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| Number | Title | Issue Date |
| 7951971 | Phenoxy carboxylic acid compounds and compositions for delivering active agents Phenoxy carboxylic acid compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well. ... | 05/31/2011 |
| 7429669 | Therapeutic compounds Disclosed herein are compounds of the formula or salts or bioisosteres thereof. Therapeutic methods, medicaments, and compositions related thereto are also disclosed. ... | 09/30/2008 |
| 7348453 | Labile linkage for compound delivery to a cell Described are ortho carboxy phenol derived acetals and compositions containing ortho carboxy phenol derived acetals which are useful for delivering biologically active compounds to cells. The acetals can be used to reversibly link up to three different molecules and... | 03/25/2008 |
| 7268248 | 3-Cyano-2,4,5-trifluorobenoxyl fluoride and intermediate products for the production thereof The present invention relates to 3-cyano-2,4,5-trifluorobenzoyl fluoride and to intermediates for its preparation and to the process for the preparation of 3-cyano-2,4,5-trifluoro-benzoyl fluoride, which starts from 5-fluoro-1,3-xylene (VIII); which is bichlorinated... | 09/11/2007 |
| 7235688 | Process for preparing histone deacetylase inhibitors and intermediates thereof A process for preparing unsaturated esters useful as intermediates for HDAC inhibitors, by reacting an aldehyde or ketone having the following formula I: wherein R1 is an aromatic group or a combined a... | 06/26/2007 |
| 7022736 | Enzyme inhibitors Diketoacids of Formula A are useful as inhibitors of viral polymerases. In particular hepatitis C virus RNA dependent RNA polymerase (HCV RdRp), hepatitis B virus polymerase (HBV pol) and reverse transcriptase of human immunodeficiency virus (HIV RT): | 04/04/2006 |
| 6943196 | NF-κB inhibitor comprising phenylmethyl benzoquinone as the active ingredient An NF-κB inhibitor having as an active ingredient a benzoquinone derivative represented by the general formula (1) wherein R1, R2, and R3 are each independently H, alkyl having 1 to 5 carbons, or alkoxy having 1 to 5 carbons; R... | 09/13/2005 |
| 6878718 | Phenylalanine enamide derivatives Phenylalanine enamide derivatives of formula (1) are described: wherein R1 is a group Ar1L2Ar2Alk- in which: Ar1 | 04/12/2005 |
| 6835848 | One-pot synthesis of alkyl 3-cyclopropylamino-2-[2,4-dibromo-3-(difluromethoxy) benzoyl]-2-propenoate as a useful intermediate for antibacterial quinolone medicaments The present invention relates to a new and industrially advantageous one-pot process for the preparation of alkyl 3-cyclopropyl amino-2-[2,4-dibromo-3-(difluoromethoxy) benzoyl]-2-propenoates of in which R represents methyl or ethyl, which are valuable intermediates... | 12/28/2004 |
| 6831194 | Surface modification of carbonaceous materials by introduction of gamma keto carboxyl containing functional groups The present invention provides a method for the preparation of carbonaceous materials comprising a plurality of gamma-keto-carboxyl containing functional groups surface bonded thereto, and further provides several surface modified carbonaceous materials resulting th... | 12/14/2004 |
| 6759548 | Dialkyl-halogenophenyl-substituted ketoenols The present invention relates to new compounds of the formula (I) in which X represents alkyl, Y represents halogen or alkyl and Z represents halogen or alkyl, with the proviso that one of the... | 07/06/2004 |
| 6706918 | 3-cyano-2,4,5-trifluoro-benzoyl fluoride and intermediate products for the production thereof The present invention relates to 3-cyano-2,4,5-trifluorobenzoyl fluoride and to intermediates for its preparation and to the process for the preparation of 3-cyano-2,4,5-trifluoro-benzoyl fluoride, which starts from 5-fluoro-1,3-xylene (VIII); which is bichlorinated... | 03/16/2004 |
| 6703421 | Methods of using phenylmethylbenzoquinone and hydroquinone compounds for treatment of myocarditis, dilated cardiomyopathy and heart failure A method for prevention or treating myocarditis, dilated cardiomyopathy and heart failure comprising administering to a patient in need of such treatment a NF-.kappa.B inhibitor in a therapeutically effective amount, wherein said NF-.kappa.B inhibitor is ... | 03/09/2004 |
| 6693199 | Method of making HIV protease inhibitors A method of making HIV protease inhibitors of general formula (1): ##STR1## These HIV compounds inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmac... | 02/17/2004 |
| 6649657 | Prevention of loss and restoration of bone mass by certain prostaglandin agonists Prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disor... | 11/18/2003 |
| 6602907 | Treatment of breast cancer Compounds of the class of 4-oxo-butenoic acid derivatives are disclosed along with the surprising use property of these compounds as a anti-tumor agents in humans against breast carcinoma, which include: 2-(N'-Fluoren-9-ylidene-hydrazino)-5,5-dimethyl-4-o... | 08/05/2003 |
| 6590119 | Methods for the synthesis of dioxoalkanoic acid compounds The invention relates to improved methods of producing aryl dioxoalkanoic acid compounds and derivatives useful as intermediates for diarylpyrrole therapeutic agents by the alcoholysis of benzoylcyclohexanone ketal compounds.... | 07/08/2003 |
| 6548546 | HIV integrase inhibitors The present invention relates to HIV integrase inhibitors of the formula ##STR1## wherein R1 and Z are as defined in the specification.... | 04/15/2003 |
