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| Number | Title | Issue Date |
| 7626054 | Biaromatic compounds which activate PPARγ-type receptors and cosmetic/pharmaceutical compositions comprised thereof Novel biaromatic compounds having the following structural formula (I): are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine, in particular in dermatology as well as in t... | 12/01/2009 |
| 7408079 | Imaging agents and methods of imaging NAALADase or PSMA The present invention relates to compounds particularly asymmetric urea compounds which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express NAALADase and/or PSMA. In anoth... | 08/05/2008 |
| 7405239 | Acylhydrazone derivatives and the use thereof in the inhibition, regulation and/or modulation of kinase signal transduction The invention relates to acylhydrazone derivatives of formula (I), which are SGK inhibitors and can be used for the treatment of diseases and afflictions associated with SGK, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systematic and pulmonary hyp... | 07/29/2008 |
| 7351857 | Methods of using substituted tetralins and indanes The invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, diabetes. ... | 04/01/2008 |
| 7312361 | Inhibitors of transthyretin amyloid fibril formation Bisaryloxime ethers and bisarylhydroazones are shown to be effective for inhibiting formation of amyloid fibrils of transthyretin. ... | 12/25/2007 |
| 7265136 | Substituted stilbene compounds with vascular damaging activity A compound for use in inducing necrosis in vascular tissue of a tumor in an animal. The compound contains a first moiety which is a cis-stilbene moiety and a second moiety which is an inhibitor of the formation or action of nitric acid. Also, a method for inducing n... | 09/04/2007 |
| 7252710 | Pigment dispersion composition, use thereof and compound for pigment treatment A pigment dispersion composition which can be suitably applied in such fields as color filters, black matrices and ink jet recording where it is necessary to finely disperse pigments still with retention of good dispersion stability and temporal stability even when ... | 08/07/2007 |
| 7223796 | Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use The invention relates to acyl-4-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives. The invention particularly relates to compounds of formula I, | 05/29/2007 |
| 7220307 | Treated pigment, use thereof, and compound for pigment treatment A treated pigment and a dispersion composition thereof having preferable dispersion stability and fluidity in a dispersion medium even the pigment has no functional group reactive with a carbodiimide group on the surface thereof, and further to provide a resist comp... | 05/22/2007 |
| 7220306 | Treated pigment, use thereof, and compound for treating pigment The present invention provides a treated pigment produced by treating at least one pigment selected from the group consisting of organic pigments and carbon black each having a functional group reactive with a carbodiimide group with a carbodiimide compound h... | 05/22/2007 |
| 7214677 | Benzamide, heteroarylamide and reverse amides The present invention relates to novel to P2X7 inhibitors of formula I and to processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them, an... | 05/08/2007 |
| 7199265 | Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones This invention relates to compounds of the formula (I) which are thyroid receptor ligands, and are preferably selective for the thyroid hormone receptor β, to methods of preparing such compounds and to methods for using such compounds such as in the regulation of m... | 04/03/2007 |
| 7119098 | Heteroarylakanoic acids as intergrin receptor antagonists The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of Formula (I), and methods of selectively antagonizing the ανβ3 and/or the... | 10/10/2006 |
| 7094911 | Biphenyl and biphenyl-analogous compounds as integrin antagonists The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the treatment and prophylaxis of can... | 08/22/2006 |
| 7078404 | Acyl-3-carboxyphenylurea derivatives, processes for preparing them and their use The invention relates to acyl-3-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives. The invention relates to compounds of formula I, in wh... | 07/18/2006 |
| 7071212 | N-(4-carbamimidoyl-phenyl)-glycine derivatives The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula: wherein R1, E, X1 to X4 and G1 and G2 are as defined in ... | 07/04/2006 |
| 7049001 | Carbodiimides with carboxyl or carboxylate groups Compounds with carbodiimide units and carboxyl or carboxylate groups (compounds V), derived from a) aliphatic or araliphatic C4 to C20 polyisocyanates (component a) b) hydroxy carboxylic acids or hydroxy carboxylic sal... | 05/23/2006 |
| 7049341 | N-benzoylureidocinnamic acid derivatives, processes for preparing them and their use N-Benzoylureidocinnamic acid derivatives, processes for preparing them and their use The invention relates to N-benzoylureidocinnamic acid derivatives and to their physiologically tolerated salts and physiologically functional derivatives. The invention thus ... | 05/23/2006 |
| 7030133 | Inhibitors of formation of advanced glycation endproducts (AGEs) The nonenzymatic glycation and crosslinking of proteins is a part of the aging process with the glycation endproducts and crosslinking of long-lived proteins increasing with age. This process is increased at elevated concentrations of reducing sugars in the blood an... | 04/18/2006 |
