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| Number | Title | Issue Date |
| 8153839 | Method for synthesis of keto acids or amino acids by hydration of acetylene compound An object of the present invention is to provide a method for synthesis of keto acids by hydration of an acetylene compound (acetylene-carboxylic acids) under mild conditions free from harmful mercury catalysts and a method for synthesis of amino acids from acetylen... | 04/10/2012 |
| 8143442 | Preparation for a cyclohexanecarboxylic acid derivative and intermediates A process for the preparation of a compound of formula (Ia): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds. ... | 03/27/2012 |
| 7868200 | Process for preparing alicyclic carboxylic acid compounds A process for preparing at least one alicyclic carboxylic acid compound by Grignard reaction, the process comprising: reacting magnesium and at least one alicyclic halide compound in at least one solvent to produce at least one ali... | 01/11/2011 |
| 7863480 | Process for alkaline hydrolysis of carboxylic acid derivatives to carboxylic acids The invention relates to a process for alkaline hydrolysis of carboxylic acid derivatives, especially carboxylic esters, to carboxylic acids, wherein, for the alkaline hydrolysis of the carboxylic acid derivatives, red mud which is produced by the Bayer process used... | 01/04/2011 |
| 7858823 | Process for cyclohexanecarboxylic acid derivatives A process for the preparation of a compound of formula (I): which are useful as intermediates in the preparation of i.a. pharmaceutically active compounds. ... | 12/28/2010 |
| 7439372 | Therapeutic compounds A compound having a structure is disclosed herein. Compositions, medicaments, and therapeutic methods related thereto are also disclosed. ... | 10/21/2008 |
| 7432390 | Production of carboxylic acids or carboxylic acid esters In the production of carboxylic acid or carboxylic acid ester, a reaction product containing the carboxylic acid or carboxylic acid ester which has been produced by the reaction of an olefin, carbon monoxide, and water or an alcohol in the presence of HF is heat-tre... | 10/07/2008 |
| 7420082 | Polycarboxylic acid production system employing hot liquor removal downstream of oxidative digestion Disclosed is an optimized system for more efficiently and economically producing terephthalic acid. The system includes an optimized post-digestion cooling stage that provides a TPA product having enhanced purity, while minimizing costs associated with removing impu... | 09/02/2008 |
| 7411031 | Synthesis of polyanhydrides The present invention provides a method for forming compounds of Formula HO—C(═O)R1—X—R2—X—R1—C(═O)—O—H wherein compound (I) can be polymerized to provide a polymer that contains therapeuticall... | 08/12/2008 |
| 7396955 | Annealed and promoted catalyst A mixed metal oxide, which may be an orthorhombic phase material, is improved as a catalyst for the production of unsaturated carboxylic acids, or unsaturated nitrites, from alkanes, or mixtures of alkanes and alkenes, by: contacting with a liquid contact member sel... | 07/08/2008 |
| 7388023 | Amino acids with affinity for the α2δ-protein Certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders. Also disclosed ar... | 06/17/2008 |
| 7381420 | Labeling reactant This invention concerns novel labeling reactants suitable for labeling of a biospecific binding reactant using solid-phase synthesis. The novel reactants are derivatives of diethylenetriaminepentaacetic acid (DTPA), wherein a suitable group is linked to the DTPA mol... | 06/03/2008 |
| 7351855 | Chemically defined non-polymeric valency platform molecules and conjugates thereof Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide duplexes of at least 20 base pairs that have significant binding activi... | 04/01/2008 |
| 7351856 | Process for the synthesis of hydroxy aromatic acids Hydroxy aromatic acids are produced in high yields and high purity (>95%) from halogenated aromatic acids in a reaction mixture containing a copper source and a ligand that coordinates to copper. ... | 04/01/2008 |
| 7348457 | Ketol fatty acid derivatives and plant growth regulators α-Ketol unsaturated fatty acid derivatives represented by the following formula (1), α-ketol unsaturated fatty acid amide derivatives represented by the following formula (6), and plant growth regulators containing, as the active ingredient, at least one of these ... | 03/25/2008 |
| 7345195 | Process for the synthesis of 2,5-dihydroxyterephthalic acid 2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions. ... | 03/18/2008 |
| 7345194 | Process for the synthesis of 2,5-dihydroxyterephthalic acid 2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions. ... | 03/18/2008 |
| 7339076 | Process for the synthesis of 2,5-dihydroxyterephthalic acid 2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions. ... | 03/04/2008 |
| 7335791 | Process for the synthesis of hydroxy aromatic acids Hydroxy aromatic acids are produced in high yields and high purity (>95%) from halogenated aromatic acids in a reaction mixture containing a copper source and a ligand that coordinates to copper. ... | 02/26/2008 |
| 7326807 | Polycarboxylic acid production system with enhanced heating for oxidative digestion Disclosed is an optimized system for more efficiently and economically producing terephthalic acid. The system includes an novel method for heating the slurry and/or reaction medium subjected to oxidative digestion. ... | 02/05/2008 |
| 7326808 | Polycarboxylic acid production system employing cooled mother liquor from oxidative digestion as feed to impurity purge system Disclosed is an optimized system for more efficiently and economically producing terephthalic acid. A solvent purification system is employed to remove of at least one aromatic impurity present in a solvent purification feed. At least about 20 weight percent of the ... | 02/05/2008 |
