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| Number | Title | Issue Date |
| 8053598 | Compounds, their preparation and use Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in th... | 11/08/2011 |
| 7662993 | Synthesis of [C] and [H] substituted methacrylic acid, [C] and [H] substituted methyl methacrylate and/or related compounds The present invention is directed to labeled compounds of the formulae wherein Q is selected from the group consisting of —S(═O)—, and —S(═O)2—, Z is selected from the group c... | 02/16/2010 |
| 7423176 | Bicyclic aromatic sulfinyl derivatives The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith. ... | 09/09/2008 |
| 7388008 | Lysine based compounds The present invention provides lysine based compounds of the formula; and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein R1 may be, for exampl... | 06/17/2008 |
| 7371895 | Salt forms of poorly soluble probucol esters and ethers Organic amine salts of compounds of the formula: and their pharmaceutically acceptable salts, and uses in medical therapy are provided. ... | 05/13/2008 |
| 7365223 | Method for selective targeting of apoptotic cells and small molecule ligands used thereof The invention provides novel methods for selective targeting of chemical compounds to cells undergoing a death process, in particular apoptosis, and to platelets undergoing activation during blood coagulation. The invention further provides compounds to be used in s... | 04/29/2008 |
| 7351825 | Cyclopropane compounds and pharmaceutical use thereof The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): | 04/01/2008 |
| 7250529 | Synthesis process for 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid A highly advantageous process for the preparation of 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid or a salt thereof is described. The process comprises subjecting 1-acetyl 3-hydroxyadamantane to liquid phase oxidation with permanganate to produce 2-(3-hydroxy-1-adaman... | 07/31/2007 |
| 7199265 | Thyroid receptor ligands, pharmaceutical compositions comprising them and their use in the treatment of disorders influenced by thyroid hormones This invention relates to compounds of the formula (I) which are thyroid receptor ligands, and are preferably selective for the thyroid hormone receptor β, to methods of preparing such compounds and to methods for using such compounds such as in the regulation of m... | 04/03/2007 |
| 7157454 | Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same The invention relates to compounds of formula: These compounds show affinity for the bradykinin receptors with selectivity towards the B1 receptors; they may be used for the preparation of medicinal pr... | 01/02/2007 |
| 7129374 | Catalytic antioxidants and methods of use The invention provides small molecules that act as catalytic antioxidants and methods of use thereof. The compounds can repeatedly bind and destroy reactive oxygen species by serving as substates for enzymes of the methionine sulfoxide reductase (Msr) class. Some em... | 10/31/2006 |
| 7091245 | Compounds, their preparation and use Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in th... | 08/15/2006 |
| 6960683 | Salt forms of poorly soluble probucol esters and ethers Organic amine salts of compounds of the formula: and their pharmaceutically acceptable salts, and uses in medical therapy are provided. ... | 11/01/2005 |
| 6946474 | Nitrogen-containing compounds and their use as glycine transport inhibitors The present invention provides trichloroethyl-sulfonylurea-containing compounds that inhibit glycing transporters, pharmaceutical compositions comprising such compounds, methods for using such compounds for inhibiting glycine transporters and methods for using such ... | 09/20/2005 |
| 6936636 | 5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity Compounds of the formula: where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects... | 08/30/2005 |
| 6916837 | Amidino derivatives and anticoagulants and thrombosis therapeutic agents containing them Amidino derivatives represented by the following general formula (I): {where X is a group represented by R1SO2NR2— (wherein R1 represents optionally substituted C6-14 ... | 07/12/2005 |
| 6916850 | Pyruvate derivatives Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, but are not limited to oximes... | 07/12/2005 |
| 6897237 | MMP-12 inhibitors A compound of the formula (I): wherein R1 is hydroxy and the like; R2 is optionally substituted lower alkyl and the like; R3 is hydrogen atom and the like; R4 is optionally s... | 05/24/2005 |
| 6884907 | Hydroxamic acids and acyl hydroxamines as naaladase inhibitors This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neurona... | 04/26/2005 |
| 6869975 | Linked biaryl compounds Compounds, compositions and methods that are useful for the treatment of metabolic disorders, inflammatory diseases and cancer are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in ... | 03/22/2005 |