| 6984661 | Urea linker derivatives for use as PPAR modulators The present invention is directed to compounds of the structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof: Formula I (a) R1, R2 and R6 are each independently selected from the group consisting of hydrogen, C1-C | 01/10/2006 |
| 6962905 | Pharmaceutical formulation comprising a low molecular weight thrombin inhibitor and its prodrug A kit of parts containing (a) a pharmaceutical formulation including a low molecular weight thrombin inhibitor, or a pharmaceutically acceptable derivative thereof, in admixture with a pharmaceutically acceptable adjuvant, diluent or carrier, and (b) a pharmaceutica... | 11/08/2005 |
| 6933304 | Heteroarylalkanoic acids as integrin receptor antagonists The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of select... | 08/23/2005 |
| 6927219 | N-alkyl-adamantyl triazinyl benzamide derivatives The present invention relates to novel to N-alkyl adamantyl triazinyl benzylamide derivatives of formmula I: and to processs for their preparation, intermediates useful in their preparation, pharmaceutical compositions... | 08/09/2005 |
| 6916837 | Amidino derivatives and anticoagulants and thrombosis therapeutic agents containing them Amidino derivatives represented by the following general formula (I): {where X is a group represented by R1SO2NR2— (wherein R1 represents optionally substituted C6-14 ... | 07/12/2005 |
| 6875760 | Glucagon antagonists/inverse agonists A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any glucagon-mediated co... | 04/05/2005 |
| 6844466 | Alkyl urea retinoid agonists The current invention provide novel compounds, methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders and methods for de... | 01/18/2005 |
| 6838472 | Substituted urea retinoid agonists The current invention provide novel compounds, methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders and methods for de... | 01/04/2005 |
| 6821960 | Glucagon antagonists/inverse agonists A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorde... | 11/23/2004 |
| 6787566 | Breakers of advanced glycation endproducts Advanced glycation endproducts (AGEs) have been implicated in the pathogenesis of a variety of debilitating diseases such as diabetes, atherosclerosis, Alzheimer's and rheumatoid arthritis, as well as in the normal aging process. Seven compounds are here reported to... | 09/07/2004 |
| 6734212 | Methods and compositions for treating or preventing bacterial infection The invention relates to compositions and methods for treating or preventing disease or disorders caused by or associated with certain bacterial infection, especially Escherichia coli (E. coli) or Helicobacter pylori (H. pylori) infection... | 05/11/2004 |
| 6730807 | Carbodiimides with carboxyl or carboxylate groups Compounds containing carbodiimide units and carboxyl or carboxylate groups (compounds V), derived from a) aliphatic or araliphatic C4 to C20 polyisocyanates (component a) b) amino carboxylic acids or amino carboxylic salts (compon... | 05/04/2004 |
| 6706744 | Glucagon antagonists/inverse agonists Novel compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases and disorders, wherein... | 03/16/2004 |
| 6649613 | Diacylhydrazine derivatives Diacylhydrazine derivatives of general formula (I) ##STR1## wherein X, Y, Z, R1, 2 and R3 are as defined herein, and their physiologically acceptable salts or solvates thereof, are integrin inhibitors and can be used to co... | 11/18/2003 |
| 6627769 | RGD-analog non-peptidic molecules having anti-adhesive, anti-migration and anti-proliferative effects Novel molecules without intramolecular peptidic bonds, able to mimic the RGD peptide, containing ARG-GLY-ASP motif "arginine-glycine-aspartic acid" (that is a potent inhibitor, in vivo and in vitro, of cellular adhesion) In vitro experimentation demonstra... | 09/30/2003 |
| 6610689 | HIV protease inhibitors based on amino acid derivatives A compound selected from the group consisting of a compound of formula I ##STR1## a compound of formula II ##STR2## and when the compound of formula I and II comprises an amino group pharmaceutically acceptable ammonium salts thereof, wherein R1 | 08/26/2003 |
| 6605642 | Inhibitors of formation of advanced glycation endproducts (AGES) The nonenzymatic glycation and crosslinking of proteins is a part of the aging process with the glycation endproducts and crosslinking of long-lived proteins increasing with age. This process is increased at elevated concentrations of reducing sugars in t... | 08/12/2003 |
| 6593315 | Salicylic acid derivatives, processes for their preparation, compositions comprising them, and their use Salicylic acid derivatives of the formula I, ##STR1## where the index and the substituents have the following meanings: X is halogen, NO2, cyano, alkyl or alkoxy; m is 0, 1, 2 or 3, it being possible for the substituents X to be different from each ... | 07/15/2003 |
| 6562807 | Glucagon antagonists/inverse agonists A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases ... | 05/13/2003 |
| 6552079 | Integrin antagonists Novel compounds, their salts and compositions related thereto having activity against mammalian integrins are disclosed. The compounds are useful in vitro or in vivo for preventing or treating thrombotic or restenotic disorders.... | 04/22/2003 |
| 6545170 | 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors The present invention contains novel compounds useful as nitric oxide synthase inhibitors.... | 04/08/2003 |
