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| Number | Title | Issue Date |
| 7429677 | Small molecule entry inhibitors The present invention concerns a compound having the formula (I) a N-oxide form, a stereochemical isomer, racemic mixture, salt, prodrug, ester or metabolite thereof. It further relates to processes for their preparation as... | 09/30/2008 |
| 7355069 | Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance The present invention provides a compound of formula (I), wherein n is 0, 1 or 2 and R1 represents halo, a C1-4alkyl group which is optionally substituted by one or more fluoro, a C1-4alkoxy group which is optionally substituted by o... | 04/08/2008 |
| 7317124 | Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates Pentafluorosulfanyl-benzenes according to Formula (I): a process for their preparation and their use as valuable synthetic intermediates for preparing, for example, medicaments, diagnostic aids, liquid crystals, ... | 01/08/2008 |
| 7282590 | Drug conjugates A compound having the formula Y-A-Z, wherein: A is a 5, 6, or 7 member ring that is monocyclic or is fused to 1 to 3 additional 4 to 8 member rings; wherein ring A and, independently, the fused additional rings are carbocyclic or h... | 10/16/2007 |
| 7232821 | (2-((2-alkoxy)-phenyl) -cyclopent-1enyl) aromatic carbo and heterocyclic acid and derivatives Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, R1, R2, Rx, R8, R9 and n are as defined in the specification, a proc... | 06/19/2007 |
| RE39682 | Farnesyl derivatives and pharmaceutical compositions containing them Novel farnesyl derivatives which are inhibitors of the prenylated protein methyltransferase enzyme, and useful as anti-cancer drugs, have the following formula: wherein R1represents f... | 06/05/2007 |
| 7138543 | Thiolalkyl benzoic acid derivatives The present invention relates to new thiolalkyl benzoic acids, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are alte... | 11/21/2006 |
| 7064229 | Succinic acid derivatives The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of inflammatory diseases ... | 06/20/2006 |
| 6992215 | Thiol-based NAALADase inhibitors This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neurona... | 01/31/2006 |
| 6946474 | Nitrogen-containing compounds and their use as glycine transport inhibitors The present invention provides trichloroethyl-sulfonylurea-containing compounds that inhibit glycing transporters, pharmaceutical compositions comprising such compounds, methods for using such compounds for inhibiting glycine transporters and methods for using such ... | 09/20/2005 |
| 6812364 | Thiol-based NAALADase inhibitors This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neurona... | 11/02/2004 |
| 6777575 | Process for the preparation of 2-alkylthio benzoic acid derivatives A process for preparing a compound of the formula comprising reacting a compound of the formula wherein R3 is nitro or halo, or a salt thereof, with a compound of ... | 08/17/2004 |
| 6768022 | Method for producing thiosalicylic acid The present invention relates to a method for causing sodium sulfide or a mixture of sodium sulfide and sulfur to react with diazonium salt formed by diazotizing anthranilic acid, wherein the Na/S atomic ratio as calculated on the basis of the employed sodium sulfid... | 07/27/2004 |
| 6649656 | Anthranilic acid derivatives The present invention relates to an anthranilic acid derivative expressed by the following formula (1) or the following formula (2), or its pharmacologically permissible salt or solvate. ##STR1##... | 11/18/2003 |
| 6610747 | Phenoxybenzylamine derivatives as SSRIs A compound of general formula (I) wherein R1 and R2 are H, C1 -C6 alkyl or (CH2)d (C3 -C6 cycloalkyl) wherein d=0, 1, 2 or 3; or R1 and R2 together wi... | 08/26/2003 |
| 6596752 | Inhibitors of 댔댡 mediated cell adhesion The present invention relates to small molecules according to the formula [I]: ##STR1## which are potent inhibitors of 댔ଲ.sub.1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing | 07/22/2003 |
| 6586623 | Thiol-based NAALADase inhibitors This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effect... | 07/01/2003 |
| 6562807 | Glucagon antagonists/inverse agonists A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases ... | 05/13/2003 |
| 6515170 | Enzymatic oxidative deamination process The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.... | 02/04/2003 |
| 6498265 | 3-amino-2-mercaptobenzoic acid derivatives and processes for their preparation Compounds of the formula I ##STR1## and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III ##STR2## In the compounds of the f... | 12/24/2002 |
| 6482849 | Inhibitors of 댔댡 mediated cell adhesion The present invention relates to small molecules according to the formula [I]: ##STR1## which are potent inhibitors of 댔ଲ.sub.1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing | 11/19/2002 |
