Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 7439386 | Therapeutic substituted cyclopentanones Compounds are disclosed herein comprising or a pharmaceutically acceptable salt, or a metabolite or a prodrug thereof; wherein a dashed line indicates the presence or absence of a bond; Y, A, an... | 10/21/2008 |
| 7439372 | Therapeutic compounds A compound having a structure is disclosed herein. Compositions, medicaments, and therapeutic methods related thereto are also disclosed. ... | 10/21/2008 |
| 7361785 | Compound protecting against ultraviolet rays An ultraviolet ray protection agent including a compound having an ultraviolet ray protection effect as an active ingredient. The compound is expressed by general formula I′: wherein X represents NH or O; Y′ represents ... | 04/22/2008 |
| 7294601 | Phosphines, transition metal complexes containing the same as the ligand, and process for production of optically active carboxylic acids [PROBLEMS] To provide a method by which desired optically active carboxylic acids may be prepared from a carboxylic acid having a carbon-carbon double bond through asymmetric hydrogenation with a catalyst consisting of a transition metal complex containing a water-s... | 11/13/2007 |
| 7259188 | Methods and pharmaceutical compositions for treatment of anti-estrogen resistant breast cancer using RXR modulators Methods and compositions for the treatment of anti-estrogen resistant breast cancer using retinoid compounds which are modulators of Retinoid X Receptors. ... | 08/21/2007 |
| 7211685 | Calcium receptor antagonists A compound of the formula [I] wherein R1 is optionally substituted aryl group or optionally substituted heteroaryl group; R2 is optionally substituted C1-6 alkyl group, C3-7 ... | 05/01/2007 |
| 7166726 | Aryl substituted 3,4-dihydroanthracene derivatives having retinoid antagonist or retinoid inverse agonist type biological activity Disclosed herein are compounds of the formula wherein R1 is independently H or alkyl of 1 to 6 carbons; R2 is optional and is defined as lower alkyl of 1 to 6 carbons, F, Cl, Br... | 01/23/2007 |
| 7138411 | Substituted benzopyran derivatives for the treatment of inflammation A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ | 11/21/2006 |
| 7102008 | Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables A, R1, R2, R3, R4, Z,... | 09/05/2006 |
| 7098025 | Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor This invention relates to the isolation and cloning of the promoter and other control regions of human PPARγ gene. It provides a method for identifying and screening for agents useful for the treatment of diseases and pathological conditions affected by the level o... | 08/29/2006 |
| 7005449 | Tolterodine salts The present invention concerns novel pharmaceutically active compounds, pharmaceutical compositions containing the same, the compounds for use as medicaments, and use of the compounds for the manufacture of specific medicaments. The present invention also concerns a... | 02/28/2006 |
| 6720425 | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity. ... | 04/13/2004 |
| 6713515 | Retinoic acid receptor antagonists as promoters of angiogenesis Methods and compositions for treating various disorders by administering a therapeutically effective amount of a retinoic acid receptor antagonist alone or in combination or in conjunction with other therapeutic agents to promote angiogenesis are provided. Also prov... | 03/30/2004 |
| 6642412 | Process for producing a high purity aromatic polycarboxylic acid A process for producing a high purity aromatic polycarboxylic acid by purifying a crude aromatic polycarboxylic acid in accordance with the steps of (I) forming an amine salt of an aromatic polycarboxylic acid from the crude polycarboxylic acid and an ami... | 11/04/2003 |
| 6627652 | Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors Process of treatment of mammals, including humans to treat diseases or conditions of the type which are normally treated with retinoid-like compounds is disclosed, with pharmaceutical compositions containing an active compound which is a selective agonist... | 09/30/2003 |
| 6617414 | Aromatic diamine/aromatic dicarboxylate and production method thereof The present invention provides aromatic diamine/aromatic dicarboxylate having the following formula (I) wherein each symbol is as defined in the specification, which is in the form of particles having a median diameter of 5-100 μm and whiteness of not le... | 09/09/2003 |
| 6610883 | Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to members of the subclass... | 08/26/2003 |
| 6610877 | Aromatic carboxylic acid derivatives Compounds of the formula ##STR1## wherein R1 is a residue of the formula ##STR2## and R2 -R10 have the significance given in the specification can be used as pharmaceuticals, particularly for the repair of photodamaged ... | 08/26/2003 |
| 6590101 | Process for the preparation of fluoroquinolonecarboxylic acids Fluoroquinolonecarboxylic acids can be prepared by hydrolysis of the corresponding C1 -C4 -alkyl esters with addition of water, acetic acid, and sulfuric acid using a drastically reduced amount of sulfuric acid if, relative to 1 mol ... | 07/08/2003 |
| 6534513 | Phenylalkanoic acid derivatives Phenylalkanoic acid derivatives of formula (1) are described: ##STR1## wherein Ar1 is an aromatic or heteroaromatic group; L1 is a covalent bond or a linker atom or group; A is an optionally substituted aliphatic, heteroaliphatic, cycloaliphat... | 03/18/2003 |
| 6492390 | Substituted benzopyran analogs for the treatment of inflammation A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR1## wherein X,... | 12/10/2002 |
| 6452045 | Process for improving yields in a disproportionation reaction (high yield Henkel) Disclosed is a process for disproportionation of potassium naphthoate to the dipotassium salt of 2,6-NDA which gives reproducible improved yields of up to 40% which comprises: a) reacting naphthoic acid in the presence of excess base to produce a dispropo... | 09/17/2002 |
