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| Number | Title | Issue Date |
| 8168821 | Cyclopropylacetic acid derivatives and use thereof The present application relates to novel cyclopropylacetic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases... | 05/01/2012 |
| 7423030 | 1-amino-phthalazine derivatives, the preparation and the therapeutic use thereof A 1-amino-phthalazine derivative of general formula (I) wherein the substituents are as defined herein. Also disclosed are a method for preparing such compounds, intermediates for use in such method and medical treatments u... | 09/09/2008 |
| 7348453 | Labile linkage for compound delivery to a cell Described are ortho carboxy phenol derived acetals and compositions containing ortho carboxy phenol derived acetals which are useful for delivering biologically active compounds to cells. The acetals can be used to reversibly link up to three different molecules and... | 03/25/2008 |
| 7238835 | Process for the preparation of substituted 2-(phenoxymethyl) benzoic acids The invention relates to a process for the preparation of a compound of the general formula (I) in which a) a compound (II) is reacted in the presence of a base B1 with a compound (III) and | 07/03/2007 |
| RE39682 | Farnesyl derivatives and pharmaceutical compositions containing them Novel farnesyl derivatives which are inhibitors of the prenylated protein methyltransferase enzyme, and useful as anti-cancer drugs, have the following formula: wherein R1represents f... | 06/05/2007 |
| 7214389 | Process A wet granulation process in which a pharmaceutical substance is granulated using a granulating fluid which is a halogenated hydrocarbon which has a normal boiling point below ambient temperature, for example 1,1,1,2-tetraflouroethane, under a pressure sufficient to... | 05/08/2007 |
| 7166726 | Aryl substituted 3,4-dihydroanthracene derivatives having retinoid antagonist or retinoid inverse agonist type biological activity Disclosed herein are compounds of the formula wherein R1 is independently H or alkyl of 1 to 6 carbons; R2 is optional and is defined as lower alkyl of 1 to 6 carbons, F, Cl, Br... | 01/23/2007 |
| 7067640 | Cross-linked chiral compounds and methods of making thereof The invention relates to a method which comprises synthesizing bifunctional compounds then chiral compounds from the bifunctional compounds, also to synthesizing supports comprising these chiral compounds, and the use of these supports for preparing or separating en... | 06/27/2006 |
| 7041659 | Compounds for the treatment of metabolic disorders Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed. ... | 05/09/2006 |
| 7012071 | Compounds for the treatment of metabolic disorders Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed. ... | 03/14/2006 |
| 6946491 | Compounds for the treatment of metabolic disorders Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed. ... | 09/20/2005 |
| 6942980 | Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities Methods of characterizing and identifying negative hormones of nuclear receptors. Also disclosed are methods of making modulators of retinoid nuclear receptor transactivation activity, assays for agonists, antagonists, and negative hormones of the RAR receptor, and ... | 09/13/2005 |
| 6909015 | Aromatic polyetherketones The invention relates to polyetherketones and to a process for the preparation of aromatic polyetherketones which process comprises: a) self-condensing a compound of formula (I) wherein n represents 0 or 1 in the presence of an alkyl or optionally substituted aryl s... | 06/21/2005 |
| 6838574 | Dicarba-closo-dodecarborane derivatives A medicament comprising as an active ingredient a compound or a physiologically acceptable salt thereof represented by general formula (I): wherein R1 represents a dicarba-closo-dodecaboran-yl which may be s... | 01/04/2005 |
| 6794538 | Process for the preparation of ethers deriving from hydroxybenzoic acids Process for the preparation of ethers of hydroxybenzoic acid having general formula (I), which comprises reacting a hydroxybenzoic acid, optionally substituted, with a halide XR1, wherein X is a halogen such as chlorine, in a basic environment and in an a... | 09/21/2004 |
| 6762329 | Diaryl ether condensation reactions One aspect of the present invention relates to novel reaction conditions that allow the efficient synthesis of diaryl ethers from arenes bearing a leaving group and arenols under relatively mild conditions. Another aspect of the present invention relates to the dram... | 07/13/2004 |
| 6747170 | Thermosensitive recording material and color developer compound therefor A thermosensitive recording material has a support and a thermosensitive coloring layer formed thereon containing a leuco dye and a color developer capable of inducing color formation in the leuco dye upon application of heat thereto, with the color developer includ... | 06/08/2004 |
| 6737544 | Method for drying phenoxymethylbenzoic acids A process for drying phenoxymethylbenzoic acids of the general formula I where X, Y, m and n have the following meanings: X, Y halogen or a C-organic radical, m a value from 0 to 4 and n a value from... | 05/18/2004 |
| 6603012 | RAR selective retinoid agonists New compounds containing bicyclic fused rings, one of which being a phenyl moiety connected by an aliphatic chain to a cycloalkyl or aryl moiety, and pharmaceutically active salts thereof are useful as RAR selective retinoid agonists. Furthermore, such re... | 08/05/2003 |
| 6566548 | Molecular compounds containing novel carboxylic acid derivatives as the constituent compound Novel molecular compounds containing carboxylic acid derivatives represented by general formula (I) or (II) as the constituent compound and exhibiting excellent performances in various technical fields including selective separation of useful substances, ... | 05/20/2003 |
