invention is related to aryl dicarboxamides of formula (I) and use thereof for the treatment and/or prevention of obesity and/or metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose... | 04/29/2008 |
| 7335673 | 2,3-Diphenylpropionic acid derivatives or their salts, medicines or cell adhesion inhibitors containing the same, and their usage A 2,3-diphenylpropionic acid derivatives or the salts represented by general formula (1) below; and pharmaceutical compositions and cell adhesion inhibitors comprising the derivatives or the salts as the active ingredient. In the formula, A, B and C independently re... | 02/26/2008 |
| 7309395 | System for forming composite polymer dielectric film A system for depositing a composite polymer dielectric film on a substrate is disclosed, wherein the composite polymer dielectric film includes a low dielectric constant polymer layer disposed between a first silane-containing layer and a second silane-containing la... | 12/18/2007 |
| 7202381 | Compounds as opioid receptor modulators This invention is directed towards novel compounds as opioid receptor modulators, antagonists, and agonists useful for the treatment of opioid modulated disorders such as pain and gastrointestinal disorders. ... | 04/10/2007 |
| 7132541 | Crystalline fluoroquinolone arginine salt form The invention relates to the new arginine salt forms of RS-(±)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid, S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]qui... | 11/07/2006 |
| 7126023 | Method for deuteration of an inert methylene The present invention relates to a method for deuteration of an inert alkane using activated palladium carbon. The present invention discloses “A method for deuteration of a hydrogen atom of a methyl group or a hydrogen atom bonded to a carbon atom at benzy... | 10/24/2006 |
| 7084299 | Process for producing Ibuprofen sodium dihydrate Disclosed herein is a novel process for producing Sodium dihydrate salt of Ibuprofen of Formula (Structure I) by treating a salt of long chain carboxylic acid of Formula (Structure III) with Ibuprofen of Formula (Structure II) in the presence of an aqueous organic s... | 08/01/2006 |
| 7019166 | Method for the production of 2,4,5-trimethylphenyl acetic acid The present invention relates to a novel process for preparing 2,4,5-trimethylphenyl-acetic acid by reacting pseudocumene with dichloroacetyl chloride in a Friedel-Crafts reaction to give 2,2-dichloro-1-(2,4,5-trimethylphenyl)ethanone, converting the 2,2-dichloro-1-... | 03/28/2006 |
| 7009047 | Ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenylpropanoate], processes for its preparation and its use The present invention relates to ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate], the preparation of ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenyl-propanoate] from (2R)-2-bromo-3-phenylpropionic acid and ethylenediamine in 2-propanol, and the use of etha... | 03/07/2006 |
| 6933408 | Intermediate for sweetener with high sweetness and process for producing the same The present invention relates to a 3-substituted-phenyl-3-merthylbutyric acid and 3-substituted-phenyl-3-merthylaldehyde derivatives, which are useful in the production of N-[N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-L-α-aspartyl]-L-phenylalanine 1-methyl est... | 08/23/2005 |
| 6770781 | Process for the preparation of alpha-arylalkanoic acids A process for the preparation of meta or para-substituted α-arylalkanoic acids of formula (I) wherein R and R1 are as defined in the disclosure. ... | 08/03/2004 |
| 6759548 | Dialkyl-halogenophenyl-substituted ketoenols The present invention relates to new compounds of the formula (I) in which X represents alkyl, Y represents halogen or alkyl and Z represents halogen or alkyl, with the proviso that one of the... | 07/06/2004 |
| 6720449 | Process for preparing optically active amino acid derivatives An optically active amino acid derivative is produced by N-protecting an optically active 3-haloalanine derivative followed by cyclization, or cyclizing this derivative followed by N-protection to thereby give an optically active N-protected-aziridine-2-carboxylic a... | 04/13/2004 |
| 6700013 | Tricyclic fused heterocycle compounds, process for preparing the same and use thereof Compounds represented by formula (1), ##STR1## wherein X is, for example, CH, CH2, CHR (wherein R is a lower alkyl group or a substituted lower alkyl group) or CRR' (wherein R and R' are the same as the above defined R); Y is, for e... | 03/02/2004 |
| 6689898 | Antihistaminic piperidine derivatives and intermediates for the preparation thereof This invention relates to novel compounds of the formula: ##STR1## wherein R1 is H or C1 -C6 alkyl and the C1 -C6 alkyl moiety is straight or branched; R2 and R3 are each independentl... | 02/10/2004 |
| 6586625 | Synthesis of 2-halobenzyl alkanoic acid A method for synthesizing compounds of Formula I ##STR1## in which R is alkyl or aryl and X is any halogen is described.... | 07/01/2003 |
| 6531597 | Process for preparation of 2-phenyl acetic acid derivatives The present invention is a process for the preparation of a compound of formula ##STR1## The compounds of formula I are valuable intermediates for the manufacture of therapeutically active compounds.... | 03/11/2003 |
