Celebrity Inventors
Glam girl Heddy Lamar may have used her good looks to good effect on the silver screen, but she put her smarts to better use as an inventor. During World War II, she co-patented a frequency-switching system for torpedo guidance that was considered years ahead of its time.
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| Number | Title | Issue Date |
| 7442808 | Antidiabetic bicyclic compounds Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful a... | 10/28/2008 |
| 7420085 | Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl) amino] butanoate The present invention relates to amorphous and polymorphic forms of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate and their use for facilitating the delivery of active agents, such as insulin, to a target. ... | 09/02/2008 |
| 7399785 | N-oxides and derivatives of melphalan for treating diseased states associated with hypoxia inducible factor This invention relates to compounds which are N-oxides and derivatives thereof, as well as their use to treat HIF related diseases. These compounds have the general formula set out below and are used to treat a variety of diseases associated with HIF: | 07/15/2008 |
| 7314889 | Compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, the... | 01/01/2008 |
| 7256307 | Substituted phenypropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor α(PPAR) The present invention provides the S enantiomer of a compound of formula (I); wherein R1 represents 2,4-difluorophenyl or cyclohexyl as well as pharmaceutically acceptable salts, solvates, crystalline forms and prodrugs thereof, to processes for preparing... | 08/14/2007 |
| 7247654 | 3,4-disubstituted benzamidines and benzylamines, and analogues thereof, useful as serine protease inhibitors The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel 3,4-disubstituted benzamidines and benzylamines, or a stereoisomer or pharmaceutically acceptable salt form thereof, which are useful as selecti... | 07/24/2007 |
| 7235688 | Process for preparing histone deacetylase inhibitors and intermediates thereof A process for preparing unsaturated esters useful as intermediates for HDAC inhibitors, by reacting an aldehyde or ketone having the following formula I: wherein R1 is an aromatic group or a combined a... | 06/26/2007 |
| 7232821 | (2-((2-alkoxy)-phenyl) -cyclopent-1enyl) aromatic carbo and heterocyclic acid and derivatives Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, R1, R2, Rx, R8, R9 and n are as defined in the specification, a proc... | 06/19/2007 |
| 7227033 | Polymorphs of sodium 4-[(4-chloro-2-hydroxybenzoyl) amino] butanoate The present invention relates to amorphous and polymorphic forms of sodium 4-[(4-chloro-2-hydroxybenzoyl)amino]butanoate and their use for facilitating the delivery of active agents, such as insulin, to a target. ... | 06/05/2007 |
| 7220880 | Amide linker peroxisome proliferator activated receptor modulators The present invention is directed to compounds, compositions, and use of compounds the structural Formula (I) ... | 05/22/2007 |
| 7196220 | Bone targeting compounds for delivering agents to the bone for interaction therewith The present invention relates to compounds of the formula or pharmaceutically acceptable salts thereof, useful for delivering agents having the capacity to diagnose, treat or prevent bone injury or disease to the b... | 03/27/2007 |
| 7138538 | Process for the separation of enantiomers and enantiopure reagent Process for the separation of enantiomers comprising at least one free functional group, in which process a reagent based on an enantiopure amino acid is reacted in basic medium with a mixture comprising enantiomers. ... | 11/21/2006 |
| 7081465 | Alpha-substituted naphthyloxy omega-substituted alky/aryl amino-substituted alkane derivatives as agent for treatment or prophylaxis of diabetes and related metabolic disorders This invention relates to novel {overscore (ω)}-substituted-naphthyloxy-amino alkanes, their preparation and use as antihyperglycemic agents and for the treatment and prevention of cardiovascular disorders (CVS) such as lipid lowering effects. ... | 07/25/2006 |
| 7067530 | Compounds, their preparation and use Novel compounds of general formula (I), the use of these compounds as medicaments, pharmaceuticaly compositions comprising the compounds and methods of treatment employing these compounds and compostiones. The present compounds may be useful in the treatment and/or ... | 06/27/2006 |
| 7057066 | Process for producing 3-amino-2-hydroxypropionic acid derivatives The present invention provides a process for preparing 3-amino-2-hydroxypropionic acid derivatives (1) which does not use dangerous reagents, is economically advantageous, and is suitable for an industrial production, which process comprises: ... | 06/06/2006 |
| 7030133 | Inhibitors of formation of advanced glycation endproducts (AGEs) The nonenzymatic glycation and crosslinking of proteins is a part of the aging process with the glycation endproducts and crosslinking of long-lived proteins increasing with age. This process is increased at elevated concentrations of reducing sugars in the blood an... | 04/18/2006 |
| 6949674 | Aromatic carboxylic acids, acid halides thereof and processes for preparing both A novel aromatic carboxylic acid useful as a material for macromolecular compounds and, in particular, for polycondensed macromolecular compounds exhibiting excellent heat resistance, an acid halide derivative thereof and a process for producing these compounds are ... | 09/27/2005 |
| 6878723 | LTA4 hydrolase inhibitors The invention concerns compounds inhibiting LTA4 hydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications. ... | 04/12/2005 |
| 6844368 | Compounds useful in pain management The present invention relates to novel oxo-aminotetralin compounds of the formula (I) wherein X, R1, R2, R3, R4, R5, and R6 are defined herein. ... | 01/18/2005 |
| 6743373 | Process for the separation of enantiomers and enantiopure reagent Process for the separation of enantiomers comprising at least one free functional group, in which process a reagent based on an enantiopure amino acid is reacted in basic medium with a mixture comprising enantiometers. ... | 06/01/2004 |
