Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 8008525 | Receptor function regulating agent An agent for regulating 14273 receptor function, which is useful as a preventing or treating drug for diabetes mellitus, hyperlipidemia or the like, is provided. An agent for regulating 14273 receptor function comprising a compound containing an aromatic ring and a ... | 08/30/2011 |
| 7432394 | Resolution of α-(phenoxy) phenylacetic acid derivatives with naphthyl-alkylamines The present invention provides a methods and compounds for producing an enantiomerically enriched α-(phenoxy)phenylacetic acid compound of the formula: from a mixture of its enantiomers, where R1 is alkyl or hal... | 10/07/2008 |
| 7429669 | Therapeutic compounds Disclosed herein are compounds of the formula or salts or bioisosteres thereof. Therapeutic methods, medicaments, and compositions related thereto are also disclosed. ... | 09/30/2008 |
| 7385082 | Preparation of 1,3-diphenylprop-2-en-1-one derivatives The invention relates to a method for the preparation of de 1,3-diphenylprop-2-en-1-one substituted on one of the two phenyl groups by a carboxyalkyloxy group or a carboxyalkylthio group. ... | 06/10/2008 |
| 7323591 | Substituted cyclopentanes or cyclopentanones as therapeutic agents Therapeutic compounds, methods, and compositions are disclosed herein. These compounds have prostaglandin EP2 activity, and are useful to treat and/or prevent glaucoma and/or ocular hypertension in a mammal. ... | 01/29/2008 |
| 7301050 | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia. ... | 11/27/2007 |
| 7105577 | Antimicrobial method using a hydroxydiphenyl ether compound The present invention relates to the use of hydroxydiphenyl ether compounds as antimicrobially active substances, to certain new compounds of this type and to processes for the preparation of these compounds. ... | 09/12/2006 |
| 7087644 | Derivatives of dicarboxylic acid having pharmaceutical properties The invention relates to compounds of formula (I) as well as the salts and stereoisomers thereof wherein the several variable groups are as defined in the specification and claims. Processes fo... | 08/08/2006 |
| 7005538 | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac arrhythmias, thyrotoxicosis and subclinical hyperthyrodism. ... | 02/28/2006 |
| 6884820 | 5,6,7,8-tetrahydronaphthalen-2-yl-7-fluoroalkyl-heptatrienoic acid derivatives having serum glucose reducing activity Compounds of the formula where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effect of reducing serum thyroxin... | 04/26/2005 |
| 6869967 | Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in th... | 03/22/2005 |
| 6864287 | Derivatives of dicarboxylic acid having pharmaceutical properties The present invention relates to the compounds of the general formula (I) and their salts and stereoisomers for the production of medicaments for the treatment of cardiovascular disorders. ... | 03/08/2005 |
| 6835848 | One-pot synthesis of alkyl 3-cyclopropylamino-2-[2,4-dibromo-3-(difluromethoxy) benzoyl]-2-propenoate as a useful intermediate for antibacterial quinolone medicaments The present invention relates to a new and industrially advantageous one-pot process for the preparation of alkyl 3-cyclopropyl amino-2-[2,4-dibromo-3-(difluoromethoxy) benzoyl]-2-propenoates of in which R represents methyl or ethyl, which are valuable intermediates... | 12/28/2004 |
| 6716877 | Method to treat chronic heart failure and/or elevated cholesterol levels A method for treating a patient having congestive heart failure by administering a therapeutically effective amount of 3′,3,5-triiodothyropropionic acid (TRIPROP) or 3,5,3′,5′-tetraiodothyropropionic acid (TETRAPROP). Also described is a method to lower choles... | 04/06/2004 |
