Did You Know...
...that one person who claimed to be the inventor of the television is Russian emigre Vladimir Zworykin? In 1929 David Sarnoff, founder of RCA, asked Zworykin what it would take to develop TV for commercial use. He said: a year and a half and $100,000. In reality, it took 20 years and $50 million! Before his death in 1982 at the age of 92, Zworykin said of his invention: "The technique is wonderful. It is beyond my expectations. But the programs! I would never let my children even come close to this thing."
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7838700 | Recovery and recycling of chiral tartaric acid resolving agents A process for the recovery of substituted tartaric acid resolving agents from resolution process liquors comprising organic solvents, wherein the substituted tartaric acid derivatives are neutralised by adding a base, extracted into an aqueous phase and crystallized... | 11/23/2010 |
| 7728167 | Process for the preparation of enantiomerically enriched amino acids The present invention is concerned with the resolution of a mixture of enantiomers of N-protected amino acids by crystallization with enantiomerically pure N-unprotected β-amino acid derivatives. ... | 06/01/2010 |
| 7700802 | Method of separating stereoisomers of dicarboxylic acid having norbornene or norbornane structure, or derivative thereof A method of efficiently extracting a high-purity stereoisomer from a mixture comprising the endo isomer and the exo isomer of a dicarboxylic acid having a norbornene or norbornane structure, or a derivative thereof. The present invention relates to a method of separ... | 04/20/2010 |
| 7619112 | Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid The invention relates to pure (R)—CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)—CMH and to the process for isolating (S)—CMH from ... | 11/17/2009 |
| 7592480 | Process for producing optically active carboxylic acid The invention provides a process for producing optically active 2,2-dimethylcyclopropanecarboxylic acid by reacting an optical isomer mixture of 2,2-dimethylcyclopropanecarboxylic acid with an optically inactive amine to form (precipitate, crystallize or the like) a... | 09/22/2009 |
| 7432394 | Resolution of α-(phenoxy) phenylacetic acid derivatives with naphthyl-alkylamines The present invention provides a methods and compounds for producing an enantiomerically enriched α-(phenoxy)phenylacetic acid compound of the formula: from a mixture of its enantiomers, where R1 is alkyl or hal... | 10/07/2008 |
| 7429675 | Process for the preparation of racemic 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]-propanoic acid The present invention provides a process for the preparation of substantially racemic 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]-propanoic acid which comprises reacting 2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(met... | 09/30/2008 |
| 7417165 | Crystalline forms of pregabalin Crystalline form of Pregabalin characterized by X-ray powder diffraction peaks at about 5.8, 18.4, 19.2, 20.7, and 23.7° 2θ±0.2° 2θ, methods for its preparation, its pharmaceutical compositions thereof, and methods for the preparation of crystalline form of Pre... | 08/26/2008 |
| 7388023 | Amino acids with affinity for the α2δ-protein Certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders. Also disclosed ar... | 06/17/2008 |
| 7388098 | Dynamic resolution of isomers and resolved isomers Provided is a dynamic resolution method of enriching a desired isomer of an alpha-substituted carboxylic acid relative to an undesired isomer, the method comprising: (a) in a solvent, contacting the alpha-substituted carboxylic acid, wherein the alpha substitution i... | 06/17/2008 |
| 7385080 | Method for producing optically active β-phenylalanine compounds Optically active β-phenylalanine compound may be prepared in an industrially advantageous manner by reacting an N-acyl-β-phenylalanine compound with a specific optically resolving agent to effect an optical resolution by formation of diastereomer salts, and removi... | 06/10/2008 |
| 7381835 | Resolution process for (R)-(-)-2-hydroxy-2-(2-chlorophenyl) acetic acid The subject of the present invention is the preparation of the (R)-(−)-2-hydroxy-2-(2-chlorophenyl)acetic acid of the formula (I) by the resolution of the corresponding racemic compound by using the compounds of the general formula (II). ... | 06/03/2008 |
| 7321055 | Production method of optically active dephenylalanine compounds Optically active diphenylalanine compounds may be conveniently prepared in a good yield by reacting a diphenylalanine compound represented by formula (1) with an optically active amine compound represented by formula (2) in the presence of an organic solvent to give... | 01/22/2008 |
