Did You Know...
...that the x-ray was discovered purely by accident? When German physicist Wilhelm Konrad von Roentgen was experimenting with cathode rays in 1895, he put an activated Crookes tube in a book and went out to lunch. When he returned, he discovered that a key that had also been placed in the book showed up as an image on the developed film!
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| Number | Title | Issue Date |
| 6956129 | Polyhalogen-substituted cinnamic acids and cinnamic acid derivatives and a process for the preparation of polyhalogen-substituted cinnamic acids and cinnamic acid derivatives Polyhalogenated cinnamic acids and cinnamic acid derivatives are prepared by reacting diazonium salts accessible from polyhalogenated anilines with acrylic acid or acrylic acid derivatives in the presence of a homogeneous, palladium-containing catalyst at about −5... | 10/18/2005 |
| 6936636 | 5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity Compounds of the formula: where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects... | 08/30/2005 |
| 6756508 | Cinnamic acid salts, processes for their preparation, and their use as medicaments The present invention relates to new cinnamic acid salts of salmeterol, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions. ... | 06/29/2004 |
| 6730798 | Process for the preparation of substituted octanoyl amides Compounds of formula (II) are simultaneously halogenated in the 5 position and hydroxylated in the 4 position under lactonization, the halolactone is converted into a hydroxylactone and then the hydroxy group into a leaving group, the leaving group is replaced with ... | 05/04/2004 |
| 6602859 | Photocurable hyaluronic acid derivative and process for producing the same, and photocured crosslinked-hyaluronic acid derivative and medical material using the same A photocurable hyaluronic acid derivative of the present invention comprises hyaluronic acid and a photoreactive crosslinking group bonded thereto, wherein a 1.0 wt. % aqueous solution of the photocurable hyaluronic acid derivative obtained by dissolving ... | 08/05/2003 |
| 6599938 | Compounds having MIF antagonist activity There is disclosed a genus of optionally substituted Schiff base condensation products (and the carba analogs thereof) comprising an amino acid component and a benzaldehyde component, that have MIF (macrophage migration inhibitory factor) antagonist activ... | 07/29/2003 |
| 6538154 | Process for the preparation of cinnamic esters The present invention relates to a process for the synthesis of cinnamic esters and/or cinnamic acids by condensation of aldehydes with carboxylic anhydrides, using iron(II) salts as catalyst.... | 03/25/2003 |
| 6452041 | Olefination process to itaconate and succinate derivatives An efficient and selective process, capable of scale-up, to make itaconate derivatives of formula (IV), and/or succinate derivatives of formula (V) and/or (VI) by asymmetric hydrogenation of the itaconate derivatives. ##STR1## wherein R, R1 and... | 09/17/2002 |
| 6331655 | Process for the preparation of aromatic carbonyl compounds from styrenes The present invention relates to a novel process for the preparation of aromatic carbonyl compounds by oxidative cleavage of styrenes using lipases and hydrogen peroxide or hydrogen peroxide donors in the presence of carboxylic acids or carboxylic esters.... | 12/18/2001 |
| 6278019 | Process for acyloxylating side chains of alkyl-substituted aromatic compounds and catalysts used therefor The present invention is a method for acyloxylating an alkyl group substituted aromatic compound at the side chain, by letting the alkyl group substituted aromatic compound and a carboxylic acid and/or a carboxylic anhydride react with each other in the p... | 08/21/2001 |
| 6162943 | Method for producing -alkoxy--trifluoromethyl-aryl acetic esters and -aryl acetic acids Process for the preparation of -alkoxy--trifluoromethyl-arylacetic esters of the formula (I) ##STR1## wherein R is a component selected from the group consisting of C1 -C6 -alkyl, C2 -C6 ... | 12/19/2000 |
| 6096770 | Anthranilic acid analogs Compounds of the formula: ##STR1## wherein: R1, R2 and R3 are, independently, hydrogen, nitro, cyano, C1-10 haloalkoxy, amino, C1-10 alkylamino, sulfo, sulfamoyl, C1-10 alkylsulfonamid... | 08/01/2000 |
