Class 562/447 - Phenoxphenyl alanines

Subclass of Class 562 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the acid contains a phenoxy group attached
No. of patents: 32
Last issue date: 04/15/2008

Number	Title	Issue Date
7357835	Production of crystalline materials by using high intensity ultrasound A crystalline material sufficiently pure for use in pharmaceuticals may be made by forming a saturated solution of the material, changing the temperature of the solution so it becomes supersaturated, and subjecting the solution to irradiation by high intensity ultra...	04/15/2008
7163918	Iodothyronine compositions The present invention relates to compositions comprising thyroxine (T4) and triiodothyronine (T3). More specifically, the invention relates to thyroxine (T4) and triiodothyronine (T3) compositions that include a peptide carrier and thyroxine (T4) and triiodothyronin...	01/16/2007
7153997	Benzamide derivatives as thyroid receptor ligands This invention relates to novel compounds, which are thyroid receptor ligands, and to methods of preparing such compounds. In addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolism dysfunction or which ...	12/26/2006
7145040	Process for the preparation of amino acids useful in the preparation of peptide receptor modulators The present invention provides process useful for the preparation of intermediates which are useful in the preparation of amino acids useful in preparing peptide receptor modulators, for example agonists or partial agonists of such peptide receptors. Such peptide re...	12/05/2006
6992216	Crystallization of amino acids using ultrasonic agitation A method for reducing the particle size of amino acid crystals using ultrasound is discussed. ...	01/31/2006
6855706	Phenylalanine derivatives Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α 4 integrin. They are used as therapeutic agents for various diseases concerning α 4 integrin. ...	02/15/2005
6716877	Method to treat chronic heart failure and/or elevated cholesterol levels A method for treating a patient having congestive heart failure by administering a therapeutically effective amount of 3′,3,5-triiodothyropropionic acid (TRIPROP) or 3,5,3′,5′-tetraiodothyropropionic acid (TETRAPROP). Also described is a method to lower choles...	04/06/2004
6610710	Phenylalanine derivatives Phenylalanine derivatives of the following formula and analogues thereof have an antagonistic activity to 댔댧 integrin and a selectivity toward 댔댡 integrin. They are used as therapeutic agents for various diseases to which ...	08/26/2003
6337064	Manganese chelates with high relaxivity in serum Compounds of formula (I) both in the racemic and optically active forms, are used in MRI diagnostic imaging. ##STR1##...	01/08/2002
6229011	N-aroylphenylalanine derivative VCAM-1 inhibitors Compounds of the formula: ##STR1## are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 ...	05/08/2001
5958979	Stabilized medicaments containing thyroid hormones The present invention relates to stabilized medicaments containing thyroid hormone the stabilizing component of which is sodium thiosulfate in a mass ratio of thyroid hormone to sodium thiosulfate of 1:0.1 to 1:50 and processes for preparing such medicame...	09/28/1999
5917087	Process for producing sodium 1-thyroxine comprising the oxidative coupling of a diido-1-tyrosine catalysed by a manganese salt in the presence of an amine Improvements to a six stage process for production of sodium l-thyroxine from l-tyrosine described in U.S. Pat. No. 2,889,363 and U.S. Pat. No. 2,889,364 (Baxter)! are described, the improvements comprising the oxidative coupling of a diiodo-l-thyrosine...	06/29/1999
5668176	Phenoxyphenylacetic acid derivatives Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral...	09/16/1997
5359093	Reagents and methods for the detection and quantification of thyroxine in fluid samples Immunoassay methods and reagents for the specific quantification of thyroxine in a test sample are disclosed employing antibodies prepared with thyroxine derivatives of the formula: ##STR1## wherein P is an immunogenic carrier material and X is a lin...	10/25/1994
5288901	2-aryl-5-(trifluoromethyl)-2-pyrroline compounds useful in the manufacture of insecticidal, nematocidal and acaricidal arylpyrroles There are provided important pyrroline and glycine intermediates, methods for the preparation of said intermediates and the use thereof in the manufacture of arylpyrrole insecticidal agents....	02/22/1994
5219764	Hapten-biotin conjugates and their use Hapten-biotin conjugates in which the hapten is linked with biotin via a spacer, which has 26 to 40 atoms in its chain and contains at least 5 heteroatoms, are novel and are suitable, in particular for use in a competitive homogeneous immunoassay in which...	06/15/1993
5169984	Synthesis and characterization of N-bromoacetyl-3,3'5-triiodo-L-thyronine using high speed countercurrent chromatography A method for synthesizing N-bromoacetyl-3,3',5-triiodo-L-thyronine which involves subjecting 3,3', 5-triiodo-L-thyronine to a one-step bromacetylation reaction wherein 3,3', 5-triiodo-L-thyronine and bromoacetyl bromide are refluxed together in a solution...	12/08/1992
