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| Number | Title | Issue Date |
| 7358386 | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic d... | 04/15/2008 |
| 7341972 | Singlet oxygen catalysts including condensed carbon molecules The present invention relates to novel singlet oxygen catalysts useful for the production of specialty chemicals. The catalysts include a core material selected from amine coated polymeric beads, amine coated glass beads and multi-generational dendrimers to which co... | 03/11/2008 |
| 7163959 | Prostagladin derivatives for the treatment of glaucoma or ocular hypertension The invention relates to ophthalmological compositions for topical treatment of glaucoma or ocular hypertension comprising an effective intraocular pressure reducing amount of a prostaglandin derivative of PGA, PGB, PGD, PGE or PGF, in which the omega chain contains... | 01/16/2007 |
| 6548546 | HIV integrase inhibitors The present invention relates to HIV integrase inhibitors of the formula ##STR1## wherein R1 and Z are as defined in the specification.... | 04/15/2003 |
| 6495546 | Propanolamine derivatives Propanolamine derivatives represented by the following formula (I): ##STR1## These derivatives may be 댣 agonists and exert sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-urinary incontinence and anti-pollakiuria ac... | 12/17/2002 |
| 6492424 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders Novel glucocorticoid and thyroid receptor ligands as provided which have the general formula (I): ##STR1## in which R1 is an aliphatic hydrocarbon, an aromatic hydrocarbon, carboxylic acid or ester thereof, alkenyl carboxylic acid or ester ... | 12/10/2002 |
| 6433021 | Indane compounds and their pharmaceutical use Indane compounds of general formulae (1) to (4) and their pharmaceutical use, particularly to achieve mast cell stabilising activity and/or anti-inflammatory activity are described. In these formulae R1 to R7 may be selected from: H,... | 08/13/2002 |
| 6403638 | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors Compounds having the formulas below, where R is H, lower alkyl, or a pharmaceutically acceptable salt, and where R1 represents i-propyl, t-butyl or n-butyl groups, have selective RXR retionoid agonist activity. ##STR1##... | 06/11/2002 |
| 6380249 | HIV integrase inhibitors Certain six-membered aromatic and heteroaromatic-dioxobutyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment ... | 04/30/2002 |
| 6291702 | Azulenyl nitrone spin trapping agents, methods of making and using same The present invention relates to chromotropic nitrone spin trapping agents, methods of making these agents, compositions comprising same, and methods of their use. In particular, azulenyl nitrones of the present invention are effective agents for trapping... | 09/18/2001 |
| 6271411 | Process for preparing 2-aryl-substituted indenes A process is disclosed for preparing 2-aryl-substituted indenes by reacting an indene with an arene compound substituted with an halogen atom, preferably a iodine atom, or with an organosulphonate group, said reaction being carried out in a basic medium i... | 08/07/2001 |
| 6187933 | O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.... | 02/13/2001 |
| 6147224 | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors Compounds of Formula 1, Formula 2 or Formula 3 where X is O, S, or (CR1 R1)n where n is 0, 1 or 2; Y is a bivalent radical having Formula 4 or Formula 5 where o is an integer from 1 to 4 ##STR1## or Y is a bivalent ar... | 11/14/2000 |
| 6143787 | Pharmaceutical composition containing 4-oxo-butynic acids The present invention relates to a pharmaceutical composition comprising, as active principle, a compound of formula: ##STR1## in which the groups A and B are chosen, independently of each other, from: a mono-, bi- or tricyclic aryl group having from... | 11/07/2000 |
| 6133303 | Bicyclic inhibitors of protein farnesyl transferase The present invention provides compounds of Formula (I). The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable comp... | 10/17/2000 |
| 6008204 | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities Aryl-substituted and aryl and (3-oxo-1-propenly)-substituted benzopyran, benzothiopyran, 1,2-dihydroquinoline, and 5,6-dihydronaphthalene derivatives have retinoid negative hormone and/or antagonist-like biological activities. The invented RAR antagonists... | 12/28/1999 |
| 5977117 | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin Methods, compositions, and compounds for modulating the activity of an endothelin peptide are provided. The methods use compositions that contain compounds of formula (I): ##STR1## where X and Y are selected from groups that include O, S, and NH; and... | 11/02/1999 |
| 5973190 | Process and intermediate compounds for the preparation of pesticidal fluoroolefin compounds The present invention provides a process for the preparation of pesticidal fluoroolefin compounds having the structural formula I ##STR1## The present invention also provides intermediate compounds which are utilized in the process of this invention.... | 10/26/1999 |
| 5814512 | Microorganism having all the identifying characteristics of absida ferm BP-4599 for producing purpurogallin derivatives Purpurogallin derivatives are produced useful for inhibiting catecholamine-O-methyltransferase. The derivative, 8-O-methylpurpurogallincarboxylic acid, is produced with a microorganism of the genus Absidia having all the identifying characteristics of FER... | 09/29/1998 |
| 5677342 | Phenoxy acetic acids as aldose reductase inhibitors and antihyperglycemic agents This invention relates to 4-formyl-2-(naphthalenylmethyl)phenoxyacetic acids and pharmaceutically acceptable salts thereof according to formula I below, pharmaceutical compositions thereof, a method of treating hyperglycemia due to non-insulin dependent d... | 10/14/1997 |