| 6525215 | HIV protease inhibitors Compounds useful as intermediates in the preparation of HIV protease inhibitors. These compounds have the following general formula: ##STR1##... | 02/25/2003 |
| 6469056 | Pharmaceutically active compounds, their preparation and use as ECE-inhibitors Pharmaceutically active compounds are prepared as described and used to produce pharmaceutical preparations for treating diseases.... | 10/22/2002 |
| 6441218 | Process for producing 2-substituted propionic acid Adipic acid diester is caused to react with alkoxide M(OR)n, wherein R is an alkyl group and M is an alkali metal or alkaline earth metal, the reaction product is successively subjected either to coupling with halomethylstyrene followed by carb... | 08/27/2002 |
| 6413936 | Glycomimetics as selectin antagonists and pharmaceuticals having antiinflammatory activity The invention relates to novel mimetics of the tetrasaccharides sialyl-Lewis-X and sialyl-Lewis-A having an improved action as inhibitors of cell adhesion, to a process for the preparation of these compounds and to their use as pharmacological active comp... | 07/02/2002 |
| 6380249 | HIV integrase inhibitors Certain six-membered aromatic and heteroaromatic-dioxobutyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment ... | 04/30/2002 |
| 6380257 | Aromatic di-keto derivatives, processes for their production and their use as a pharmaceutical The present invention relates to new aromatic di-keto derivatives and to their pharmaceutically acceptable salts, esters, ethers and other chemical equivalents. The derivatives are glucose-6-phosphate translocase inhibitors and can be used in the treatmen... | 04/30/2002 |
| 6346546 | Biaromatic compounds and pharmaceutical and cosmetic compositions comprising them Biaromatic compounds connected by a propynylene or ailenylene bond, corresponding to the formula (I). ##STR1##... | 02/12/2002 |
| 6329547 | Vinylbenzene derivatives The present invention provides compounds represented by the following general formula [I] and salts thereof, which are useful as therapeutic agents for glaucoma, ##STR1## wherein R1 is H, lower alkyl or phenyl, and the phenyl can be substi... | 12/11/2001 |
| 6323240 | 4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity 4-phenyl-4-oxo-butanoic acid derivatives for use in the treatment of the human or animal body by therepy; particularly as kynurenine-3-hydroxylase inhibitors, in the prevention and/or treatment of a neurodegenerative disease wherein the inhibition of such... | 11/27/2001 |
| 6307089 | Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases Biphenyl butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) an... | 10/23/2001 |
| 6265607 | Process for the preparation of 4-(4'-chlorobiphenyl-4-yl)-4-keto-2-methylenebutyric acid The invention relates to a process for the preparation of 4-(4'-chlorobiphenyl-4-yl)-4-keto-2-methylenebutyric acid of the formula (I) ##STR1## by Friedel-Crafts acylation of 4-chlorbiphenly with itaconic anhydride, which comprises carrying out the F... | 07/24/2001 |
| 6251833 | 2-arylcyclopentan-1,3-diones The present invention relates to novel 2-aryl-3-hydroxy-Ɗ2 -cyclopentene-1-one derivatives of the formula (I) ##STR1## in which A, B, D1, D2, G, W, X, Y and Z are each as defined in the description, to processes for their... | 06/26/2001 |
| 6214877 | 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure ##STR1## wherein: B, C, D, and R1 are as defined hereinbefore in the specification, or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disord... | 04/10/2001 |
| 6180816 | Anti-viral compounds The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.... | 01/30/2001 |
| 6180815 | Anti-viral compounds The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.... | 01/30/2001 |
| 6175034 | Anti-viral compounds The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.... | 01/16/2001 |
| 6166082 | Substituted 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula (T)x A--B--D--E--G whe... | 12/26/2000 |
| 6143787 | Pharmaceutical composition containing 4-oxo-butynic acids The present invention relates to a pharmaceutical composition comprising, as active principle, a compound of formula: ##STR1## in which the groups A and B are chosen, independently of each other, from: a mono-, bi- or tricyclic aryl group having from... | 11/07/2000 |
| 6096762 | Neurotrophic difluoroamide agents The present invention relates to the design, synthesis, and the peptidyl-prolyl isomerase (PPIase or rotamase) inhibitory activity of novel ,-difluoroacetamido compounds that are neurotrophic agents (i.e. compounds capable of stimulating gro... | 08/01/2000 |
| 6051584 | Hemoregulatory compounds Novel compounds of the general formula (I) which have hemoregulatory activities and can be used to stimulate haematopolesis and for the treatment of viral, fungal and bacterial infectious diseases ##STR1##... | 04/18/2000 |
| 6048896 | 4-phenyl-4-oxo-2-butenoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity 4-Phenyl-4-oxo-butenoic acid derivatives for use in the treatment of the human or animal body by therapy; particularly as kynurenine-3-hydroxylase inhibitors, in the prevention and/or treatment of a neurodegenerative disease wherein the inhibition of such... | 04/11/2000 |
| 6046220 | Propynyl or dienyl biaromatic compounds The invention relates to novel propynyl or dienyl biaromatic compounds which have the general formula (I) ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatologica... | 04/04/2000 |
