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Apparatus for Simulating a High Five
A self-righting hand-arm configuration which is adapted to pivot when struck by a user, thereby simulating a "high five."
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| Number | Title | Issue Date |
| 7728169 | Pharmaceutical compositions of isolated orthorhombic crystalline 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid and methods of use A pharmaceutical composition comprising a compound of formula (1) in polymorphic crystalline Form A: together with a pharmaceutically acceptable carrier or excipient, wherein the compound of formula (1) is present... | 06/01/2010 |
| 7470810 | Alkyl and aryl-thiotrifluoroacetates and process Novel C3-C19 alkyl- and aryl-thiotrifluoroacetates are provided which have the structure wherein Q is C9-C19 alkyl or aryl, and are useful protecting agents for the amino or hydro... | 12/30/2008 |
| 7385082 | Preparation of 1,3-diphenylprop-2-en-1-one derivatives The invention relates to a method for the preparation of de 1,3-diphenylprop-2-en-1-one substituted on one of the two phenyl groups by a carboxyalkyloxy group or a carboxyalkylthio group. ... | 06/10/2008 |
| 7365224 | Pharmaceutical compositions of isolated orthorhombic crystalline 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid and methods of use A pharmaceutical composition comprising a compound of formula (1) in polymorphic crystalline Form A: together with a pharmaceutically acceptable carrier or excipient, wherein the compound of formula (1) is present... | 04/29/2008 |
| 7365085 | Compounds and methods Disclosed is a compound having the formula: pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined... | 04/29/2008 |
| 7345191 | Process for preparation of probucol derivatives A method is described for the preparation of polymorphic forms of water-soluble derivatives of probucol compounds having the following formula where R1, R2, R3, R4, R5,... | 03/18/2008 |
| 7305045 | Low voltage swing pad driver and receiver Low voltage swing pad driver and receiver. A transmitter portion and a receiver portion are implemented within various devices that communicate using low voltage swing pads communicatively coupled via a trace. The transmitter portion of one device generates a curren... | 12/04/2007 |
| 7301050 | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia. ... | 11/27/2007 |
| 7294737 | Process of preparing esters and ethers of probucol and derivatives thereof Provided are methods for manufacturing compounds of Formula I wherein all substituents are described herein. ... | 11/13/2007 |
| 7273948 | Process of preparing esters and ethers of probucol and derivatives thereof A probucol or a probucol derivative can be efficiently converted to a monoester or monoether of probucol by reacting the free hydroxyl-containing probucol or a derivative thereof (by which is meant a probucol compound with at least one substituent that is different ... | 09/25/2007 |
| 7271274 | Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease The invention relates to compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds, wherein the compounds are of the following Formulas: or a pharmaceutically acceptable ... | 09/18/2007 |
| 7138543 | Thiolalkyl benzoic acid derivatives The present invention relates to new thiolalkyl benzoic acids, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are alte... | 11/21/2006 |
| 7064146 | Pharmaceutical compositions of isolated orthorhombic crystalline 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid and methods of use A pharmaceutical composition, comprising: a compound of formula (1) in polymorphic crystalline Form A: together with a pharmaceutically acceptable carrier or excipient, wherein ... | 06/20/2006 |
| 7060854 | Process for making polymorphic form A of 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid Process for making a pharmaceutical composition, comprising: a compound of formula (1) in crystalline form: together with a pharmaceutically acceptable carrier or excipient, wherein the compound of formul... | 06/13/2006 |
| 7053222 | Semi-synthetic process for the preparation of N-debenzoylpaclitaxel A process for the preparation of N-debenzoylpaclitaxel (I) through esterification of 7-protected baccatin III with a carboxylic acid reactive derivative of general formula (II), and elimination of the ester-protecting groups in acid conditions and in a single step. ... | 05/30/2006 |
| 6992215 | Thiol-based NAALADase inhibitors This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neurona... | 01/31/2006 |
| 6984661 | Urea linker derivatives for use as PPAR modulators The present invention is directed to compounds of the structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof: Formula I (a) R1, R2 and R6 are each independently selected from the group consisting of hydrogen, C1-C | 01/10/2006 |
| 6930106 | Inhibitors of HCV NS5B polymerase The present invention provides compounds of Formula I, compositions and methods that are useful for treating viral infections and associated diseases, particularly HCV infections and associated diseases. ... | 08/16/2005 |
| 6777442 | Diphenyl derivatives The present invention relates to compounds of the general formula (I) in which X represents O, S, SO, SO2, CH2, CHF, CF2 or NR8, and Z represents a group of the formula | 08/17/2004 |
