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| Number | Title | Issue Date |
| 7432388 | Disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity Compounds of the formula where the variables have the values described in the specification are antagonists of RARγretinoid receptors. ... | 10/07/2008 |
| 7220876 | Arylcycloalkyl derivatives having branched side chains, processes for their preparation and their use as pharmaceuticals Arylcycloalkyl derivatives having branched side chains, processes for their preparation and their use as pharmaceuticals The invention relates to arylcycloalkyl derivatives having branched side chains and to their physiologically acceptable salts and physiolo... | 05/22/2007 |
| 7208520 | Crystals of hydroxynorephedrine derivative The present invention provides ethyl (−)-2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-2,5-dimethylphenoxy]acetate hydrochloride, crystalline forms thereof and pharmaceutical compositions containing them, which have excellent β3 | 04/24/2007 |
| 7144978 | Multidrop tree branching functional polyethylene glycol, methods of preparing and using same Multi-armed functional polyethylene glycol polymers with active terminal groups may be used in conjugation with small molecule pharmaceuticals, proteins and peptides to enhance half-life and bioavailability of the drug and improve solubility, stability and immunolog... | 12/05/2006 |
| 7112596 | Prenylation inhibitors and methods of their synthesis and use The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylatio... | 09/26/2006 |
| 7030160 | Propanolaminotetralines, preparation thereof and compositions containing same The invention relates to phenoxypropanolamines, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of diseases that are improved by beta-3 agonist action. ... | 04/18/2006 |
| 6916956 | Calcium receptor antagonist A compound of the formula [I] wherein R1 is optionally substituted aryl group or optionally substituted heteroaryl group; R2 is optionally substituted C1-6 alkyl group, C3-7 c... | 07/12/2005 |
| 6884821 | Carboxylic acid derivatives and drugs containing the same Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the derivatives as the active ingredient. In said formula, R1 is hydro... | 04/26/2005 |
| 6849756 | Process for making optically active α-amino ketones and selected novel optically active α-amino ketones The invention includes selected novel optically active α-amino ketones which either are themselves useful or are intermediates for the preparation of known ketomethylene pseudopeptides useful as antibiotics, antibiotic enhancers, or enzyme inhibitors. Further, the ... | 02/01/2005 |
| 6849761 | Substituted naphthoic acid derivatives useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure wherein: R1 is hydroxyl, alkoxy of 1-4 carbons or —O(CH2)nX; n is an integer of 1-13; | 02/01/2005 |
| 6706763 | O-anisamide derivatives O-anisamide compounds and their addition salts effective for the prevention and/or therapy of metabolic diseases such as hyperlipidemia and diabetes, in which peroxisome proliferator-activated receptor (PPAR) being intranuclear receptor, in particular, human PPAR pa... | 03/16/2004 |
| 6699904 | PPAR agonists PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-c... | 03/02/2004 |
| 6673794 | Substituted aminomethyl-phenyl-cyclohexane derivatives A substituted aminomethyl-phenyl-cyclohexane derivative of formula I or Ia, ##STR1## and their a diastereomer, enantiomer, or of a salt formed with a physiologically tolerated acid. Also disclosed are method for preparing the substituted aminomethyl-pheny... | 01/06/2004 |
| 6669937 | Monoclonal antibody antagonists for treating medical problems associated with d-amphetamine-like drugs The invention includes synthetic immunochemical haptens for the generation of antibodies, the antibodies, and the medical treatment applications for using the antibodies. The antibodies are designed to recognize the common molecular features of d-methamph... | 12/30/2003 |
| 6642411 | Compounds and compositions for delivering active agents Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided Methods of administration and preparation are provided as well.... | 11/04/2003 |
| 6632836 | Carbocyclic potassium channel inhibitors The present invention relates to a class of carbocyclic compounds of Formula I that are useful as potassium channel inhibitors to treat autoimmune disorders, cardiac arrhythmias, and the like. ##STR1##... | 10/14/2003 |
| 6576766 | Signal transduction inhibitors, compositions containing them This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediate by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to p... | 06/10/2003 |
| 6566550 | Substituted aromatic ethers as inhibitors of glycine transport This invention relates to a series of substituted aromatic ethers of the formula I ##STR1## wherein ring A and X and Y are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmaceutically acceptable salts... | 05/20/2003 |
| 6541654 | Process for making optically active -amino ketones and selected novel optically active -amino ketones The invention includes selected novel optically active -amino ketones which either are themselves useful or are intermediates for the preparation of known ketomethylene pseudopeptides useful as antibiotics, antibiotic enhancers, or enzyme inhibitor... | 04/01/2003 |
| 6538152 | Phenoxyacetic acid derivatives and medicinal compositions containing the same The present invention provides novel phenoxyacetic acid derivatives represented by the general formula: ##STR1## wherein R1 represents a hydroxy group, a lower alkoxy group, an aralkoxy group, an amino group, or a mono or di(lower alkyl)amino g... | 03/25/2003 |
