Class 562/449 - Halogen

Subclass of Class 562 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the acid contains halogen covalently bonded.
No. of patents: 147
Last issue date: 06/06/2006

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Number	Title	Issue Date
7056935	Rotamase enzyme activity inhibitors This invention relates to methods of using neurotrophic compounds having an affinity for FKBP-type immunophilins to stimulate or promote neuronal growth or regeneration and to prevent neuronal degeneration. ...	06/06/2006
6992207	Melphalan derivatives and their use as cancer chemotherapeutic drugs The invention refers to new alkylating di- and tripeptides based on a melphalan unit, and one or two additional amino acids or amino acid derivatives, which can be used in the treatment of carcinogenic diseases. Further, the invention refers to a pharmaceutical comp...	01/31/2006
6989402	Thyroid receptor ligands and method II New thyroid receptor ligands are provided which have general formula (I) in which: n is an integer from 0 to 4; R1 is halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; R2 and R3 are the same or dif...	01/24/2006
6849648	Phenylene alkyne matrix metalloproteinase inhibitors A compound of Formula I or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein G1, G2, and B are as defined in the application, are selective inhibi...	02/01/2005
6806365	N-alkanoylphenylalamine derivatives Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related t...	10/19/2004
6803384	Diaminopropionic acid derivatives A compound of formula Id and pharmaceutically acceptable salts and esters thereof, wherein the substituent designations are as provided in the specification. Compounds of the invention are useful for treating reperfusi...	10/12/2004
6720306	Tetrapartate prodrugs A compound of Formula I, providing tetrapartate prodrugs is provided wherein: L1 is a bifunctional linking moiety; D is a moiety that is a leaving group, or a residue of a compound to be delivere...	04/13/2004
6709679	Antineoplastic conjugates of transferin, albumin and polyethylene glycol Conjugates of transferrin, albumin and polyethylence glycol consisting of native or thiolated transferrin or albumin or of polyethylene glycol (MW between approximately 5,000 and 20,0000) with at least one HS—, HO— or H2N group and cytostatic compound...	03/23/2004
6664291	Malonamic acids and derivatives thereof as thyroid receptor ligands The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula I, which are useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac ...	12/16/2003
6610710	Phenylalanine derivatives Phenylalanine derivatives of the following formula and analogues thereof have an antagonistic activity to 댔댧 integrin and a selectivity toward 댔댡 integrin. They are used as therapeutic agents for various diseases to which ...	08/26/2003
6579987	Diaryl-enynes Provided, among other things, is a compound of Formula I: ##STR1## wherein: Ar1 and Ar2 are independently selected aryl groups, optionally substituted with up to five substituents independently selected from the group consisting of a...	06/17/2003
6469210	Process for the preparation of phenylalkanoic acid amides and intermediates therefor A process for producing a phenylalkanoic acid amide of the formula [3] ##STR1## by reacting a carboxylic acid of the formula [1] ##STR2## with a dehydrating agent to produce an oxazolinone compound of the formula [2] ##STR3## and then reacting the ox...	10/22/2002
6426364	Diaryl-enynes Provided, among other things, is a compound of Formula I: ##STR1## wherein: Ar1 and Ar2 are independently selected aryl groups, optionally substituted with up to five substituents independently selected from the group consisting of a...	07/30/2002
6395784	Benzamide ligands for the thyroid receptor New thyroid receptor ligands are provided which have the general formula ##STR1## in which: X is --O--, --S--, --CH2 --, --CO--, or --NH--; R1 is halogen, trifluoromethyl, or alkyl of 1 to 6 carbons or cycloalkyl of 3 to 7 carbons; R...	05/28/2002
6344590	Adamantanemethanol derivatives and production processes thereof An adamantanemethanol derivative of the invention is represented by the following formula (1), wherein Ra is a hydrogen atom or a hydrocarbon group; Rb is a hydrocarbon group having a carbon atom, to which carbon atom at least one hy...	02/05/2002
6339170	Method for producing optically active phenylpropionic acid derivative Optically active N-(S-2-acetylthiomethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester useful as an enkephalin inhibitory agent or ACE inhibitory agent can be produced at low cost in an industrial manner, by a method comprising subjecting optically active 2-...	01/15/2002
6331640	Diaminopropionic acid derivatives A compound of formula 1a ##STR1## which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds....	12/18/2001
6274762	Preparation of tri-iodo benzene compounds The invention provides an improved process for the preparation of a compound containing a 2,4,6-triiodinated benzene ring, said process comprising reacting a 2,4,6-unsubstituted 5-amino-benzoic acid or derivative there of with an iodine halide iodinating ...	08/14/2001
6242607	Disubstituted glutarimide method for preparing same, and use thereof The invention relates to glutarimides of formula (I): ##STR1## in which Ar represents a phenyl non substituted or substituted one or more times with one of the substituents selected from a halogen atom, a hydroxyl, a (C1 -C4)alkoxy, ...	06/05/2001
6235929	Tripeptide ଱-ketoamides A novel class of tripeptide ଱-ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally inhibiting all cysteine proteases, having the formula M	05/22/2001
6229011	N-aroylphenylalanine derivative VCAM-1 inhibitors Compounds of the formula: ##STR1## are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 ...	05/08/2001
6153591	Dipeptide caspase inhibitors and the use thereof The present invention is directed to novel dipeptides represented by the general Formula I: ##STR1## where R1 -R2 and AA are defined herein. The present invention relates to the discovery that compounds having Formula I are pote...	11/28/2000