| 6417178 | Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits Amyloid binding compounds which are derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, suc... | 07/09/2002 |
| 6395939 | Diaryl ether condensation reactions One aspect of the present invention relates to novel reaction conditions that allow the efficient synthesis of diaryl ethers from arenes bearing a leaving group and arenols under relatively mild conditions. Another aspect of the present invention relates ... | 05/28/2002 |
| 6395930 | Quenching reagents for solution phase synthesis A method for enhancing the purity of a desired compound comprising: Step (a) treating a crude reaction product which contains at least one desired compound, unreacted starting materials and/or byproducts with at least one bifunctional quenching agent that is c... | 05/28/2002 |
| 6384273 | Method for orthometalation of a carbocyclic aromatic derivative bearing at least an electron donor group The invention concerns a method for orthometalation of a carbocyclic aromatic derivative bearing at least an electron donor group, characterised in that it consists in reacting said carbocyclic aromatic derivative with an efficient amount of at least one ... | 05/07/2002 |
| 6376546 | Biphenyl-5-alkanoic acid derivatives and use thereof ##STR1## Compounds represented by general formula I or salts thereof, wherein n is an integer of 2 or 3; R represents a straight-chain or branched saturated alkyl group having 4 or 4 carbon atoms, a cyclopentyl group, a cyclohexyl group or the like, Y rep... | 04/23/2002 |
| 6369225 | Compounds having activity as inhibitors of cytochrome P450RAI Compounds having Formula 8 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. ##STR1##... | 04/09/2002 |
| 6365773 | Process for producing fluoroaromatic carboxylates This invention describes processes for producing halomagnesium fluoroaryl carboxylates. In one such process, a fluoroaryl Grignard reagent is added to an anhydrous liquid ethereal medium pretreated with carbon dioxide.... | 04/02/2002 |
| 6342592 | Chiral compounds, their synthesis and use as a support The invention relates to a method which comprises synthesising bifunctional compounds then chiral compounds from the bifunctional compounds, also to synthesising supports comprising these chiral compounds, and the use of these supports for preparing or se... | 01/29/2002 |
| 6262293 | ω-Cycloalkly-prostaglandin e2 derivatives ω-Cycloalkyl-prostaglandin E2 derivatives of formula (I) ##STR1## (wherein all symbols are as defined in the description); and non-toxic salts thereof, prodrugs thereof and cyclodextrin clathrates thereof. Compounds of formula (I) strongly bind on ... | 07/17/2001 |
| 6187950 | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological Compounds of the formula Y3 (R4)--X--Y1 (R1 R2)--Z--Y2 (R2)--A--B where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist or retinoid inverse ag... | 02/13/2001 |
| 6168776 | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition Amyloid binding compounds which are non-azo derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloido... | 01/02/2001 |
| 6162943 | Method for producing -alkoxy--trifluoromethyl-aryl acetic esters and -aryl acetic acids Process for the preparation of -alkoxy--trifluoromethyl-arylacetic esters of the formula (I) ##STR1## wherein R is a component selected from the group consisting of C1 -C6 -alkyl, C2 -C6 ... | 12/19/2000 |
| 6150412 | Catechol derivatives The invention relates to compounds of formula (I) ##STR1## wherein R1 is an electronegative substituent, preferably nitro, cyano, formyl or carboxy, R2 is --A--R4, wherein A is a branched or straight chain C1-9 | 11/21/2000 |
| 6121460 | Process for the preparation of an optically active indoline-2-carboxylic acid or derivative thereof Process for the preparation of an optically active N-acyl-indoline-2-carboxylic acid in which a mixture of enantiomers of N-acyl-indoline-carboxylic acid is contacted with an optically active resolving agent and the optically active N-acyl-indoline-2-carb... | 09/19/2000 |
| 6103762 | Bi-aromatic compounds and pharmaceutical and cosmetic compositions containing same The invention concerns bi-aromatic compounds of formula (I) in which Ar represents (a), Z being O or S, R1 is --CH3, --CH2 --O--R6, --OR6 or --COR7 ; R2 is --OR8, --SR... | 08/15/2000 |
| 6046220 | Propynyl or dienyl biaromatic compounds The invention relates to novel propynyl or dienyl biaromatic compounds which have the general formula (I) ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatologica... | 04/04/2000 |
| 5977117 | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin Methods, compositions, and compounds for modulating the activity of an endothelin peptide are provided. The methods use compositions that contain compounds of formula (I): ##STR1## where X and Y are selected from groups that include O, S, and NH; and... | 11/02/1999 |
| 5965741 | Ortho-substituted aromatic ether compounds and their use in pharmaceutical compositions for pain relief The invention provides compounds of formula I: ##STR1## wherein A, B, D, X, R1, and R3 have any of the values defined in the specification, as well as N-oxides thereof, S-oxides thereof, pharmaceutically acceptable salts thereof... | 10/12/1999 |
| 5952382 | Adamantyl-substituted retinoids and pharmaceutical/cosmetic compositions comprised thereof Pharmaceutically/cosmetically-active adamantyl-substituted retinoid compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formula (a) - (d): ##STR2## and are useful for the treatment of disorders and/or ai... | 09/14/1999 |
| 5929116 | Cyclopentene derivatives as endothelin receptor antagonists Novel cyclopentane derivatives are described which are endothelin receptor antagonists.... | 07/27/1999 |