| 6710205 | Benzoic acid derivatives, processes for producing the same and drugs containing the same as the active ingredient An agent comprising the benzoic acid of formula (I) wherein A, B, R6, R7 are carbocyclic ring, heterocyclic ring, etc.; R1 is hydroxy etc.; R2, R3, R4 are... | 03/23/2004 |
| 6696489 | 2-Methylpropionic acid derivatives and medicinal compositions containing the same The present invention provides novel 2-methylpropionic acid derivatives represented by the general formula: ##STR1## (wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group; R2 represents a hydrogen atom a low... | 02/24/2004 |
| 6673967 | Method of processing of hydrogen for reductive acylation of nitro, azido and cyano arenes A method for processing of hydrogen for the reductive acylation of nitro, azido and cyano arenes is disclosed. More particularly, improved process for the preparation of amides and anilides using C3 -C7 carboxylic acids as proton sou... | 01/06/2004 |
| 6638977 | Plasminogen activator inhibitor antagonists Compounds and pharmaceutical compositions useful as plasminogen activator inhibitor (PAI) antagonists are provided. In particular, methods of antagonizing PAI with substituted and unsubstituted aryl and heteroaryl ethers and thioethers are provided.... | 10/28/2003 |
| 6624153 | Halogenated antituberculosis agents Halogenated derivatives of two synthetic anti-tuberculosis agents, thioacetazone and p-aminosalicylic acid, have been synthesized. In general, the halogenated compound has the structure of Structure I: ##STR1## wherein X1 is a halogen and X | 09/23/2003 |
| 6600069 | Benzene tricarboxylic acid derivatives as insulin receptor activators Compounds of Formula I, and pharmaceutical compositions containing these compounds, activate the insulin receptor kinase, which leads to an increased sensitivity to insulin and an increase in glucose uptake, and are therefore useful for the treatment of a... | 07/29/2003 |
| 6531632 | Bis-o-aminophenols and o-aminophenolcarboxylic acids and process for preparing the same Bis-o-aminophenols and o-aminophenolcarboxylic acids have the following structures: ##STR1## A1 to A7 are, independently of each other, H, F, CH3, CF3, OCH3 or OCF3. T is an aromatic or het... | 03/11/2003 |
| 6498004 | Silver halide light sensitive emulsion layer having enhanced photographic sensitivity This invention provides a photographic element comprising at least one silver halide emulsion layer in which the silver halide is sensitized with a compound of the formula (a): Ɗ-(t)m -XY' (a) XY'-(t)m -Ɗ (b) Ɗ-(t)m -XY'-(... | 12/24/2002 |
| 6437178 | O-aminophenolcarboxylic acid and o-aminothiophenolcarboxylic acid The invention relates to novel o-aminophenolcarboxylic acids or o-aminothiophenolcarboxylic acids of the following structure ##STR1## in which: A1 to A7 are--independently of one another--H, CH3, OCH3, CH2 | 08/20/2002 |
| 6391915 | Propanolamine derivatives This invention relates to new propanolamine derivatives presented by the following formula [I]: ##STR1## wherein R1 hydrogen or lower alkenyloxy, R2 is carboxy(lower)alkoxy or protected carboxy(lower)alkoxy, R3 is hyd... | 05/21/2002 |
| 6380249 | HIV integrase inhibitors Certain six-membered aromatic and heteroaromatic-dioxobutyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment ... | 04/30/2002 |
| 6369261 | Compounds having activity as inhibitors of cytochrome P450RAI Compounds having Formula 2 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. ##STR1##... | 04/09/2002 |
| 6339159 | Optically active -aminonitrile and process for producing -amino acid An aldehyde compound is reacted with an amino compound and hydrogen cyanate in the presence of a chiral zirconium catalyst obtained by mixing a zirconium alkoxide with an optically active binaphthol compound.... | 01/15/2002 |
| 6337350 | Inhibitors of formation of advanced glycation endproducts (AGEs) Derivatives of aryl and heterocyclic ureido and aryl and heterocyclic carboxamido phenoxy isobutyric acids have been found to inhibit the nonenzymatic glycation of proteins which often results in formation of advanced glycation endproducts and crosslinks.... | 01/08/2002 |
| 6258982 | Process for the preparation of substituted aromatic amino compounds The present invention relates to a hydrogenation process for the preparation of aromatic amino compounds containing directly on the aryl ring or in a side chain one or more entities that may also undergo hydrogenation, such as carbon multiple bonds, nitri... | 07/10/2001 |
| 6248781 | Compounds useful in the treatment of conditions mediated by peroxisome proliferator-activated receptors (PPAR) The present invention relates to compounds of formula (I) ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, Ar, X, Q, A, Y and Z are as defined in the specification. These ... | 06/19/2001 |
| 6245938 | 4-pentenoyl groups for derivatization and protection of amino acids A method of separating a racemic mixture of amino acid enantiomers, which entails reacting the mixture with a 4-pentenoyl compound, thereby derivatizing the enantiomers to form two diastereomers, and separating the diastereomers.... | 06/12/2001 |
| 6225351 | N-(aroyl) glycine hydroxamic acid derivatives and related compounds Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, AA and Y are as defined herein, inhibit phosphodiesterase type IV or inhibit the production of tumor necrosis factor, and therefore are useful in... | 05/01/2001 |
| 6172239 | Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors, their preparation and pharamaceutical compositions containing them The invention relates to compounds of the formula ##STR1## The compounds have agreat affinity for the neurotensin receptors.... | 01/09/2001 |
| 6169206 | 4-(n,n-dialkylamino)aniline compound, photographic processing composition containing the same and color image-forming method 4-(N,N-Dialkylamino)aniline compounds of the following general formula (I): ##STR1## wherein R1 represents an alkyl group, an aryl group or a heterocyclic group, R2 to R5 each represent a hydrogen atom or a substituent, an... | 01/02/2001 |