| 6713514 | PPAR-γ agonists as agents for the treatment of type II diabetes N-(substituted)carbamoylaryl- and heteroaryl substituted aminopropanoic and butanoic acid compounds which are highly selective agonists for the PPAR-γ receptor or prodrugs of agonists for the PPAR-γ receptor, and are useful in the treatment of Type II diabetes (NI... | 03/30/2004 |
| 6586623 | Thiol-based NAALADase inhibitors This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effect... | 07/01/2003 |
| 6548699 | Compounds and methods for the inhibition of the expression of VCAM-1 This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases.... | 04/15/2003 |
| 6521619 | Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents The present invention relates to novel cyclopropane-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or ... | 02/18/2003 |
| 6492550 | Alpha-substituted thio, -oxo trifluoromethylketones as phospholipase inhibitors Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula ##STR1## where X, Z, X1, R1, ... | 12/10/2002 |
| 6369261 | Compounds having activity as inhibitors of cytochrome P450RAI Compounds having Formula 2 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. ##STR1##... | 04/09/2002 |
| 6320072 | Method for isolation of n-protected s-phenylcysteine This invention provides a method of isolating N-protected-S-phenylcysteine (1) of high purity, expediently, efficiently and in good yield, which comprises causing said N-protected-S-phenylcysteine to be salted out in the form of a base salt in the presence of ... | 11/20/2001 |
| 6306854 | Chemical compounds Novel compounds of Formula (1) and esters, salts, and physiologically functional derivatives thereof are disclosed. Methods for preparing and using the compounds are also disclosed. Many of these compounds are selective activators of PPAR alpha. The compo... | 10/23/2001 |
| 6306873 | Substituted ଲ-thiocarboxylic acids This invention relates to compounds of general formula (I): ##STR1## in which Ar is a group selected from: ##STR2## A1, A2, B, C, D, E, Q1-Q3, R1-R9, Z1 and Z2 are as defined in the disclosure, and Y represents carboxy or an acid bioisostere. These c... | 10/23/2001 |
| 6303612 | Derivatives of hydroxyphenylsulfanylbenzoic and hydroxphenylsulfanylarylacetic acids Processes for the preparation of derivatives of hydroxyphenylsulfanylbenzoic and hydroxyphenylsulfanylarylacetic acids of Formula (I) and pharmaceutical compositions including these compounds are provided: ##STR1## wherein X is H, halogen or NO2... | 10/16/2001 |
| 6300514 | Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient Pharmaceutical composition containing aryl (sulfide, sulfoxide, sulfone) derivatives of the formula (1) and the salts thereof as active ingredient (wherein R1 is H, alkyl; R2 is COOR7, CONHOR8 ; E is --CONR... | 10/09/2001 |
| 6262084 | Compounds that inhibit the binding of integrins to their receptors A method for the inhibition of the binding of 댔ଲ.sub.1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions the... | 07/17/2001 |
| 6229041 | Preparation of S-aryl-cysteine and its derivatives The present invention provides a method for preparing S-aryl cysteine. Specifically, the present invention provides enantioselective method for preparing S-aryl cysteine starting from cystine, cysteine or serine amino acid. The methods of the present inve... | 05/08/2001 |
| 6221898 | Amidino derivatives and their use as thrombin inhibitors There is provided compounds of formula I, ##STR1## wherein R1, R2, R3, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in partic... | 04/24/2001 |
| 6153650 | Substituted gamma aminobutyric acids as pharmaceutical agents Novel gamma aminobutyric acids of formula (I) are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorder... | 11/28/2000 |
| 6130352 | Method for producing (+) (2S,3S)-3-(2-aminophenylthio)-2-hydroxy-3(4'-methoxyphenyl)-propionic acid A process for the preparation of (+) (2S, 3S)-3-(2-aminophenylthio)-2-hydroxy-3-(4'-methoxyphenyl)-propionic acid which comprises treating the (&#b1;) compound of (2RS, 3RS) 3-(2-aminophenylthio)-2-hydroxy-3-(4'-methoxyphenyl)-propionic acid (formula... | 10/10/2000 |
| 6127392 | Anthranilic acid analogs Compounds of the formula: wherein: R1, R2, R3, R4,R5, R6, R7 and R8 are, independently, hydrogen, COOR15, halogen, nitro, cyano, C1-10 alkoxy, C1... | 10/03/2000 |
| 6114523 | Process for the recycle of a waste product of diltiazem synthesis A process which allows the re-use of compounds of formula ##STR1## in diltiazem synthesis through a process of conversion to a mixture of enantiomers III-(2R,3R) and III-(2S,3S) is described.... | 09/05/2000 |
| 6096773 | Compounds that inhibit the binding of integrins to their receptors A method for the inhibition of the binding of 댔 댡 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositi... | 08/01/2000 |
| 6093799 | Universal linker for combinatorial synthesis A substrate for solid phase synthesis of the formula: ##STR1## is disclosed. Also disclosed are processes for preparing the substrate and intermediates useful therein. Among the novel intermediates are compounds of the formula: ##STR2## whe... | 07/25/2000 |
| 6017889 | Metalloproteinase inhibitors Matrix metalloproteinase inhibiting compounds of formula (I), wherein X is a --CO2 H or --CONHOH group; and one of the groups proximate to the amide bonds is a steric bulky group, showing enhanced oral absorption. ##STR1##... | 01/25/2000 |