| 6469196 | Dialkyl phenyl halide-substituted keto-enols for use as herbicides and pesticides The present invention relates to new compounds of the formula (I) ##STR1## in which X represents alkyl, Y represents halogen or alkyl and Z represents halogen or alkyl, with the proviso that one of the radicals Y and Z always represents halogen and the other a... | 10/22/2002 |
| 6465700 | Coupling reactions of 2-substituted, 7-haloindenes with aryl substituents to produce metallocene catalyst ligands Novel 2-substituted 7-haloindenes and methods for synthesizing such indenes are described. The 2-substituted 7-haloindenes may be coupled with any aryl group to produce a metallocene catalyst intermediate.... | 10/15/2002 |
| 6452041 | Olefination process to itaconate and succinate derivatives An efficient and selective process, capable of scale-up, to make itaconate derivatives of formula (IV), and/or succinate derivatives of formula (V) and/or (VI) by asymmetric hydrogenation of the itaconate derivatives. ##STR1## wherein R, R1 and... | 09/17/2002 |
| 6437177 | -hydroxy, -amino, and halo derivatives of ଲ-sulfonyl hydroxamic acids as matrix metallopropteinases inhibitors The present invention provides a compound of formula I ##STR1## or pharmaceutical acceptable salts thereof wherein R1 is C4-12 alkyl, C4-12 alkenyl, C4-12 alkynyl, --(CH2)h --C3-8 | 08/20/2002 |
| 6414186 | Process for producing chloromethylphenylacetic acid A method for preparing chloromethylphenylacetic acids represented by formula (II): ##STR1## wherein a methylphenylacetic acid represented by formula (I): ##STR2## is reacted with a chlorine gas, in an inert solvent, under the irradiation with light o... | 07/02/2002 |
| 6414187 | Asymmetric hydrogenation The present invention pertains to a process for the preparation of an enantiomerically enriched chiral carboxylic acid derivative having the partial formula: C--C--C--COOX wherein X is a cation, comprising formation of a dehydro precursor salt having the ... | 07/02/2002 |
| 6372938 | Synthesis of 4-phenylbutyric acid A method of synthesizing compounds of Formula I: ##STR1## by reacting aromatic compounds with butyrolactone, followed by neutralization with base. The reaction can be conducted in the presence of a catalyst. Preferred catalysts are Lewis acids. A preferre... | 04/16/2002 |
| 6331655 | Process for the preparation of aromatic carbonyl compounds from styrenes The present invention relates to a novel process for the preparation of aromatic carbonyl compounds by oxidative cleavage of styrenes using lipases and hydrogen peroxide or hydrogen peroxide donors in the presence of carboxylic acids or carboxylic esters.... | 12/18/2001 |
| 6300517 | Phosphine ligands with amino acid groups, method for their production and use thereof as catalyst components A description is given of new chiral phosphine ligands containing amino acid groups and having the formula I ##STR1## where R1 is hydrogen, a C1 -C7 -alkyl radical, a C6 -C10 -aryl radical or a monova... | 10/09/2001 |
| 6281383 | Process for the preparation of ,- dimethylphenylacetic acid from ,-dimethylbenzyl cyanide under normal pressure A process for obtaining ,-dimethylphenylacetic acid wherein ,댝imethylbenzyl cyanide is reacted in the presence of sodium hydroxide, water and a C4 - and/or C5 -alcohol at temperatures above about 100° C. ... | 08/28/2001 |
| 6258979 | Chiral ferrocene phosphines active in asymmetric catalysis The invention pertains to chiral ferrocene phosphine derivatives and their use with transition metals as asymmetric catalysts in asymmetric hydrogenation.... | 07/10/2001 |
| 6103931 | Process for preparing (R)-2-bromo-3-phenyl-propionic acid It is described a process for preparing (R)-2-bromo-3-phenyl-propionic acid starting from (D)-phenyl-alanine, sodium nitrite and concentrated hydrobromic acid in a mixture of an aqueous solvent and a solvent selected from the group consisting of halogenat... | 08/15/2000 |
| 6096920 | Preparation of carboxylic compounds and their derivatives Palladium-catalyzed arylation of an olefin (e.g., ethylene) with an aromatic halide (e.g., 2-bromo-6-methoxynaphthalene, m-bromobenzophenone, or 4-isobutyl-1-bromobenzene) is conducted in specified media. After a special acid or base phase separation proc... | 08/01/2000 |
| 6020524 | Process for the preparation of 2-(pyrid-2-yloxymethyl)phenylacetates as pesticide intermediates A compound of the following formula ##STR1## wherein M is an alkali metal or alkaline earth metal atom and a process for the preparation of the compound is provided.... | 02/01/2000 |
| 6013832 | Process for the production of benzene derivatives The present invention relates to a process for the production of benzene derivatives represented by formula (I), which are useful as intermediates for agricultural chemicals, fine chemical products or pharmaceuticals such as anti inflammatory analgesics. ... | 01/11/2000 |
| 6001877 | Phenylalkan(en)oic acid The phenylalkan(en)oic acids of the formula: ##STR1## as defined herein, posses an antagonistic activity on leukotriene B4.... | 12/14/1999 |