| 6452044 | Benzenedicarboxylic acid derivatives New benzenedicarboxylic acid derivative compounds; pharmaceutical compositions, diagnostic methods, and diagnstic kits that include those compounds; and methods of using those compounds for inhibiting NAALADase enzyme activity, detecting diseases where NA... | 09/17/2002 |
| 6420603 | Process for the preparation of n,n'-bis[2,3-dihydroxypropyl]-5-[(hydroxyacetyl) methylamino]-2, 4,6-triiodo-1, 3-benzenedi carboxamide A novel process for the preparation of N,N'-bis[2,3-dihydroxypropyl]-5-[(hydroxyacetyl) methylamino]-2,4,6-triiodo-1, 3-benzenedi carboxamide of formula (I), commonly known as lomeprol, a novel non-ionic contrast agent which shows very good safety an... | 07/16/2002 |
| 6420561 | Amide compounds and use thereof An amide compound of the formula (I): ##STR1## wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R1, R2, R3 and R4 are H, hydroxy and the like, R | 07/16/2002 |
| 6395930 | Quenching reagents for solution phase synthesis A method for enhancing the purity of a desired compound comprising: Step (a) treating a crude reaction product which contains at least one desired compound, unreacted starting materials and/or byproducts with at least one bifunctional quenching agent that is c... | 05/28/2002 |
| 6303612 | Derivatives of hydroxyphenylsulfanylbenzoic and hydroxphenylsulfanylarylacetic acids Processes for the preparation of derivatives of hydroxyphenylsulfanylbenzoic and hydroxyphenylsulfanylarylacetic acids of Formula (I) and pharmaceutical compositions including these compounds are provided: ##STR1## wherein X is H, halogen or NO2... | 10/16/2001 |
| 6262293 | ω-Cycloalkly-prostaglandin e2 derivatives ω-Cycloalkyl-prostaglandin E2 derivatives of formula (I) ##STR1## (wherein all symbols are as defined in the description); and non-toxic salts thereof, prodrugs thereof and cyclodextrin clathrates thereof. Compounds of formula (I) strongly bind on ... | 07/17/2001 |
| 6207837 | Process for producing dibenzo[b,f]thiepine derivatives Efficient synthesis of diaryl sulfide derivatives useful as intermediates for pharmaceutical compounds. Provision of a convenient process for producing large quantities of dibenzo[b,f]thiepine derivatives using such intermediates. Halogen-substituted phen... | 03/27/2001 |
| 6140528 | Intermediates to herbicidal isoxazole and 2-cyano-1,3-dione compounds The invention relates to intermediates to herbicidal compounds of formulae (Ia), (Ib) or (Ic): ##STR1##... | 10/31/2000 |
| 6127392 | Anthranilic acid analogs Compounds of the formula: wherein: R1, R2, R3, R4,R5, R6, R7 and R8 are, independently, hydrogen, COOR15, halogen, nitro, cyano, C1-10 alkoxy, C1... | 10/03/2000 |
| 6015911 | Process for preparing 1-alkyl-4-(2-chloro-3-alkoxy-4-alkylsulfonylbenzoyl)-5-hydroxypyrazole and related compounds Herbicidal 1-alkyl-4-(2-chloro-3-alkoxy-4-alkylsulfonylbenzoyl)-5-hydroxypyrazole compounds, as well as 1-halo-2-chloro-3-alkoxy-4-alkylsulfonylbenzene compounds and 2-chloro-3-alkoxy-4-alkylsulfonylbenzoic acid compounds, were prepared in good yield... | 01/18/2000 |
| 5912248 | Excitatory amino acid receptor antagonists Compounds of the formula ##STR1## in which X represents a bond, S, SO or SO2 ; and R is as defined in the specification are useful as modulators of metabotropic glutamate receptor function.... | 06/15/1999 |
| 5891909 | Amidinohydrazones as protease inhibitors Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R1 -R4, R6 -R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically ac... | 04/06/1999 |
| 5872282 | Allosteric modifiers of hemoglobin A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood dur... | 02/16/1999 |
| 5863947 | Phenylglycine derivatives useful for treating disorders of the central nervous system A pharmaceutical compound of the formula: ##STR1## in which R1 is hydrogen, hydroxy or C1-6 alkoxy, R2 is hydrogen, carboxy, tetrazolyl, --SO2 H, --SO3 H, --OSO3 H, --CONHOH, or --P(OH... | 01/26/1999 |
| 5847147 | 3-Amino-2-mercaptobenzoic acid derivatives and processes for their preparation Compounds of the formula I ##STR1## and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III ##STR2## In the compound... | 12/08/1998 |
| 5770758 | 3-amino-2-mercaptobenzoic acid derivatives and processes for their preparation Compounds of the formula I ##STR1## and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III ##STR2## In the compound... | 06/23/1998 |
| 5766610 | Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease... | 06/16/1998 |
| 5753715 | 2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents The invention relates to cyclohexenyl antibacterial compounds of the formula I: ##STR1## and pharmaceutical compositions containing the compounds, methods for their production and use.... | 05/19/1998 |
| 5721103 | Trienoic retinoid compounds and methods Novel trienoic compounds having activity for retinoic acid receptors and retinoid X receptors are provided. Also provided are pharmaceutical compositions incorporating such compounds and methods for their use.... | 02/24/1998 |