4820860	Novel thyronine derivatives The invention relates to novel thyronine derivatives of the formula ##STR1## in which n is 10-400, R denotes H, alkyl or N-carbonylthyronine, R1 and R2 are identical or different and denote hydrogen or iodine, and R3 ...	04/11/1989
4801742	N-formylation of amino carboxylates with alkyl formates Formylating the amino nitrogen of an alkali metal salt of an amino carboxylic acid, by reacting the salt with an alkyl formate in an alkanol solvent. In one embodiment, the alkyl formate is added to the reaction as such; in another embodiment, the alkyl f...	01/31/1989
4741897	Thyroxine analogs and reagents for thyroid hormone assays The present invention relates to new compounds of the general formula: ##STR1## where X is iodine or hydrogen; A is a linking portion; and R is an iodinatable aryl or heteroaryl group having electron donating substituents. These compounds are useful ...	05/03/1988
4675439	Preparation process of N-acylphenylalanines A process for preparing an N-acylphenylalanine represented by the formula (II): ##STR1## wherein R3 and R4 mean individually a hydrogen atom or an alkyl, alkoxy, phenoxy, hydroxy or methylenedioxy group, and R denotes a methyl ...	06/23/1987
4613691	Preparation of amino acids from unsaturated hydantoins Amino acids can be easily prepared by reducing unsaturated hydantoins to the corresponding saturated hydantoins by hydrogenating the unsaturated hydantoin using either Raney Nickel catalyst in the presence of more than a stoichiometric amount of caustic o...	09/23/1986
4612388	Process for producing N-acylphenylalanines Disclosed herein is a process for producing an N-acyl-substituted or unsubstituted phenylalanine comprising hydrolyzing a 2-substituted-4-substituted or unsubstituted benzylidene-5-oxazolone with alkali, adjusting pH of the reaction solution containing it...	09/16/1986
4540792	Process for the preparation of a free L ଱-amino acid This invention relates to a process for the preparation of free L ଱-amino acids by the complete conversion of their D antipodes taken individually or possibly in racemic mixtures. The process according to the present invention is characterized in that th...	09/10/1985
4510251	Fluorescent polarization assay for ligands using aminomethylfluorescein derivatives as tracers This disclosure relates to a method for determining ligands in biological fluids such as serum, plasma, spinal fluid, amnionic fluid and urine, wherein a novel class of aminomethylfluorescein derivative tracer compounds are employed as reagents in fluores...	04/09/1985
4452783	Derivatives of substituted phenylacetic acids and compositions containing them Aminoacid and peptide derivatives of the formula: in which A, R1, R2, x and y have the meanings specified in claim 1 for formula I, and R4 is a residue of an ଱-aminoacid which, when A is 4-allyloxy-3-chloro-phenylacetyl and x and y ...	06/05/1984
4423227	Process for the preparation of reactive, couplable derivatives of the thyroid hormones Process for the preparation of reactive, couplable derivatives of the thyroid hormones 3,3',5-triiodothyronine (T3) and 3,3',5,5'-tetraiodothyronine (T4) by reaction with reactive carboxylic acid derivatives, which process comprises ...	12/27/1983
4399121	Iodothyronine immunogens and antibodies Immunogen conjugates comprising N-aminoalkyl derivatives of iodothyronines, e.g., thyroxine and its lower alkyl esters, coupled to an immunogenic carrier material, and antibodies raised against such immunogen conjugates....	08/16/1983
4358604	N-Aminoalkyl iodothyronine derivatives N-Aminoalkyl derivatives of iodothyronines, e.g., thyroxine and its lower alkyl esters, immunogen conjugates comprising the derivatives coupled to an immunogenic carrier material, and antibodies raised against such immunogen conjugates....	11/09/1982
4311853	Selenium derivatives of thyroxine and tri-iodothyronine Novel Selenium derivatives of thyroxine and tri-iodothyronine have the formula: ##STR1## wherein M is I or H and either (a) R1 is OH or a carboxyl protecting group and R2 contains at least one Se, preferably 75 Se, at...	01/19/1982
4261919	Catalytic asymmetric hydrogenation Process for the homogeneous catalytic hydrogenation of ଲ-substituted-଱-acylamido-acrylic acids which yields, after hydrogenation, an optically active mixture. The process comprises the hydrogenation of ଲ-substituted-଱-acylamidoacry...	04/14/1981
4133753	Method of ion exchange chromatography The separation of constituents is carried out in such a way that a mixed amino acid sample is supplied to a separation column packed with a cation exchange resin and that, during the analysis of the single sample, five sorts of elutes of different composi...	01/09/1979

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Class 562/447 - Phenoxphenyl alanines