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| Number | Title | Issue Date |
| 7977506 | Compounds and compositions for delivering active agents Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well. ... | 07/12/2011 |
| 7488844 | Therapeutic agents The present invention provides a compound of formula I processes for preparing such compounds, their the utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance, methods for their therapeuti... | 02/10/2009 |
| 7432388 | Disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity Compounds of the formula where the variables have the values described in the specification are antagonists of RARγretinoid receptors. ... | 10/07/2008 |
| 7388105 | Compounds and use to reduce the formation of malodour Malodour formation reducing compounds alpha-N-(3-Methyl-5-phenylpentanoxycarbonyl)-L-glutamine, alpha-N-(2-Methyl-5-phenylpentanoxycarbonyl)-L-glutamine, and alpha-N-(2,4-Dimethyl-4-phenylbutanoxycarbonyl)-L-glutamine, and their salts, compositions comprising such c... | 06/17/2008 |
| 7342127 | Substituted anilide ligands for the thyroid receptor Novel thyroid receptor ligands are provided having the general formula I wherein X, R1, R2, R3, R4, R5, R6, R7,... | 03/11/2008 |
| 7329777 | Methods for treating heart failure, thromboembolic disorders, and pulmonary fibrosis This invention relates to methods for treating heart failure, thromboembolic disorders, and pulmonary fibrosis, comprising administering an effective amount of a compound of formula (I) in which the several varia... | 02/12/2008 |
| 7256307 | Substituted phenypropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor α(PPAR) The present invention provides the S enantiomer of a compound of formula (I); wherein R1 represents 2,4-difluorophenyl or cyclohexyl as well as pharmaceutically acceptable salts, solvates, crystalline forms and prodrugs thereof, to processes for preparing... | 08/14/2007 |
| 7220876 | Arylcycloalkyl derivatives having branched side chains, processes for their preparation and their use as pharmaceuticals Arylcycloalkyl derivatives having branched side chains, processes for their preparation and their use as pharmaceuticals The invention relates to arylcycloalkyl derivatives having branched side chains and to their physiologically acceptable salts and physiolo... | 05/22/2007 |
| 7220880 | Amide linker peroxisome proliferator activated receptor modulators The present invention is directed to compounds, compositions, and use of compounds the structural Formula (I) ... | 05/22/2007 |
| 7153997 | Benzamide derivatives as thyroid receptor ligands This invention relates to novel compounds, which are thyroid receptor ligands, and to methods of preparing such compounds. In addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolism dysfunction or which ... | 12/26/2006 |
| 7071225 | Arylaminopropane analogues and their use for the treatment of glaucoma Arylaminopropane analogues are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the prese... | 07/04/2006 |
| 7067694 | Halogen-substituted amino dicarboxylic acid derivatives as medicaments for treating cardiovascular diseases Compounds of the general formula (I) wherein R1 represents halogen, R2 and R3 represent H or halogen, and R4 represents C3-8-cycloalkyl or optionally substituted p... | 06/27/2006 |
| 7049342 | Substituted phenylpropionic acid derivatives The invention provides novel substituted phenylpropionic acid derivatives that bind to the receptor as ligands of human peroxisome proliferator-activated receptor α (PPARα) to activate and exhibit potent lipid-decreasing action, and processes for preparing them. | 05/23/2006 |
| 6979566 | Method of treatment of viral infection including HIV using water soluble fullerenes—III A water soluble derivative of buckministerfullerene (C50) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containi... | 12/27/2005 |
| 6939990 | Derivatives of dicarboxylic acid having pharmaceutical properties The invention relates to compounds of the general formula (I) wherein R1 represents H, halogen, or OCF3; R2 and R3 each represents H or halogen; R4 represents C | 09/06/2005 |
| 6939989 | Side-chain halogenated amino dicarboxylic acid derivatives as medicaments for treating cardiovascular diseases Compounds of the general formula (I) wherein R1 represents halogen, R2 represent H or halogen, and R3 represents C3-8-cycloalkyl, C3-8-cycloalkenyl, or optionally ... | 09/06/2005 |
| 6890955 | Aryloxypropanolamine derivatives, method of preparation and applications thereof The invention concerns aryloxypropanolamine derivatives having at least an anti-diabetic and anti-fat activity and their methods of preparation and applications, particularly as human and veterinary medicine and animal food additive. These derivatives comply with th... | 05/10/2005 |
| 6809207 | Amino acid derivatives The present invention provides certain alpha-amino acids and derivatives thereof, such as, but not limited to, esters, amides and salts. These derivatives may comprise such representative side groups as a phenyl, pyridyl, piperidinyl, tetrahydropyranyl, tetrahydroth... | 10/26/2004 |
| 6780998 | Substituted 2-aminoalkyl-1,4-diaminobenzene compounds and oxidation dye precursor compositions containing same The oxidation hair dye precursor composition contains from 0.005 to 20.0 percent by weight of one or more coupler compounds and from 0.005 to 20.0 percent by weight of one or more developer compounds. The one or more developer compounds include at least one substitu... | 08/24/2004 |
| 6777418 | Retinoid compounds (I) The current invention provide novel retinoid compounds and methods for their synthesis, methods of treating or preventing emphysema, cancer and dermatological disorders and pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and... | 08/17/2004 |
