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| Number | Title | Issue Date |
| 8022247 | Process for production of 2,3,4-trifluoro-5-(iodo or bromo)-benzoic acid The invention provides a process for production of 2,3,4-trifluoro-5-(iodo or bromo)benzoic acid, the process comprising a halogenation step in which direct iodination or bromination of 2,3,4-trifluorobenzoic acid is performed with an iodinating agent or brominating... | 09/20/2011 |
| 7989656 | Biaryl carboxylic acid apoptosis promoters The present invention relates to biaryl carboxylic acid compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing these compounds and methods of treating diseases which express the Mcl-1 protein. ... | 08/02/2011 |
| 7943795 | Vitamin D receptor modulators The present invention relates to novel, non-secosteroidal, phenyl-naphthalene compounds of Formula (I): wherein R, R1, RP, ZP, LP1, LP2 LNP, RP3, RN, and ZNP are defined herein, their preparation, pha... | 05/17/2011 |
| 7884230 | Process for chemical recycling of post consumption poly(ethylene terephthalate) and apparatus for chemical recycling of post consumption polyethylene terephthalate A process for the chemical recycling of post consumption polyethylene terephthalate which includes the steps of performing the depolymerization of polyethylene terephthalate based upon a hydrolysis reaction which causes a rupture in of the ester bonds formed between... | 02/08/2011 |
| 7851649 | Process for the mononitration of alkanediols A process for the preparation of compounds of formula HO-A-ONO2 (I) wherein A is a C2-C6 alkylene chain by nitration of the corresponding alkanediols with “stabilized” nitric acid is herein disc... | 12/14/2010 |
| 7777072 | Process for the synthesis of 2,5-dihydroxyterephthalic acid 2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions. ... | 08/17/2010 |
| 7759515 | Catalyst comprising N-substituted cyclic imide compound and process for producing organic compounds using the catalyst A catalyst of the invention includes an imide compound having a N-substituted cyclic imide skeleton represented by following Formula (I): wherein R is a hydroxyl-protecting group. Preferred R is a hydrolyzable protecting gr... | 07/20/2010 |
| 7741514 | Catalyst comprising N-substituted cyclic imide compound and process for producing organic compound using the catalyst A catalyst of the invention includes an imide compound having a N-substituted cyclic imide skeleton represented by following Formula (I): wherein R is a hydroxyl-protecting group. Preferred R is a hydrolyzable protecting gr... | 06/22/2010 |
| 7626053 | Process for the synthesis of hydroxy aromatic acids Hydroxy aromatic acids are produced in high yields and high purity (>95%) from halogenated aromatic acids in a reaction mixture containing a copper source and a ligand that coordinates to copper. ... | 12/01/2009 |
| 7592481 | Process for the synthesis of hydroxy aromatic acids Hydroxy aromatic acids are produced in high yields and high purity (>95%) from halogenated aromatic acids in a reaction mixture containing a copper source and a ligand that coordinates to copper. ... | 09/22/2009 |
| 7585999 | Process for the synthesis of 2, 5-dihydroxyterephthalic acid 2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions. ... | 09/08/2009 |
| 7576237 | Process for the synthesis of 2,5-Dihydroxyterephthalic acid 2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions. ... | 08/18/2009 |
| 7553990 | Process for the synthesis of 2, 5-dihydroxyterephthalic acid 2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions. ... | 06/30/2009 |
| 7538244 | Process for the synthesis of hydroxy aromatic acids Hydroxy aromatic acids are produced in high yields and high purity (>95%) from halogenated aromatic acids in a reaction mixture containing a copper source and a ligand that coordinates to copper. ... | 05/26/2009 |
| 7511170 | Process for liquid/solid reaction A process for carrying out a liquid/solid reaction comprises a) preparing a reaction suspension in which a first reactant is present in suspended form and a second reactant is present in dissolved form in a suspension medium, where... | 03/31/2009 |
| 7453009 | Hydroxybiphenyl carboxylic acids and derivatives, method for producing the same and their use Disclosed are novel compound of formula I, As defined herein and their use as pharmaceutically active compounds for reducing blood glucose, and/or treating one or more of type II diabetes, disturbances of lipid and carbohyd... | 11/18/2008 |
| 7439372 | Therapeutic compounds A compound having a structure is disclosed herein. Compositions, medicaments, and therapeutic methods related thereto are also disclosed. ... | 10/21/2008 |
| 7439383 | Sodium channel blockers The present invention is directed to novel phenytoin derivative compounds and the use of such compounds as sodium channel blockers. Such compositions have utility as anti-cancer agents and can be used to limit or prevent PCa growth and/or metastasis. ... | 10/21/2008 |
| 7432394 | Resolution of α-(phenoxy) phenylacetic acid derivatives with naphthyl-alkylamines The present invention provides a methods and compounds for producing an enantiomerically enriched α-(phenoxy)phenylacetic acid compound of the formula: from a mixture of its enantiomers, where R1 is alkyl or hal... | 10/07/2008 |
| 7429669 | Therapeutic compounds Disclosed herein are compounds of the formula or salts or bioisosteres thereof. Therapeutic methods, medicaments, and compositions related thereto are also disclosed. ... | 09/30/2008 |