| 6096918 | Aryl-acrylic acid esters The acrylic acid esters of Formula I are useful for the delivery of organoleptic compounds, especially for flavors, fragrances, masking agents and antimicrobial compounds. They can also deliver fluorescent whitening agents.... | 08/01/2000 |
| 6087519 | Rubber-to-metal adhesion promoter, metal reinforcement, composition made of rubber, metal reinforcement and rubber-to-metal adhesion promoter, and use of the rubber-to-metal adhesion promoter The invention relates to an adhesive substance for improved adhesion between a vulcanizable polymer and a metallic reinforcing carrier. The use of an adhesive substance with the following structure is proposed in order to produce an improved adhesion between r... | 07/11/2000 |
| 6028110 | Succinyl hydroxamic acid, N-formyl-N-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors A pharmaceutical or veterinary composition comprising a compound of formula I ##STR1## wherein X is a --CO2 H group and R1, R2, R3, R4, R5 are as defined in the specification, or a sal... | 02/22/2000 |
| 5981620 | Dental compounds, compositions, products and methods The invention provides polymerizable dental, compounds, compositions, including the compounds and products for mixing the compositions and methods of using the compositions. Aryl acid compounds are provided in accordance with the invention. The compositio... | 11/09/1999 |
| 5972839 | 2-fluoroacrylic acid derivatives, novel mixtures of herbicides and antidotes, and their use The invention relates to novel -fluoroacrylic acid derivatives, to active compound/antidote combinations which comprise -fluoroacrylic acid derivatives and are outstandingly suitable for use in crops of useful plants, to their use and to met... | 10/26/1999 |
| 5925637 | Inhibition of matrix metalloproteases by substituted biaryl oxobutyric acids Matrix metalloprotease inhibiting compounds, pharmaceutical compositions thereof and a method of disease treatment using such compounds are presented. The compounds of the invention have the generalized formulas: ##STR1## wherein r is 0-2, T is selec... | 07/20/1999 |
| 5910606 | Process for making ,ଲ-unsaturated carboxylic acids , ଲ-Unsaturated acids of the formula ##STR1## wherein R1 signifies C1 -C5 -alkyl and Ar signifies an aryl group which is optionally substituted by one or more substituents selected from the group consisti... | 06/08/1999 |
| 5905127 | Polymerizable mesophases based on substituted unsaturated carboxylic acids Mesogens are provided based on substituted unsaturated carboxylic acids such as acrylic and methacrylic acid. Substitution of a variety of hydrophobic tails onto the carboxylic acid or acid derivative via the vinyl carbon proximal to the carbonyl of the c... | 05/18/1999 |
| 5840751 | 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the tre... | 11/24/1998 |
| 5817862 | Process for the preparation of cinnamic acid derivatives The invention relates to a process for the preparation of cinnamic acid derivatives which involves reacting chlorinated aromatic compounds and acrylic acid derivatives in the presence of palladium catalysts.... | 10/06/1998 |
| 5808148 | Preparation of ,ଲ-unsaturated carboxylic acids and esters Disclosed is a process for the preparation of ,ଲ-unsaturated carboxylic acids and esters thereof which comprises contacting formaldehyde or a source of formaldehyde with a carboxylic acid, ester or anhydride in the presence of a catalyst comp... | 09/15/1998 |
| 5786494 | Process for the synthesis of -substituted acrylic acids and their application Process for the synthesis of a-substituted acrylic acids and their application. Process for the synthesis of a-substituted acrylic acids of general formula (I) and their application to the synthesis of N- (mercaptoacyl) aminoacid derivatives of formula (I... | 07/28/1998 |
| 5710194 | Dental compounds, compositions, products and methods The invention provides polymerizable dental, compounds, compositions, including the compounds and products for mixing the compositions and methods of using the compositions. Aryl acid compounds are provided in accordance with the invention. The compositio... | 01/20/1998 |
| 5705167 | Aromatic polyenic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active aromatic polyenic compounds have the structural formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic,... | 01/06/1998 |