| 7271280 | Process for preparing a biaryl compound A process for preparing an optically active biaryl compound the formula (4): which comprises reacting an aromatic sulfonic acid ester compound of the formula (1): ... | 09/18/2007 |
| 7241866 | Using amines or amino acids as mobile phase modifiers in chromatography This invention relates to the use of amine, amino acid and amino acid ester mobile modifiers in normal phase chromatography to improve the resolution and or productivity of peptide and lipopeptide purification. This chromatographic method can be sued for either anal... | 07/10/2007 |
| 7214820 | Process for producing optically active flurbiprofen The present invention provides a method for producing optically active flurbiprofen. The method of the present invention includes mixing racemic flurbiprofen and (S)- or (R)-3-methyl-2-phenylbutylamine in an organic solvent to produce a diastereomeric salt; and trea... | 05/08/2007 |
| 7199264 | Method of resolving optical isomers of amino acid derivative Provided is a separating method for an optical isomer mixture comprising the steps of mixing an amino acid derivative such as N-(tert-butoxycarbonyl)-DL-alanine in which optical isomers of a D type and an L type are present in a mixture with a hydrophilic compound s... | 04/03/2007 |
| 7105698 | Process for the separation of R(-)-and S(+)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2- methoxybenzenesulfonamide The process for separating the R(−)- and S(+)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzene-sulfonamide enantiomers comprises (a) reacting a mixture of said enantiomers with an optically active organic acid to form diastereoisomeric salts with sai... | 09/12/2006 |
| 7098229 | (+)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions and uses thereof The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable salts thereof, compositions comprising (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and metho... | 08/29/2006 |
| 7034178 | Process for the production of 3-phenylisoserine This invention is drawn to a process for the production of (R,R)-phenylisoserine or a 1–4C-alkyl ester thereof. ... | 04/25/2006 |
| 7022737 | Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses Mammals are treated for infections or for conditions associated with pathologically proliferating mammalian cell growth by administration of a manipulator of nitrosative stress to selectively kill or reduce the growth of the microbes or helminths causing the infecti... | 04/04/2006 |
| 6864389 | Method for producing α-hydroxycarboxylic acid The present invention relates to: a method for producing α-hydroxycarboxylic acid, which comprises hydrolyzing cyanohydrin in the presence of a hydrocarbon solvent; a method for producing optically active α-hydroxycarboxylic acid, which c... | 03/08/2005 |
| 6794537 | Manufacturing processes for Se-methyl-L-selenocysteine Convenient processes are described for the synthesis of L-Se-methyselenocysteine from chloroalanine derivatives. The process is easily extendable to other selenium substituted amino acids. DL-Se-methyselenocysteine is easily obtained by a benzaldehyde-catalyzed race... | 09/21/2004 |
| 6781012 | Process for the preparation of optically and chemically highly pure (R)- or (S)-α-hydroxycarboxylic acids Process for the preparation of optically highly pure (R)- and (S)-α-hydroxycarboxylic acids, in which either isolated, impure (R)- and (S)-α-hydroxycarboxylic acids prepared by acidic hydrolysis of the (R)- and (S)- cyanohydrins obtained by enzyme-catalyzed additi... | 08/24/2004 |
| 6750370 | Process for racemizing optically active vinyl-substituted cyclopropanecarboxylic acid compound There is disclosed a process for the racemization of a vinyl-substituted cyclopropanecarboxylic acid or a derivative thereof, which is characterized by reacting an optically active vinyl-substituted cyclopropanecarboxylic acid compound of formula (1): | 06/15/2004 |
| 6743944 | Process for producing optically active aminoalcohol An industrially advantageous process for producing optically active 4-amino-2-methylbutane-1-ol which is useful as an intermediate in synthesizing optically active medicines and pesticides. Racemic 4-amino-2-methylbutane-1-ol is treated with an optically active orga... | 06/01/2004 |
