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| Number | Title | Issue Date |
| 8119834 | Process for the preparation of adapalene and related compounds The invention provides an improved process for the preparation of a benzonaphthalene derivative including, in particular, the manufacture of high purity adapalene. The invention further includes a method for assessing the color of adapalene by means of a quantitativ... | 02/21/2012 |
| 8119835 | Method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphtoic acid A method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid is disclosed based on “one pot” synthesis approach including a direct synthesis of boronic acid derivative from 2-(1-adamantyl)-4-bromoanisole and cycloboranes with a subsequent Suz... | 02/21/2012 |
| 8101793 | Retinoid derivatives with antiangiogenic, antitumoral and proapoptotic activities Are described compounds of Formula (I) in which R, R′, R″, A, and D have the meanings described in the text, as useful agents in the cure of pathologies characterized by altered angiogenesis and as antitumorals. ... | 01/24/2012 |
| 7498461 | Method for the preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid A novel method for preparing 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid includes a Suzuki reaction between 3-adamantyl-4-methoxyphenylboronic acid of formula (II): and 6-bromo-2-naphthoic acid of formula (III): | 03/03/2009 |
| 7354928 | Small molecule inhibitors targeted at Bcl-2 The present invention relates to small molecule antagonists of Bcl-2 family proteins such as Bcl-2 and/or Bcl-XL. In particular, the present invention provides non-peptide cell permeable small molecules (e.g., tricyclo-dibenzo-diazocine-dioxides) that bin... | 04/08/2008 |
| 7342046 | Gossypol co-crystals and the use thereof This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (... | 03/11/2008 |
| 7314900 | Aqueous dispersions and aqueous electrodepositable primers The invention relates to aqueous dispersions and aqueous electrodepositable primers made with the aqueous dispersions of the invention. The aqueous dispersion of the invention requires the use of a polymer (a) comprising one or more water dispersible groups per mole... | 01/01/2008 |
| 7201928 | Extracts of orange peel for prevention and treatment of cancer Compositions and methods of inhibiting tumor cell growth and treating and preventing cancer are provided based on administration of an orange peel extract either alone or in combination with other phytochemicals. ... | 04/10/2007 |
| 7179401 | Thermotropic liquid-crystalline polymer A thermotropic liquid crystalline polymer, which is obtainable by copolymerizing a trifunctional hydroxynaphthalene carboxylic acid represented by the general formula (I) and/or reactive derivative thereof with other polymerizing monomer(s) | 02/20/2007 |
| 7148311 | Liquid crystal polymers Liquid crystal polyester derived from phenylene-naphthalene monomers and one or more comonomers display an improved balance of properties, including low melt viscosity, fast cycle time in molding, very low mold shrinkage, high tensile and/or flexural strength, solve... | 12/12/2006 |
| 7109386 | Method for preparing a halogenated olefin Process for the preparation of a halogenated olefin by reaction of an alkyne and/or of an allene compound with a hydrogen halide in a liquid medium comprising at least one hydrohalogenation catalyst comprising at least one palladium compound. ... | 09/19/2006 |
| 7008998 | Method for making an aqueous dispersion The invention relates to a method for preparing aqueous dispersions, especially electrodepositable aqueous dispersions. The invention requires the use of a polymer (a) comprising one or more water dispersible groups per molecule and one or more functional groups (f)... | 03/07/2006 |
| 6849742 | Binaphthol derivative and process for producing the same The present invention provides a binaphthol compound represented by formula [1]: and a salt thereof. The binaphthol compound of the present invention is useful for manufacturing antiseptic compounds or chiral catalysts... | 02/01/2005 |
| 6686386 | Use of a RAR-γ-specific agonist ligand for increasing the rate of apoptosis The present invention relates to pharmaceutical and cosmetic compositions comprising at least one agonist ligand, which is specific for receptors of the RAR-γ type, which are characterized as inducers of apoptosis in at least one cell population in which... | 02/03/2004 |