6121491	Process for the preparation of (+/-)3-(3,4-dichlorophenyl)-2-dimethylamino-2-methylpropan-1-OL or cericlamine (INN) Process for the preparation of cericlamine which consists: i) in arylating methacrylic acid with the diazonium chloride of 3,4-dichloroaniline, to obtain (+/-)2-chloro-3-(3,4-dichlorophenyl)-2-methylpropionic acid, ii) in aminating the acid with dimethyla...	09/19/2000
6071510	Modified amino acids and compositions comprising the same for delivering active agents The present invention provides modified amino acids for delivering active agents, and particularly biologically or chemically active agents. The preferred modified amino acids of the present invention include N-acylated or sulfonated amino acids. These mo...	06/06/2000
6046235	Sulfur-containing amino acid derivatives A sulfur-containing amino acid compound having a high inhibitory activity on LTA4 hydrolase which is represented by the following formula: ##STR1## wherein R1 represents H, alkyl, optionally substituted phenyl alkyl, alkanoyl or...	04/04/2000
6034266	Gem-difluoro derivative of phenylacetamide and phenylacetic acid and their pharmaceutical uses The present invention refers to novel gem-difluoro compounds of formula: ##STR1## wherein: R1 can be hydrogen, acyl or acyl substituted; R2 is hydrogen, lower alkyl, lower alkyl substituted, nitro, halogen, methylenedioxy, trifl...	03/07/2000
6017956	N,N-disubstituted amic acid derivatives The present invention relates to a compound of the formula (I): ##STR1## wherein Ar1, Ar2, Ar3 and Ar4 represent an aryl group or a heteroaromatic ring group; A represents a hydrocarbon group which may be s...	01/25/2000
6018050	Method of preparing optically active ଱-amino acids and ଱-amino acid derivatives The invention relates to a new process for the preparation of optically active amino acids and amino acid derivatives of the general formula (I), wherein *, X and R1 to R4 have the meaning given in the description. Starting from comm...	01/25/2000
5981794	γ-oxo-homophenylalanine derivatives and process for producing homophenylalanine derivatives by reducing the same The present invention provides an economically advantageous and efficient process for producing an optically active homophenylalanine derivative of the general formula (IV), and an intermediate therefor and a process for producing it. The present inventio...	11/09/1999
5973006	Fluoro-substituted benzoylpropionic acid derivatives A fluoro-substituted benzoylpropionic acid compound of formula (I) either as a single optical isomer or as a mixture of optical isomers ##STR1## wherein R is hydroxy, amino, hydroxylamine, --OR', --NHR', N(R')2 or --NHOR' in which R' is C	10/26/1999
5919786	N,N-disubstituted amic acid derivatives The present invention relates to a compound of the formula (I): ##STR1## wherein Ar1, Ar2, Ar3 and Ar4 represent an aryl group or a heteroaromatic ring group; A represents a hydrocarbon group which may be s...	07/06/1999
5907043	Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase The present invention relates to pyrrolidine derivatives, and more particularly to the compound (S)-1-(S)-2-(4-methoxybenzamido)-3-methylbutyryl!-N-(S)-2-methyl-1-(trif luoroacetyl)propyl!pyrrolidine-2-carboxamide, shown by formula I, and solvates...	05/25/1999
5905127	Polymerizable mesophases based on substituted unsaturated carboxylic acids Mesogens are provided based on substituted unsaturated carboxylic acids such as acrylic and methacrylic acid. Substitution of a variety of hydrophobic tails onto the carboxylic acid or acid derivative via the vinyl carbon proximal to the carbonyl of the c...	05/18/1999
5871755	Dehydroalanine derivatives for protecting the skin, the mucous membranes and/or the hair from oxidative stress, cosmetic or dermatological compositions containing them The present invention relates to the use of dehydroalanine derivatives of formula (I) ##STR1## with R1 : H or linear- or branched-chain C1 C4 alkyl, ##STR2## or linear- or branched-chain C1 -C20	02/16/1999
5863947	Phenylglycine derivatives useful for treating disorders of the central nervous system A pharmaceutical compound of the formula: ##STR1## in which R1 is hydrogen, hydroxy or C1-6 alkoxy, R2 is hydrogen, carboxy, tetrazolyl, --SO2 H, --SO3 H, --OSO3 H, --CONHOH, or --P(OH...	01/26/1999
5804581	Inhibition of matrix metalloproteases by substituted phenalkyl compounds Matrix metalloprotease inhibiting compounds, pharmaceutical compositions thereof and a method of disease treatment using such compounds are presented. The compounds of the invention have the generalized formula: ##STR1## wherein T is a substituent an...	09/08/1998
5783735	Process for preparing polymeric amides useful as additives in fuels and lubricating oils A process for preparing polymeric amides is disclosed. The process comprises sequentially reacting a hydrocarbon polymer functionalized (e.g., via the Koch reaction) to contain acid, ester, thioacid and/or thioester groups with a heavy polyamine to form a...	07/21/1998
5719306	LTA₄ hydrolase inhibitors The present invention provides compounds of the formula Ar1 --Q--Ar2 --Y--R--Z and pharmaceutically acceptable salts thereof wherein Ar1 and Ar2 are optionally substituted aryl moieties, Z is an optionally subst...	02/17/1998
5703095	Use of N-arylmethylene, ethylenediaminetriacetates, N-arymethylene iminodiacetates or N,N'-diarylmethylene ethylenediamineacetates against oxidative stress N-arylmethylene ethylenediaminetriacetate, N-arylmethylene iminodiacetate or N,N'-diarylmethylene ethylenediaminediacetate type compounds and their use in combatting oxidative stress, and pharmaceutical and cosmetic compositions comprising said compounds....	12/30/1997
5643958	Substituted amide derivatives The present invention relates to a compound of the formula (I): ##STR1## wherein Ar1, Ar2 and Ar3 represent an aryl group or a heteroaromatic ring group; A represents a hydrocarbon group which may be substituted; Q re...	07/01/1997

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Class 562/449 - Halogen