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| Number | Title | Issue Date |
| 7427689 | ErbB-2 selective small molecule kinase inhibitors A novel method for erbB-2 kinase inhibition by compounds identifies through computational modeling and data processing and/or rational and de novo drug design is provided the compounds bind erbB-2 kinase molecules and which can be used as erbB-2 kinase agonists or a... | 09/23/2008 |
| 7351339 | Method for the separation of acids from chemical reaction mixtures by means of ionic fluids A process for removing acids from reaction mixtures using an auxiliary base, in which the auxiliary base: combines with the acid to form a salt which is liquid at temperatures at which the product of value does not significantly decompose during the removal of the l... | 04/01/2008 |
| 7294740 | Process for the synthesis of N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids The invention claimed herein provides a process to oxidize N-(5-alkoxy-2-methyl-4-nitrophenyl)acetamides to N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids using potassium permanganate in the presence of magnesium sulfate in aqueous sulfolane or aqueous pyridine. ... | 11/13/2007 |
| 7138538 | Process for the separation of enantiomers and enantiopure reagent Process for the separation of enantiomers comprising at least one free functional group, in which process a reagent based on an enantiopure amino acid is reacted in basic medium with a mixture comprising enantiomers. ... | 11/21/2006 |
| 7094923 | Method for producing substituted nitro benzoic acids by oxidation of corresponding nitro toluenes, nitro benzyl alcohols, esters and/or ethers The present invention relates to the preparation of nitrobenzoic acids by oxidizing particular nitrotoluenes, nitrobenzyl alcohols, esters and/or ethers in the presence of nitric acid at elevated temperature and elevated pressure. It has been found that the particul... | 08/22/2006 |
| 7074536 | Alkylenebisnaphtol derivative and charge control agent which consists of the same The present invention provides an alkylenebisnaphthol derivative represented by formula [I]: and a salt thereof. The compound of the present invention has an excellent triboelectric charge property and useful as ... | 07/11/2006 |
| 7056903 | Carboxylic acid derivatives as IP antagonists This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein: R1, R2, and R3 ... | 06/06/2006 |
| 7049308 | C-nitroso compounds and use thereof A C-nitroso compound having a molecular weight ranging from 225 to 1,000 (from 225 to 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation of a carbon acid having a pKa less th... | 05/23/2006 |
| 7012151 | Method for nitrating aniline derivatives The present invention relates to a process for the highly regioselective aromatic nitration of alkyl 4-alkanoylamino-3-alkyl-benzoates in the 5-position in a mixture containing nitric acid and the use of the resulting products for preparing, in particular, pharmaceu... | 03/14/2006 |
| 6906231 | Aromatic nitration reactions A process for the nitration of an aromatic compound, wherein the aromatic compound is admixed with a nitrating agent in the presence of an ionic liquid is described. The method for the nitration of aromatic compounds in (e.g. neutral) ionic liquids has advantages ov... | 06/14/2005 |
| 6900349 | Method for producing substituted nitro benzoic acids by oxidation of corresponding nitro toluenes, nitrol benzyl alcohols, esters and/or ethers The present invention relates to the preparation of nitrobenzoic acids by oxidizing particular nitrotoluenes, nitrobenzyl alcohols, esters and/or ethers in the presence of nitric acid at elevated temperature and elevated pressure. It has been found that the particul... | 05/31/2005 |
| 6884907 | Hydroxamic acids and acyl hydroxamines as naaladase inhibitors This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neurona... | 04/26/2005 |
| 6855842 | Intermediates for making a bezofuran or benzothiophene derivative nitrated in position 5 and uses thereof The invention concerns novel nitroaromatic compounds of general formula (I′) wherein: R, R′1, R2, Z and n are as defined in claim 1. The invention also concerns a method for preparing nitroaromatic compounds nitrated in position 4. The invention further c... | 02/15/2005 |
| 6780995 | Activated iododerivatives for the treatment of cancer and aids A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thiol trapping group and an activating group. The presumptive mechanism of action in preventing cancer... | 08/24/2004 |
| 6780849 | Lipid-based nitric oxide donors Novel nitric-oxide releasing lipid molecules are provided which comprise a lipid molecule selected from (a) phosphoglycerides, (b) lipids having a sphingosine base as a backbone, (c) monoacylglyerols, (d) diacylglycerols, (e) glycosylacylglycerols, wherein the lipid... | 08/24/2004 |
| 6743373 | Process for the separation of enantiomers and enantiopure reagent Process for the separation of enantiomers comprising at least one free functional group, in which process a reagent based on an enantiopure amino acid is reacted in basic medium with a mixture comprising enantiometers. ... | 06/01/2004 |
| 6562807 | Glucagon antagonists/inverse agonists A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases ... | 05/13/2003 |
| 6511988 | Activated iododerivatives for the treatment of cancer and aids A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thiol trapping group and an activating group. The presumptive mechanism of action in preven... | 01/28/2003 |
| 6452044 | Benzenedicarboxylic acid derivatives New benzenedicarboxylic acid derivative compounds; pharmaceutical compositions, diagnostic methods, and diagnstic kits that include those compounds; and methods of using those compounds for inhibiting NAALADase enzyme activity, detecting diseases where NA... | 09/17/2002 |