| 6562998 | Granules of 2-hydroxynaphthalene-3-carboxylic acid and method for preparing the same Granular product of 2-hydroxynaphthalene-3-carboxylic acid with well-suppressed dusting tendency, and process for preparing the same is provided. Granular product of 2-hydroxynaphthalene-3-carboxylic acid having an average particle size of 150 μm or more... | 05/13/2003 |
| 6548703 | Toning agent A toning agent for an azo pigment, an azo pigment with a modified tone, and process for preparing the same are provide. 2-hydroxynaphthalene-3,6-dicarboxylic acid or a derivative thereof is admixed with a primary coupler component for an azo pigment and t... | 04/15/2003 |
| 6479549 | Carnosic acid derivatives for promoting synthesis of nerve growth factor A novel carnosic acid derivative for promoting the synthesis of nerve growth factor (NGF), a composition comprising the carnosic acid derivative as an effective ingredient, as well as, a method of promoting the synthesis of NGF comprising administering an... | 11/12/2002 |
| 6465515 | Solid compositions suitable for oral administration containing non-hydroscopic salts of L-carnitine and alkanoyl L-carnitines Non-hygrocopic salts of L-carnitine and of the lower alkanoyl L-carnitines with pamoic acid are described, which are used to prepare solid compositions suitable for oral administration. Solid compositions containing such salts are also described.... | 10/15/2002 |
| 6417178 | Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits Amyloid binding compounds which are derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, suc... | 07/09/2002 |
| 6403827 | Crystal of 2-hydroxynaphthalene-3-carboxylic acid and process for the preparation thereof The present invention provides crystalline 2-hydroxynaphthalene-3-carboxylic acid (BON) characterized in that the average particle size is equal to or more than 157 μm and the proportion of the particles of which particle size is less than 74 μm is... | 06/11/2002 |
| 6316665 | Process for producing diacids by carboxylation of phenolic compounds An oxidation free process for converting a hydroxy substituted aromatic to an aromatic diacid which comprises reacting a hydroxy substituted aromatic with excess basic salt in the presence of carbon dioxide at disproportionation/isomerization reaction con... | 11/13/2001 |
| 6316396 | Amphiphilic compounds with at least two hydrophilic and at least two hydrophobic groups based on di-, oligo- or polyolethers The invention relates to amphiphilic compounds of the general formula (I) with at least two hydrophilic and at least two hydrophobic groups based on di, oligo or polyolethers. The amphiphilic compounds of this invention are highly surface active and are s... | 11/13/2001 |
| 6284924 | Compounds A novel compound represented by the general formula (1) ##STR1## or salts thereof. The compound is useful as a structural component of polymers such as polyesters and polyamides. The compound wherein Y1, Y2, Y3, and/or Y | 09/04/2001 |
| 6242609 | Method for manufacturing a color coupler used in a silver halide photographic light-sensitive material A method for manufacturing a color coupler used in a silver halide photographic light-sensitive material using an ammonium trihalide. Said method for manufacturing the color coupler comprising the following step: a step for halogenating a coupling position of ... | 06/05/2001 |
| 6194608 | Process for separating and purifying alkali metal salts of hydroxynaphthalenecarboxylic acids The present invention provides a process for separating and purifying alkali metal salts of hydroxynaphthalenecarboxylic acids, in which alkali metal salt(s) of hydroxynaphthalenecarboxylic acid(s) are separated and purified from a mixture of alkali metal... | 02/27/2001 |
| 6156750 | Bioactive bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic,... | 12/05/2000 |
| 6143905 | 1,7-diaroxy- or 1,7-arylthio-substituted perylene-3,4,9,10-tetracarboxylic acids, their dianhydrides and diimides 1,7-Disubstituted perylene-3,4,9,10-tetracarboxylic dianhydrides I and perylene-3,4,9,10-tetracarboxylic acids Ia ##STR1## where R is substituted or unsubstituted aryloxy, arylthio, hetaryloxy or hetarylthio, their preparation and use as pigments, la... | 11/07/2000 |