| 7429676 | Process for preparing enantiomerically enriched 2-alkoxy-3-phenylpropionic acids The present invention relates to a process for preparing enantiomerically enriched, optionally substituted 2-alkoxy-3-phenylpropionic acids by asymmetrically hydrogenating alkoxycinnamic acids. ... | 09/30/2008 |
| 7427688 | Production method of optically active diphenylalanine compounds The present invention provides a production method including reacting a diphenylmethylene halide compound represented by the following formula (1) with a malonic acid diester compound represented by the following formula (2) in an organic solvent selected from N-met... | 09/23/2008 |
| 7427685 | Therapeutic substituted cyclopentanes Therapeutic compounds according to one of the structures below are disclosed herein. ... | 09/23/2008 |
| 7411031 | Synthesis of polyanhydrides The present invention provides a method for forming compounds of Formula HO—C(═O)R1—X—R2—X—R1—C(═O)—O—H wherein compound (I) can be polymerized to provide a polymer that contains therapeuticall... | 08/12/2008 |
| 7399786 | Derivatives of amino acids for treatment of obesity and related disorders Novel amino acid derivatives are provided that are useful for management of disorders such as obesity and immunological diseases. The derivatives are also useful in lowering blood glucose levels in hyperglycemic disorders and for treating related disorders such as b... | 07/15/2008 |
| 7385081 | Terephthalic acid composition and process for the production thereof Terephthalic acid is prepared by reacting a 2,5-furandicarboxylate with ethylene in the presence of a solvent to produce a bicyclic ether; and then dehydrating the bicyclic ether. The process of the present invention effectively produces terephthalic acid, while red... | 06/10/2008 |
| 7381836 | Optimized liquid-phase oxidation Disclosed is an optimized process and apparatus for more efficiently and economically carrying out the liquid-phase oxidation of an oxidizable compound. Such liquid-phase oxidation is carried out in a bubble column reactor that provides for a highly efficient reacti... | 06/03/2008 |
| 7365091 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX The present invention relates to derivatives of succinic and glutaric acids and analogues thereof, having the following general formula: useful as inhibitors of PHEX. These derivatives are useful fo... | 04/29/2008 |
| 7351856 | Process for the synthesis of hydroxy aromatic acids Hydroxy aromatic acids are produced in high yields and high purity (>95%) from halogenated aromatic acids in a reaction mixture containing a copper source and a ligand that coordinates to copper. ... | 04/01/2008 |
| 7345195 | Process for the synthesis of 2,5-dihydroxyterephthalic acid 2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions. ... | 03/18/2008 |
| 7345194 | Process for the synthesis of 2,5-dihydroxyterephthalic acid 2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions. ... | 03/18/2008 |
| 7339076 | Process for the synthesis of 2,5-dihydroxyterephthalic acid 2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions. ... | 03/04/2008 |
| 7335791 | Process for the synthesis of hydroxy aromatic acids Hydroxy aromatic acids are produced in high yields and high purity (>95%) from halogenated aromatic acids in a reaction mixture containing a copper source and a ligand that coordinates to copper. ... | 02/26/2008 |
| 7329777 | Methods for treating heart failure, thromboembolic disorders, and pulmonary fibrosis This invention relates to methods for treating heart failure, thromboembolic disorders, and pulmonary fibrosis, comprising administering an effective amount of a compound of formula (I) in which the several varia... | 02/12/2008 |
| 7309718 | Dibenzocycloheptene compound The present invention discloses a dibenzocycloheptene compound represented by the formula (I): wherein R1: hydrogen atom, halogen atom, etc., R2: hydrogen atom, halo... | 12/18/2007 |
| 7288676 | Arylphenyl-substituted cyclic ketoenols The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulph... | 10/30/2007 |
| 7285680 | β-alanine derivatives and the use thereof A compound of the general formula (I) (wherein the symbols are as defined in the description), or a prodrug or a salt thereof. This compound engages in LPA receptor bonding and antagonism and hence is use... | 10/23/2007 |
| 7279596 | Stable crystals of substituted phenylpropionic acid derivative and process for producing the same Preparation of (S)-2-[[3-[N-[4-[(4-fluorophenoxy)phenyl]methyl]carbamoyl]-4-methoxyphenyl]methyl]butanoic acid (referred to as compound (I)) on an industrial scale lies in the finding of crystals homogeneous and excellent in the stability and the establishment of a ... | 10/09/2007 |
| 7259278 | Anti-S-phase tubulin ligands It is presently accepted that the mechanism of action for all anti-tumor tubulin ligands involves the perturbation of microtubule dynamics during the G2/M phase of cell division and subsequent entry into apoptosis (1). In this invention, we report a novel tubulin li... | 08/21/2007 |
| 7244861 | Benzene compound and salt thereof The present invention provides a medicament comprising a benzene compound useful as an insulin sensitizer, a salt thereof or a hydrate of them and a derivative of them as the active ingredient. Specifically, it provides a benzene compound represented by the followin... | 07/17/2007 |