| 6492424 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders Novel glucocorticoid and thyroid receptor ligands as provided which have the general formula (I): ##STR1## in which R1 is an aliphatic hydrocarbon, an aromatic hydrocarbon, carboxylic acid or ester thereof, alkenyl carboxylic acid or ester ... | 12/10/2002 |
| 6337306 | Phenoxyacetic acid derivatives and their use as herbicides Phenoxyacetic acid derivatives of the formula: ##STR1## wherein R1, R2, Xn and A are as defined herein, and a process for preparing the derivatives. The derivatives are used as herbicides.... | 01/08/2002 |
| 6316666 | Method for producing purified phenylenedioxydiacetic acids A method for producing phenylenedioxydiacetic acids of high purity at high yield from crude phenylenedioxydiacetic acids which mainly contains phenylenedioxydiacetic acids represented by the following general formula (I): ##STR1## wherein, R represen... | 11/13/2001 |
| 6274385 | Attached tags for use in combinatorial chemistry synthesis The present invention relates to a process of coding and identifying individual members of a chemical combinatorial library synthesized on a plurality of solid supports which undergo mix and split synthesis. The process provides for tagging the solid supp... | 08/14/2001 |
| 6093799 | Universal linker for combinatorial synthesis A substrate for solid phase synthesis of the formula: ##STR1## is disclosed. Also disclosed are processes for preparing the substrate and intermediates useful therein. Among the novel intermediates are compounds of the formula: ##STR2## whe... | 07/25/2000 |
| 6048895 | Aromatic C16-C20 substituted tetrahydro prostaglandins useful as FP agonists The invention provides novel PGF analogs. In particular, the present invention relates to compounds having a structure according to the following formula: ##STR1## wherein R1, R2, R3, R4, X, and Z are as de... | 04/11/2000 |
| 6008321 | Universal linker for combinatorial synthesis A substrate for solid phase synthesis of the formula: ##STR1## is disclosed. Also disclosed are processes for preparing the substrate and intermediates useful therein. Among the novel intermediates are compounds of the formula: ##STR2## whe... | 12/28/1999 |
| 5985927 | Medicaments for the selective treatment of tumor tissues Medicinal products for the selective control of tumor tissue and a method for control of such tumor tissue by administration of such product to a host. The products comprise: (a) two different compounds having a pH below 7 when the compounds are present i... | 11/16/1999 |
| 5985920 | Difluoroprostaglandin derivatives and their use A fluorine-containing prostaglandin derivative of the formula (1) (or a salt thereof) and a medicine containing it, particularly, a preventive or therapeutic medicine for an eye disease: ##STR1## wherein A is a vinylene group or the like, R1 | 11/16/1999 |
| 5766610 | Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease... | 06/16/1998 |
| 5512595 | Substituted phenoxyisobutyric acids and esters New substituted phenoxyisobutyric acids and esters that can be used as medicaments and correspond to the formula: ##STR1## wherein X, A, R, R1, R2, R3, R4, R5, R6, R7 and Z ... | 04/30/1996 |
| 5453443 | Bis(aryloxy)alkanes as inhibitors of phospholipase A2 enzymes Compounds having the formula I: ##STR1## are inhibitors of the PLA2 s enzymes. These compounds are useful as anti-allergic, anti-asthmatic, they are also useful in treating various inflammatory diseases such as rheumatoid arthritis, osteoa... | 09/26/1995 |
| 5332857 | 3,5-dihydroxy-6,8-nonadienoic acids and derivatives as hypocholesterolemic agents Variously substituted 3,5-dihydroxy-6,8-nonadienoic acids and esters, are blood cholesterol lowering agents and so are useful in the prevention and treatment of cardiovascular diseases such as atherosclerosis.... | 07/26/1994 |