| 6124498 | Hydroxynaphthoic acids and derivatives In one embodiment, the present invention provides a compound comprising: ##STR1## wherein A=H or OH X=OH, a halogen, OR, NHR, NR'R" where R, R', and R"=H, C1-8 alkyl, C2-8 alkenyl, or C2-8 alkynyl, cycloalkyl, cycloalkenyl... | 09/26/2000 |
| 6080888 | Preparation of olefinic compounds and carboxylic derivatives thereof Arylolefinic compounds are prepared by reacting aryl halide with an olefinic compound in the presence of a polar liquid reaction medium containing (a) secondary or tertiary amine as a hydrogen halide acceptor (b) a catalyst system formed from (i) Pd or Pd... | 06/27/2000 |
| 5936120 | Deoxygossylic compounds The invention provides deoxygossylic compounds having useful biological activities, and methods for the synthesis of these and related compounds. The invention further provides valuable intermediates for the synthesis of the compounds, and pharmaceutical ... | 08/10/1999 |
| 5925487 | Composition, compound and use A toner resin composition comprising a toner resin and the metal salt or complex of a carbocyclic hydroxy caboxylic acid containing at least one methylene group optionally substituted by hydroxy or amino such as 4-(N-methyl-N-2-hydroxyethyl)aminomethyl-3-... | 07/20/1999 |
| 5919970 | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity Compounds of the formula Y3 (R4)--X--Y1 (R1 R2)--Z--Y2 (R2)--A--B where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist or retinoid inverse ag... | 07/06/1999 |
| 5874614 | Sodium (S)-2-(6-methoxy-2-naphthyl)propionate monohydrate Novel and very useful forms of sodium (S)-2-(6-methoxy-2-naphthyl)propionate are provided. These forms are sodium (S)-2-(6-methoxy-2-naphthyl)propionate monohydrate having an average particle size significantly larger than about 70 microns--the size ... | 02/23/1999 |
| 5859292 | Preparation of high purity sodium (S)-2(6-methoxy-2-naphthyl)propionate Sodium (S)-2-(6-methoxy-2-naphthyl)propionate of at least 99% chiral purity is formed from (S)-2-(6-methoxy-2-naphthyl)propionic acid having a chiral purity of at least about 82%, but below 99%. This is done by distilling a two-phase mixture formed from (... | 01/12/1999 |
| 5859293 | High purity carnosic acid from rosemary and sage extracts by pH-controlled precipitation A process for the extraction and isolation of concentrated carnosic acid from plant matter of the Labiatae family including contacting the plant matter with a water-miscible solvent to form a plant extract and adjusting the pH of the plant extract to a le... | 01/12/1999 |
| 5827855 | Hexahydronaphthalene ester derivatives their preparation and their therapeutic uses Compounds of formula (I): ##STR1## wherein R1 represents a group of formula (II) or (III): ##STR2## R2 is alkyl, alkenyl or alkynyl; R3 and R4 are each hydrogen, alkyl, alkenyl or alkynyl; R5 | 10/27/1998 |
| 5808142 | Process for the preparation of 2-hydroxynaphthalene-6-carboxylic acid A process for the preparation of 2-hydroxynaphthalene-6-carboxylic acid using potassium carbonate and CO at temperatures above 260° C. and at a pressure of at least 10 bar comprises using 2-hydroxynaphthalene-3-carboxylic acid and/or 2-hydroxynaphth... | 09/15/1998 |
| 5792876 | Process for producing acetals A process is described for producing acetals comprising reacting an aldehyde or a ketone with an alcohol in the presence of a titanium compound having an acetylacetone as a ligand, or in the presence of a compound selected from the group consisting of sta... | 08/11/1998 |
| 5780675 | Deoxygossylic compounds The invention provides deoxygossylic compounds having useful biological activities, and methods for the synthesis of these and related compounds. The invention further provides valuable intermediates for the synthesis of the compounds, and pharmaceutical ... | 07/14/1998 |
| 5770766 | Method for separating and purifying hydroxynaphtalenecarboxylic acids The present invention provides a method for effectively separating independent hydroxynaphthalene-carboxylic acids by treating a mixture containing various kinds of hydroxynaphthalene-carboxylic acids with nonionic porous synthetic adsorbents having as a ... | 06/23/1998 |