| 6369225 | Compounds having activity as inhibitors of cytochrome P450RAI Compounds having Formula 8 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. ##STR1##... | 04/09/2002 |
| 6358995 | Carboxylic acid derivatives having fused rings The present invention provides a medicament exhibiting excellent retinoic acid receptor agonism. A Carboxylic acid derivative having a fused ring which is represented by the following formula or a pharmacologically acceptable salt thereof: ##STR1## {where... | 03/19/2002 |
| 6342636 | Process for preparing optically active amines and optically active carboxylic acids, and intermediates for preparation Disclosed is a process for preparing an optically active 1-aryl- or 2-aryl-alkylamines of formulas Ia, Ib and Ic with high optical purity and high yield. The process uses an optically active 1- or 2-naphthylglycolic acid of the general formula II as a res... | 01/29/2002 |
| 6320074 | Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to members of the subclass... | 11/20/2001 |
| 6319948 | Retinoid antagonists and uses thereof Retinoid antagonist compounds have been found to be useful in the prevention and/or minimization of surgical adhesion formation. Also provided by the invention are certain novel substituted (5,6)-dihydronaphthalenyl compounds which are retinoid antagonists and... | 11/20/2001 |
| 6265423 | Aromatic polycyclic retinoid-type derivatives, method for preparing same, and use thereof for making pharmaceutical and cosmetic compositions Novel aromatic polycyclic retinoid-type derivatives of general formula (I), ##STR1## wherein groupings R3 and R4 attached to the double bond between carbons 11 and 12 are cis groupings, and pharmaceutical and cosmetic compositions co... | 07/24/2001 |
| 6242493 | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment Compounds of formula I: ##STR1## as well as pharmaceutically acceptable salts, hydrates and esters thereof, are disclosed. The compounds are useful for treating or preventing prostaglandin mediated diseases. Pharmaceutical compositions containing such com... | 06/05/2001 |
| 6239284 | Aromatic tetracyclic compounds of the retinoid type method for preparing and use The invention concerns aromatic tetralcyclic compounds of the retinoid type of general formula (I). The invention also concerns the method for preparing them and the pharmaceutical compositions containing at least one of said compounds.... | 05/29/2001 |
| 6184413 | Supported phase catalyst Supported phase catalysts in which the support phase is highly polar, most preferably ethylene glycol or glycerol, are disclosed. An organometallic compound, preferably a metal complex of chiral sulfonated 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl is di... | 02/06/2001 |
| 6172115 | Method for preventing onset of restenosis after angioplasty employing an RXR-specific retinoid A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering a retinoid, such as an RXR-selective retinoid, e.g. the compound of the formula: ##STR1## and pharmaceutically acceptable salts and esters and am... | 01/09/2001 |
| 6168913 | Coding combinatorial libraries with fluorine tags The present invention relates to coding combinatorial chemical libraries synthesized on a plurality of solid supports by attaching "tags" that comprise fluorine containing compounds in combinations and/or ratios. The tags can be decoded while attached to ... | 01/02/2001 |
| 6162948 | Naphthalenedicarboxylic acid particles and process for the production thereof The present invention provides particles of naphthalenedicarboxylic acid (NDA) exhibiting excellent slurry fluidity, which have an EG slurry property value of 2.7 or below, the above EG slurry property value being defined as a molar ratio of ethylene glyc... | 12/19/2000 |
| 6162810 | Inadone and tetralone compounds for inhibiting cell proliferation A new family of inadone and tetralone tubulin-binding compounds (TBs) is disclosed. Unlike classical TBs, which inhibit mitosis among affected dividing cells, the TBs of the invention possess two unique properties: (1) they induce apoptosis among stationa... | 12/19/2000 |
| 6162943 | Method for producing -alkoxy--trifluoromethyl-aryl acetic esters and -aryl acetic acids Process for the preparation of -alkoxy--trifluoromethyl-arylacetic esters of the formula (I) ##STR1## wherein R is a component selected from the group consisting of C1 -C6 -alkyl, C2 -C6 ... | 12/19/2000 |
| 6127573 | Oxidaton of primary alcohols to carboxylic acids with a TEMPO catalyst using NaClO2 and NaClO The present invention relates to a TEMPO-catalyzed oxidation of primary alcohols, RCH2 OH to corresponding carboxylic acids, RCOOH in the presence of catalytic in the presence of catalytic amount of NaClO and stoichiometric amount of NaClO... | 10/03/2000 |
| 6127415 | Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents The present invention relates to specific adamantyl or adamantyl group derivative containing retinoid compounds induce apoptosis of cancer cells. These adamantyl retinoid derivatives are useful for the treatment of many cancers and solid tumors, especiall... | 10/03/2000 |
| 6087519 | Rubber-to-metal adhesion promoter, metal reinforcement, composition made of rubber, metal reinforcement and rubber-to-metal adhesion promoter, and use of the rubber-to-metal adhesion promoter The invention relates to an adhesive substance for improved adhesion between a vulcanizable polymer and a metallic reinforcing carrier. The use of an adhesive substance with the following structure is proposed in order to produce an improved adhesion between r... | 07/11/2000 |
| 6028211 | Composition and method for reducing fouling in process equipment used for manufacturing aromatic materials Methods for reducing the fouling of process equipment used in the manufacture of aromatic compounds such as dimethyl-2,6-naphthalenedicarboxylate are disclosed. The methods require treating manufacturing process streams with a metal complexing agent. ... | 02/22/2000 |