| 5650439 | Purpurogallin derivatives The present invention relates to purpurogallin derivatives useful for inhibiting catecholamine-O-methyl transferase.... | 07/22/1997 |
| 5599967 | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity Compounds of the formula ##STR1## wherein the symbols have the meaning defined in the specification have retinoid-like biological activity.... | 02/04/1997 |
| 5457124 | Carboxylic acid Leukotriene B4 antagonists The invention relates to compounds selected from the group consisting of the formulas: ##STR1## wherein R2 and Ph are as described herein. These compounds are potent leukotriene B4 antagonists and are therefore useful in the tre... | 10/10/1995 |
| 5457237 | Dihydroxyindanone tyrosine kinase inhibitors Certain dihydroxyindanone compounds, and their pharmaceutically-acceptable salts, are inhibitors of tyrosine kinase enzymes, and so are useful for the control of tyrosine kinase dependent diseases (e.g., cancer, atherosclerosis).... | 10/10/1995 |
| 5434186 | Carboxylic acid leukotriene B4 antagonists Compounds of the formula ##STR1## wherein X is O or CH2 ; Y is O, --CH2 --CH2 --, --CH.dbd.CH--, --C.tbd.C--, or --OCH2 C6 H4 --; Z is --CH2 --CH2 --, --CH.dbd.CH-- or... | 07/18/1995 |
| 5399588 | Naphthalenylmethyl cycloalkenone acetic acids and analogs thereof useful as aldose reductase inhibitors The compounds of this invention which have the formula: ##STR1## wherein: R1 and R2 are independently hydrogen, C1 -C8 alkyl, halogen, C1 -C8 alkoxy, or trifluoromethyl; R3 is --... | 03/21/1995 |
| 5344959 | Tetrahydronaphthyl and cyclopropyl substituted 1,3-butadienes having retinoid-like activity Compounds of the formula ##STR1## wherein m is 1-4; R1 -R4 independently are hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, or I; R5 is hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, I, lower alkoxy or lower thioa... | 09/06/1994 |
| 5338881 | Process for preparing diketones This invention concerns a process for preparing diketones and keto-acids by reacting a dicarboxylic acid and an aromatic compound in the presence of an alkylsulfonic acid such as methanesulfonic acid and a phosphorus pentoxide. The diketones and keto-acid... | 08/16/1994 |
| 5223640 | Preparation of optically active -aryl propionic acids This invention provides a process to prepare optically active -aryl propionic acids without the need for resolving a racemic mixture. In one embodiment of the process, an acetophenone is sequentially converted to a 1-alkyne, then to an -aryl... | 06/29/1993 |
| 5194664 | Aromatic keto compounds, the preparation thereof, and drugs and cosmetics containing these Compounds of the general formula I ##STR1##... | 03/16/1993 |
| 5194663 | Aromatic derivatives of butyric acid, a process for their preparation and their use in cosmetics and in human and veterinary medicine An aromatic derivative of butyric acid has the formula ##STR1## These aromatic derivatives of butyric acid are useful in human and veterinary medicines as well as in cosmetic compositions.... | 03/16/1993 |
| 5179092 | Compound effective as cerebral insufficiency improver A compound having the formula (I): ##STR1## wherein A is --CH2 --, --O--, or --S--; R1 is CH3 or OCH3 ; R2 is hydroxy or carboxy which may be optionally esterized or amidated; R3 is H ... | 01/12/1993 |
| 5149859 | Naphthalene derivatives A naphthalene derivative having the formula (I): ##STR1## wherein R1 represents a hydrogen atom, a C1 -C5 alkyl group or a non-toxic salt moiety; R2 and R3 independently represent a hydrogen atom... | 09/22/1992 |
| 5128479 | Oxidized diphenylheteroalkanes Oxidized diphenylheteroalkanes of the formula I ##STR1## where R1 to R6 and A have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for controlling diseases and as... | 07/07/1992 |
| 5126371 | Diarylacetylenes, their preparation and their use Novel diarylacetylenes of the formula I ##STR1## where A, R1, R2, R3, R4, R5 and R6 have the meanings stated in the description, are useful for the treatment of disorders.... | 06/30/1992 |
| 5120862 | Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof There is provided a novel and efficient stereoselective total synthesis of epipodophyllotoxin and related epipodophyllotoxin compounds of the and present invention ##STR1## wherein R1 and R2 each are independently hydrogen or ... | 06/09/1992 |
| 5106407 | Iodones and methods for antimicrobial use The present invention discloses the antimicrobial utility of certain iodonium ylide compounds. The particular iodonium ylide compounds are phenyl iodonium ylides having an ortho substituent that stabilizes the positive charge on the polyvalent iodine by a... | 04/21/1992 |
| 5107014 | Prostaglandin I analogue The present invention relates to a new prostagrandine I analogous compounds represented by the following formula (I) and (II). ##STR1## wherein R1 is a hydrogen atom or alkyl group, at least one of R2 and/or R2 ' are ... | 04/21/1992 |
| 5097064 | Process for preparing optically active 2-arylpropionic acids This invention relates to a process for preparing an optically active 2-arylpropionic acid of general formula (I), by the hydrogenation, in a heterogeneous aqueous-organic medium, of a 2-arylacrylic acid of general formula (II) in the presence of a cataly... | 03/17/1992 |
| 5084592 | Azulenesquaric acid dyes, azulene intermediates therefor, and optical recording medium Azulenesquaric acid dyes of the formula ##STR1## where R1, R2, R3, R4 and R5 each have specified meanings are prepared from azulene derivatives of the formula ##STR2## where R1, R... | 01/28/1992 |