| 7323590 | Process for rectificatively separating a liquid comprising acrylic acid and/or methacrylic acid A process for rectificatively separating a liquid which comprises acrylic acid, methacrylic acid or a mixture thereof, and additionally comprises low molecular weight aldehydes and acetone. ... | 01/29/2008 |
| 7309718 | Dibenzocycloheptene compound The present invention discloses a dibenzocycloheptene compound represented by the formula (I): wherein R1: hydrogen atom, halogen atom, etc., R2: hydrogen atom, halo... | 12/18/2007 |
| 7294739 | Basic amine esters or oleic acid and their use as anti-inflammatory or immunobodulatory agents This invention is directed to compounds of the following formula (I): wherein R is either: | 11/13/2007 |
| 7285572 | CaSR antagonist The present invention provides a compound having a calcium-sensitive receptor antagonistic action, a pharmaceutical composition containing the compound, particularly a calcium receptor antagonist and a therapeutic drug for osteoporosis. A compound represented by the... | 10/23/2007 |
| 7285680 | β-alanine derivatives and the use thereof A compound of the general formula (I) (wherein the symbols are as defined in the description), or a prodrug or a salt thereof. This compound engages in LPA receptor bonding and antagonism and hence is use... | 10/23/2007 |
| 7279595 | Process for the preparation of high purity perindopril The invention relates to 1-{2(S)-[1(S)-(ethoxycarbonyl)butylamino]propionyl}-(3aS,7aS)octahydroindol-2(S)-carboxylic acid of the Formula I and the t-butylamine salt of the Formula I′ thereof free of contaminations derivable from dicyclohexyl carbodiimide, and a pr... | 10/09/2007 |
| 7279594 | Thermoplastic composition, articles thereof, and method of making the articles A thermoplastic composition comprises greater than or equal to about 60 wt. % polycarbonate; and about 10 wt. % to about 40 wt. % of a polyimide; wherein weight percents are based on a total weight of the thermoplastic composition. ... | 10/09/2007 |
| 7247745 | Process for preparing 1,5-diaryl-3-substituted pyrazoles A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III | 07/24/2007 |
| 7235357 | Method of reducing background in fluoresence detection The present invention provides a method for detecting fluorescence by using a solid support to which a probe molecule to be detected is fixed, wherein background is reduced by using a quenching agent. By using present invention, detection sensitivity of a DNA chip c... | 06/26/2007 |
| 7148377 | 4-Alkoxy cyclohexane-1-amino-carboxylic acid esters and method for the production thereof The invention relates to novel 4-alkoxy-cyclohexane-1-amino-carboxylic esters of the formula (IV) in which R1 represents OR3, R2 represents alkyl, and R3 represents alk... | 12/12/2006 |
| 7138542 | Method of treating tinnitus The invention relates to a method of treating tinnitus by administering an alpha2delta ligand such as, for example, a compound of Formula and pharmaceutically acceptable salts thereof, wherein R1 is hy... | 11/21/2006 |
| 7109370 | Substituted phenylketoenols The invention relates to novel phenyl-substituted cyclic ketoenols of the formula (I) in which A, B, G, X, Y, Z and W are each as defined in the description, to processes and intermediat... | 09/19/2006 |
| 7078564 | Process for the preparation of ωbenzyl esters of amino diacids and of alkanesulphonates of these esters, and these alkanesulphonates The invention relates to a process for the preparation of an ω-benzyl ester of an amino diacid, characterized in that the amino diacid is reacted with a benzyl alcohol derivative of formula (I) in which the R1 | 07/18/2006 |
| 7071350 | Method of introducing amino group and method of synthesizing amino acid compound The present invention relates to a method for introducing an amino group into an organic acid or an organic ester by reacting an organic salt or an organic ester and ammonia under high-temperature and high-pressure water conditions, a method for synthesizing an amin... | 07/04/2006 |
| 7060250 | Diagnostic imaging contrast agents with extended blood retention The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a ... | 06/13/2006 |
| 7026505 | Method of treating tinnitus The invention relates to a method of treating tinnitus by administering an alpha2delta ligand such as, for example, a compound of Formula and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen ... | 04/11/2006 |
| 7022875 | Thiobutacin and antifungal and antioomycete composition for controlling plant diseases using the same A novel antibiotic thiobutacin, obtainable from Lechevalieria aerocolonigenes strain VK-A9, and antifungal and antioomycete compositions comprising thiobutacin as an active ingredient for control of plant diseases, e.g., those attributable to pathogens such a... | 04/04/2006 |
| 7019165 | Polyoxometallate catalysts and catalytic processes An active and selective hydrocarbon partial oxidation catalyst comprises an activated partially-reduced polyoxometallate, preferably niobium polyoxomolybdate, that is prepared from a suitable polyoxoanion, which has been exchanged with a suitable cation and activate... | 03/28/2006 |
| 7005539 | Ferulic acid dimers and their pharmaceutically acceptable salts, their preparation and use thereof for treating dementia The present invention relates to ferulic acid dimers and their pharmaceutically acceptable salts, preparation method and use thereof for treating dementia, which have excellent effect on the learning and memory-retention ability in vivo, thus it can be use for demen... | 02/28/2006 |