| 6528655 | Aromatic derivatives with HIV integrase inhibitory properties A compound of formula I' ##STR1## and pharmaceutically acceptable derivatives thereof including, for example, where applicable or appropriate pharmaceutically acceptable salts thereof. Ar and Ar' are aromatic or aryl type groups. The compounds have HIV ... | 03/04/2003 |
| 6504052 | Excitatory amino acid receptor modulators Compounds of the formula (I) in which R1 is C1-10 allyl; C2-10 alkenyl; C2-10 alkynyl; phenyl-C2-10 alkyl or phenyl-C2-10 alkenyl; and salts and esters thereof, modulate metabotropic glutam... | 01/07/2003 |
| 6420561 | Amide compounds and use thereof An amide compound of the formula (I): ##STR1## wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R1, R2, R3 and R4 are H, hydroxy and the like, R | 07/16/2002 |
| 6414031 | Bisoximether derivatives, methods and intermediate products for the production thereof, and their use for combating fungicidal pests and animal pests There are disclosed bisoxime ether derivatives of the formula I ##STR1## in which the variables have the following meanings: R1 is halogen, C1 -C4 -alkyl, C1 -C4 -haloalkyl, C1 -C4 -a... | 07/02/2002 |
| 6410585 | Inhibitors of protein tyrosine phosphatase The present invention comprises small molecular weight, non-peptidic inhibitors of formulae I-VII of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM).... | 06/25/2002 |
| 6395919 | Calcilytic compounds Novel calcilytic compounds, pharmaceuticals compositions cotaining said compounds and their use as calcium receptor antagonists.... | 05/28/2002 |
| 6380249 | HIV integrase inhibitors Certain six-membered aromatic and heteroaromatic-dioxobutyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment ... | 04/30/2002 |
| 6376707 | Crystal polymorphism of aminoethylphenoxyacetic acid derivative The present invention relates to a crystalline polymorph of 2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxy-phenyl)-1-methylethyl]amino]ethyl ]phenoxy]acetic acid having strong diffraction peaks (diffraction angle: 2θ&#b1;0.1°) at 10.8, 19.1, 19.3, 19.8, 20.6 a... | 04/23/2002 |
| 6362165 | Hydroxyphenyl derivatives with HIV integrase inhibitory properties An hydroxyphenyl derivative selected from the group consisting of a compound of formula ##STR1## and when a compound of formula I comprises a carboxylic acid group pharmaceutically acceptable salts thereof and when a compound of formula I comprises a... | 03/26/2002 |
| 6353025 | Phenylaminoalkylcarboxylic acid derivatives and pharmaceutical compositions comprising the same The present invention provides novel phenylaminoalkyl-carboxylic acid derivatives represented by the general formula: ##STR1## (wherein R1 represents a hydroxy group, a lower alkoxy group, an aralkoxy group, an amino group, an alicyclic amino g... | 03/05/2002 |
| 6306911 | Substituted amino acids as neutral sphingomyelinase inhibitors This invention relates to a series of substituted amino acids of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are small molecules that bind to neutral sphingomye... | 10/23/2001 |
| 6297395 | Calixarenes and their use for sequestration of metals Disclosed are "acid-amide" calixarenes of formula (I) wherein: L is [--CH2 --] or [--O--CH2 --O--] and may be the same or different between each aryl group; R5 is H, halogen, or C1- C10 aliphatic hydr... | 10/02/2001 |
| 6288277 | Benzylamine and phenylethylamine derivatives, processes for preparing the same and their use as medicaments The present invention relates to new phenylamine derivatives, processes for preparing them and their use as pharmaceutical compositions. The phenylamines according to the invention correspond to the general formula I ##STR1##... | 09/11/2001 |
| 6265604 | (R)-3-hydroxy-3-(2-phenylethyl)-hexanoic acid derivatives The compound of the present invention (R)-3-hydroxy-3-(2-phenylethyl)-hexanoic acid ##STR1## is an intermediate in the preparation of the anti-AIDS compound, [R-(R*,R*)]-N-[3-[1-5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl -2H-pyran-3-yl]pro... | 07/24/2001 |
| 6252104 | Naphthol derivatives and process for producing the same A naphthol derivative represented by the general formula (I), [wherein Y and Y' indicate --(CONH)n --X or --COR; X is a phenyl group, a naphthyl group, an anthraquinonyl group, a benzimidazolonyl group or a carbazolyl group; R is a hydroxyl gro... | 06/26/2001 |
| 6251925 | Therapeutic biaryl derivatives The present invention relates to therapeutic biaryl derivatives of formula (I), and pharmaceutically acceptable derivatives thereof ##STR1## wherein R1 is a phenyl, naphthyl, pyridyl, thiazolyl, phenoxymethyl, or pyrimidyl group, optionally sub... | 06/26/2001 |
| 6242492 | N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid in iron chelating therapy The use of a novel mono-cationic salt of N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid (HBED) in iron chelating therapy is disclosed. In particular, the invention relates to the subcutaneous use of a mono cationic salt of HBED for treating a... | 06/05/2001 |
| 6197817 | Phenylpropionic acids and esters: compounds and methods for inducing beta-blockade for the treatment of cardiac disorders Disclosed are compounds of the formula: ##STR1## R represents hydrogen or is a C-3 to C-6 cycloalkyl or C-4 to C-10 straight or branched carbon chain alkyl-cycloalkyl or a group --B--D, where B is C-2 to C-10 straight or branched carbon chain alkyl and D ... | 03/06/2001 |
| 6172058 | Compounds with pharmaceutical properties A pharmaceutical compound of the formula ##STR1## in which R1 is C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-10 alkyl, C3-10 cyclo... | 01/09/2001 |
| 6160013 | 14-aza prostaglandins for the treatment of glaucoma and ocular hypertension 14-Aza analogs of PGF2, PGD2, and PGE2 and methods of their use in treating glaucoma and ocular hypertension are disclosed.... | 12/12/2000 |