| 6750312 | Process for the preparation of supports for solid phase synthesis A method for preparing a solid support material for carrying out a chemical reaction, said method comprising the following steps: (i) reacting an amino functionalised solid material with a carboxylic acid having at least two similarly protected amino groups t... | 06/15/2004 |
| 6706763 | O-anisamide derivatives O-anisamide compounds and their addition salts effective for the prevention and/or therapy of metabolic diseases such as hyperlipidemia and diabetes, in which peroxisome proliferator-activated receptor (PPAR) being intranuclear receptor, in particular, human PPAR pa... | 03/16/2004 |
| 6677360 | Biphenyl and biphenyl-analogous compounds as integrin antagonists The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the treatment and prophyl... | 01/13/2004 |
| 6656737 | Isocynate derivatizing agent and methods of production and use An organic compound useful for detecting the total quantity of isocyanate in an environmental sample is provided. The compound is 9-anthrcenylmethyl-1-piperazinecarboxylate (PAC), an isocyanate derivatizing agent. A process for producing PAC and methods f... | 12/02/2003 |
| 6627767 | Amino(oxo) acetic acid protein tyrosine phosphatase inhibitors ##STR1## or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.... | 09/30/2003 |
| 6528685 | Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives Novel derivatives of 1-aminoindan and their salts are described. Optically active 1-aminoindan derivatives are prepared by reacting a N-benzyl analog of the desired compound with an enantiomer of mandelic acid. Parkinson's disease, dementia, epilepsy, con... | 03/04/2003 |
| 6506797 | Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor (PPAR) The invention provides novel substituted phenylpropanoic acid derivatives that activate by binding to receptor as ligands of human peroxisome preliferant-activated receptor (PPAR), and exhibit potent decreasing action on lipids in blood (ch... | 01/14/2003 |
| 6504052 | Excitatory amino acid receptor modulators Compounds of the formula (I) in which R1 is C1-10 allyl; C2-10 alkenyl; C2-10 alkynyl; phenyl-C2-10 alkyl or phenyl-C2-10 alkenyl; and salts and esters thereof, modulate metabotropic glutam... | 01/07/2003 |
| 6495522 | Substituted alpha-hydroxy acid caspase inhibitors and the use thereof The present invention is directed to novel substituted -hydroxy acid thereof, represented by the general Formula I: ##STR1## where R1 -R5, X and Z are defined herein. The present invention also relates to the discovery that co... | 12/17/2002 |
| 6448254 | Substituted amides, their production and their use Amides of the general formula I ##STR1## and their tautomeric and isomeric forms, possible enantiomeric and diastereomeric forms, as well as possible physiologically tolerable salts, in which the variables have the following meanings: R1 [sic] can be C | 09/10/2002 |
| 6414180 | Synthesis of chiral ଲ-amino acids The invention herein is directed to a process for the preparation of chiral ଲ-amino acids and esters of the formula ##STR1## wherein X and Y are the same or different halo groups, R2 is H or lower alkyl and isomers and pharmaceutically ac... | 07/02/2002 |
| 6410585 | Inhibitors of protein tyrosine phosphatase The present invention comprises small molecular weight, non-peptidic inhibitors of formulae I-VII of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM).... | 06/25/2002 |
| 6399660 | Aminoethylphenoxyacetic acid derivatives and drugs for pain remission and calculi removal promotion in urinary lithiasis Novel aminoethylphenoxyacetic acid derivatives represented by the general formula: ##STR1## (wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group; R2 represents a hydrogen atom or a halogen atom; the ca... | 06/04/2002 |
| 6395930 | Quenching reagents for solution phase synthesis A method for enhancing the purity of a desired compound comprising: Step (a) treating a crude reaction product which contains at least one desired compound, unreacted starting materials and/or byproducts with at least one bifunctional quenching agent that is c... | 05/28/2002 |
| 6384236 | N-(aroyl)glycine hydroxamic acid derivatives and related compounds Compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof, wherein R1, R2, AA and Y are as defined herein, inhibit phosphodiesterase type IV or inhibit the production of tumor necrosis factor, and therefore are ... | 05/07/2002 |
| 6376707 | Crystal polymorphism of aminoethylphenoxyacetic acid derivative The present invention relates to a crystalline polymorph of 2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxy-phenyl)-1-methylethyl]amino]ethyl ]phenoxy]acetic acid having strong diffraction peaks (diffraction angle: 2θ&#b1;0.1°) at 10.8, 19.1, 19.3, 19.8, 20.6 a... | 04/23/2002 |
| 6310074 | Substituted dimeric compounds The invention relates to compound of formula (I): A--G1 --Cy--G2 --Cy'--G3 --B (I) wherein: A represents a grouping NR1 C(Q)R2, C(Q)NR2 R3 or NR1 C(Q)NR2 R3 | 10/30/2001 |
| 6306911 | Substituted amino acids as neutral sphingomyelinase inhibitors This invention relates to a series of substituted amino acids of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are small molecules that bind to neutral sphingomye... | 10/23/2001 |
| 6245938 | 4-pentenoyl groups for derivatization and protection of amino acids A method of separating a racemic mixture of amino acid enantiomers, which entails reacting the mixture with a 4-pentenoyl compound, thereby derivatizing the enantiomers to form two diastereomers, and separating the diastereomers.... | 06/12/2001 |
| 6225351 | N-(aroyl) glycine hydroxamic acid derivatives and related compounds Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, AA and Y are as defined herein, inhibit phosphodiesterase type IV or inhibit the production of tumor necrosis factor, and therefore are useful in... | 05/01/2001 |