| 6403638 | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors Compounds having the formulas below, where R is H, lower alkyl, or a pharmaceutically acceptable salt, and where R1 represents i-propyl, t-butyl or n-butyl groups, have selective RXR retionoid agonist activity. ##STR1##... | 06/11/2002 |
| 6344484 | Tyrosine alkoxyguanidines as integrin inhibitors The present invention relates to novel tyrosine alkoxyguanidine compounds that are inhibitors of alpha V (v) integrins, for example v댣 and v댥 integrins, their pharmaceutically acceptable salts, and pharmaceutical composi... | 02/05/2002 |
| 6329547 | Vinylbenzene derivatives The present invention provides compounds represented by the following general formula [I] and salts thereof, which are useful as therapeutic agents for glaucoma, ##STR1## wherein R1 is H, lower alkyl or phenyl, and the phenyl can be substi... | 12/11/2001 |
| 6326403 | Diacylhydrazine derivatives as integrin inhibitors Compounds of the formula I ##STR1## wherein X, Y, Z, R1 and R2 are as defined in claim 1, and their salts and solvates, can be used as integrin inhibitors in particular for the prophylaxis and treatment of circulatory disorders, for ... | 12/04/2001 |
| 6306871 | Activated iododerivatives for the treatment of cancer and AIDS A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thiol trapping group and an activating group. The presumptive mechanism of action in preven... | 10/23/2001 |
| 6284914 | Highly water-soluble metalloproteinase inhibitors New compounds of general formulae (III), (IV) and (V). ##STR1##... | 09/04/2001 |
| 6271416 | Quinolinone derivative, method for preparing the same, and anti-allergic agent The present invention relates to a simple method for preparing a quinolinone derivative, which is effective as a medicine, e.g., as an agent for treating allergic diseases and the like; novel amide derivatives effective as an intermediate in the method, n... | 08/07/2001 |
| 6177463 | Oxime derivatives and their use as pesticides The invention relates to new oxime derivatives, to a plurality of processes for their preparation, and to their use as pesticides.... | 01/23/2001 |
| 6162943 | Method for producing -alkoxy--trifluoromethyl-aryl acetic esters and -aryl acetic acids Process for the preparation of -alkoxy--trifluoromethyl-arylacetic esters of the formula (I) ##STR1## wherein R is a component selected from the group consisting of C1 -C6 -alkyl, C2 -C6 ... | 12/19/2000 |
| 6147224 | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors Compounds of Formula 1, Formula 2 or Formula 3 where X is O, S, or (CR1 R1)n where n is 0, 1 or 2; Y is a bivalent radical having Formula 4 or Formula 5 where o is an integer from 1 to 4 ##STR1## or Y is a bivalent ar... | 11/14/2000 |
| 6054609 | Method of separating isomers of nitrotoluic acid A method of separating 3-nitro-o-toluic acid and 5-nitro-o-toluic acid from a mixture of said isomers, comprising producing salts by adding an aromatic organic base, for example, aniline or pyridine, to the said mixture, separating said salts into solids ... | 04/25/2000 |
| 6048896 | 4-phenyl-4-oxo-2-butenoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity 4-Phenyl-4-oxo-butenoic acid derivatives for use in the treatment of the human or animal body by therapy; particularly as kynurenine-3-hydroxylase inhibitors, in the prevention and/or treatment of a neurodegenerative disease wherein the inhibition of such... | 04/11/2000 |
| 6028219 | Process for the nitration of diphenylethers A process for the preparation of a compound of general formula I: ##STR1## wherein: R1 is hydrogen or C1 -C6 alkyl, C2 -C6 alkenyl or C2 -C6 alkynyl, any of which may optionally ... | 02/22/2000 |
| 5998661 | Preparations of organic nitro compounds through mixed oxidizing agents A process for selective, direct oxidation of amine or amine hydrochloride mpounds is described. It uses mixed oxidizing agents of monopersulfate and ozone.... | 12/07/1999 |
| 5990165 | Pharmaceutical compounds A pharmaceutical compound of the formula: ##STR1## in which n is 1 or 2, R1 is --CO2 H, R2 is hydrogen or C1-4 alkyl and R3 is hydrogen, C1-10 alkyl, C2-10 alkenyl, optionally ... | 11/23/1999 |
| 5955505 | Glutamic acid receptor agonist A method comprising administering a sulfonamide derivative to a patient requiring activation of glutamate receptors, the sulfonamide derivative represented by the formula ##STR1## wherein A is a napthyl group, a pyridyl group, a phenyl group, a pheny... | 09/21/1999 |
| 5952531 | Nitration process A process for the nitration of an aromatic or heteroaromatic compound with a nitrating agent comprising nitric acid or a mixture of nitric and sulphuric acids, characterised in that nitration is performed in a solvent comprising at least 50% v/v of a C | 09/14/1999 |
| 5932616 | Potent inducers of terminal differentiation and methods of use thereof The present invention provides the compound having the structure: ##STR1## wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each is a substi... | 08/03/1999 |
| 5932763 | Inhibition of matrix metalloproteases by 2-(ω-arolalkyl)-4-biaryl-4-oxobutyric acids The present invention provides pharmaceutical compositions and methods for treating certain conditions comprising administering an amount of a compound or composition of the invention which is effective to inhibit the activity of at least one matrix metal... | 08/03/1999 |
| 5929117 | Immunotherapeutic agents Cyano and carboxy derivatives of substituted styrenes are inhibitors of tumor necrosis factor , nuclear factor .kappa.B, and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory con... | 07/27/1999 |
| 5869734 | Preparation of optically active (S)-(-) and (R)-(+)-deoxyspergualin and novel intermediates thereof A process for preparing optically active (S)-(-) and (R)-(+)-deoxyspergualin and salts thereof of the formula I ##STR1## by reacting a compound of formula II ##STR2## with a compound of formula III ##STR3## in the presence of a condens... | 02/09/1999 |