| 6777418 | Retinoid compounds (I) The current invention provide novel retinoid compounds and methods for their synthesis, methods of treating or preventing emphysema, cancer and dermatological disorders and pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and... | 08/17/2004 |
| 6767920 | 3, 7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; | 07/27/2004 |
| 6747148 | Sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion Sulfonamide derivatives, their physiologically tolerable salts and their prodrugs according to the present invention are vitronectin receptor antagonists and inhibitors of cell adhesion, as well as inhibit bone resorption by osteoclasts. These derivatives, salts and... | 06/08/2004 |
| 6693136 | Fluorenes and anthracenes that inhibit P2X3 and P2X2/3 containing receptors Compounds of formula (I) ##STR1## are novel P2X3 and P2X2 /P2X3 containing receptor antagonists and are useful in treating pain, urinary incontinence, and bladder overactivity.... | 02/17/2004 |
| 6653483 | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.... | 11/25/2003 |
| 6632816 | Aromatic derivatives as HIV aspartyl protease inhibitors The present invention provides HIV aspartyl protease inhibitors of the formula; ##STR1## and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein n is 3 or 4, wherein R1 may b... | 10/14/2003 |
| 6613782 | Certain thiol inhibitors of endothelin-converting enzyme Disclosed as endothelin converting enzyme inhibitors are the compounds of the formula ##STR1## wherein the variables have the meanings as defined hereinbefore.... | 09/02/2003 |
| 6610882 | N-(arylsulphonyl) amino acid derivatives The invention relates to compounds of formula ##STR1## in which R1 to R9, R16 and R17 are as defined in claim 1. These compounds are pharmacologically active.... | 08/26/2003 |
| 6603041 | Bicyclic enamide derivatives Enamide derivatives of formula (1) are described: ##STR1## wherein R1 is a group Ar1 L2 Ar2 Alk- in which Ar1 is an optionally substituted aromatic or heteroaromatic group, L2 is a covalent... | 08/05/2003 |
| 6603012 | RAR selective retinoid agonists New compounds containing bicyclic fused rings, one of which being a phenyl moiety connected by an aliphatic chain to a cycloalkyl or aryl moiety, and pharmaceutically active salts thereof are useful as RAR selective retinoid agonists. Furthermore, such re... | 08/05/2003 |
| 6495546 | Propanolamine derivatives Propanolamine derivatives represented by the following formula (I): ##STR1## These derivatives may be 댣 agonists and exert sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-urinary incontinence and anti-pollakiuria ac... | 12/17/2002 |
| 6492422 | Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases Tricyclic sulfonamide compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and strome... | 12/10/2002 |
| 6448254 | Substituted amides, their production and their use Amides of the general formula I ##STR1## and their tautomeric and isomeric forms, possible enantiomeric and diastereomeric forms, as well as possible physiologically tolerable salts, in which the variables have the following meanings: R1 [sic] can be C | 09/10/2002 |
| 6433021 | Indane compounds and their pharmaceutical use Indane compounds of general formulae (1) to (4) and their pharmaceutical use, particularly to achieve mast cell stabilising activity and/or anti-inflammatory activity are described. In these formulae R1 to R7 may be selected from: H,... | 08/13/2002 |
| 6423727 | Certain thiol inhibitors of endothelin-converting enzyme Disclosed as endothelin converting enzyme inhibitors are the compounds of the formula ##STR1## wherein the variables have the meanings as defined hereinbefore.... | 07/23/2002 |
| 6387951 | Compounds having activity as inhibitors of cytochrome P450RAI Compounds having Formulas 5 and 6 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. ##... | 05/14/2002 |
| 6313119 | Sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion Sulfonamide derivatives, their physiologically tolerable salts and their prodrugs according to the present invention are vitronectin receptor antagonists and inhibitors of cell adhesion, as well as inhibit bone resorption by osteoclasts. These derivatives... | 11/06/2001 |
| 6291702 | Azulenyl nitrone spin trapping agents, methods of making and using same The present invention relates to chromotropic nitrone spin trapping agents, methods of making these agents, compositions comprising same, and methods of their use. In particular, azulenyl nitrones of the present invention are effective agents for trapping... | 09/18/2001 |
| 6265603 | Inhibitors of isoprenyl transferase Peptidomimetic isoprenyl transferase inhibitors R6SCHR1'CHR1WCHR2YC(:X)NR3CHR5COR4 wherein R1=OH, H, alkyl, amino group or R1 and R6 together form a heterocyclic ring; R1'=H, alkyl, aryl; R2=H, alkyl, arylalkyl, heteroarylalkyl; R3=H, alkyl, arylalkyl; R4... | 07/24/2001 |
| 6248781 | Compounds useful in the treatment of conditions mediated by peroxisome proliferator-activated receptors (PPAR) The present invention relates to compounds of formula (I) ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, Ar, X, Q, A, Y and Z are as defined in the specification. These ... | 06/19/2001 |
