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| Number | Title | Issue Date |
| 7468457 | Ligand inhibitors of the RAR receptors, process for preparing same and therapeutic/cosmetic applications thereof Novel biaryl compounds having the structural formula (I): are useful in a variety of pharmaceutical applications, whether human or veterinary, and also in cosmetics. ... | 12/23/2008 |
| 7429676 | Process for preparing enantiomerically enriched 2-alkoxy-3-phenylpropionic acids The present invention relates to a process for preparing enantiomerically enriched, optionally substituted 2-alkoxy-3-phenylpropionic acids by asymmetrically hydrogenating alkoxycinnamic acids. ... | 09/30/2008 |
| 7429669 | Therapeutic compounds Disclosed herein are compounds of the formula or salts or bioisosteres thereof. Therapeutic methods, medicaments, and compositions related thereto are also disclosed. ... | 09/30/2008 |
| 7427691 | Resolution of p-hydroxyphenyl-2-alkoxypropionic acids The present invention is aimed at a process for the preparation of enantiomerically enriched compounds of general formula (I). These are obtained by classical resolution of the corresponding acid using a chiral amino base in organic solvents. | 09/23/2008 |
| 7365076 | Substituted aryl cycloalkanol derivatives and methods of their use The present invention is directed to substituted aryl cycloalkanoyl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor sym... | 04/29/2008 |
| 7338960 | Phenylalkanoic acid and phenyloxyalkanoic acid derivatives as hPPAR activators A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, wherein: ... | 03/04/2008 |
| 7319096 | Thyroid hormone receptor antagonists for cardiac and metabolic disorders II This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac and metabolic disorders, such as cardiac arrhythmias, thyrotoxicosis, subclinical hyperthyrodism... | 01/15/2008 |
| RE39916 | Compounds that modulate PPAR activity and methods for their preparation This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds of their salts, and methods of using them as therapeutic a... | 11/06/2007 |
| 7285680 | β-alanine derivatives and the use thereof A compound of the general formula (I) (wherein the symbols are as defined in the description), or a prodrug or a salt thereof. This compound engages in LPA receptor bonding and antagonism and hence is use... | 10/23/2007 |
| 7259188 | Methods and pharmaceutical compositions for treatment of anti-estrogen resistant breast cancer using RXR modulators Methods and compositions for the treatment of anti-estrogen resistant breast cancer using retinoid compounds which are modulators of Retinoid X Receptors. ... | 08/21/2007 |
| 7259276 | Polyenecarboxylic acid derivatives, processes for preparing them, and their use The present invention relates to novel compounds, termed serpentemycins, of the formula (I) in which Y, R, R2, R3, R4, X, X2, X3, n, m and o are as defined i... | 08/21/2007 |
| 7192982 | Modulators of peroxisome proliferator activated receptors Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH2— or —CH2CH2—; W is a substituted or unsubstituted alkylene or a substituted or uns... | 03/20/2007 |
| 7173141 | Chiral lactones Lactones represented by the formula 2a or 2b: are provided, where each Ph is, independently, an unsubstituted or substituted phenyl group. These lactones are suitable for the synthesis of various α... | 02/06/2007 |
| 7169810 | Guanidine and amidine acid derivatives and analogs and methods of using the same The present invention releates to certain novel guanidine or amidine acid derivatives and analogs, to a process for preparing such compounds, having the utility in clinical conditions associated with insulin resistance, to methods for their therapeutic use and to ph... | 01/30/2007 |
| 7109371 | Prostaglandin synthesis A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C1–C6 alkyl groups; C7–C16 aralk... | 09/19/2006 |
| 7098025 | Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor This invention relates to the isolation and cloning of the promoter and other control regions of human PPARγ gene. It provides a method for identifying and screening for agents useful for the treatment of diseases and pathological conditions affected by the level o... | 08/29/2006 |
| 7022876 | Preparation of mandelic acid derivatives A process is provided for the preparation of mandelic acid derivatives. The process comprises the steps of: (a) stereoselectively cyanating a compound of Formula (2) to yield the corresponding cyanohydrin; | 04/04/2006 |
| 7005538 | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac arrhythmias, thyrotoxicosis and subclinical hyperthyrodism. ... | 02/28/2006 |
| 7005539 | Ferulic acid dimers and their pharmaceutically acceptable salts, their preparation and use thereof for treating dementia The present invention relates to ferulic acid dimers and their pharmaceutically acceptable salts, preparation method and use thereof for treating dementia, which have excellent effect on the learning and memory-retention ability in vivo, thus it can be use for demen... | 02/28/2006 |
| 6964983 | Compounds that modulate PPAR activity and methods for their preparation This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic a... | 11/15/2005 |
| 6939875 | Compounds that modulate PPAR activity and methods for their preparation This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic a... | 09/06/2005 |
| 6936597 | Prodrugs of anticancer agents employing substituted aromatic acids Polymeric prodrugs of the formula: wherein B is selected from the group consisting of OH, leaving groups, residues of amine-containing moieties and a residues of hydroxyl-containing m... | 08/30/2005 |