| 6683207 | Production method of (R)-3 hydroxy-3-(2-phenylethyl) hexanoic acid and intermediate thereof The present invention relates to a production method of (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid which comprises optical resolution of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid with an optically active amine of the formula (VIII) ##STR1## ... | 01/27/2004 |
| 6653501 | Chiral resolution method for producing compounds useful in the synthesis of taxanes A method is provided for processing a solution having optical isomers to obtain a (2R,3S) target isomer: ##STR1## wherein P1 is H or a hydroxyl protecting group, R1 is H, an alkyl group, an olefinic group or an aromatic group, and R | 11/25/2003 |
| 6608221 | Process for the preparation of (2R)-2-propyloctanoic acid A process for the preparation of (2R)-2-propyloctanoic acid which is characterized by subjecting (2S)-2-(2-propynyl)octanoic acid or (2S)-2-(2-propenyl)octanoic acid to reduction using platinum on carbon. This process gives (2R)-2-propyloctanoic acid havi... | 08/19/2003 |
| 6559338 | Method for racemate splitting of 2-hydroxypropionic acids A process for racemate resolution of 2-hydroxypropionic acids by reacting the racemic acid with an optically active base and subsequently separating off a diastereomeric salt of acid and base comprises using 1-(4-chlorophenyl)ethylamine as optically activ... | 05/06/2003 |
| 6525214 | Therapeutic agent The use of S(-)sodium 2-(4-isobutylphenyl)-propionate (the sodium salt of S(+)-ibuprofen) in pharmaceutical compositions for the treatment of inflammation, pain and pyrexia is described. Preferred compositions comprise S(-)sodium 2-(4-isobutylphenyl)-prop... | 02/25/2003 |
| 6495729 | (+)- and (-)-2-cyclododecylpropanol and (+)- and (-)-2-cyclododecylpropionic acid and the preparation and use thereof The compounds are (+)- and (-)-2-cyclododecylpropanol and (+)- and (-)-2-cyclododecylpropionic acid, and salts thereof. (-)-2-cyclododecylpropanol is suitable as a fragrance while the virtually odorless (+) enantiomer is suitable as a fixative for other f... | 12/17/2002 |
| 6458955 | Process for preparation of pharmaceutically desired enantiomers Improved processes for preparation of high enantiomeric purity compounds center on resolution using simulated moving bed chromatography of a racemic precursor early in the synthesis. Resolution is effected with high enantiomeric purity, and subsequent rea... | 10/01/2002 |
| 6437175 | Process for racemization of n-acylamino acids by means of transition metal catalysts The present invention relates to a process for the racemization of N-acylamino acids of the formula (I) R--CH(NR1 COR2)CO2 H (I) in which, in a solvent, an enantiomerically enriched mixture or an enantiomerically pure compoun... | 08/20/2002 |
| 6407284 | Method of resolving 2-oxobicyclo [3.1.0] hexane-6-carboxylic acid derivatives There is disclosed a method of resolving 2-oxobicyclo[3.1.0]hexane-6-carboxylates having the following relative configuration of formula (1): ##STR1## wherein X1, X2, R1, R2 and R3 have the same ... | 06/18/2002 |
| 6407282 | Process for producing monoester from dicarboxylic acid fluoride Monoester monoacid fluoride of dicarboxylic acid is produced by allowing dicaroxylic acid fluoride represented by the following general formula: FOCCF(CF3)OCF2 (A)p(CF2)qCOF where A is a bifunctional perfluorinated group having 1 to... | 06/18/2002 |
| 6372936 | Optical resolution of aminoisobobutyric acid A process for resolving amino protected racemic 3-amino-2-methylpropionic acid which comprises the steps of: (1) reacting said amino protected acid with a protected amino group with an enantiomer of a chiral amine to form diastereomeric salts; (2) recryst... | 04/16/2002 |
| 6342629 | Process for production of optically active n-protected-n-methyl-phenylalanine derivative There is provided a process for industrially and efficiently producing an optically active N-protected-N-methyl-4-halogenophenylalanine at a high purity, which is useful as an intermediate for the production of pharmaceutical agents. An optically active N... | 01/29/2002 |
| 6340762 | Method for optical resolution of piperidine carboxylic acid derivative A method for producing an optically active piperidine carboxylic acid derivative, which comprises subjecting a piperidine carboxylic acid derivative of the formula (1): ##STR1## wherein Z is a protecting group for the carboxyl group, to optical resol... | 01/22/2002 |
| 6320069 | Production of optically active ketone Process for producing an optically active ester by reaction of a racemic alcohol with an optically active amino or tartaric acid derivative, a process for producing an optically active alcohol by hydrolysis of the optically active ester, a process for con... | 11/20/2001 |