| 5290812 | Phenoxyalkylcarboxylic acid derivatives and process of preparing the same Phenoxyalkylcarboxylic acid derivatives represented by the following formula (I) ##STR1## having a strong and selective leukotriene antagonistic action and useful for prophylaxis and therapy of allergic diseases as asthma and processes of prepar... | 03/01/1994 |
| 5183925 | Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents The invention relates to leukotriene-B4 derivatives of formula I, ##STR1## in which n=1-10, R1 means radical CH2 OH, radical COOR4, radical CONHR5 or radical CONR6 R7, A means a ... | 02/02/1993 |
| 5167696 | Herbicidal aryloxy- and arylamino-indanes A compound of formula (I): ##STR1## in which Ar is an optionally substituted aryl or heterocyclic ring system; W is O or NR1 where R1 is hydrogen or lower alkyl; A is .dbd.CH or >CH2 and G is .dbd.C--R2, >CR | 12/01/1992 |
| 5166377 | 1,3-dioxan-5-ylalkenoic acids The invention concerns novel 4-phenyl-1,3-dioxan-5-ylalkenoic acid derivatives of the formula I having cis relative stereochemistry at positions 4 and 5 of the dioxane ring and wherein Ra and Rb are variously hydrogen, alkyl, halogenoalkyl, alkenyl, and o... | 11/24/1992 |
| 5151545 | 3,5-dihydroxy-6,8-nonadienoic acids and derivatives as hypocholesterolemic agents Variously substituted 3,5-dihydroxy-6,8-nonadienoic acids and esters, are blood cholesterol lowering agents and so are useful in the prevention and treatment of cardiovascular diseases such as atherosclerosis.... | 09/29/1992 |
| 5145992 | Process and preparation of -alkoxy acetic acids and their salts A process for producing an -alkoxy acetic acids and salts thereof which comprises reacting an alcohol of the formula ##STR1## wherein R1, R2 and R3 can be hydrogen, alkyl, alkoxy, halo, phenyl, substituted phen... | 09/08/1992 |
| 5098613 | Anti-inflammatory agents This invention provides benzene derivatives, pharmaceutical formulations of those derivatives, and a method of using the derivatives for the treatment of inflammation in mammals.... | 03/24/1992 |
| 5043257 | Azo dyes for photographic silver dye bleach material Azo dyes of the formula ##STR1## where X is alkyl or alkoxy each of 1 to 4 carbon atoms or halogen, X' is hydrogen, alkyl or alkoxy each of 1 to 4 carbon atoms or halogen, Y and Y' are independently of each other hydrogen or halogen, Z is hydrogen, a... | 08/27/1991 |
| 5041638 | Alkenoic acid derivatives An alkenoic acid derivative of the formula ##STR1## in which X and Y are identical or different and represent sulfur, sulfoxide, sulfone, an alkylene chain, --SCH2 --, or oxygen or a direct bond, W represents --CH.dbd.CH-- or --CH2 | 08/20/1991 |
| 5021602 | Reactive compounds containing perfluorocyclobutane rings Novel compounds have at least one perfluorocyclobutane ring and at least two functional groups suitable for forming condensation polymers. Preferably the compounds have a structures represented by Formula II: ##STR1## wherein R and R' independently r... | 06/04/1991 |
| 5013864 | Process for preparation of -alkoxy acetic acids and their salts A process for producing an -alkoxy acetic acids and salts thereof which comprises reacting an alcohol of the formula R--OH wherein R is alkyl, substituted alkyl, or cycloalkyl, or cycloalkyl alkyl with a base in an aprotic organic solvent to give a... | 05/07/1991 |
| 5004832 | Preparing alpha-arylalkanoic acids Compounds are described of formula ##STR1## in which: Ar represents an aryl, possibly substituted; R represents a C1 -C4 alkyl; R' represents a hydroxyl, an alkoxy, an amino group possibly mono or di-alkyl substituted, or an O--... | 04/02/1991 |
| 4983629 | 11-haloprostane derivatives, processes for their preparation and their use as medicinal agents 11-Haloprostane derivatives of general Formula I ##STR1## wherein X is F, Cl or Br, R1 is the residue CH2 OH or ##STR2## wherein R2 means a hydrogen atom, an alkyl, cycloalkyl, aryl, phenacyl or heterocyclic res... | 01/08/1991 |