| 6932789 | Needle-less injector of miniature type Needle-less injectors for liquids are known in many different forms which are adapted to different conditions of use. The needle-less injector according to the invention is in the form of a hand-held unit. It includes a locking stressing mechanism, an energy-storing... | 08/23/2005 |
| 6930197 | Antihistaminic piperidine derivatives and intermediates for the preparation thereof This invention relates to a process for the preparation of compounds of the formula: wherein R1 is C1-C6alkyl and the C1-C6alkyl moiety is straight or branched. | 08/16/2005 |
| 6927300 | Process for the preparation of Latanoprost Disclosed is a process for the preparation of the anti-glaucoma drug Latanoprost, in good yield, in large amounts and with desired purity. Also disclosed are novel intermediates for the above process. ... | 08/09/2005 |
| 6924307 | Aminobutyric acid derivatives and pharmaceutical composition containing the same as active ingredient Aminobutylic acid derivatives of the formula (I): wherein the symbols are as defined in specification; and non-toxic salts thereof. Because of inhibiting matrix metalloproteinase, the compounds of the formula (I) are u... | 08/02/2005 |
| 6878718 | Phenylalanine enamide derivatives Phenylalanine enamide derivatives of formula (1) are described: wherein R1 is a group Ar1L2Ar2Alk- in which: Ar1 | 04/12/2005 |
| 6852880 | Process for preparing prostalglandin derivatives and stereospecific starting material thereof The present invention relates to a process for effectively preparing prostaglandin derivatives and to a stereospecific alkyl halide containing 15S-alcohol group as a starting material. ... | 02/08/2005 |
| 6787562 | Substituted aryl and heteroaryl compounds as E-type prostaglandin antagonists Compounds of the formula I; useful for the treatment of pain wherein A, Z, B, R1, X and D are as defined in the specification, methods of making such compounds, methods of using such compounds and pharmaceutical c... | 09/07/2004 |
| 6689901 | Process and intermediates to prepare latanoprost The present invention is a novel intermediate, compound of the formula (VI) ##STR1## and salts thereof. In addition, the invention includes a process for the preparation of a 15(S)-prostaglandin intermediates compounds (IV) and (XVIII) which comprises (1)... | 02/10/2004 |
| 6689902 | Arylpropyl aldehyde derivatives, processes for producing the same, and methods of using the same 3-(3-Methyl-4-hydroxyphenyl)-3-methylbutyl aldehyde may be produced from 3-(3-methyl-4-hydroxyphenyl)-3-methylbutyric acid by converting the carboxyl group into a formyl group. N-[N-[3-(3-methyl-4-hydroxyphenyl)-3-methylbutyl]-L--aspartyl]-L-ph ... | 02/10/2004 |
| 6683206 | Preparation of (R -2-alkyl-3-phenylpropionic acids Compounds of formula (I), wherein R1 and R2 are, independently of one another, H, C1 -C6 alkyl, C1 -C6 halogenalkyl, C1 -C6 alkoxy, C1 -C6 alkoxy-C | 01/27/2004 |
| 6639095 | Process for preparing optically active -hydroxy acids and derivatives thereof The present invention provides a process for preparing optically active -hydroxy acids and derivatives thereof by subjecting the alkylated 1,3-dioxolanones of formula (IV) wherein R1 and R2 are the same or different and are ea... | 10/28/2003 |
| 6630600 | 3-aryl propionic acid derivatives and analogs Novel 3-aryl propionic acid derivatives and analogs, process and intermediate for their manufacture, pharmaceutical preparations containing them and the use of the compounds in clinical conditions associated with insulin resistance.... | 10/07/2003 |
| 6593493 | RXR modulators with improved pharmacologic profile The present invention provides a novel class of RXR modulator compounds that exhibit an improved pharmacologic profile relative to the profile of previously studied RXR modulators, including those that share common structural features with the presently c... | 07/15/2003 |
| 6569899 | 4-aminobutanoic acid derivatives and drugs containing these derivatives as the active ingredient Aminobutylic acid derivatives of the formula (I) ##STR1## wherein the symbols are as defined in specification; and non-toxic salts thereof. Because of inhibiting matrix metalloproteinase, the compounds of the formula (I) are useful for prevention and/or t... | 05/27/2003 |
| 6569901 | Alkynyl-substituted propionic acid derivatives, their preparation and use The present invention relates to compounds of formula (I) ##STR1## The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).... | 05/27/2003 |
| 6562998 | Granules of 2-hydroxynaphthalene-3-carboxylic acid and method for preparing the same Granular product of 2-hydroxynaphthalene-3-carboxylic acid with well-suppressed dusting tendency, and process for preparing the same is provided. Granular product of 2-hydroxynaphthalene-3-carboxylic acid having an average particle size of 150 μm or more... | 05/13/2003 |
| 6525093 | Compounds to treat diabetes and associated conditions Compounds are provided that lower blood glucose concentrations, lower serum triglyceride concentrations, lower systolic blood pressure, and increase glucose uptake by adipose tissue, but do not affect the expression of PPAR-γ by adipose tissue.... | 02/25/2003 |
| 6492424 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders Novel glucocorticoid and thyroid receptor ligands as provided which have the general formula (I): ##STR1## in which R1 is an aliphatic hydrocarbon, an aromatic hydrocarbon, carboxylic acid or ester thereof, alkenyl carboxylic acid or ester ... | 12/10/2002 |