| 5672746 | Antiproliferative and neurotrophic molecules Neurotrophic and antiproliferative compounds related to the antiepileptic drug valproate are provided. These compounds are useful for promoting neuronal function as in neurodegenerative disorders and for treating neoplastic disease.... | 09/30/1997 |
| 5639894 | Carbonylation of allylic alcohols and synthesis of an ambergris fragrance compound A process for the carbonylation of allylic alcohols such as nerolidol, farnesol, or their monocyclic analogues with carbon monoxide at a pressure of at least 30 bar in the presence of a polar solvent and a palladium halide catalyst, optionally an alkali m... | 06/17/1997 |
| 5516932 | Halogenated cinnamic acids and esters thereof, processes for the preparation thereof and halogenated aryldiazonium salts The present invention relates to compounds of the formula ##STR1## in which R1 and R2 are identical or different and are hydrogen or an alkyl radical having 1 to 18 carbon atoms and optionally containing oxygen, nitrogen or halo... | 05/14/1996 |
| 5436369 | Alicyclic phospholipase A2 inhibitors Certain novel alicyclic compounds are effective phospholipase A2 (PLA2) inhibitors.... | 07/25/1995 |
| 5414108 | Process for the preparation of carboxylic acids and derivatives of them The subject matter of the invention is a process for the preparation of carboxylic acids and derivatives of them of the general formula ##STR1## wherein R means hydrogen, or a C1-4 alkyl or a (C1-5 alkoxy)carbonyl group, R1... | 05/09/1995 |
| 5391819 | Process of making chiral 2-aryl-1,4-butanediamine derivatives as useful neurokinin-A antagonists Disclosed herein is a process of making chiral 2-aryl-1,4-butanediamine derivatives useful as neurokinin-A antagonists of Formula 7 ##STR1##... | 02/21/1995 |
| 5360924 | Process for preparing aromatic olefins Process for preparing aromatic olefins of the formula (1) ##STR1## in which R1 -R3 are hydrogen, alkyl (C1 -C8) , alkoxy-(C1 -C5), phenyl, fluorine, chlorine, bromine, --OH, --NO2... | 11/01/1994 |
| 5359122 | Preparation of 3-arylacrylic acids and their derivatives The preparation of 3-arylacrylic acids and their derivatives I ##STR1## where Ar is aryl which can additionally have substituents which do not react with ketene and are stable under the conditions of the reaction described below, and R1 is... | 10/25/1994 |
| 5350872 | Process for the preparation of carboxylic acids and derivatives of them The subject matter of the invention is a process for the preparation of carboxylic acids and derivatives of them of the general formula ##STR1## wherein R means hydrogen, or a C1-4 alkyl or a (C1-5 alkoxy)carbonyl group, R1... | 09/27/1994 |
| 5349112 | Cyclic anti-tumor promoter compounds, compositions and methods for production and use Novel cyclic anti-tumor promoter compounds and therapeutic compositions are disclosed, along with method for their production and use as anti-cancer and cancer-prevention agents.... | 09/20/1994 |
| 5344843 | Cat-1 inhibitors, pharmaceutical compositions and methods of use The invention relates to compounds of the formula ##STR1## wherein R1, R2, R2 ' X, Y, Z, A, B, Q and n are as described herein. Their pharmaceutically acceptable salts, and when appropriate, enantiomers, racemates, di... | 09/06/1994 |
| 5334750 | Process for the preparation of cinnamic acid derivatives Cinnamic acid derivatives, in particular 2-ethylhexyl p-methoxycinnamate and 2-isoamyl p-methoxycinnamate, are prepared avoiding particular effort for workplace hygiene and ecology by using bromoaromatic and acrylic acid derivatives in the presence of pal... | 08/02/1994 |
| 5276217 | Cyclic anti-tumor promoter compounds, compositions and methods for production and use Novel cyclic anti-tumor promoter compounds and therapeutic compositions are disclosed, along with method for their production and use as anti-cancer and cancer-prevention agents.... | 01/04/1994 |
| 5274171 | Process for the palladium catalyzed coupling of a diazonium salt with an olefinic bond A "one-pot" process for the palladium catalyzed coupling of a diazonium salt with an olefinic bond, in the aqueous medium in which the diazonium salt is made, by employing a carboxylic acid as a solvent. Arylacrylic acids and their esters, e.g. the cinnam... | 12/28/1993 |
